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Ear, Nose, & Throat Journal Jun 2020
Topics: Aged; Cysts; Female; Humans; Laryngeal Diseases; Larynx; Medical Illustration; Oxyphil Cells; Recurrence
PubMed: 30987461
DOI: 10.1177/0145561319840208 -
Journal of Clinical Pathology Feb 2011
Topics: Adenocarcinoma; Aged; Humans; Male; Mitochondria; Oxyphil Cells; Prostatic Neoplasms
PubMed: 21131313
DOI: 10.1136/jcp.2010.085720 -
Mitochondrion May 2019We conducted the first systematic omics study of the oncocytic phenotype in 488 papillary thyroid carcinomas (PTC) from The Cancer Genome Atlas. Oncocytic phenotype is...
We conducted the first systematic omics study of the oncocytic phenotype in 488 papillary thyroid carcinomas (PTC) from The Cancer Genome Atlas. Oncocytic phenotype is secondary to PTC, being unrelated to several pathologic scores. The nuclear genome had low impact on this phenotype (except in specific copy number variation), which was mostly driven by the significant accumulation of mitochondrial DNA non-synonymous and frameshift mutations at high heteroplasmy levels. Energy and mitochondrial-related pathways were significantly enriched in oncocytic tumors that also displayed increased levels of expression for genes involved in autophagy and fusion of mitochondria. Our in vitro tests confirmed that autophagy is increased and functional while mitophagy is decreased in these tumors.
Topics: Autophagy; DNA, Mitochondrial; Energy Metabolism; Gene Expression Profiling; Humans; Mitophagy; Mutation; Oxyphil Cells; Thyroid Neoplasms
PubMed: 29631022
DOI: 10.1016/j.mito.2018.04.001 -
Cancer Cytopathology May 2021
Topics: Humans; Oxyphil Cells; Thyroid Neoplasms
PubMed: 33045148
DOI: 10.1002/cncy.22377 -
Human Pathology Apr 1998We report a case of oncocytic lipoadenoma of the submandibular gland, previously unrecognized benign tumor of the salivary gland. The patient was a 66-year-old Japanese...
We report a case of oncocytic lipoadenoma of the submandibular gland, previously unrecognized benign tumor of the salivary gland. The patient was a 66-year-old Japanese woman with a left submandibular mass, measuring 11 x 7.5 x 5 cm. Microscopically, the mass was completely surrounded by a thin fibrous connective tissue capsule, and was composed of an intimate admixture of mature fat cells and oncocytes. There have been no English reports of such a neoplasm in the salivary gland with the exception of one recent case report of lipoadenoma of the parotid gland without oncocytic features. We propose the diagnostic term "oncocytic lipoadenoma" for this benign tumor.
Topics: Adenoma; Adenoma, Oxyphilic; Aged; Female; Humans; Lipoma; Submandibular Gland Neoplasms
PubMed: 9563794
DOI: 10.1016/s0046-8177(98)90125-3 -
Virchows Archiv. A, Pathological... 1983A case of ovarian adenocarcinoma mainly composed of oncocytes was studied by light and electron microscopy. Oncocytes, characterized by granular and eosinophilic...
A case of ovarian adenocarcinoma mainly composed of oncocytes was studied by light and electron microscopy. Oncocytes, characterized by granular and eosinophilic cytoplasm by light microscopy possessed numerous mitochondria at the ultrastructural level. These oncocytes were classified into two types: typical and condensed oncocytes. Typical oncocytes seemed to be active, whereas condensed oncocytes were thought to be involved in a degenerative process. The two types of cells showed a close similarity to oncocytes in other organs (e.g., thyroid, parathyroid and salivary glands). This appears to be the first report of an ovarian oncocytic tumor.
Topics: Adenocarcinoma; Adult; Cytoplasm; Female; Humans; Microscopy, Electron; Mitochondria; Ovarian Neoplasms
PubMed: 6407190
DOI: 10.1007/BF00612952 -
Acta Radiologica (Stockholm, Sweden :... Jun 2015The literature is sparse concerning 18F-fluorodeoxyglucose (18F-FDG) accumulation in the Hürthle cell neoplasm (HCN) of the thyroid. Given the difficulty of accurately...
BACKGROUND
The literature is sparse concerning 18F-fluorodeoxyglucose (18F-FDG) accumulation in the Hürthle cell neoplasm (HCN) of the thyroid. Given the difficulty of accurately diagnosing HCN, even with ultrasound (US) and fine needle aspiration biopsy (FNAB), the ability to accurately characterize these lesions by 18F-FDG positron emission tomography (PET) would be of value.
PURPOSE
To describe six cases of oncocytic proliferation in the thyroid gland that mimics the presence of metastatic disease and was detected incidentally by an 18F-FDG PET scan.
MATERIAL AND METHODS
We conducted whole-body 18F-FDG PET examinations for cancer staging in 1862 oncological patients from 2012 to 2013. Among them, six subjects (4 women, 2 men; age range, 45-85 years) with focal-enhanced 18F-FDG accumulation in the thyroid gland were selected from the study population. This study group was further investigated using 99 m-Tc-pertechnetate scintigraphy, US, and FNAB. Two experienced nuclear physicians reviewed the images. Gray-scale US and color Doppler (CD) sonographic examinations of the thyroid were undertaken for all subjects using a sonographic device Logiq 5 Expert (GE Medical Systems, Osaka, Japan) equipped with a 7-12 MHz linear array transducer.
RESULTS
In all six cases, abnormal 18F-FDG uptake was found locally in the thyroid. The average SUVmax of the HCN was 5.8 (range, 2.6-16). In all six cases, 99 m-Tc-pertechnetate scintigraphy showed a cold spot. Compared with normal parenchymal vascularity, five of the six masses were shown to be hypervascular by CD ultrasonography.
CONCLUSION
On PET scans, oncocytic proliferations of the thyroid may mimic metastases of other malignancies. The focal-enhanced uptake of 18F-FDG PET may be associated with a focal increase in the metabolic activity of the thyroid parenchyma due to the presence of oncocytes. Our study emphasizes the importance of obtaining cytological evidence before making a diagnosis of metastatic disease.
Topics: Adenoma, Oxyphilic; Aged; Aged, 80 and over; Diagnosis, Differential; Female; Fluorodeoxyglucose F18; Humans; Male; Middle Aged; Positron-Emission Tomography; Radiopharmaceuticals; Thyroid Neoplasms
PubMed: 24948789
DOI: 10.1177/0284185114537928 -
Diagnostic Cytopathology May 2012Fine-needle aspiration (FNA) diagnosis of oncocytic lesions is challenging. In fact, oncocytic changes occur in inflammatory, hyperplastic, and neoplastic settings,...
Multicentric encapsulated papillary oncocytic neoplasm of the thyroid: A case diagnosed by a combined cytological, histological, immunohistochemical, and molecular approach.
Fine-needle aspiration (FNA) diagnosis of oncocytic lesions is challenging. In fact, oncocytic changes occur in inflammatory, hyperplastic, and neoplastic settings, including both benign and malignant tumors. The rare oncocytic variant of papillary thyroid carcinoma (PTC), shows papillae composed by cells with large oncocytic granular cytoplasm featuring clear PTC nuclear features. A morphological similar, but biologically distinct lesion, is the encapsulated papillary oncocytic neoplasia. Here, we first report on FNA, its cytological features together with histological, immunohistochemical, and molecular correlates.
Topics: Adult; Biopsy, Fine-Needle; Carcinoma, Papillary; Female; Genome, Human; Humans; Immunohistochemistry; Oxyphil Cells; Thyroid Gland; Thyroid Neoplasms; Thyroidectomy
PubMed: 21965084
DOI: 10.1002/dc.21828 -
Endocrine Pathology May 2015The proposed diagnostic criteria for poorly differentiated thyroid carcinoma (known as the Turin classification) were defined based on growth pattern (solid, trabecular,...
The proposed diagnostic criteria for poorly differentiated thyroid carcinoma (known as the Turin classification) were defined based on growth pattern (solid, trabecular, or insular) and high-grade morphologic features (nuclear pleomorphism, mitoses including abnormal forms, and coagulative tumor necrosis). The development of this classification specifically did not include tumors with oncocytic or Hürthle cell cytology, and only sparse literature describing poorly differentiated oncocytic carcinomas is available. In this study, we examined a cohort of 284 cases of oncocytic follicular carcinoma/Hürthle cell carcinoma (OFC/HCC) and identified 17 cases of oncocytic variant of poorly differentiated carcinoma (OV-PDTC) based on Turin criteria. Compared to minimally invasive and angioinvasive OFC/HCC, these tumors arose in older patients (range 44-88 years; average 71 years), were larger (average size 4.5 cm), and all had extensive vascular invasion (5-15 foci), and coagulative tumor necrosis and the tumor cells were arranged in a trabecular or solid growth pattern. All showed an admixture of oncocytic follicular/Hürthle cells arranged in solid and trabecular growth pattern. Aggregates of small sized cells with minimal eosinophilic cytoplasm, comprising 10-20% of the entire tumor mass were also seen in 16/17 cases. Clinical follow-up was available in 12 cases and ranged from 6 to 120 months (average 41 months). Distant metastases were seen in 10/12 (83%) patients; two had lung and one had bone metastases at the time of thyroid surgery, and four subsequently developed cervical lymph node metastases. Two patients died of disease, and ten are alive either with or free of tumor. The OV-PDTC is a distinct entity which can be identified based on Turin criteria and the presence of a distinct "small cell" component. It is frequently associated with regional recurrence and distant metastases and can lead to tumor-related demise.
Topics: Adenocarcinoma, Follicular; Adenoma, Oxyphilic; Adult; Aged; Aged, 80 and over; Cell Differentiation; Female; Follow-Up Studies; Humans; Male; Middle Aged; Oxyphil Cells; Retrospective Studies; Survival Analysis; Thyroid Neoplasms
PubMed: 25898815
DOI: 10.1007/s12022-015-9367-6 -
Otolaryngology--head and Neck Surgery :... Jun 2002Oncocytic neoplasms of the parotid gland are a rare collection of salivary gland tumors that include oncocytosis, oncocytoma, and oncocytic carcinoma. Mounting evidence...
BACKGROUND
Oncocytic neoplasms of the parotid gland are a rare collection of salivary gland tumors that include oncocytosis, oncocytoma, and oncocytic carcinoma. Mounting evidence has linked the presence of oncocytes to acquired mitochondrial dysfunction.
OBJECTIVES
The study goals were to further delineate this poorly understood group of salivary gland tumors and to search for genetic alterations indicative of mitochondrial dysfunction.
METHODS
Cases were identified by search of the surgical pathology archival files from 1984 through 2000. Corresponding medical records were reviewed. Tumor mitochondrial DNA (mtDNA) was evaluated for mtDNA mutations within the control region (C-tract).
RESULTS
Twenty-one parotid oncocytic neoplasms were identified. Oncocytoma was the most frequent morphology (62%), followed by oncocytosis (28.5%) and oncocytic carcinoma (9.5%). One specimen displayed synchronous oncocytic morphologies (oncocytoma, oncocytosis, and oncocytic metaplasia). One oncocytoma specimen displayed the mtDNA C-tract alteration.
CONCLUSIONS
Oncocytic neoplasia of the parotid gland is a rare form of salivary gland disease with obscure etiology. The presence of multiple oncocytic morphologies in a single specimen is suggestive of transition between forms. Although oncocytic tumorigenesis secondary to acquired mitochondrial dysfunction is a plausible mechanism, few of these tumors actually harbor mtDNA alterations within the control region.
Topics: Adenocarcinoma; Base Sequence; Biopsy, Needle; DNA, Mitochondrial; Female; Hospitals, University; Humans; Immunohistochemistry; Incidence; Male; Mitochondria; Molecular Sequence Data; Parotid Neoplasms; Polymerase Chain Reaction; Prognosis; Registries; Retrospective Studies; Risk Factors; Survival Rate
PubMed: 12087334
DOI: 10.1067/mhn.2002.124437