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Journal of Zoo and Wildlife Medicine :... Sep 2016A 15-yr-old sexually intact female vampire bat ( Desmodus rotundus ) was diagnosed with myositis ossificans traumatica of the abdominal wall. The bat presented with a...
A 15-yr-old sexually intact female vampire bat ( Desmodus rotundus ) was diagnosed with myositis ossificans traumatica of the abdominal wall. The bat presented with a large ulcerated firm mass along the abdomen. Radiographs and cytology were performed, followed by surgical exploration. The mass was determined to be nonresectable and the bat was euthanized. Histopathology showed severe necrotizing, degenerative, and pyogranulomatous myositis with osseous and cartilaginous metaplasia, fibrosis, and ulceration, which were consistent with myositis ossificans traumatica. Myositis ossificans traumatica is commonly associated with previous trauma to skeletal muscle. Two years prior, this bat had an emergency Caesarian section at this site, which was postulated to elicit a marked tissue response leading to this condition. Myositis ossificans traumatica is infrequently reported in humans, dogs, cats, pigs, and horses. To the author's knowledge, this is the first report of this condition in a bat.
Topics: Animals; Chiroptera; Female; Myositis Ossificans; Postoperative Complications
PubMed: 27691970
DOI: 10.1638/2015-0289.1 -
Disease Models & Mechanisms Nov 2012Fibrodysplasia ossificans progressiva (FOP; MIM #135100) is a debilitating genetic disorder of connective tissue metamorphosis. It is characterized by malformation of... (Review)
Review
Fibrodysplasia ossificans progressiva (FOP; MIM #135100) is a debilitating genetic disorder of connective tissue metamorphosis. It is characterized by malformation of the great (big) toes during embryonic skeletal development and by progressive heterotopic endochondral ossification (HEO) postnatally, which leads to the formation of a second skeleton of heterotopic bone. Individuals with these classic clinical features of FOP have the identical heterozygous activating mutation (c.617G>A; R206H) in the gene encoding ACVR1 (also known as ALK2), a bone morphogenetic protein (BMP) type I receptor. Disease activity caused by this ACVR1 mutation also depends on altered cell and tissue physiology that can be best understood in the context of a high-fidelity animal model. Recently, we developed such a knock-in mouse model for FOP (Acvr1(R206H/+)) that recapitulates the human disease, and provides a valuable new tool for testing and developing effective therapies. The FOP knock-in mouse and other models in Drosophila, zebrafish, chickens and mice provide an arsenal of tools for understanding BMP signaling and addressing outstanding questions of disease mechanisms that are relevant not only to FOP but also to a wide variety of disorders associated with regenerative medicine and tissue metamorphosis.
Topics: Activin Receptors; Animals; Bone Development; Disease Models, Animal; Humans; Metamorphosis, Biological; Mutation; Myositis Ossificans
PubMed: 23115204
DOI: 10.1242/dmm.010280 -
Canadian Medical Association Journal Jan 1969
Topics: Humans; Metabolism, Inborn Errors; Myositis Ossificans
PubMed: 5762238
DOI: No ID Found -
Harefuah Dec 1998
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Foot & Ankle International Jan 1997Myositis ossificans is a non-neoplastic lesion characterized by heterotopic ossification of soft tissue. At varying stages of maturity, it shares similar histologic... (Review)
Review
Myositis ossificans is a non-neoplastic lesion characterized by heterotopic ossification of soft tissue. At varying stages of maturity, it shares similar histologic characteristics with sarcomatous lesions or maturing bone. Misdiagnosis can result in unnecessary radical treatment. This lesion has only rarely been reported in the foot. We present the case of a patient with plantar forefoot myositis ossificans.
Topics: Adolescent; Female; Foot Diseases; Humans; Myositis Ossificans
PubMed: 9013113
DOI: 10.1177/107110079701800108 -
AJR. American Journal of Roentgenology Dec 1991We reviewed retrospectively the MR images of eight histologically proved cases of myositis ossificans and correlated the MR appearance with the histologic findings, as...
We reviewed retrospectively the MR images of eight histologically proved cases of myositis ossificans and correlated the MR appearance with the histologic findings, as well as with other radiologic studies. Patients with available MR images were chosen from a group of 326 cases in our radiologic archives of histologically proved and radiologically correlated myositis ossificans. In addition to MR images, all patients had plain radiographs, six had CT scans, and two had arteriograms. On T2-weighted spin-echo MR, the lesions were relatively well defined and inhomogeneous and had intermediate to high signal intensity. The latter corresponded to a central proliferating core of fibroblasts and myofibroblasts with a myxoid stroma resembling nodular fasciitis, rimmed by osteoblasts with bone production. Edema surrounded lesions less than a few months old. T1-weighted images of early lesions were normal or showed evidence of a mass by displacement of fat planes. Hemorrhage and fluid-fluid levels were seen in one lesion of intermediate duration. Mature lesions tended to be well defined with inhomogeneous signal intensity, similar to that of fat, representing areas of fat situated between bone trabeculae within the lesion. We present the MR appearance of myositis ossificans and correlate it with other radiologic studies and the histologic findings. The varying appearance of myositis ossificans relates to the histologic changes that occur as the disorder progresses. Knowledge of the MR appearance of myositis ossificans is important in that the lesion has many of the MR imaging characteristics frequently associated with malignancy.
Topics: Adolescent; Adult; Aged; Child; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Myositis Ossificans; Retrospective Studies; Tomography, X-Ray Computed
PubMed: 1950874
DOI: 10.2214/ajr.157.6.1950874 -
Anales de Pediatria (Barcelona, Spain :... Nov 2006
Topics: Bone Morphogenetic Protein Receptors; Calcinosis; Child; Diagnosis, Differential; Female; Humans; Myositis Ossificans; Neck; Radiography; Scapula
PubMed: 17184619
DOI: 10.1157/13094262 -
The Annals of Otology, Rhinology, and... 1981Myositis ossificans traumatica is an uncommon disorder in which there is posttraumatic bone formation in muscle and other soft tissues near bone. The lesion is...
Myositis ossificans traumatica is an uncommon disorder in which there is posttraumatic bone formation in muscle and other soft tissues near bone. The lesion is exceedingly rare in the head and neck. A case is presented in which myositis ossificans of the platysma occurred following radical neck dissection. Because recurrence may follow excision of the abnormal bone, removal is recommended only if there are significant symptoms associated with the lesion. If surgery is indicated, it should be delayed for 6 to 12 months following the initial trauma to allow for maturation of the lesion.
Topics: Aged; Diagnosis, Differential; Humans; Male; Myositis Ossificans; Neck Dissection; Postoperative Complications
PubMed: 7224517
DOI: 10.1177/000348948109000215 -
The American Journal of Sports Medicine 1980Myositis ossificans is a benign condition resulting from severe muscular contusion manifested by heterotrophic bone formation. The process is common in the anterior...
Myositis ossificans is a benign condition resulting from severe muscular contusion manifested by heterotrophic bone formation. The process is common in the anterior thigh but the literature dealing with myositis ossificans in the upper arm is limited. Ten cases of the condition in the upper arm were seen in our practice. All 10 were the result of football injuries and exhibited one or more of the triad of local pain, a hard palpable mass in the muscle, and a flexion contracture of the elbow. Seven of the cases (70%) were asymptomatic or signficantly improved in less than 3 months with conservative nonoperative management. Three patients (30%) underwent surgery because the painful mass persisted. In two (66%) of the surgically managed cases, there was clinical and radiographic evidence of recurrence postoperatively in spite of delaying excision until radiographic parameters of maturation were present.
Topics: Adolescent; Adult; Arm; Athletic Injuries; Contusions; Football; Humans; Male; Myositis Ossificans; Radiography; Retrospective Studies
PubMed: 7435759
DOI: 10.1177/036354658000800607 -
Reumatologia Clinica 2014Fibrodysplasia ossificans progressiva is the most severe and disabling disorder of ectopic ossification in humans. It is characterized by congenital skeletal... (Review)
Review
Fibrodysplasia ossificans progressiva is the most severe and disabling disorder of ectopic ossification in humans. It is characterized by congenital skeletal abnormalities in association with extraskeletal widespread endochondral osteogenesis. Virtually all patients show the same mutation in the "Activin A type-I/activin-like kinase-2" receptor encoding gene. As a result of this discovery there have been significant advances in the knowledge of the cellular and molecular basis of the disease. Besides allowing a better understanding of ossification process, recent evidence indicates that the primary disturbance lies within basic mechanisms of cell differentiation that are key in several physiological pathways and in the genesis of diseases with a major impact on health. In this article we summarize these breakthroughs, with implications that go beyond the limits of this devastating disease to insinuate a new model of human pathophysiology.
Topics: Genetic Markers; Genetic Predisposition to Disease; Humans; Models, Biological; Mutation; Myositis Ossificans; Vascular Diseases
PubMed: 25107346
DOI: 10.1016/j.reuma.2014.05.001