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Laboratory Animal Science Apr 1994
Review
Topics: Animals; California; Deltaretrovirus; Humans; National Institutes of Health (U.S.); Oncogenes; Oncogenic Viruses; Program Evaluation; Retroviridae; United States
PubMed: 8028270
DOI: No ID Found -
Philosophical Transactions of the Royal... May 2019One out of 10 cancers is estimated to arise from infections by a handful of oncogenic viruses. These infectious cancers constitute an opportunity for primary prevention...
One out of 10 cancers is estimated to arise from infections by a handful of oncogenic viruses. These infectious cancers constitute an opportunity for primary prevention through immunization against the viral infection, for early screening through molecular detection of the infectious agent, and potentially for specific treatments, by targeting the virus as a marker of cancer cells. Accomplishing these objectives will require a detailed understanding of the natural history of infections, the mechanisms by which the viruses contribute to disease, the mutual adaptation of viruses and hosts, and the possible viral evolution in the absence and in the presence of the public health interventions conceived to target them. This issue showcases the current developments in experimental tissue-like and animal systems, mathematical models and evolutionary approaches to understand DNA oncoviruses. Our global aim is to provide proximate explanations to the present-day interface and interactions between virus and host, as well as ultimate explanations about the adaptive value of these interactions and about the evolutionary pathways that have led to the current malignant phenotype of oncoviral infections. This article is part of the theme issue 'Silent cancer agents: multi-disciplinary modelling of human DNA oncoviruses'.
Topics: Animals; DNA Virus Infections; DNA Viruses; Evolution, Molecular; Humans; Oncogenic Viruses; Tumor Virus Infections; Virulence
PubMed: 30955496
DOI: 10.1098/rstb.2019.0041 -
Guy's Hospital Reports 1963
Review
Topics: Adenoviridae; Adenoviridae Infections; Humans; Neoplasms; Oncogenic Viruses; Polyomavirus; Simian virus 40
PubMed: 14043913
DOI: No ID Found -
Journal of Virology Mar 1975Oncornaviruses, which contain a virion-associated protein kinase, were found to possess phosphoproteins as virion structural components. One major phosphoprotein common...
Oncornaviruses, which contain a virion-associated protein kinase, were found to possess phosphoproteins as virion structural components. One major phosphoprotein common to strains of laboratory and wild mouse oncornaviruses and a strain of feline leukemia virus was shown to be a polypeptide of about 12, 000 mol wt. In addition to this, the Kirsten strain of murine sarcoma virus contained a second major phosphoprotein of about 10, 000 mol wt, and mouse erythroblastosis virus contained a second major phosphoprotein that was either identical to or comigrated with the virion glycoprotein of about 74, 000 mol wt. The major phosphoprotein of RD-114 virus was found to be of about 16, 000 mol wt. The major phosphoamino acid of the 12, 000-mol wt polypeptide of the mouse erythroblastosis virus was identified as phosphoserine, and that of the 16, 000-mol wt polypeptide of the RD-114 virus was identified as phosphothreonine.
Topics: Electrophoresis, Paper; Electrophoresis, Polyacrylamide Gel; Gammaretrovirus; Leukemia Virus, Feline; Molecular Weight; Oncogenic Viruses; Peptides; Phosphoproteins; Phosphorus Radioisotopes; RNA Viruses; Rauscher Virus; Retroviridae; Tritium
PubMed: 163371
DOI: 10.1128/JVI.15.3.540-549.1975 -
National Cancer Institute Monograph May 1978The genetic conservation and evolution of virogenes in mammalian species are described in relation to the horizontal, vertical, and congenital transmission of type C RNA... (Review)
Review
The genetic conservation and evolution of virogenes in mammalian species are described in relation to the horizontal, vertical, and congenital transmission of type C RNA oncogenic viruses within members of a given species, or among members of near and/or distantly related species. Examples of oncogenic virus infection between ancestors of the mouse, cat, pig, and primates as well as the integration of the virus into the host's genome are documented. The possible normal functions of the virogenes as a part of the cellular genome of many species are explored. Recent evidence of genetic recombination (genetic mixing) among distinct type C viruses is also reviewed, thus completing an overview of the evolutionary past, present, and complex future relationships of oncogenic RNA viruses and mammalian species.
Topics: Animals; Biological Evolution; DNA, Recombinant; Epidermal Growth Factor; Genes, Viral; Humans; Mice; Neoplasms; Primates; Retroviridae; Sarcoma, Experimental; Transformation, Genetic
PubMed: 219352
DOI: No ID Found -
Health Laboratory Science Apr 1964
Review
Topics: Adenoviridae; Animals; Avian Leukosis Virus; Avian Sarcoma Viruses; Leukemia; Leukemia Virus, Murine; Leukemia, Experimental; Leukemia, Lymphoid; Leukemia, Myeloid; Lymphoma; Lymphoma, Non-Hodgkin; Mammary Neoplasms, Animal; Mammary Neoplasms, Experimental; Mice; Neoplasms; Neoplasms, Experimental; Oncogenic Viruses; Papillomaviridae; Polyomavirus; Poxviridae; Research; Rous sarcoma virus; Simian virus 40
PubMed: 14166691
DOI: No ID Found -
Acta Orthopaedica Belgica 1973
Topics: Bone Neoplasms; Fibroma; Humans; Knee Joint; Male; Middle Aged; Neoplasms; Oncogenic Viruses; Retroviridae; Thoracic Neoplasms; Virus Cultivation
PubMed: 4356446
DOI: No ID Found -
La Semaine Des Hopitaux : Organe Fonde... Jul 1983Human oncogenic viruses are ubiquitous pathogens which only in frequently exhibit their malignant potential under natural conditions. They are either ARN viruses, also...
Human oncogenic viruses are ubiquitous pathogens which only in frequently exhibit their malignant potential under natural conditions. They are either ARN viruses, also called retroviruses, of which little is known in man, or DNA viruses belonging to various families (papovavirus, adenovirus, herpes virus, hepatitis B virus), some of which are very specifically associated with certain human carcinomas. In vitro, these viruses induce "cell transformation" producing malignant cells with unregulated growth. In vivo, in man as well as in animals, viral oncogenesis requires multiple cofactors so that the transformed cell can escape control mechanisms.
Topics: Animals; Cell Transformation, Neoplastic; DNA, Viral; Humans; Oncogenic Viruses; RNA, Viral
PubMed: 6312566
DOI: No ID Found -
Progress in Medical Virology.... 1963
Review
Topics: Animals; Arginase; Avian Leukosis Virus; Avian Sarcoma Viruses; Bacteriophages; Carbon Dioxide; Chick Embryo; DNA; DNA, Viral; Drosophila; Fibroblasts; Fibroma; Genetics; Herpesviridae Infections; Insect Viruses; Leukemia; Leukemia, Experimental; Measles virus; Mice; Oncogenic Viruses; Papilloma; Papillomaviridae; Polyomavirus; Poxviridae Infections; RNA; RNA, Viral; Rabbits; Research; Rous sarcoma virus; Simian virus 40; Tissue Culture Techniques; Ultraviolet Rays
PubMed: 14157340
DOI: No ID Found -
In Vitro 1975
Review
Topics: Adenoviridae; BK Virus; Cell Transformation, Neoplastic; Cytomegalovirus; Herpesvirus 4, Human; Humans; Neoplasms; Oncogenic Viruses; Papillomaviridae; Retroviridae; Simplexvirus
PubMed: 170197
DOI: 10.1007/BF02615423