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Medicine Dec 2017Malignant myopericytoma is extremely rare, with a few cases described in the English literature. (Review)
Review
RATIONALE
Malignant myopericytoma is extremely rare, with a few cases described in the English literature.
PATIENT CONCERNS
This novel study aimed to report a case of malignant myopericytoma with cancer cachexia arising in the left armpit. Also, it presented a review of the English literature regarding primary malignant myopericytoma, aiming to clarify the clinical features and potentially curative treatment. A 56-year-old male presented with an ulcerated and smelly mass involving her left armpit. The patient had obvious symptoms of cancer cachexia, including emaciation, anemia, and lower extremity edema.
DIAGNOSES
Computer tomography (CT) scan demonstrated a mass in the left armpit, with no evidence of metastasis according to the chest CT, abdominal ultrasound, and emission CT. The patient underwent a core biopsy of the mass, and a diagnosis of malignant myopericytoma was rendered.
INTERVENTIONS
He received 2 standard courses of theprubicin combined with ifosfamide chemotherapy regimen with no tumor response. Then, he subsequently underwent complete excision of the tumor.
OUTCOMES
The symptoms of cancer cachexia disappeared gradually after operation. Recurrence and metastasis were not shown during follow-up for 5 years.
LESSONS
Myopericytoma are generally considered benign with an indolent clinical course, and a few reports have described malignant myopericytoma in the literature. No standard treatment is available, and complete surgical excision of the lesion may be the only potentially curative treatment. The efficacy of chemotherapy and radiation is uncertain.
Topics: Axilla; Biopsy; Cachexia; Hemangiopericytoma; Humans; Male; Middle Aged; Tomography, X-Ray Computed
PubMed: 29245316
DOI: 10.1097/MD.0000000000009064 -
Frontiers in Oncology 2022Myopericytoma (MPC) is a benign soft tissue tumor that develops from perivascular myoid cells and is part of the perivascular tumor group. MPC most commonly occurs in...
Myopericytoma (MPC) is a benign soft tissue tumor that develops from perivascular myoid cells and is part of the perivascular tumor group. MPC most commonly occurs in the subcutaneous soft tissues of the extremities, while intracranial MPC is remarkably rare. Herein, we report the case of a 45-year-old woman with myopericytoma who had a 2-week history of recurrent dizziness. Magnetic resonance imaging (MRI) revealed an irregular mass in the pons, with nodular enhancement of the mass on contrast-enhanced scans. The mass was considered a vascular lesion and was highly suspected to be a hemangioblastoma, prompting surgical intervention for the patient. The postoperative pathological report corrected the initial diagnosis, hemangioblastoma, to MPC. Intracranial MPC is extremely rare and there are no detailed imaging sources for this condition; furthermore, MPC occurrence in the pons has not been reported previously. This report presents the etiological characteristics intracranial MPC as visualized through MRI data alongside a comparative discussion on other reported diagnoses that resemble MPC. The case findings will provide a more widespread understanding for radiologists regarding the differential diagnosis of intracranial blood-rich supply lesions.
PubMed: 35651813
DOI: 10.3389/fonc.2022.903655 -
Medicine Apr 2021Myopericytoma of the parotid gland is a rare condition of which preoperative definitive diagnosis is relatively challenging. The purpose of this case report is to... (Review)
Review
RATIONALE
Myopericytoma of the parotid gland is a rare condition of which preoperative definitive diagnosis is relatively challenging. The purpose of this case report is to highlight the radiologic features of myopericytoma of parotid gland.
PATIENT CONCERNS
A 62-year-old man presented with a history of a walnut-size mass in left parotid gland when yawned for half-month, and a 48-year-old woman complaint about a grape-size, painless mass behind the right ear for a month.
DIAGNOSES
Radiological examinations suggested that both lesions were cyst-solid mixed lesions with relatively smoothed margins, with or without significant enhancement while the lesion without enhancement had a hemorrhage. Then a diagnosis of benign tumor arising from the parotid gland was made. Final diagnosis of myopericytoma was confirmed by histopathological and immunohistochemical examinations after surgical resection.
INTERVENTIONS
Both patients underwent excision of the tumor and the superficial parotidectomy with facial nerve preservation.
OUTCOMES
Both patients recovered without any intraoperative or postoperative complication and had no signs of recurrence during a 17-month and 5-year follow-up.
LESSONS
Parotid gland myopericytoma is an exceedingly rare tumor which diagnosis can be challenging, and this is the first published report specifying the magnetic resonance features of the disease.
Topics: Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Myopericytoma; Parotid Neoplasms; Tomography, X-Ray Computed
PubMed: 33832162
DOI: 10.1097/MD.0000000000025471 -
Medical Ultrasonography May 2022
Topics: Humans; Myopericytoma
PubMed: 35617613
DOI: 10.11152/mu-3631 -
Respiratory Medicine Case Reports 2021Myopericytoma is a benign neoplasm presenting cells with different shapes, from oval to spindle, and myoid showing with perivascular growth, which frequently originates...
Myopericytoma is a benign neoplasm presenting cells with different shapes, from oval to spindle, and myoid showing with perivascular growth, which frequently originates from the skin and soft tissues of distal extremities, trunk, head, and neck regions. These tumors rarely have been reported to occur in visceral sites. There is only one case of myopericytoma showing pulmonary involvement with multiple nodules. Although most myopericytomas behave in a benign manner, some cases of malignant myopericytoma arising in both superficial soft tissue and visceral locations have been described. We describe two cases of pulmonary tumors with myopericytoma-like features.
PubMed: 33614407
DOI: 10.1016/j.rmcr.2021.101355 -
The Journal of Foot and Ankle Surgery :... Jul 2019Myopericytoma is a rare soft tissue tumor found in the subcutaneous and superficial soft tissues in the extremities. The present study reports a unique case of...
Myopericytoma is a rare soft tissue tumor found in the subcutaneous and superficial soft tissues in the extremities. The present study reports a unique case of myopericytomas found in the first and second toes of a patient. The masses were surgically excised, and on pathologic and immunohistochemical examination, the diagnosis of myopericytoma was made. At the follow-up visit, the patient had no recurrence of the soft tissue tumor.
Topics: Female; Foot Diseases; Humans; Magnetic Resonance Imaging; Middle Aged; Myopericytoma; Toes
PubMed: 31079984
DOI: 10.1053/j.jfas.2018.11.026 -
Journal of Cutaneous Pathology Oct 2002Myopericytoma is a benign tumor composed of cells that show apparent differentiation towards putative perivascular myoid cells called myopericytes. It arises most...
BACKGROUND
Myopericytoma is a benign tumor composed of cells that show apparent differentiation towards putative perivascular myoid cells called myopericytes. It arises most commonly in the dermis or subcutaneous tissue of the extremities in adults.
METHODS
We describe a myopericytoma that was unusual in its intravascular location.
RESULTS
A 54-year-old man presented with a 10-year history of a painful slowly growing 1.5-cm nodule in the subcutaneous tissue of the thigh. Histologic examination of the excised lesion showed that is was entirely contained within the lumen of a vein. It was composed of a proliferation of myoid-appearing spindle cells, which were arranged in a striking concentric pattern around numerous blood vessels, in a manner that accentuated the vessel walls. This pattern is characteristic of myopericytoma. In some areas, fascicles of spindle cells, embedded in a myxoid stroma, bulged into the lumina of lesional vessels, reminiscent of myofibroma/myofibromatosis. Lesional spindle cells were diffusely positive for smooth muscle actin, focally positive for CD34 and were negative for desmin, cytokeratin, S100 protein, HMB-45 and CD31.
CONCLUSION
This case illustrates that myopericytoma can be entirely intravascular in its location.
Topics: Biomarkers, Tumor; Humans; Immunoenzyme Techniques; Male; Middle Aged; Myoma; Neoplasm Proteins; Neoplasms, Vascular Tissue; Pericytes; Soft Tissue Neoplasms; Subcutaneous Tissue
PubMed: 12358814
DOI: 10.1034/j.1600-0560.2002.290908.x -
Medicine Mar 2015Intravascular myopericytoma (IVMP), regarded as a variant of myopericytoma, is a rare tumor. Very few cases have been described, none in the foot.The first case of IVMP... (Review)
Review
Intravascular myopericytoma (IVMP), regarded as a variant of myopericytoma, is a rare tumor. Very few cases have been described, none in the foot.The first case of IVMP located in the heel of the foot is described in this article. A literature review is reported of all cases of IVMP published in the English literature.A 48-year-old man possessed an IVMP on the heel of the right foot. The physical examination and histopathological and ultrasound studies are described. The literature review yielded 5 cases of IVMP, 2 of which were in the thigh and 1 each in the oral mucosa, the periorbital region, and the leg.The possibility that these lesions may be malignant suggests that the histopathological study of vascular tumors should include immunohistochemical tests.
Topics: Heel; Humans; Male; Middle Aged; Neoplasms, Connective and Soft Tissue; Vascular Neoplasms
PubMed: 25789958
DOI: 10.1097/MD.0000000000000642 -
Child's Nervous System : ChNS :... Mar 2022Myopericytomas are benign soft tissue tumors which are rarely found as intracranial masses. (Review)
Review
BACKGROUND
Myopericytomas are benign soft tissue tumors which are rarely found as intracranial masses.
METHODS
A review of SCOPUS and PubMed databases for case reports and case series was done for patients with intracranial myopericytomas. Data on demographics, clinical features, imaging, surgical management employed, and outcomes were collected.
RESULTS
We found a total of 9 cases in the literature and we describe an additional case from our own experience. The mean age at presentation was 50.1 years (32-64 years), with a female predominance. Most tumors were in the posterior fossa and were multifocal in AIDS patients. The most common clinical manifestations were visual disturbances, headaches, and vomiting. An association with EBV was reported in two cases and was also found in our own case. Gross total excision and even subtotal excision were definitive therapies with no recurrences reported with a mean follow-up of 22.7 months. Our case is the first EBV-associated intracranial myopericytoma in a child.
CONCLUSION
Intracranial myopericytomas are rare; some have an association with EBV and immunodeficient states. Surgery is the only necessary treatment and outcomes are generally favorable for these benign neoplasms.
Topics: Brain Neoplasms; Child; Epstein-Barr Virus Infections; Female; Herpesvirus 4, Human; Humans; Male; Myopericytoma; Soft Tissue Neoplasms
PubMed: 34104988
DOI: 10.1007/s00381-021-05220-w -
Cureus Jan 2022Myopericytoma (MPC) is an uncommon benign neoplasm of the skin and soft tissues belonging to a spectrum of tumors that are histologically recognized by their distinctive...
Myopericytoma (MPC) is an uncommon benign neoplasm of the skin and soft tissues belonging to a spectrum of tumors that are histologically recognized by their distinctive perivascular myoid cell differentiation. These distinct tumors are more prevalent among middle-aged males, and they arise more frequently in the subcutaneous tissue of the four extremities. In this paper, myopericytoma is reported in a 59-year-old Saudi male, presented with a painless small cyst involving the left ankle suspected clinically to be a ganglion cyst. Following surgical excision of the cyst, the diagnosis of myopericytoma was made based on the histopathological pattern of the disease. This paper focuses on the clinical and histopathological findings of myopericytoma and emphasizes the importance of immunohistochemistry as well as molecular testing in reaching the final diagnosis.
PubMed: 35186568
DOI: 10.7759/cureus.21307