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Journal of Glaucoma Dec 2022
Topics: Humans; United States; Metabolic Syndrome; Intraocular Pressure; Ocular Hypertension; Glaucoma
PubMed: 36223295
DOI: 10.1097/IJG.0000000000002127 -
Ocular Immunology and Inflammation Dec 2017Vogt-Koyanagi-Harada (VKH) syndrome is a systemic inflammatory autoimmune disease with associated ophthalmic pathology. Glaucoma has been reported in patients with VKH....
PURPOSE
Vogt-Koyanagi-Harada (VKH) syndrome is a systemic inflammatory autoimmune disease with associated ophthalmic pathology. Glaucoma has been reported in patients with VKH. The purpose of this report is to examine the frequency and types of glaucoma associated with VKH.
METHODS
This was a retrospective case series. Electronic medical records of patients with VKH were reviewed from two medical centers: Duke University and the University of North Carolina.
RESULTS
Of 45 eyes with VKH, 28 (62%) developed ocular hypertension (OHT) or glaucoma. In the patients with VKH and OHT/glaucoma, 18/28 (64%) had posterior synechiae and/or peripheral anterior synechiae.
CONCLUSIONS
We have shown a high prevalence of OHT and glaucoma in eyes with VKH. Furthermore, in addition to secondary open angle from corticosteroid treatment and uveitis, secondary angle closure resulting from posterior synechiae, frequently associated with iris bombé configuration, is an important cause of glaucoma in VKH eyes.
Topics: Adult; Female; Glaucoma; Glucocorticoids; Humans; Immunosuppressive Agents; Intraocular Pressure; Male; Middle Aged; Ocular Hypertension; Retrospective Studies; Uveomeningoencephalitic Syndrome; Visual Acuity
PubMed: 27438521
DOI: 10.1080/09273948.2016.1189578 -
Asia-Pacific Journal of Ophthalmology... 2016Glaucoma suspect is a diagnosis reserved for individuals who do not definitively have glaucoma at the present time but have characteristics suggesting that they are at... (Review)
Review
Glaucoma suspect is a diagnosis reserved for individuals who do not definitively have glaucoma at the present time but have characteristics suggesting that they are at high risk of developing the disease in the future based on a variety of factors. This review provides a practical approach to individuals classified as glaucoma suspects caused by one or more of the following risk factors or indicators of disease: ocular hypertension, optic nerve features suggestive of glaucoma, visual field abnormalities, and other characteristics placing them at greater risk than the average population. In addition to diagnostic considerations, this overview provides information on therapeutic approaches to the glaucoma suspect.
Topics: Disease Management; Glaucoma; Humans; Intraocular Pressure; Ocular Hypertension; Optic Nerve; Risk Factors; Vision Disorders; Visual Fields
PubMed: 26886117
DOI: 10.1097/APO.0000000000000173 -
Basic & Clinical Pharmacology &... Nov 2020To create a novel animal model of ocular hypertension via the intracameral injection of Healaflow. Unilateral chronic ocular hypertension model of rats was created by...
To create a novel animal model of ocular hypertension via the intracameral injection of Healaflow. Unilateral chronic ocular hypertension model of rats was created by the intracameral injection of 3 μL Healaflow. The IOP of subjects was monitored. Dynamic morphological changes were evaluated by fundus imaging, OCT and histological examination. Visual function changes were measured by electroretinography and flash visual-evoked potentials. 24 and 72 hours after injection, the retinal tissue was collected for transcriptome analysis. The expression levels of related genes and proteins were further evaluated by qRT-PCR and Western blotting. The IOP peaked within 1 day after a single intracameral injection of Healaflow and then decreased gradually within 4 weeks. Furthermore, the persistently degenerating retinal ganglion cells occurred within 4 weeks. The visual function of these rats was also impaired. The results of transcriptome analyses, qRT-PCR and Western blotting showed that the expression levels of B2m, Ikzf1 and Stat3 were up-regulated, while the expression levels of Six3 and Prss56 were down-regulated in the retinal tissues. Intracameral injection of Healaflow is an effective approach to induce glaucomatous neurodegeneration in rats. Six3 and Prss56 may be involved in the pathogenesis of progressive glaucomatous damage.
Topics: Animals; Disease Models, Animal; Hyaluronic Acid; Hydrogels; Intraocular Pressure; Male; Ocular Hypertension; Rats; Retina; Vision, Ocular
PubMed: 32383327
DOI: 10.1111/bcpt.13430 -
JAMA Ophthalmology Oct 2021
Topics: Glaucoma; Humans; Ocular Hypertension
PubMed: 34383004
DOI: 10.1001/jamaophthalmol.2021.3041 -
Current Opinion in Ophthalmology Mar 2017The purpose of this review is to summarize the role of central corneal thickness (CCT) in the clinical management of a glaucoma patient. (Review)
Review
PURPOSE OF REVIEW
The purpose of this review is to summarize the role of central corneal thickness (CCT) in the clinical management of a glaucoma patient.
RECENT FINDINGS
The prognostic value of CCT is well recognized in patients with ocular hypertension. However, its predictive value in other glaucoma suspects and patients with established glaucoma is less certain. Tonometry artefacts can result from variations in CCT. However, an adequately validated correction algorithm for Goldmann applanation tonometry measurements does not exist. Newer methods of tonometry are potentially less influenced by CCT but are limited in their clinical use. There may also be biological and genetic associations between corneal thickness and glaucoma. Demographics, environmental factors, glaucoma treatment and the measurement device used have a significant influence on CCT, and should be considered when interpreting the effect of cornea thickness in patients with glaucoma. New measurements of the biomechanical properties of the cornea are likely to be better approximations of the globe biomechanics than CCT, but these require further evaluation.
SUMMARY
The clinical significance of CCT is well recognized in the context of glaucoma diagnosis and management, though the extent of its importance remains debatable. Corneal biomechanical properties may be more significantly associated with glaucoma than CCT.
Topics: Cornea; Corneal Pachymetry; Glaucoma; Humans; Intraocular Pressure; Ocular Hypertension; Tonometry, Ocular
PubMed: 27764022
DOI: 10.1097/ICU.0000000000000335 -
Bulletin de La Societe Belge... 1988
Review
Topics: Graves Disease; Humans; Ocular Hypertension; Posture
PubMed: 3077334
DOI: No ID Found -
Acta Ophthalmologica Scandinavica.... 2000A retrospective 12-year study on 35 patients having IOP values higher than 21 mmHg in repeated tonometric curves with no clinical glaucomatous-type signs was carried out...
A retrospective 12-year study on 35 patients having IOP values higher than 21 mmHg in repeated tonometric curves with no clinical glaucomatous-type signs was carried out with the aim of discovering the incidence of the eyes which evolved towards the glaucomatous disease, to evaluate the role of the preventive therapy and to observe how response to the ibopamine provocation test (which assesses outflow pathway compromission) was modified with time. The data obtained showed that, in 39.13% of the eyes, there was an evolution towards the disease. The ibopamine test was positive at time "0" (study begins) in 48.14% in the evolutive eyes and in 66.66% of the eyes which remained stable, while, at time "12" (study ends), almost all of the eyes (92-95%) had become positive. The role of precociously initiated ocular hypotensive therapy concurring with the test positivity is put in evidence.
Topics: Deoxyepinephrine; Female; Follow-Up Studies; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Male; Middle Aged; Mydriatics; Ocular Hypertension; Retrospective Studies; Tonometry, Ocular; Visual Fields
PubMed: 11235532
DOI: 10.1111/j.1600-0420.2000.tb01099.x -
Journal Francais D'ophtalmologie Jun 2005In cases of high intraocular pressure, the patient's hypertension must first be confirmed and its characteristics delineated with a diurnal IOP curve or at least several... (Review)
Review
In cases of high intraocular pressure, the patient's hypertension must first be confirmed and its characteristics delineated with a diurnal IOP curve or at least several different measures. Central corneal thickness should be measured, since a thin cornea is a risk factor of progression toward glaucomatous neuropathy. Later, the optic nerve head and retinal nerve fibers should be tested (HRT, GDx, and OCT), to determine whether the ocular hypertension is associated with other findings, and visual field analysis should be carried out (standard automated perimetry, blue-yellow perimetry, FDT), completed by a search for associated risk factors. Therapeutic decisions will be based on this workup, keeping in mind that in the majority of cases, monitoring and information are sufficient but necessary; treatment should, however, be initiated in cases of ocular hypertension with a high risk of progression.
Topics: Humans; Ocular Hypertension; Risk Assessment
PubMed: 16208235
DOI: No ID Found -
Documenta Ophthalmologica. Advances in... 1994A case-control study was planned as a part of the Casteldaccia Eye Study in order to investigate about risk factors of ocular hypertension and glaucoma. Cases were 44...
A case-control study was planned as a part of the Casteldaccia Eye Study in order to investigate about risk factors of ocular hypertension and glaucoma. Cases were 44 subjects with glaucoma or intraocular pressure of 24 mm Hg or more. Controls were 220 subjects with intraocular pressure of 20 mm Hg or less and no signs of glaucoma. A number of environmental, behavioral, systemic and ocular variables were studied. Among the others we investigated the following: sunlight exposure, smoking, alcohol intake, pregnancies, systemic hypertension, diabetes, use of corticosteroids, refractive status, anterior chamber depth, lens nuclear sclerosis, iris color and texture. After univariate analysis the use of ocular corticosteroids and antibiotics, myopia, shallow anterior chamber and myopic macular degeneration were associated with ocular hypertension or glaucoma. However, the logistic regression showed that only the use of ocular corticosteroids (odds ratio = 7.79) and the myopia (odds ratio = 5.56) were independently associated.
Topics: Adult; Aged; Aged, 80 and over; Case-Control Studies; Chronic Disease; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Italy; Male; Middle Aged; Ocular Hypertension; Risk Factors
PubMed: 7924848
DOI: 10.1007/BF01664928