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Canadian Medical Association Journal Jan 1977
Topics: Adolescent; Athletic Injuries; Child; Forearm Injuries; Hockey; Humans; Leg Injuries; Male; Myositis Ossificans; Radiography; Thigh
PubMed: 832222
DOI: No ID Found -
Canadian Journal of Sport Sciences =... Mar 1989Myositis ossificans traumatica (MOT) is often encountered by young male athletes participating in contact sports. The purpose of this paper is to review this disorder,... (Review)
Review
Myositis ossificans traumatica (MOT) is often encountered by young male athletes participating in contact sports. The purpose of this paper is to review this disorder, characterized by a localized bone formation within muscle and other connective tissues as a result of a single or repeated contusion. MOT merits close attention because it may cause protracted disability and absence from competitive and recreational activities. Moreover, it may be mistaken for serious pathologies such as sarcoma. Confusion regarding the optimal management of MOT may also arise because the literature proposes conservative, experimental and surgical treatment approaches.
Topics: Adolescent; Adult; Athletic Injuries; Hematoma; Humans; Male; Muscular Diseases; Myositis Ossificans; Wounds, Nonpenetrating
PubMed: 2647253
DOI: No ID Found -
Biomolecules Mar 2024Heterotopic ossification (HO) is a debilitating pathology where ectopic bone develops in areas of soft tissue. HO can develop as a consequence of traumatic insult or as... (Review)
Review
Heterotopic ossification (HO) is a debilitating pathology where ectopic bone develops in areas of soft tissue. HO can develop as a consequence of traumatic insult or as a result of dysregulated osteogenic signaling, as in the case of the orphan disease fibrodysplasia ossificans progressiva (FOP). Traumatic HO (tHO) formation is mediated by the complex interplay of signaling between progenitor, inflammatory, and nerve cells, among others, making it a challenging process to understand. Research into the pathogenesis of genetically mediated HO (gHO) in FOP has established a pathway involving uninhibited activin-like kinase 2 receptor (ALK2) signaling that leads to downstream osteogenesis. Current methods of diagnosis and treatment lag behind pre-mature HO detection and progressive HO accumulation, resulting in irreversible decreases in range of motion and chronic pain for patients. As such, it is necessary to draw on advancements made in the study of tHO and gHO to better diagnose, comprehend, prevent, and treat both.
Topics: Humans; Myositis Ossificans; Ossification, Heterotopic; Osteogenesis; Bone and Bones
PubMed: 38540768
DOI: 10.3390/biom14030349 -
Calcified Tissue International Aug 1990Fibrodysplasia (myositis) ossificans progressiva (FOP) is a rare autosomal dominant disorder characterized by symmetrical congenital malformations of the blastemal... (Review)
Review
Fibrodysplasia (myositis) ossificans progressiva (FOP) is a rare autosomal dominant disorder characterized by symmetrical congenital malformations of the blastemal anlage of the hands and feet and by progressive heterotopic chondrogenesis and ossification of the soft connective tissues. There is neither an established pathogenesis nor an effective treatment for this disabling disorder. We reevaluated the published data on the natural history of FOP and discovered an array of developmental gradients (characteristic patterns of disease expression) similar to developmental anomalies induced by pleiotropic mutations of the decapentaplegic (dpp) locus in Drosophila melanogaster. The protein encoded by the dpp locus is a member of the transforming growth factor-beta (TGF-beta) family of molecules. It shares 75% sequence homology with the c-terminal region of two recently cloned human bone morphogenetic proteins (BMP-2A, BMP-2B), also members of the TGF-beta family. The striking sequence identity across so large an evolutionary distance suggests that the BMP-2 genes in man and the dpp gene in the fly may be derived from a common ancestral gene. BMP is the only molecule discovered thus far that is capable of inducing endochondral ossification in vivo. Expression of endochondral bone formation is the basis for limb formation in embryogenesis, longitudinal bone growth in postnatal life, and local bone regeneration (fracture healing) following injury. We believe that FOP is a genetic disorder characterized by a disturbed developmental expression of this endochondral program and may represent a mutation resulting in a dominant gain of function. The developmental similarities between decapentaplegic in the fly and FOP in man suggest a useful model for the study of FOP. The use of such a model might be especially fruitful in suggesting a molecular basis for FOP.
Topics: Animals; Disease Models, Animal; Drosophila melanogaster; Myositis Ossificans; Transforming Growth Factors
PubMed: 2117991
DOI: 10.1007/BF02555995 -
Wiadomosci Lekarskie (Warsaw, Poland :... 2003Myositis ossificans progressiva (MOP) is a rare hereditary connective tissue disorder. Skeletal abnormalities and progressive ectopic ossifications are features of this... (Review)
Review
Myositis ossificans progressiva (MOP) is a rare hereditary connective tissue disorder. Skeletal abnormalities and progressive ectopic ossifications are features of this condition. Diagnosis is often delayed because of heterogenous picture of MOP. Treatment is unknown, so MOP leads to prolonged disability.
Topics: Diagnosis, Differential; Humans; Myositis Ossificans
PubMed: 15058170
DOI: No ID Found -
Ryoikibetsu Shokogun Shirizu 2001
Review
Topics: Connective Tissue; Diagnosis, Differential; Disease Progression; Humans; Muscle, Skeletal; Myositis Ossificans; Prognosis
PubMed: 11555959
DOI: No ID Found -
The Journal of the Arkansas Medical... Dec 1977
Topics: Adolescent; Athletic Injuries; Football; Humans; Leg Injuries; Male; Myositis Ossificans; Wounds and Injuries
PubMed: 145428
DOI: No ID Found -
The Journal of Pathology and... Oct 1954
Topics: Humans; Myositis Ossificans
PubMed: 14354543
DOI: 10.1002/path.1700680210 -
The Journal of Craniofacial Surgery Sep 2012Myositis ossificans traumatica (MOT) is a disease in which muscular ossification develops following trauma. Almost all cases of MOT are found in skeletal muscle. The...
Myositis ossificans traumatica (MOT) is a disease in which muscular ossification develops following trauma. Almost all cases of MOT are found in skeletal muscle. The authors report in a 39-year-old man MOT involving several muscles in the head and neck, namely, bilateral masseter muscles, the left temporal muscle, the left lateral pterygoid muscle, and the left frontal muscle. Involvement of the lateral pterygoid muscle is especially rare.
Topics: Adult; Eyebrows; Facial Injuries; Humans; Male; Masticatory Muscles; Myositis Ossificans; Occlusal Splints; Rhinoplasty; Tomography, X-Ray Computed
PubMed: 22976727
DOI: 10.1097/SCS.0b013e31825b33de -
Reumatologia Clinica 2019
Topics: Adult; Diagnosis, Differential; Elbow; Female; Humans; Myositis Ossificans; Sarcoma; Soft Tissue Neoplasms
PubMed: 28641932
DOI: 10.1016/j.reuma.2017.05.007