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Ultrasound in Obstetrics & Gynecology :... Apr 2019
Topics: Fatal Outcome; Female; Humans; Infant, Newborn; Myofibromatosis; Pregnancy; Ultrasonography, Prenatal; Young Adult
PubMed: 29749081
DOI: 10.1002/uog.19082 -
Hua Xi Kou Qiang Yi Xue Za Zhi = Huaxi... Oct 2020Infantile myofibromatosis is a rare benign childhood myofibroblastoma. A case of infantile myofibromatosis of the left mandible was reported, and relevant literature was...
Infantile myofibromatosis is a rare benign childhood myofibroblastoma. A case of infantile myofibromatosis of the left mandible was reported, and relevant literature was reviewed to discuss the clinical characteristics, pathogenesis, imaging characteristics, pathological characteristics, differential diagnosis, and the treatment of the tumor to improve the understanding of the tumor.
Topics: Child; Diagnosis, Differential; Humans; Mandible; Myofibromatosis; Neoplasms, Muscle Tissue
PubMed: 33085248
DOI: 10.7518/hxkq.2020.05.021 -
Zeitschrift Fur Geburtshilfe Und... Jun 2023Infantile myofibromatosis is a rare benign congenital tumour that often regresses spontaneously but may pose therapeutic challenges in its widespread visceral form. We...
Infantile myofibromatosis is a rare benign congenital tumour that often regresses spontaneously but may pose therapeutic challenges in its widespread visceral form. We present the case of a full-term neonate with generalized infantile myofibromatosis including ubiquitous subcutaneous and muscular nodules, a tumour in the mastoid and disseminated intestinal involvement. The intestinal tumours led to a mechanical ileus with intestinal perforation within the first days of life. After partial small bowel resection and necessary proximal jejunostomy the boy was dependent on total parenteral nutrition. Chemotherapy with vinblastine and methotrexate was started and was temporarily supplemented with imatinib. Feeding stayed impossible despite tumour shrinkage. At the age of 4.5 months, restoration of intestinal continuity with further stricturoplasties was performed which - for the first time - allowed complete oral feeding. Chemotherapy was continued for further two months. Currently, the child is in good general condition with growth and further disease regression. This report suggests that massive visceral involvement of infantile myofibromatosis may require extensive intestinal surgery, as conservative therapy cannot resolve the disease and its sequelae.
Topics: Infant, Newborn; Male; Child; Humans; Infant; Myofibromatosis; Imatinib Mesylate
PubMed: 36921614
DOI: 10.1055/a-2018-5454 -
Annales de Dermatologie Et de... Mar 2005
Review
Topics: Adult; Child; Diagnosis, Differential; Humans; Immunohistochemistry; Myofibroma; Myofibromatosis
PubMed: 15924056
DOI: 10.1016/s0151-9638(05)79263-2 -
Anales de Pediatria (Barcelona, Spain :... Jul 2015
Topics: Humans; Infant, Newborn; Male; Myofibromatosis; Soft Tissue Neoplasms
PubMed: 25616547
DOI: 10.1016/j.anpedi.2014.12.007 -
Journal of Clinical Periodontology Nov 2002This case report describes a rare benign tumour, which presented as discrete areas of gingival hyperplasia affecting both the mandible and the maxilla. (Review)
Review
BACKGROUND
This case report describes a rare benign tumour, which presented as discrete areas of gingival hyperplasia affecting both the mandible and the maxilla.
METHOD
Surgical excision of the lesions was carried out under local anaesthetic. Histopathological examination confirmed the diagnosis of oral myofibromatosis.
RESULTS
The condition responded to surgical excision and appears to have limited growth potential. It affects a wide spectrum of ages and can be alarming due to rapid enlargement and ulceration, so careful diagnosis is important to avoid unnecessary aggressive treatment.
Topics: Actins; Adolescent; Diagnosis, Differential; Fibroblasts; Gingival Hyperplasia; Gingival Neoplasms; Humans; Male; Muscle, Smooth; Myofibromatosis
PubMed: 12472999
DOI: 10.1034/j.1600-051x.2002.291111.x -
Dermatologic Surgery : Official... Apr 2023
Topics: Humans; Myofibromatosis
PubMed: 36943733
DOI: 10.1097/DSS.0000000000003731 -
Annales de Dermatologie Et de... 1992
Review
Topics: Female; Fibroma; Humans; Infant, Newborn; Microscopy, Electron; Myofibrils; Neoplasms, Multiple Primary; Skin Neoplasms
PubMed: 1301684
DOI: No ID Found -
The Turkish Journal of Pediatrics 2000An autopsy case of congenital infantile myofibromatosis and neonatal hemochromatosis is reported. A thirty-six-hour-old baby girl had multiple subcutaneous nodules in... (Review)
Review
An autopsy case of congenital infantile myofibromatosis and neonatal hemochromatosis is reported. A thirty-six-hour-old baby girl had multiple subcutaneous nodules in addition to multiple visceral involvement of heart, lungs, pharynx, larynx, stomach, small bowel, large bowel, pancreas, kidneys, spleen, thyroid, adrenal glands, lymph nodes, peripheral nerves, meninges and soft tissues. In these tumoral nodules, three types of histological patterns were observed: 1-hemangiopericytoma-like, 2-mixed, and 3-pure spindle cell. Tumor cells were immunohistochemically positive for actin, and negative for desmin, muscle-specific antigen, and estrogen, related protein. The histological and immunohistochemical findings of the case suggested that a close relationship may exist between infantile myofibromatosis and infantile hemangiopericytoma. In addition to infantile myofibromatosis, neonatal hemochromatosis characterized by iron deposition in parenchymatous organs such as liver, pancreas, lungs, thyroid, and adrenal glands was another important characteristic of the case.
Topics: Fatal Outcome; Female; Hemochromatosis; Humans; Immunohistochemistry; Infant, Newborn; Iron Overload; Liver Diseases; Myofibromatosis
PubMed: 11196755
DOI: No ID Found -
American Journal of Medical Genetics.... Apr 2004We present three families with infantile myofibromatosis (IM; OMIM no. 228550) inherited in an autosomal dominant (AD) manner. These three pedigrees prompted... (Comparative Study)
Comparative Study Review
We present three families with infantile myofibromatosis (IM; OMIM no. 228550) inherited in an autosomal dominant (AD) manner. These three pedigrees prompted re-assessment of pedigrees available within the genetic, oncologic, surgical, and pathologic literature, which suggest autosomal recessive (AR) inheritance. All familial IM may be interpreted as AD or, alternatively, there may be genetic heterogeneity for IM. As most nodules tend to regress spontaneously, familial history may be difficult to obtain and/or confirm. Clinical diagnosis and establishment of inheritance pattern can be important for prognosis and the recognition that other family members may be affected.
Topics: Adult; Child, Preschool; Female; Genes, Dominant; Humans; Infant; Infant, Newborn; Male; Myofibromatosis; Pedigree; Phenotype; Skin Neoplasms
PubMed: 15054839
DOI: 10.1002/ajmg.a.20598