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Giornale Italiano Di Dermatologia E... Feb 2018
Topics: Female; Fibroma; Fingers; Humans; Middle Aged
PubMed: 29319280
DOI: 10.23736/S0392-0488.17.05443-8 -
Mayo Clinic Proceedings Jun 2017Aggressive fibromatosis, also known as desmoid-type fibromatosis (DTF) or desmoid tumor, is an uncommon locally invasive tumor. Because of its low incidence and variable... (Review)
Review
Aggressive fibromatosis, also known as desmoid-type fibromatosis (DTF) or desmoid tumor, is an uncommon locally invasive tumor. Because of its low incidence and variable behavior, DTF is often first seen by physicians who are not familiar with it, and recent advances in understanding this disease have led to changes in treatment approaches. The Wnt (β-catenin) pathway appears to play a key role in DTF pathogenesis, and recent studies of DTF biology suggest a possible model of DTF pathogenesis. Histologically, DTF shows a poorly circumscribed proliferation of myofibroblast-like cells with variable collagen deposition, similar to the proliferative phase of wound healing, and DTF has been associated with trauma and pregnancy. Desmoid-type fibromatosis may be a useful model of the tumor stroma in carcinomas as well as other fibrosing diseases such as progressive pulmonary fibrosis. The clinical course of DTF can vary greatly among patients, complicating the determination of the optimal treatment approach. Treatment options include surgery, nonsteroidal anti-inflammatory drugs with or without hormonal manipulation, chemotherapy, radiation therapy, and other forms of local therapy. Many treatments have been used, but these are not without toxicities. Because of the variable nature of the disease and the potential morbidity of treatment, some cases of DTF may do better without treatment; simple observation is often the best initial treatment. This review used a PubMed search from January 1, 1980, through October 31, 2016, using the terms fibromatosis and desmoid and discusses DTF disease characteristics, pathophysiology, and treatment options as well as examines several cases illustrating key points in the biology and treatment of this heterogeneous disease.
Topics: Fibroma; Humans; Mutation; beta Catenin
PubMed: 28578783
DOI: 10.1016/j.mayocp.2017.02.012 -
European Journal of Dermatology : EJD 2007
Topics: Female; Fibroma; Humans; Magnetic Resonance Imaging; Soft Tissue Neoplasms; Thoracic Wall; Tomography, X-Ray Computed
PubMed: 17337409
DOI: 10.1684/ejd.2007.0138 -
Journal of the American Academy of... Apr 1982
Topics: Adult; Aged; Female; Fibroma; Humans; Male; Middle Aged; Skin Neoplasms
PubMed: 7076901
DOI: 10.1016/s0190-9622(82)80362-9 -
Tumori Oct 1981A case of subscapular elastofibroma in a 61-year-old male was studied by light and electron microscopy. Sixty-two cases of this lesion have been to date reported. At...
A case of subscapular elastofibroma in a 61-year-old male was studied by light and electron microscopy. Sixty-two cases of this lesion have been to date reported. At light microscopy, the mass was unencapsulated and consisted of dense collagen bundles with many thick elastinophilic fibers and globules. The ultrastructural examination showed the fibers contained a clear core of mature elastic tissue surrounded by a more electron-dense fibrillar material, which was attributed to newly formed elastin. After elastase digestion, the fibers failed to stain with orcein. The cells were very scanty and identified as fibroblasts. The hypothesis formulated by various authors about the nature of elastinophilic fibers and about the pathogenesis of elastofibroma are reviewed. Our findings seems to support those of most authors, who consider the lesion an abnormally increased reactive production of elastic tissue by fibroblasts in response to a mechanical stimulus.
Topics: Fibroma; Humans; Male; Middle Aged; Shoulder
PubMed: 7324180
DOI: 10.1177/030089168106700519 -
The Annals of Thoracic Surgery Oct 2006A 29-year-old woman who presented with persistent ventricular premature beat during her delivery was referred to us. Her cardiac echocardiography showed a giant tumor...
A 29-year-old woman who presented with persistent ventricular premature beat during her delivery was referred to us. Her cardiac echocardiography showed a giant tumor located in the posterior wall of the left ventricle. She had no symptoms of heart failure. Partial resection of the mass was safely conducted using cardiopulmonary bypass. The histopathologic finding was fibroma. She has been doing well 6 years after operation. Periodic echocardiography has showed no growth in this tumor.
Topics: Adult; Female; Fibroma; Heart Neoplasms; Humans; Ultrasonography
PubMed: 16996969
DOI: 10.1016/j.athoracsur.2006.01.101 -
The Annals of Thoracic Surgery Jul 2006
Topics: Aged, 80 and over; Female; Fibroma; Heart Atria; Heart Neoplasms; Humans; Incidental Findings; Male; Middle Aged; Ultrasonography
PubMed: 16798262
DOI: 10.1016/j.athoracsur.2005.12.021 -
British Journal of Plastic Surgery Jun 2005Superficial acral fibromyxoma is a rare soft tissue tumour affecting the digits, particularly the nail bed region. The condition was first described in 2001. We report...
Superficial acral fibromyxoma is a rare soft tissue tumour affecting the digits, particularly the nail bed region. The condition was first described in 2001. We report the case of a 71-year-old man who presented with a long standing history of a lump affecting the pulp of the his right ring finger. This was surgically excised and subsequent pathological analysis confirmed the lesion to have been a superficial acral fibromyxoma. We use this case to highlight the features of this rare clinical entity, which has never previously been described in the surgical literature.
Topics: Aged; Fibroma; Fingers; Humans; Male; Soft Tissue Neoplasms
PubMed: 15897044
DOI: 10.1016/j.bjps.2004.03.006 -
Breast Disease 2023Desmoid fibroma (DF) is a disorder characterized by strong clonal proliferation of myofibroblasts and fibroblasts. We describe a case of DF that mimicked a breast tumor,... (Review)
Review
INTRODUCTION
Desmoid fibroma (DF) is a disorder characterized by strong clonal proliferation of myofibroblasts and fibroblasts. We describe a case of DF that mimicked a breast tumor, along with a review of the literature on the clinical manifestation, diagnostic process, and course of therapy for this combative disease.
CASE REPORT
A 34-year-old female patient with breast lump at the junction of the upper quadrants of the left breast. After the diagnosis of DF, it was decided to perform a sectorectomy of the left breast associated with post-quadrant reconstruction, with immunohistochemistry and findings compatible with DF.
DISCUSSION
Clinically manifests as a solid mass that is often painless and occasionally adherent to the chest wall. A treatment strategy should be idealized for each patient. Thus, there is the possibility of performing radical surgery for resection and/or radiotherapy, and surgery may be followed by radiotherapy.
Topics: Female; Humans; Adult; Fibromatosis, Aggressive; Breast Neoplasms; Fibroma; Thoracic Wall; Fibroblasts
PubMed: 37899051
DOI: 10.3233/BD-230028 -
Journal de Chirurgie Nov 1990Ledderhose's syndrome, or plantar fibromatosis, is a rare fibrous dystrophy and the plantar equivalent of Dupuytren's disease. It occurs mainly in adult subjects, as a... (Review)
Review
Ledderhose's syndrome, or plantar fibromatosis, is a rare fibrous dystrophy and the plantar equivalent of Dupuytren's disease. It occurs mainly in adult subjects, as a plantar fibrous nodule. The authors report 7 operated cases of Ledderhose's syndrome, including one in a 14-year-old adolescent. When the plantar nodule becomes symptomatic, surgery is the only means of treatment. Plantar aponeurotomy must then be as extensive as possible to prevent recurrent.
Topics: Adolescent; Adult; Dupuytren Contracture; Fascia; Fasciotomy; Female; Fibroma; Foot Diseases; HLA Antigens; Humans; Male; Middle Aged; Recurrence
PubMed: 2269689
DOI: No ID Found