Did you mean: myositis ossificans
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The Journal of the American Academy of... Oct 2015Myositis ossificans is a self-limiting, benign ossifying lesion that can affect any type of soft tissue, including subcutaneous fat, tendons, and nerves. It is most... (Review)
Review
Myositis ossificans is a self-limiting, benign ossifying lesion that can affect any type of soft tissue, including subcutaneous fat, tendons, and nerves. It is most commonly found in muscle as a solitary lesion. Ossifying soft-tissue lesions historically have been inconsistently classified. Fundamentally, myositis ossificans can be categorized into nonhereditary and hereditary types, with the latter being a distinct entity with a separate pathophysiology and treatment approach. The etiology of myositis ossificans is variable; however, clinical presentation generally is characterized by an ossifying soft-tissue mass. Advanced cross-sectional imaging alone can be nonspecific and may appear to be similar to more sinister etiologies. Therefore, the evaluation of a suspicious soft-tissue mass often necessitates multiple imaging modalities for accurate diagnosis. When imaging is indeterminate, biopsy may be required for a histologic diagnosis. However, histopathology varies based on stage of evolution. The treatment of myositis ossificans is complex and is often made in a multidisciplinary fashion because accurate diagnosis is fundamental to a successful outcome.
Topics: Biopsy; Diagnosis, Differential; Diagnostic Imaging; Humans; Myositis Ossificans; Soft Tissue Neoplasms
PubMed: 26320160
DOI: 10.5435/JAAOS-D-14-00269 -
JCI Insight Jul 2022Heterotopic ossification (HO) is the formation of ectopic bone that is primarily genetically driven (fibrodysplasia ossificans progressiva [FOP]) or acquired in the... (Review)
Review
Heterotopic ossification (HO) is the formation of ectopic bone that is primarily genetically driven (fibrodysplasia ossificans progressiva [FOP]) or acquired in the setting of trauma (tHO). HO has undergone intense investigation, especially over the last 50 years, as awareness has increased around improving clinical technologies and incidence, such as with ongoing wartime conflicts. Current treatments for tHO and FOP remain prophylactic and include NSAIDs and glucocorticoids, respectively, whereas other proposed therapeutic modalities exhibit prohibitive risk profiles. Contemporary studies have elucidated mechanisms behind tHO and FOP and have described new distinct niches independent of inflammation that regulate ectopic bone formation. These investigations have propagated a paradigm shift in the approach to treatment and management of a historically difficult surgical problem, with ongoing clinical trials and promising new targets.
Topics: Bone and Bones; Humans; Myositis Ossificans; Ossification, Heterotopic
PubMed: 35866484
DOI: 10.1172/jci.insight.158996 -
Pediatric Endocrinology Reviews : PER Jun 2013Fibrodysplasia ossificans progressiva (FOP), a rare and disabling genetic condition characterized by congenital malformations of the great toes and progressive... (Review)
Review
Fibrodysplasia ossificans progressiva (FOP), a rare and disabling genetic condition characterized by congenital malformations of the great toes and progressive heterotopic endochondral ossification (HEO) which is the most catastrophic of HEO disorders in humans. Flare-ups of FOP are episodic; immobility is cumulative. Heterozygous activating mutations in activin receptor IA/activin-like kinase-2 (ACVRI/ ALK2), a bone morphogenetic protein (BMP) type I receptor, exist in all sporadic and familial cases of FOP. The discovery of the FOP gene established a critical milestone in our understanding of FOP, and revealed a highly conserved therapeutic target in the BMP signaling pathway. This discovery has advanced efforts to develop novel therapies for this disabling disorder of tissue metamorphosis. While effective treatment of FOP will likely be based on interventions that modulate overactive ACVR1/ALK2 signaling, or that specifically block postnatal HEO, current management is focused on early diagnosis, assiduous avoidance of injury or iatrogenic harm, symptomatic amelioration of painful flare-ups, and optimization of residual function.
Topics: Animals; Disease Models, Animal; Humans; Myositis Ossificans
PubMed: 23858627
DOI: No ID Found -
Journal of Manipulative and... 1990Myositis ossificans is a fairly common disorder that typically involves progressive heterotropic bone formation. A typical case is discussed in this paper. The... (Review)
Review
Myositis ossificans is a fairly common disorder that typically involves progressive heterotropic bone formation. A typical case is discussed in this paper. The radiographic findings in myositis ossificans are relevant in differentiating it from a malignant bone tumor and a benign process. Myositis ossificans can cause impairment to a joint with poor rehabilitative results. Limitation of joint function and little reabsorption of the heterotopic bone formation is common. Most cases are posttraumatically related with the brachialis and the quadricep femoris muscles frequently involved. This is especially true for sport injuries.
Topics: Hematoma; Humans; Male; Middle Aged; Myositis Ossificans; Radiography; Thigh
PubMed: 2203862
DOI: No ID Found -
Seminars in Musculoskeletal Radiology Jun 2010Myositis ossificans (MO) is characterized by abnormal heterotopic bone formation involving striated muscle, tendons, ligaments, fasciae, and aponeuroses. Myocardium, the... (Review)
Review
Myositis ossificans (MO) is characterized by abnormal heterotopic bone formation involving striated muscle, tendons, ligaments, fasciae, and aponeuroses. Myocardium, the diaphragm, tongue, larynx, smooth muscle, and sphincters are all spared. Several subtypes of myositis ossificans exist: posttraumatic myositis ossificans (PTMO), nontraumatic/pseudomalignant myositis ossificans, and myositis ossificans progressiva (MOP). This article reviews the clinical features and differential diagnoses of each subtype of MO and illustrates the typical imaging features demonstrated by plain radiography, ultrasound, radionuclide bone scans, computed tomography, and magnetic resonance imaging.
Topics: Diagnosis, Differential; Diagnostic Imaging; Disease Progression; Humans; Myositis Ossificans; Prognosis
PubMed: 20486028
DOI: 10.1055/s-0030-1253161 -
Pediatric Radiology Mar 2022Myositis ossificans is a benign, ossifying, soft-tissue pseudotumor that most commonly occurs in men ages 30-40 years after trauma. Myositis ossificans may also occur...
Myositis ossificans is a benign, ossifying, soft-tissue pseudotumor that most commonly occurs in men ages 30-40 years after trauma. Myositis ossificans may also occur in children, but it is extremely rare in those younger than 10 years of age. While myositis ossificans can often mimic malignant soft-tissue tumors, it has many unique findings that can aid in diagnostic differentiation. This differentiation is critical to avoid unnecessary risk with potentially harmful procedures. We present a very unusual presentation of myositis ossificans in the immediate post-birth perinatal period, as well as a review of key imaging findings.
Topics: Adult; Child; Humans; Infant, Newborn; Magnetic Resonance Imaging; Male; Myositis Ossificans; Sarcoma; Soft Tissue Neoplasms
PubMed: 34601621
DOI: 10.1007/s00247-021-05204-7 -
Journal of Clinical Rheumatology :... Jun 2022
Topics: Humans; Myositis Ossificans; Sciatica
PubMed: 32101909
DOI: 10.1097/RHU.0000000000001344 -
European Journal of Orthopaedic Surgery... May 2017The formation of lamellar bone in the soft tissues, where bone normally does not exist, is called myositis ossificans. However, it would be more accurate to describe as...
The formation of lamellar bone in the soft tissues, where bone normally does not exist, is called myositis ossificans. However, it would be more accurate to describe as myositis ossificans the involvement of skeletal muscles and as ectopic or heterotopic ossification the involvement of soft tissues in general. The lesion is subdivided in genetic and non-genetic or acquired types. Myositis or fibrodysplasia ossificans progressiva is a debilitating rare genetic disorder. Clinical suspicion of the disease in the newborn on the basis of malformed great toes may lead to early clinical diagnosis, confirmatory diagnostic genetic testing and avoidance of iatrogenic harmful procedures. Acquired lesions involve the neurogenic myositis ossificans and the non-neurogenic disorder. The latter is defined either as circumscribed myositis ossificans that is post-traumatic or as idiopathic/pseudomalignant myositis ossificans that is non-traumatic and may be a form fruste of fibrodysplasia ossificans progressiva. Ossification in fibrodysplasia ossificans progressiva is irreversible, unlike other forms of heterotopic ossification. In this retrospective study, a total of 22 children with myositis ossificans treated in a 20-year period were identified and classified. Two patients were diagnosed with myositis/fibrodysplasia ossificans progressiva, one with neurogenic myositis ossificans, one with idiopathic/pseudomalignant myositis ossificans and 18 patients with circumscribed myositis ossificans. The clinical features, imaging and histological findings as well as treatment modalities and complications of myositis ossificans in our patients are presented and discussed.
Topics: Age Factors; Biopsy, Needle; Child; Child, Preschool; Cohort Studies; Conservative Treatment; Databases, Factual; Disease Progression; Early Diagnosis; Female; Follow-Up Studies; Genetic Predisposition to Disease; Humans; Immunohistochemistry; Infant; Infant, Newborn; Magnetic Resonance Imaging; Male; Monitoring, Physiologic; Myositis Ossificans; Orthopedic Procedures; Retrospective Studies; Risk Assessment; Severity of Illness Index; Sex Factors; Tomography, X-Ray Computed
PubMed: 28275867
DOI: 10.1007/s00590-017-1932-x -
Orthopaedic Review Nov 1992Myositis ossificans is a benign condition of heterotopic bone formation. It is a generalized term for four separate clinical entities. Although not a rare disease... (Review)
Review
Myositis ossificans is a benign condition of heterotopic bone formation. It is a generalized term for four separate clinical entities. Although not a rare disease process, diagnosis often remains difficult. This article reviews the various forms of myositis ossificans, as well as the pathology, diagnostic tests, and treatment options.
Topics: Adolescent; Adult; Child; Contusions; Diagnosis, Differential; Humans; Myositis Ossificans; Radiography; Soft Tissue Neoplasms
PubMed: 1461667
DOI: No ID Found -
Revista Medica Del Instituto Mexicano... Feb 2022Myositis ossificans progressiva (MOP) is a low prevalence hereditary connective tissue disease (1:2,000,000 habitants). It is characterized by heterotopic ossification...
BACKGROUND
Myositis ossificans progressiva (MOP) is a low prevalence hereditary connective tissue disease (1:2,000,000 habitants). It is characterized by heterotopic ossification with an uncertain behavior that has been exceptionally related to neoplasms. The objective was to know the coexistence of MOP with neoplasms of mesodermal origin, so that they can be considered in the diagnosis of other patients, as well as formulate hypotheses to clarify their association.
CLINICAL CASE
27-year-old female with right gluteal and ischitiobial muscle pain that increased with exercise, without remission with analgesics until limiting the mobility of both extremities. A bone series was requested where areas of heterogeneous radiolucency were evidenced in the region of, both, thighs and pelvis in an irregular manner, similar to bone density, which was compatible with the ultrasound and tomographic findings; we concluded that they were images of myositis ossificans of the hip. The patient reported gastric symptoms and an endoscopy was requested, which histopathologically reported diffuse gastric carcinoma with signet ring cells; cabinet images showed an ovarian tumor.
CONCLUSION
MOP is a low prevalence disease, which is why its knowledge and suspicion are essential for the diagnosis. We found little literature that involves the three entities; therefore, their pathophysiology and understanding is limited. Regarding MOP, at this moment there is no curative treatment; however, an accurate diagnosis allows to start rehabilitation in a timely manner with an improvement in the quality of life.
Topics: Adult; Connective Tissue Diseases; Exercise; Female; Humans; Myositis Ossificans; Quality of Life; Tomography, X-Ray Computed
PubMed: 35274918
DOI: No ID Found