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Archives of Dermatology Sep 1980
Topics: Adult; Humans; Hyperthyroidism; Leg Dermatoses; Male; Myxedema; Recurrence; Skin Transplantation; Transplantation, Autologous; Triamcinolone Acetonide
PubMed: 6998380
DOI: No ID Found -
Medicine Jun 2020Myxedema psychosis (MP) is a rare presentation of hypothyroidism. Although known for >70 years, a significant lack of systematic literature describing this condition...
BACKGROUND
Myxedema psychosis (MP) is a rare presentation of hypothyroidism. Although known for >70 years, a significant lack of systematic literature describing this condition exists. This limits the clinician's ability to identify and manage this entity properly. Hence, we aimed to systematically review the literature and summarize the presentation, diagnosis, management, and outcomes of this rare entity.
METHODS
Systematic review following PRISMA guidance. We will perform a comprehensive search of PubMed, Medline, Embase, Google Scholar (first 300 hits), and Cochrane databases for published observational studies, case series, and case reports. We will use descriptive statistics to provide summary estimates of demographics, common presenting features, laboratory test results, imaging findings, treatment administered, and outcomes. Moreover, continuous variables will be compared by the Wilcoxon Mann Whitney test, whereas categorical variables will be assessed by the χ test. Bivariate and multivariate regression will be performed to assess risk factors associated with poor outcome. A scoping review revealed that a meta-analysis might not be feasible owing to the paucity of systematic studies describing the condition.
RESULTS
This is the first systematic review examining this rare entity. Thus, the result of which will be significant. We hope that this review will help in identifying relevant predictive clinical or laboratory characteristics. Additionally, it identifies the best treatment strategies. The findings of this review will help increase our knowledge of this condition so as to recognize this condition promptly. Also, it will assist in differentiating MP from masqueraders, such as Hashimoto encephalopathy (HE). The results of this review will be published in a peer-reviewed journal.
CONCLUSION
This is the first systematic review exploring MP demographics, diagnosis treatment, and outcomes. The information gathered by this review will be necessary for patients, clinicians, researchers, and guideline makers.
PROSPERO REGISTRATION NUMBER
CRD42020160310.
Topics: Disease Management; Humans; Myxedema; Prognosis; Psychotic Disorders; Research Design; Systematic Reviews as Topic
PubMed: 32590756
DOI: 10.1097/MD.0000000000020778 -
The Journal of the Indiana State... Dec 1961
Topics: Electrocardiography; Myxedema
PubMed: 13893086
DOI: No ID Found -
The American Journal of Medicine Mar 2022
Topics: Coma; Humans; Hypothyroidism; Myxedema
PubMed: 34597614
DOI: 10.1016/j.amjmed.2021.08.034 -
International Journal of Dermatology Jan 2021
Topics: Graves Disease; Humans; Leg Dermatoses; Myxedema
PubMed: 32614072
DOI: 10.1111/ijd.15034 -
Saishin Igaku. Modern Medicine Mar 1970
Comparative Study Review
Topics: Diuretics; Heart Diseases; Humans; Myxedema; Thyroid Diseases; Thyroid Hormones; Thyronines; Thyroxine
PubMed: 4915819
DOI: No ID Found -
Harefuah May 1972
Review
Topics: Aged; Animals; Coma; Dogs; Humans; Hypothermia; Hypothyroidism; Myxedema; Thyroid Hormones; Ventilation
PubMed: 4557368
DOI: No ID Found -
Hormones (Athens, Greece) Mar 2018Pretibial myxedema (PM) is a rare extrathyroidal manifestation of Graves' disease (GD), usually during the hyperthyroid state, coexisting with orbitopathy. We describe a...
Pretibial myxedema (PM) is a rare extrathyroidal manifestation of Graves' disease (GD), usually during the hyperthyroid state, coexisting with orbitopathy. We describe a rare case of a biopsy-proven PM in a euthyroid patient, without history of GD or Hashimoto's thyroiditis. Assessment of commonly reported thyroid autoantibodies, such as thyroid peroxidase and thyroglobulin autoantibodies, thyroid stimulating immunoglobulins and thyroid binding inhibitory immunoglobulins, was negative. Resolution of skin pathology was achieved after topical application of corticosteroids and was sustained 1 year later.
Topics: Adrenal Cortex Hormones; Autoantibodies; Female; Humans; Leg Dermatoses; Middle Aged; Myxedema; Treatment Outcome
PubMed: 29858862
DOI: 10.1007/s42000-018-0008-6 -
Nihon Rinsho. Japanese Journal of... May 2006
Review
Topics: Autoantibodies; Humans; Immunoglobulins, Thyroid-Stimulating; Myxedema; Prognosis; Receptors, Thyrotropin; Thyroid Hormones; Thyroiditis, Autoimmune
PubMed: 16776158
DOI: No ID Found -
Deutsche Medizinische Wochenschrift... Mar 2018Thyroid storm and myxedema coma are the most severe clinical forms of thyroid dysfunction. While both hyper- and hypothyroidsm are common diseases, thyroid storm and...
Thyroid storm and myxedema coma are the most severe clinical forms of thyroid dysfunction. While both hyper- and hypothyroidsm are common diseases, thyroid storm and myxedema coma are rare. Due to their unspecific signs and symptoms they are often difficult to diagnose. Both disorders are medical emergencies, which still show a significant mortality. The following article summarizes diagnostic tools and treatment options for these disorders.
Topics: Coma; Humans; Myxedema; Thyroid Crisis
PubMed: 29544235
DOI: 10.1055/s-0043-111728