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International Journal of Oral and... Dec 2017Sclerosing odontogenic carcinoma (SOC) is a primary intraosseous carcinoma of the jaws that has been listed as a separate entity for the first time in the latest version... (Review)
Review
Sclerosing odontogenic carcinoma (SOC) is a primary intraosseous carcinoma of the jaws that has been listed as a separate entity for the first time in the latest version of the World Health Organization classification of Head and Neck Tumours (2017). The aim of this study was to analyse and interpret the existing literature on SOC in the context of a clinical case treated in the authors' department. A systematic search of the PubMed database was performed in accordance with the PRISMA guidelines, yielding nine cases of SOC reported so far. In summary, characteristic clinical and radiological features of SOC include asymptomatic swelling, location predominantly in the mandible, tumour primarily lytic in appearance, presence of cortical bone destruction, and lack of metastatic spread. Due to the rarity of the disease, close collaboration between oral/maxillofacial surgeons and pathologists is crucial to avoid misdiagnosis. With complete excision, no recurrence of SOC should be expected.
Topics: Carcinoma; Head and Neck Neoplasms; Humans; Odontogenic Tumors; World Health Organization
PubMed: 28641898
DOI: 10.1016/j.ijom.2017.05.024 -
Journal of Clinical Periodontology Oct 1996True neoplasms are rarely localised to the periodontium. However, early recognition and diagnosis of neoplastic lesions resides within the realm of responsibility of the... (Review)
Review
True neoplasms are rarely localised to the periodontium. However, early recognition and diagnosis of neoplastic lesions resides within the realm of responsibility of the dentist. In recent years, a number of odontogenic tumors has been described characterized by an occurrence on the gingiva or in the intrabony part of the periodontium. One such neoplasm, the squamous odontogenic tumor (SOT) originally described 20 years ago is now a well-recognized entity localized to the periodontium, be it in the periodontal ligament or in the gingivae. A review of 36 acceptable cases of this tumor published sofar, forms the basis of the present paper.
Topics: Adolescent; Adult; Age Factors; Aged; Alveolar Process; Child; Female; Gingival Neoplasms; Humans; Male; Middle Aged; Odontogenic Tumors; Periodontal Diseases; Periodontal Ligament; Radiography; Sex Factors
PubMed: 8915020
DOI: 10.1111/j.1600-051x.1996.tb00512.x -
Journal of Oral and Maxillofacial... May 2014Clear cell odontogenic carcinoma (CCOC) is an extremely rare neoplasm, with only 74 cases in the English-language literature. It displays a propensity for the mandible,... (Review)
Review
Clear cell odontogenic carcinoma (CCOC) is an extremely rare neoplasm, with only 74 cases in the English-language literature. It displays a propensity for the mandible, most commonly presenting in the fifth to seventh decades. Histopathologically, CCOC is characterized by sheets and islands of vacuolated and clear cells. The aggressive nature of CCOC was noted in its first description in 1985, although it was not formally classified as malignant by the World Health Organization until 2005. This report describes a case of CCOC presenting atypically in a young patient and at an uncommon site. The authors review the details of this case, outlining management strategies referencing their experience and that described in the other limited cases in the literature.
Topics: Adenocarcinoma, Clear Cell; Adult; Diagnosis, Differential; Humans; Male; Maxillary Neoplasms; Neck Dissection; Neoplasm Staging; Odontogenic Tumors; Radiotherapy, Adjuvant
PubMed: 24359996
DOI: 10.1016/j.joms.2013.10.023 -
Head and Neck Pathology Jun 2019Ameloblastomas are benign but aggressive odontogenic tumors that most commonly affect the posterior mandible. Approximately 15% occur in the maxilla, with a subset...
Ameloblastomas are benign but aggressive odontogenic tumors that most commonly affect the posterior mandible. Approximately 15% occur in the maxilla, with a subset thought to originate from the epithelial lining of the sinonasal cavities. Histologically, sinonasal ameloblastomas are identical to those of the oral cavity, with classical features of palisaded columnar basilar cells surrounding a central proliferation that resembles the stellate reticulum of a developing tooth. Unlike the gnathic variant, sinonasal ameloblastomas tend to affect males more than females, and the incidence of diagnosis peaks at a later age, approximately 60 years old. The overall prognosis is favorable, with local recurrence being the most common long-term sequalae.
Topics: Adult; Ameloblastoma; Humans; Male; Maxillary Sinus Neoplasms
PubMed: 29846904
DOI: 10.1007/s12105-018-0933-3 -
Seminars in Diagnostic Pathology Nov 1999The odontogenic myxoma is an uncommon tumor that has the potential for extensive bony destruction, extension into surrounding structures, and a relatively high... (Review)
Review
The odontogenic myxoma is an uncommon tumor that has the potential for extensive bony destruction, extension into surrounding structures, and a relatively high recurrence rate. Treatment often requires bone resection. The bland histologic features of a monotonous proliferation of a loose, mesenchymal fibrous tissue that lacks atypia may easily lead to a misdiagnosis. The primitive dental pulp, the dental papilla, and the tooth follicle are histologically similar to myxoma. These soft tissue fragments often separate from extracted developing teeth that are submitted to the pathologist and may easily be misinterpreted as an odontogenic myxoma. The pathologist must have good clinical and radiographic correlation to avoid a misdiagnosis and to prevent unnecessary additional surgery.
Topics: Dental Papilla; Dental Pulp; Dental Sac; Diagnostic Errors; Humans; Jaw Neoplasms; Mexico; Myxoma; Neoplasm Recurrence, Local; Odontogenic Tumors
PubMed: 10587272
DOI: No ID Found -
Revista Medica Del Instituto Mexicano... 2012the odontogenic myxoma is a recurrent benign neoplasm that when it grows can generate pain, tooth mobility and dysesthesia. Prevalent in adults with an average between...
BACKGROUND
the odontogenic myxoma is a recurrent benign neoplasm that when it grows can generate pain, tooth mobility and dysesthesia. Prevalent in adults with an average between the 28.8 years and is rare in minors; It is more common in women. His prognosis is good after enucleation and its malignant transformation is rare.
CASE REPORT
53 years old woman who attended the service of maxillofacial surgery by increase of volume in right geniana region, without other symptoms; He referred traumatic background by fall of 5 m in height at age 33. Her studies were carried out laboratory; the results were normal. Computerized axial tomography revealed poorly delimited hipodensa central image. The histopathology of the incisional biopsy report indicated Odontogenic myxoma, so it was decided to resection in block, with margins of safety. In the follow-up to a year without complications or recurrence.
CONCLUSIONS
described odontogenic myxoma presented in the right upper jaw, so it represented a challenge given the characteristics of the unusual location, it is crucial to recognize the progress of the lesion to individually regulate the therapeutic procedure.
Topics: Female; Humans; Middle Aged; Myxoma; Odontogenic Tumors
PubMed: 22768821
DOI: No ID Found -
Oral Oncology May 2011Odontogenic myxoma (OM) is a benign odontogenic neoplasm that tends to recur due to bone infiltration. This review focuses on the molecular aspects of the OM. The... (Review)
Review
Odontogenic myxoma (OM) is a benign odontogenic neoplasm that tends to recur due to bone infiltration. This review focuses on the molecular aspects of the OM. The following topics are discussed: clonal nature, matrix metalloproteinases, apoptosis and cell proliferation, genetic alterations, and other markers. Translational studies are necessary to identify the prognostic markers of this lesion, and also, molecular biology studies may help to identify the etiologic factors and to develop more effective and less aggressive approaches, other than surgery, to the treatment of this infiltrating odontogenic tumor.
Topics: Apoptosis; Biomarkers, Tumor; Cell Proliferation; Humans; Mandibular Neoplasms; Matrix Metalloproteinases; Maxillary Neoplasms; Myxoma; Odontogenic Tumors; Prognosis
PubMed: 21444236
DOI: 10.1016/j.oraloncology.2011.03.006 -
Journal of Oral Pathology & Medicine :... Mar 2014Central granular cell odontogenic tumor (CGCOT) is a rare benign odontogenic neoplasm reported with various terms and is not included in the 2005 WHO classification of... (Review)
Review
Central granular cell odontogenic tumor (CGCOT) is a rare benign odontogenic neoplasm reported with various terms and is not included in the 2005 WHO classification of odontogenic tumors. It shows a predilection for middle-aged women, usually presenting as an asymptomatic swelling of the mandibular premolar-molar region. Radiographic manifestations include unilocular or multilocular radiolucent lesion, but mixed density lesions can also occur. Histopathology shows sheets and lobules of round to polygonal cells with abundant eosinophilic, granular cytoplasm and eccentrically placed nuclei. Immunohistochemical and ultrastructural features suggest the histiocytic origin of granular cells. The neoplasm does not exhibit an aggressive biological behavior and hence enucleation or curettage ensuring complete removal remains the treatment of choice. We present a systematic review on clinical, radiological, histopathological, immunohistochemical and treatment aspect of CGCOT. Published articles were identified through a literature search using online databases (PubMed, MEDLINE, Scopus) and cross-references for papers published from the year 1950 to March 2013. From a total of 37 papers, 26 (38 cases) were extracted from the database for systematic review.
Topics: Epithelial Cells; Granular Cell Tumor; Humans; Immunohistochemistry; Odontogenic Tumors; Terminology as Topic
PubMed: 23668324
DOI: 10.1111/jop.12085 -
Der Pathologe May 2008Malignant odontogenic tumors are extremely rare. As with benign odontogenic tumors, malignant epithelial odontogenic tumors or odontogenic carcinomas are distinguished... (Review)
Review
Malignant odontogenic tumors are extremely rare. As with benign odontogenic tumors, malignant epithelial odontogenic tumors or odontogenic carcinomas are distinguished from the even rarer mesenchymal ones, the odontogenic sarcomas. The existence of odontogenic carcinosarcomas is not yet acknowledged by the World Health Organization. Odontogenic carcinomas comprise ameloblastic carcinoma (AmCa), primary intraosseous carcinoma (PIOC), clear cell odontogenic carcinoma, odontogenic ghost cell carcinoma (OGCC), and the special case of metastasizing ameloblastoma. Odontogenic sarcomas consist of ameloblastic fibrosarcoma and ameloblastic fibrodentinosarcoma and fibroodontosarcoma. Whereas metastasizing ameloblastoma can be diagnosed only after having metastasized, all other malignant odontogenic tumors present with atypia, increased cellularity and mitoses, and invasion. Odontogenic sarcomas are regarded as low-grade tumors that rarely metastasize. Odontogenic carcinomas, however, especially AmCa, OGCC, and PIOC, are more aggressive, with a 5-year survival rate of about 70% for AmCa and OGCC and a 3-year survival rate of about 37% for PIOC. Radical surgery, eventually in combination with radiotherapy, is the treatment of choice.
Topics: Ameloblastoma; Carcinoma; Carcinosarcoma; Diagnosis, Differential; Humans; Jaw; Jaw Neoplasms; Neoplasm Invasiveness; Odontogenic Tumors; Sarcoma
PubMed: 18392827
DOI: 10.1007/s00292-008-0998-y -
Oral Oncology Oct 2018The aim of this study was to integrate the available data published on odontogenic carcinosarcoma into a comprehensive analysis of their features, treatment and...
The aim of this study was to integrate the available data published on odontogenic carcinosarcoma into a comprehensive analysis of their features, treatment and recurrence. An electronic search with no publication date or language restriction was undertaken in March 2018 in the following databases: Medline Ovid, PubMed, Web of Science, Scopus and LILACS. Eligibility criteria included publications having enough clinical, imaginological and histopathological information to confirm a definite diagnosis of the neoplasm. Data were evaluated descriptively and statistically using the MedCalc software. The Kaplan-Meier method was used for survival analysis. The systematic review detected nine articles from eight countries. Six cases with no age predilection occurred in male individuals complaining of painful swelling in the posterior mandible. Radiographically, the lesions were large, with expansive radiolucency and with ill-defined borders and seven cases were associated with preexisting odontogenic lesions. Radical surgery was the treatment of choice in the majority of cases. Recurrences (n = 6), metastasis (n = 4) and death (n = 4) were frequently observed in many cases. Odontogenic carcinosarcoma is a very aggressive neoplasm with a poor prognosis. This study provides knowledge that could help surgeons, oncologists, otorhinolaryngologists and oral maxillofacial pathologists with the diagnosis and management of these lesions.
Topics: Adult; Age Distribution; Aged; Carcinosarcoma; Child; Female; Humans; Kaplan-Meier Estimate; Male; Mandibular Neoplasms; Middle Aged; Neoplasm Metastasis; Neoplasm Recurrence, Local; Odontogenic Tumors; Sex Distribution; Young Adult
PubMed: 30220320
DOI: 10.1016/j.oraloncology.2018.08.017