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Radiographics : a Review Publication of... 2019
Topics: Adult; Ependymoma; Humans; Magnetic Resonance Imaging; Middle Aged; Neuroimaging; Spinal Cord; Spinal Cord Neoplasms
PubMed: 30844350
DOI: 10.1148/rg.2019184014 -
Current Oncology Reports Aug 2022To review state of art and relevant advances in the molecular genetics and management of ependymomas of children and adults. (Review)
Review
PURPOSE OF REVIEW
To review state of art and relevant advances in the molecular genetics and management of ependymomas of children and adults.
RECENT FINDINGS
Ependymomas may occur either in the brain or in the spinal cord. Compared with intracranial ependymomas, spinal ependymomas are less frequent and exhibit a better prognosis. The new WHO classification of CNS tumors of 2021 has subdivided ependymomas into different histomolecular subgroups with different outcome. The majority of studies have shown a major impact of extent of resection; thus, a complete resection must be performed, whenever possible, at first surgery or at reoperation. Conformal radiotherapy is recommended for grade 3 or incompletely resected grade II tumors. Proton therapy is increasingly employed especially in children to reduce the risk of neurocognitive and endocrine sequelae. Craniospinal irradiation is reserved for metastatic disease. Chemotherapy is not useful as primary treatment and is commonly employed as salvage treatment for patients failing surgery and radiotherapy. Standard treatments are still the mainstay of treatment: the discovery of new druggable pathways will hopefully increase the therapeutic armamentarium in the near future.
Topics: Adult; Brain Neoplasms; Child; Ependymoma; Humans; Prognosis; Salvage Therapy
PubMed: 35384591
DOI: 10.1007/s11912-022-01260-w -
Medical Archives (Sarajevo, Bosnia and... Apr 2023Myxopapillary ependymoma is a rare type of primary spinal tumor, it is distinctly a slow-growing tumor that originates in the conus medullaris, cauda equina, or film... (Review)
Review
BACKGROUND
Myxopapillary ependymoma is a rare type of primary spinal tumor, it is distinctly a slow-growing tumor that originates in the conus medullaris, cauda equina, or film terminals and is rarely identified as a multicentric type. Myxopapillary ependymoma has a unique histological characteristic and is associated with a generally better prognosis.
OBJECTIVE
We present a case of a rare multicentric myxopapillary ependymoma.
CASE PRESENTATION
A 28-year-old male with 1-year history of low back pain and 3 months of radiating pain to left lower limb with perianal anesthesia. Magnetic resonance imaging (MRI) exhibited a large intradural intramedullary lesion from the level of the conus medullaris extending to the filum terminals at the level of T12 to L3 with smaller multiple enhancing lesions seen opposite to L4 and L5 level as well as within the exiting nerve roots, at the left side of L1/L2 and L2/L3 and right side of L3/L4 and L5/S1 level. The patient underwent surgical resection with significant improvement in symptoms and no tumor progression on follow up MRI scan.
CONCLUSION
We hereby present a case of multicentric myxopapillary ependymoma with a literature review of the previous reported cases. We believe that our study will make a significant contribution to the literature and will be of interest to the readership regarding of the rarity of multicentric Myxopapillary ependymoma and it will help in decision making for the proper surgical Intervention on these kinds of cases.
Topics: Male; Humans; Adult; Ependymoma; Cauda Equina; Spinal Cord Neoplasms; Low Back Pain; Magnetic Resonance Imaging
PubMed: 37260799
DOI: 10.5455/medarh.2023.77.150-154 -
British Journal of Neurosurgery Apr 2022We report a case of isolated myxopapillary ependymoma (MPE) of the fourth ventricle. This is the thirteenth reported case of primary intracranial MPE and the fourth... (Review)
Review
We report a case of isolated myxopapillary ependymoma (MPE) of the fourth ventricle. This is the thirteenth reported case of primary intracranial MPE and the fourth reported case of MPE originating from the fourth ventricle. We suggest that exhaustive clinical and radiological investigation of a spinal ependymoma must be undertaken in all cases of intracranial ependymoma.
Topics: Brain Neoplasms; Ependymoma; Fourth Ventricle; Humans; Spinal Cord Neoplasms
PubMed: 30317890
DOI: 10.1080/02688697.2018.1524847 -
ANZ Journal of Surgery Sep 2022
Topics: Ependymoma; Humans; Magnetic Resonance Imaging
PubMed: 35102662
DOI: 10.1111/ans.17492 -
BMJ Case Reports Jan 2021This report presents the longest spanning intradural myxopapillary ependymoma consisting of 23 vertebral segments in the literature. An 11-year-old boy presented with... (Review)
Review
This report presents the longest spanning intradural myxopapillary ependymoma consisting of 23 vertebral segments in the literature. An 11-year-old boy presented with right arm pain, mid back pain and progressive paraparesis associated with urinary retention. On MRI, the patient was found to have an intradural lesion extending from C5 to S3. The patient underwent T7 and T8 laminectomies with an almost total resection except for a minimal residual adhering to the spinal cord. The patient with the largest spanning spinal cord ependymoma was managed satisfactorily without significant morbidity. A small laminectomy may be used in some occasions despite the tumour's extensive size because it may have a single point of attachment to the cord.
Topics: Cervical Vertebrae; Child; Ependymoma; Humans; Laminectomy; Lumbar Vertebrae; Magnetic Resonance Imaging; Male; Radiotherapy, Adjuvant; Sacrum; Spinal Cord Neoplasms; Thoracic Vertebrae; Tumor Burden
PubMed: 33509888
DOI: 10.1136/bcr-2020-239453 -
World Neurosurgery Feb 2022Myxopapillary ependymomas (MPEs) with anaplastic features are rarely reported, with only 21 cases identified to date, and long-term recurrence is rarely presented. A... (Review)
Review
BACKGROUND
Myxopapillary ependymomas (MPEs) with anaplastic features are rarely reported, with only 21 cases identified to date, and long-term recurrence is rarely presented. A case series is presented to expand understanding of this disease by describing 3 unique cases, including 2 that arose from MPE after a prolonged clinical course.
METHODS
A literature review was performed, and 3 cases of MPE with anaplastic features from our institution were included.
RESULTS
Patient 1 was a 13-year-old boy who presented with an avidly enhancing intradural lumbar mass. On gross total resection, the tumor was found to be a solid mass with areas of myxopapillary architecture and MIB-1 (Ki-67) index of 12%. Patient 2 was a woman who initially presented at age 22 with a lumbosacral tumor that was treated with surgery and radiation. A recurrent tumor was resected at age 24. At age 50, the patient presented with a large heterogeneous exophytic mass in the sacrum extending into the presacral space and Ki-67 index of 8%. This was treated with complete resection. Patient 3 was a man who initially presented at age 35 with a lower thoracic, upper lumbar mass at L2 extending into the sacrum. Following resection and radiation, a metastatic focus followed an indolent course until causing pain at the age of 48. Ki-67 index was 16%.
CONCLUSIONS
The presented cases of MPE with anaplastic features make a total of 24 cases on record in the medical literature and demonstrate 2 examples of late recurrence.
Topics: Adolescent; Adult; Ependymoma; Female; Humans; Ki-67 Antigen; Lumbosacral Region; Male; Middle Aged; Sacrum; Spinal Cord Neoplasms; Young Adult
PubMed: 34800728
DOI: 10.1016/j.wneu.2021.11.053 -
Acta Neurologica Belgica Feb 2020
Topics: Ependymoma; Female; Humans; Incidental Findings; Sacrum; Spinal Cord Neoplasms; Young Adult
PubMed: 31555979
DOI: 10.1007/s13760-019-01210-7 -
The Pan African Medical Journal 2021
Topics: Ependymoma; Humans; Magnetic Resonance Imaging; Musculoskeletal System; Spinal Cord Neoplasms
PubMed: 34539960
DOI: 10.11604/pamj.2021.39.164.29765 -
Acta Clinica Croatica Jun 2020Myxopapillary ependymomas (MPE) of the spinal cord are slow-growing benign tumors most frequently found in adults between 30 and 50 years of age. They arise from the... (Review)
Review
Myxopapillary ependymomas (MPE) of the spinal cord are slow-growing benign tumors most frequently found in adults between 30 and 50 years of age. They arise from the ependyma of the filum terminale and are located in the area of the medullary conus and cauda. The recommended treatment option is gross total resection, while patients undergoing subtotal resection usually require radiotherapy. Complete resection without capsular violation can be curative and is often accomplished by simple resection of the filum above and below the tumor mass. Nevertheless, dissemination and distant treatment failure may occur in approximately 30% of the cases. In this paper, we propose an original MPE classification, which is based upon our personal series report concerned with tumor location and its correlation with the extent of resection. We also provide literature review, discussing surgical technique, tumor recurrence rate and dissemination, and adjuvant treatment. In conclusion, our findings suggest that MPE management based on the proposed 5-type tumor classification is favorable when total surgical resection is performed in carefully selected patients. Yet, further studies on a much broader model is obligatory to confirm this.
Topics: Adult; Ependymoma; Humans; Neoplasm Recurrence, Local; Spinal Cord Neoplasms; Treatment Outcome
PubMed: 33456121
DOI: 10.20471/acc.2020.59.02.17