-
Journal of Veterinary Cardiology : the... Jun 2020An 8-year-old female spayed German Shepherd cross was presented for acute onset of respiratory distress. Four days before presentation, the owner noticed a reduced...
An 8-year-old female spayed German Shepherd cross was presented for acute onset of respiratory distress. Four days before presentation, the owner noticed a reduced appetite and reluctance to move. Clinical examination identified muffled lung sounds and a left base, diamond-shaped systolic murmur graded 4/6. Echocardiography identified pleural and pericardial effusion, ascites and a myxoid mass (39 mm/18.9 mm) obstructing the right ventricular outflow tract and interfering with the pulmonary valve function. Given the poor prognosis, the dog was euthanatised, and a postmortem examination was performed. Grossly, a mass with a heterogeneous appearance was identified below the pulmonary valve leaflets. Based on histopathological and immunohistochemical findings, a diagnosis of intracardiac myxosarcoma affecting the subvalvular region of the pulmonary artery was made. To the author's knowledge, this is the first report of right ventricle out flow tract myxosarcoma in the canine species.
Topics: Animals; Dog Diseases; Dogs; Echocardiography; Female; Heart Neoplasms; Myxosarcoma; Ventricular Outflow Obstruction
PubMed: 32464578
DOI: 10.1016/j.jvc.2020.04.001 -
Journal of Veterinary Diagnostic... Jun 2024Synovial myxoma, a rare joint tumor in dogs, has traditionally been considered benign, acknowledging that local invasion into regional tissues including bone may be...
Synovial myxoma, a rare joint tumor in dogs, has traditionally been considered benign, acknowledging that local invasion into regional tissues including bone may be present. Given the diagnostic challenges in distinguishing synovial myxoma from other joint lesions through clinical features and diagnostic imaging, definitive diagnosis relies on characteristic gross and histologic features. Within the inner surface of the joint capsule, synovial myxomas form nodules of stellate-to-spindle cells within abundant myxomatous matrix. We present here 2 cases of synovial myxoma with metastasis to regional lymph nodes and compare these 2 cases to 3 cases without evidence of lymph node metastasis. Aside from lymphovascular invasion in one case with metastasis, there were no overt histologic features of the primary tumor to suggest aggressive biologic behavior. The finding of lymph node metastasis warrants reconsideration of the term "synovial myxoma" for this neoplasm. We suggest the term "synovial myxosarcoma," considering that histologic features of the primary tumor do not predict biologic behavior. Our case series highlights the importance of lymph node sampling in suspected synovial myxosarcoma cases as well as thorough histologic examination, emphasizing careful evaluation for lymphovascular invasion.
PubMed: 38828841
DOI: 10.1177/10406387241257254 -
Asian Cardiovascular & Thoracic Annals Mar 2002From January 1978 to February 1999, 120 patients (42 males and 78 females) with cardiac myxoma (115) or myxosarcoma (5) underwent surgical excision or biopsy. There were...
From January 1978 to February 1999, 120 patients (42 males and 78 females) with cardiac myxoma (115) or myxosarcoma (5) underwent surgical excision or biopsy. There were 5 early postoperative deaths (mortality, 4.2%). Seventy-three survivors were followed up for 0.75 to 20.25 years (mean, 9.42 years); they comprised 4 myxosarcoma patients who all had recurrence or metastasis, and 69 myxoma patients who had no evidence of recurrence or metastasis. Neither familial myxoma nor Carney complex was found. The 5 cases of myxosarcoma and 18 randomly selected cases of myxoma were evaluated for proliferative activity, metastatic potential, and oncogene products by immunohistochemistry. The expression of p53 and Bcl-2 was similar in both groups. Overexpression of proliferating cell nuclear antigen and low expression of nm23 in myxosarcoma are consistent with the high rate of recurrence and metastasis of this tumor. Surgical resection of sporadic myxoma is a safe and effective treatment with satisfactory early and long-term results. However, the prognosis of myxosarcoma is still disappointing. Regular echocardiography and chest radiography or computed tomography are necessary for early detection of recurrence or metastasis of myxosarcoma.
Topics: Adolescent; Adult; Cyclin D1; Female; Heart Neoplasms; Humans; Immunohistochemistry; Male; Middle Aged; Myxoma; Myxosarcoma; Neoplasm Recurrence, Local; Prognosis; Tumor Suppressor Protein p53
PubMed: 12079962
DOI: 10.1177/021849230201000103 -
Veterinary Ophthalmology May 2015The aim of this study was to evaluate important clinical, morphological, histopathological, histochemical, and immunohistochemical characteristics in order to establish...
OBJECTIVE
The aim of this study was to evaluate important clinical, morphological, histopathological, histochemical, and immunohistochemical characteristics in order to establish the diagnosis and prognosis of a low-grade intra-orbital myxosarcoma.
ANIMAL STUDIED
A mongrel dog presented a 2-year history of a neoplastic mass behind the right eye.
RESULTS
The neoplasm presented a mesenchymal spindle and stellate cell proliferation with an abundant myxoid matrix, moderate anisocariosis, and a low mitotic index. It stained positive for vimentin, moderately positive for periodic acid-Schiff, and negative for Gomori trichrome stain and α-smooth muscle actin.
CONCLUSIONS
One year following surgical excision, the patient remains disease free. The histological findings established a diagnosis of a rare canine intra-orbital low-grade myxosarcoma.
Topics: Animals; Dog Diseases; Dogs; Eye Neoplasms; Myxosarcoma
PubMed: 24837165
DOI: 10.1111/vop.12183 -
The Veterinary Record Nov 2007
Topics: Animals; Dog Diseases; Dogs; Fatal Outcome; Jaw Neoplasms; Male; Myxosarcoma; Neoplasm Recurrence, Local; Prognosis; Radiotherapy
PubMed: 17993660
DOI: 10.1136/vr.161.19.663 -
General Thoracic and Cardiovascular... Jul 2014Echocardiography revealed a left atrial tumor in a 59-year-old man with back pain that concurrently worsened with left foot drop and loss of the left ankle reflex soon...
Echocardiography revealed a left atrial tumor in a 59-year-old man with back pain that concurrently worsened with left foot drop and loss of the left ankle reflex soon after admission to our hospital. Magnetic resonance imaging of the spine revealed an epidural tumor extending from Th5 with spinal cord compression. The patient was immediately treated by emergency Th4-5 laminectomy and epidural decompression. One month later, a cardiac tumor excised via the left atrial approach was histopathologically diagnosed as myxosarcoma, and the Th5 tumor was consistent with this finding. This is the first report to describe spinal metastasis of cardiac myxosarcoma.
Topics: Decompression, Surgical; Epidural Space; Heart Atria; Heart Neoplasms; Humans; Laminectomy; Magnetic Resonance Imaging; Male; Middle Aged; Myxosarcoma; Spinal Neoplasms
PubMed: 23677508
DOI: 10.1007/s11748-013-0261-1 -
Indian Journal of Ophthalmology Mar 1971
Topics: Child, Preschool; Exophthalmos; Humans; Male; Myxosarcoma; Ophthalmologic Surgical Procedures; Orbital Neoplasms; Treatment Outcome
PubMed: 15744961
DOI: No ID Found -
Tierarztliche Praxis 1984
Topics: Animals; Cattle; Cattle Diseases; Female; Myxosarcoma; Neoplasm Metastasis; Peritoneal Neoplasms; Urinary Bladder Neoplasms
PubMed: 6484961
DOI: No ID Found -
The Cornell Veterinarian Apr 1992A large fibrotic mass originating from the cecal base was discovered upon surgical exploration of the abdomen in a Thoroughbred mare with a history of chronic colic and...
A large fibrotic mass originating from the cecal base was discovered upon surgical exploration of the abdomen in a Thoroughbred mare with a history of chronic colic and weight loss. The mass protruded intraluminally resulting in partial obstruction. Surgical excision was not feasible due to the location of the mass and the inability to exteriorize it adequately from the abdominal cavity. The mass was fibrous with a shiny, gelatinous material present throughout the neoplasm. Histologically, large confluent spaces filled with mucopolysaccharides were identified by staining with Alcian blue. The diagnosis of myxosarcoma was based upon finding of atypical fibroblastic cells, mucinous stroma, local invasiveness, and metastasis to the regional lymph nodes. Myxomatous tumors have not previously been documented to occur in the equine intestinal tract.
Topics: Animals; Cecal Neoplasms; Colic; Female; Horse Diseases; Horses; Myxosarcoma
PubMed: 1623729
DOI: No ID Found -
Journal of the American Veterinary... Dec 2014
Topics: Animals; Bone Neoplasms; Dog Diseases; Dogs; Male; Myxosarcoma
PubMed: 25406700
DOI: 10.2460/javma.245.11.1221