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Revista Espanola de Cardiologia May 2002Myxomas are the most common type of primary cardiac tumors. The aim of this study was to analyze the clinical forms of presentation of cardiac myxoma, the postoperative...
INTRODUCTION AND OBJECTIVES
Myxomas are the most common type of primary cardiac tumors. The aim of this study was to analyze the clinical forms of presentation of cardiac myxoma, the postoperative evolution, and the possibility of recurrence and tumoral embolism.
PATIENTS AND METHOD
From July 1992 to March 1999, 31 patients with myxoma were studied. Cell cycles (ploidy pattern of the tumoral DNA) were studied in 12 patients to evaluate the risk of recurrence and tumoral embolism.
RESULTS
The most frequent clinical manifestations were constitutional symptoms (74%), dyspnea (45%), and embolism (41%). Smaller-diameter myxomas correlated independently with tumoral embolism (45%). The in-hospital mortality was 3.2%, no deaths were observed during follow-up (mean: 4.8 years). No patients had clinical or echocardiographic signs of tumoral recurrence. Patients with tumoral embolism (n = 8) were compared with patients without embolism (n = 4). Patients who suffered embolism had higher S phase > 7 and/or DNA index > 1.2 (4/4 patients [100%], p= 0.061) than patients without embolism (2/8 patients [25%]). Cytometry of the only recurrent tumor (second operation) revealed a diploid tumor with a significantly more frequent S phase (10%) than in sporadic myxomas (4.27 2.32%, p = 0.039).
CONCLUSIONS
Constitutional symptoms, dyspnea, and tumor embolism were the most frequent clinical manifestations. Clinical and anatomopathologic characteristics and the cell cycle were not significantly related to tumoral embolism, but there was a tendency toward a higher proportion of cells in S phase and a higher DNA index in tumors associated with embolism. The S phase was significantly more frequent in the only case of recurrent myxoma and could be a potential marker of recurrence.
Topics: Adult; Aged; DNA, Neoplasm; Female; Heart Neoplasms; Humans; Male; Middle Aged; Myocardium; Myxoma; Neoplastic Cells, Circulating; Recurrence; Retrospective Studies
PubMed: 12015931
DOI: 10.1016/s0300-8932(02)76643-8 -
Journal of Pediatric Hematology/oncology Feb 2005The authors report a case of a rare facial myxoma arising from the maxillary sinus in a 20-month-old child. The diagnosis was confirmed by a biopsy, and the patient...
The authors report a case of a rare facial myxoma arising from the maxillary sinus in a 20-month-old child. The diagnosis was confirmed by a biopsy, and the patient underwent a partial maxillectomy to achieve a total resection of the mass due to the locally aggressive nature of the lesion. Myxomas should be differentiated from malignant sarcomas, in particular embryonal rhabdomyosarcoma, which can arise from the same location and require multimodality therapy consisting of surgery, irradiation, and chemotherapy.
Topics: Biopsy; Diagnosis, Differential; Female; Humans; Infant; Maxillary Sinus Neoplasms; Myxoma
PubMed: 15701983
DOI: 10.1097/01.mph.0000153443.36193.de -
Echocardiography (Mount Kisco, N.Y.) Jan 2004Infected cardiac myxomas are extremely rare with only forty cases described in the literature. We report a case of an infected cardiac myxoma that presented in a manner...
Infected cardiac myxomas are extremely rare with only forty cases described in the literature. We report a case of an infected cardiac myxoma that presented in a manner similar to bacterial endocarditis. Our case is the first to be diagnosed using previously defined criteria, and is unusual in that transesophageal echocardiography was required to make the diagnosis.
Topics: Adult; Echocardiography, Transesophageal; Heart Neoplasms; Humans; Male; Myxoma; Staphylococcal Infections
PubMed: 14717724
DOI: 10.1111/j.0742-2822.2004.02177.x -
The American Journal of Case Reports Apr 2021BACKGROUND This report is of a nerve sheath myxoma presenting as a slow-growing mass in the back of the left ankle of a 36-year-old man that was investigated by...
BACKGROUND This report is of a nerve sheath myxoma presenting as a slow-growing mass in the back of the left ankle of a 36-year-old man that was investigated by ultrasound and magnetic resonance imaging (MRI) before the diagnosis was confirmed by histopathology. CASE REPORT We report a nerve sheath myxoma of the ankle in a 36-year-old man. The palpable abnormality was falsely assumed to be a ganglion cyst prior to advanced imaging. Magnetic resonance imaging demonstrated a lobular mass with high T2 and intermediate T1 signal as well as moderate enhancement. T2 sequences also demonstrated distinctive internal septae. These internal septae were also noted on sonographic evaluation prior to biopsy. The patient was treated with surgical excision, and pathologic analysis showed myxoid nodules with loose arrangements of spindled cells separated by fibrous septae. S-100 protein and glial fibrillary acidic protein positivity by immunohistochemistry staining was demonstrated. Follow-up imaging at 12 months showed no evidence of tumor recurrence. CONCLUSIONS This case highlights that while nerve sheath myxomas are rare tumors, they should be considered in cases of cutaneous soft-tissue masses with myxoid imaging features. Ultrasound and magnetic resonance imaging features of thin internal septae may be present and correspond well with the unique histopathological characteristics of these lesions. This report shows the importance of imaging of peripheral soft-tissue masses, including ultrasound and MRI, which can identify localized and benign features and the solid, cystic, and myxoid areas, which were characteristic in this case of benign nerve sheath myxoma.
Topics: Adult; Humans; Immunohistochemistry; Lower Extremity; Magnetic Resonance Imaging; Male; Myxoma; Neoplasm Recurrence, Local; Neurothekeoma
PubMed: 33814549
DOI: 10.12659/AJCR.927922 -
The Annals of Thoracic Surgery Sep 1997Myxomas rarely are located on the mitral valve. We report the case of a 44-year-old man operated on successfully with mitral valve conservation, which is the 21st case... (Review)
Review
Myxomas rarely are located on the mitral valve. We report the case of a 44-year-old man operated on successfully with mitral valve conservation, which is the 21st case of mitral valve myxoma reported in the western literature. Among the cases reported in the literature, the diagnosis was made at the time of autopsy in 6 cases, with premortem heart failure in 1 case. A clinical diagnosis was made in 15 cases on the basis of the following symptoms: peripheral embolism in 9 cases, cardiac signs in 4 cases, and constitutional manifestations in 2 cases. The clinical presentation of mitral valve myxoma differs slightly from that of other cardiac myxomas in that it has a lower incidence of constitutional manifestations. The gold standard for noninvasive diagnosis and localization of cardiac myxomas is transesophageal echocardiography. It allows for the detection of early, small valvular tumors and may help to characterize better their location and echostructure, facilitating the choice of an optimal surgical approach through preoperative study of the integrity and mobility of the valve. Conservative operative treatment by resection of the area of implantation of the myxoma followed by suture repair of the valve and annuloplasty may be recommended as the most appropriate treatment option for this rare condition.
Topics: Adult; Angiography, Digital Subtraction; Aortic Diseases; Echocardiography, Transesophageal; Heart Neoplasms; Humans; Iliac Artery; Male; Mitral Valve; Myxoma; Neoplastic Cells, Circulating; Patient Care Planning; Suture Techniques
PubMed: 9307503
DOI: 10.1016/s0003-4975(97)00695-4 -
Journal of Cardiac Surgery Feb 2020Cardiac myxomas (CM) is by far the most common type of primary cardiac neoplasm that commonly arise within the left atria and is composed of primitive connective tissue...
Cardiac myxomas (CM) is by far the most common type of primary cardiac neoplasm that commonly arise within the left atria and is composed of primitive connective tissue cells and stroma. Despite the benign nature, the CMs are often surgically removed because they can lead to severe complications. Large, thin, and hypermobile forms are unusual. The frequency of recurrence is about 22% for complex forms and 12% for other familial forms and 1% to 3% for sporadic myxomas, which seldom recur after surgery. Although transesophageal echocardiography shows usually accurate imaging capabilities to detect the myxoma, further imaging methods including computed tomography, cardiovascular magnetic resonance imaging, and F-fluorodeoxyglucose positron-emission tomography/computed tomography may be useful to diagnosis for it. Surgery is the mainstay of treatment.
Topics: Diagnosis, Differential; Echocardiography, Transesophageal; Female; Heart Atria; Heart Neoplasms; Humans; Middle Aged; Mitral Valve Annuloplasty; Myxoma; Neoplasm Recurrence, Local; Thrombosis
PubMed: 31794111
DOI: 10.1111/jocs.14391 -
The New England Journal of Medicine Dec 1995Although cardiac myxomas are histologically benign, they may be lethal because of their strategic position. They can mimic not only every cardiac disease but also... (Review)
Review
Although cardiac myxomas are histologically benign, they may be lethal because of their strategic position. They can mimic not only every cardiac disease but also infective, immunologic, and malignant processes. Myxomas must therefore be included in the differential diagnosis of valvular heart disease, cardiac insufficiency, cardiomegaly, bacterial endocarditis, disturbances of ventricular and supraventricular rhythm, syncope, and systemic or pulmonary embolism. The symptoms depend on the size, mobility, and location of the tumor. Echocardiography, including the transesophageal approach, is the most important means of diagnosis; CT and MRI may also be helpful. Coronary arteriography in patients over 40 years of age is generally required to rule out concomitant coronary artery disease. Surgical removal of the tumor should be performed as soon as possible; the long-term prognosis is excellent, and recurrences are rare. In follow-up examinations as well, echocardiography is essential.
Topics: Diagnosis, Differential; Echocardiography; Female; Heart Neoplasms; Humans; Magnetic Resonance Imaging; Myxoma; Neoplasm Recurrence, Local
PubMed: 7477198
DOI: 10.1056/NEJM199512143332407 -
The Journal of Heart and Lung... Aug 2007Myxomas are the most common primary cardiac tumors but their presence in the transplanted heart is extremely rare. We report a case of left atrial myxoma in a patient...
Myxomas are the most common primary cardiac tumors but their presence in the transplanted heart is extremely rare. We report a case of left atrial myxoma in a patient after heart transplantation. DNA analysis confirmed a donor origin. To our knowledge, this is the first report of myxoma of donor origin in a transplanted heart.
Topics: Diagnosis, Differential; Echocardiography, Transesophageal; Fatal Outcome; Follow-Up Studies; Heart Atria; Heart Failure; Heart Neoplasms; Heart Transplantation; Humans; Male; Middle Aged; Myxoma; Tissue Donors
PubMed: 17692794
DOI: 10.1016/j.healun.2007.05.021 -
Annals of Internal Medicine Sep 1975Two siblings 14 years apart were found to have atrial myxomas. The brother's right atrial myxoma was found at age 21 and his sister's left atrial myxoma, with peripheral...
Two siblings 14 years apart were found to have atrial myxomas. The brother's right atrial myxoma was found at age 21 and his sister's left atrial myxoma, with peripheral cerebral and coronary aneurysms, at age 30. Both tumors were excised successfully. These findings support previous reports suggesting that atrial myxoma may be familial. Echocardiography can be used effectively in the diagnosis of atrial myxoma, detection of its possible recurrence, and screening other members of the family.
Topics: Adult; Echocardiography; Female; Heart Atria; Heart Neoplasms; Humans; Male; Myxoma
PubMed: 1180432
DOI: 10.7326/0003-4819-83-3-358 -
Bulletin (Hospital For Joint Diseases... 1993Intramuscular myxoma is a distinct benign tumor confined to muscles. This tumor usually favors the thigh and shoulder. We are reporting a case of intramuscular myxoma of...
Intramuscular myxoma is a distinct benign tumor confined to muscles. This tumor usually favors the thigh and shoulder. We are reporting a case of intramuscular myxoma of the forearm in an elderly female, a very rare site for this tumor. The magnetic resonance features of intramuscular myxoma are described. The differential diagnosis that included acute hematoma, acute abscess, intramuscular synovial cyst, schwannoma and malignant soft tissue tumors with myxomatous degeneration is discussed. The association between intramuscular myxomas and fibrous dysplasia has been emphasized.
Topics: Aged; Biopsy; Diagnosis, Differential; Female; Forearm; Humans; Magnetic Resonance Imaging; Muscular Diseases; Myxoma
PubMed: 8012261
DOI: No ID Found