-
Oral Surgery, Oral Medicine, Oral... Dec 2003This article reports 3 cases of oncocytic mucoepidermoid carcinoma of the parotid gland and compares them with 9 cases from the literature with emphasis on clinical... (Comparative Study)
Comparative Study Review
This article reports 3 cases of oncocytic mucoepidermoid carcinoma of the parotid gland and compares them with 9 cases from the literature with emphasis on clinical behavior, treatment, and recurrence rate. The tumor occurs most often in the middle-aged to elderly, with a decided predilection for the parotid gland. All three oncocytic mucoepidermoid carcinomas from the Armed Forces Institute of Pathology series were low grade with extensive oncocytic change. Treatment modalities consisted of superficial parotidectomy, total parotidectomy, or total parotidectomy. The mean follow-up interval was 5.5 years. Only one case from the literature, a high-grade mucoepidermoid carcinoma, recurred. Results of this study indicate that the parotid gland oncocytic mucoepidermoid carcinoma behaves in a fashion similar to typical mucoepidermoid carcinoma, with prognosis dependent on clinical stage, histopathologic grade, and adequacy of treatment. Recognizing the spectrum of oncocytic differentiation in salivary gland tumors will serve to establish appropriate diagnoses and treatment.
Topics: Aged; Aged, 80 and over; Carcinoma, Mucoepidermoid; Cell Differentiation; Female; Follow-Up Studies; Humans; Male; Middle Aged; Oxyphil Cells; Parotid Gland; Parotid Neoplasms; Prognosis
PubMed: 14676764
DOI: 10.1016/s1079-2104(03)00377-9 -
Oral Oncology Mar 2022
Topics: Carcinoma, Mucoepidermoid; Humans; Mouth Neoplasms; Oxyphil Cells; Parotid Neoplasms
PubMed: 35092877
DOI: 10.1016/j.oraloncology.2022.105732 -
Annals of Surgical Oncology Sep 2022
Topics: Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Humans; Oxyphil Cells
PubMed: 35536522
DOI: 10.1245/s10434-022-11635-9 -
International Forum of Allergy &... May 2017Oncocytomas and oncocytic carcinomas are rare tumors of the sinonasal cavity with the propensity for local invasion. This report and systematic review details a case of... (Review)
Review
BACKGROUND
Oncocytomas and oncocytic carcinomas are rare tumors of the sinonasal cavity with the propensity for local invasion. This report and systematic review details a case of a nasal oncocytoma involving the lacrimal sac and provides an update of the current literature.
METHODS
A systematic literature review was performed using PubMed and Ovid databases. The data obtained from published articles with sinonasal oncocytoma/oncocytic carcinoma as the primary diagnosis included patient demographics, presentation, radiographic and histologic findings, management, and recurrence rates.
RESULTS
Twenty cases were identified. The most common symptoms were epistaxis (n = 11) and nasal obstruction (n = 11). Involvement of the nasal cavity was most common (n = 17), followed by the paranasal sinuses (n = 13) and nasolacrimal apparatus (n = 4). Recurrence occurred in 55% of cases. Recurrence was associated with invasion or infiltration found on histology or the presence of both invasion/infiltration and mitotic figures/pleomorphism (p < 0.05), with no significant relationship between recurrence and age at diagnosis (p = 0.42), sex (p = 0.65), and location of tumor (p = 0.14). The authors present the case of a 73-year-old woman with a 5-month history of worsening epistaxis and biopsy-proven oncocytoma. Complete surgical resection of the tumor using combined endonasal endoscopic and anterior orbitotomy approach is described.
CONCLUSION
Oncocytomas and oncocytic carcinomas are rare tumors of the sinonasal cavity with a high rate of local recurrence and orbital involvement. Surgical resection is the treatment of choice and complete resection can be achieved with an endoscopic endonasal approach.
Topics: Adenoma, Oxyphilic; Carcinoma; Humans; Neoplasm Recurrence, Local; Paranasal Sinus Neoplasms
PubMed: 28092140
DOI: 10.1002/alr.21902 -
Pathology Annual 1992
Review
Topics: Adenoma; DNA, Neoplasm; Female; Granular Cell Tumor; Humans; Kidney Neoplasms; Liver Neoplasms; Male; Mitochondria; Pituitary Neoplasms; Salivary Gland Neoplasms; Thyroid Neoplasms
PubMed: 1736246
DOI: No ID Found -
Modern Pathology : An Official Journal... Dec 2001Biliary cystadenocarcinoma with oncocytic differentiation was first reported in 1992. This is a report of a second case. The patient (a 71-year-old man) was admitted to...
Biliary cystadenocarcinoma with oncocytic differentiation was first reported in 1992. This is a report of a second case. The patient (a 71-year-old man) was admitted to our hospital complaining of abdominal fullness. Multicystic lesions were identified in the left hepatic lobe radiologically. The patient died of peritoneal dissemination of carcinoma 20 months later. At autopsy, the tumor of the left hepatic lobe was found to be composed of adjoining multiple cystic lesions and a solid lesion with infiltration of the hepatic hilus and peritoneal dissemination. Histologically, the multicystic lesions were covered by papillary neoplastic epithelial cells with an eosinophilic granular cytoplasm resembling that of oncocytes and a fine fibrovascular core. The cyst wall was fibrous, but there was no mesenchymal stroma. In the solid lesion and infiltrated areas, acidophilic and granular carcinoma cells formed small glandular or solid cord patterns with much mucin secretion (mucinous carcinoma). Immunohistochemically, carcinoma cells of both components were found to contain many mitochondria and showed the phenotypes of hepatocytes and cholangiocytes. Interestingly, the intrahepatic biliary tree also was invaded by carcinoma cells. This may be a case of intraductal oncocytic papillary neoplasm of the left hepatic lobe followed by secondary cystic dilatation of the affected bile duct.
Topics: Adenoma, Oxyphilic; Aged; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Biomarkers, Tumor; Cystadenocarcinoma, Papillary; Fatal Outcome; Humans; Liver Neoplasms; Male; Neoplasm Proteins; Oxyphil Cells; Tomography, X-Ray Computed
PubMed: 11743055
DOI: 10.1038/modpathol.3880479 -
Annals of Diagnostic Pathology Jun 2008An oncocyte is a cell containing an abundant amount of deeply eosinophilic finely granular cytoplasm, rounded nuclei, and variable presence of nucleoli in conventional... (Review)
Review
An oncocyte is a cell containing an abundant amount of deeply eosinophilic finely granular cytoplasm, rounded nuclei, and variable presence of nucleoli in conventional hematoxylin-eosin-stained sections. In the head and neck, a small number of lesions are constructed overwhelmingly of oncocytes; a larger number of nononcocytic lesions composed of cells that imitate this morphology are also encountered. Correlating the fine-needle aspiration cytology and histology of both oncocytic and oncocyte-like neoplasms can assist in avoiding interpretive pitfalls among these lesions.
Topics: Adenoma, Oxyphilic; Biopsy, Fine-Needle; Head and Neck Neoplasms; Humans; Oxyphil Cells; Salivary Gland Neoplasms; Thyroid Neoplasms
PubMed: 18486901
DOI: 10.1016/j.anndiagpath.2008.04.007 -
Diagnostic Cytopathology Feb 2021Mucoepidermoid carcinoma is the most common malignant salivary gland neoplasm comprising approximately 10% of all tumours of the major salivary gland. Owing to a...
Mucoepidermoid carcinoma is the most common malignant salivary gland neoplasm comprising approximately 10% of all tumours of the major salivary gland. Owing to a plethora of morphological variations, it poses a diagnostic challenge on fine-needle aspiration cytology. Oncocytic variant of mucoepidermoid carcinoma is a rare subtype seen in the age group of 20-80 years. It is crucial to make the correct diagnosis on cytology as it has therapeutic implications. Oncocytes can be present in a wide range of salivary gland lesions ranging from non-neoplastic conditions to benign and malignant lesions. We report a case of oncocytic mucoepidermoid carcinoma of the parotid gland in a 12-year-old boy which is the youngest age reported for the same. On cytology, this case was initially diagnosed as Warthin's tumour and was supported by radiology. However, histomorphological findings clinched the diagnosis of an oncocytic variant of mucoepidermoid carcinoma with the aid of immunohistochemistry.
Topics: Biopsy, Fine-Needle; Carcinoma, Mucoepidermoid; Child; Cytodiagnosis; Humans; Male; Oxyphil Cells; Parotid Gland; Parotid Neoplasms; Salivary Gland Neoplasms; Salivary Glands
PubMed: 33237638
DOI: 10.1002/dc.24581 -
QJM : Monthly Journal of the... Jun 2019
Topics: Aged; Bone Neoplasms; Carcinoma; Fatal Outcome; Humans; Lung Neoplasms; Male; Oxyphil Cells; Thyroid Neoplasms; Tomography, X-Ray Computed
PubMed: 30576521
DOI: 10.1093/qjmed/hcy297 -
Human Pathology Nov 2016Malignant gastrointestinal neuroectodermal tumor (MGNET) is a very rare, aggressive malignant neoplasm that may occur in any location in the gastrointestinal tract....
Malignant gastrointestinal neuroectodermal tumor (MGNET) is a very rare, aggressive malignant neoplasm that may occur in any location in the gastrointestinal tract. Malignant gastrointestinal neuroectodermal tumors typically consist of sheet-like to pseudopapillary proliferation of primitive-appearing epithelioid cells with a moderate amount of lightly eosinophilic cytoplasm, round nuclei and small nucleoli, often in association with osteoclast-like giant cells. By immunohistochemistry, these tumors show expression of S100 protein and SOX10, in the absence of expression of more specific melanocytic markers (eg, HMB45, Melan A). Genetically, malignant gastrointestinal neuroectodermal tumors are characterized by rearrangements of the EWSR1 or FUS genes with CREB1 or ATF1. We report a case of gastric malignant gastrointestinal neuroectodermal tumor occurring in a 46-year-old woman and showing striking oncocytic cytoplasmic change, a previously undescribed potential diagnostic pitfall. An initial needle biopsy showed large, eosinophilic cells with S100 protein and SOX10 expression and lacking expression of KIT, DOG1, Melan A, keratin, chromogranin, or smooth muscle actin, and was interpreted as representing a granular cell tumor. The subsequent excision specimen showed similar-appearing areas, but also contained small more primitive-appearing areas, lacking oncocytic change and having high nuclear grade and brisk mitotic activity. This resection specimen was initially diagnosed as a malignant granular cell tumor. However subsequent gene expression profiling studies showed an EWSR1-ATF1 fusion, confirmed with fluorescence in situ hybridization for EWSR1, and a final diagnosis of MGNET with oncocytic change was made. This case highlights a previously undescribed pitfall in the diagnosis of MGNET, oncocytic change, and suggests that MGNET should be included in the differential diagnosis for unusual oncocytic neoplasms of the gastrointestinal tract.
Topics: Biomarkers, Tumor; Biopsy, Needle; Female; Humans; Immunohistochemistry; In Situ Hybridization, Fluorescence; Middle Aged; Neuroectodermal Tumors, Primitive, Peripheral; Oncogene Proteins, Fusion; Oxyphil Cells; Predictive Value of Tests; Stomach Neoplasms
PubMed: 27346570
DOI: 10.1016/j.humpath.2016.05.026