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Current Opinion in Virology Oct 2018Viruses exploit cellular ubiquitination machinery to shape the host proteome and promote productive infection. Among the cellular processes influenced by viral... (Review)
Review
Viruses exploit cellular ubiquitination machinery to shape the host proteome and promote productive infection. Among the cellular processes influenced by viral manipulation of ubiquitination is the DNA damage response (DDR), a network of cellular signaling pathways that sense and respond to genomic damage. This host-pathogen interaction is particularly important during virus replication and transformation by DNA tumor viruses. Manipulating DDR pathways can promote virus replication but also impacts host genomic instability, potentially leading to cellular transformation and tumor formation. We review ways in which viruses are known to hijack the cellular ubiquitin system to reshape host DDR pathways.
Topics: Cell Transformation, Neoplastic; DNA Damage; DNA Repair; Genomic Instability; Host-Pathogen Interactions; Humans; Oncogenic Viruses; Tumor Virus Infections; Ubiquitination; Virus Replication
PubMed: 30261451
DOI: 10.1016/j.coviro.2018.08.017 -
Annual Review of Medicine 1977
Review
Topics: Adenoviridae; Animals; Cell Transformation, Neoplastic; DNA Viruses; Genes; Helper Viruses; Herpesviridae; Humans; Leukemia; Leukemia Virus, Murine; Mammary Tumor Virus, Mouse; Neoplasms; Oncogenic Viruses; Papillomaviridae; Polyomaviridae; RNA Viruses; Sarcoma; Viral Proteins
PubMed: 193432
DOI: 10.1146/annurev.me.28.020177.001523 -
Advances in Virus Research 1976
Review
Topics: Alpharetrovirus; Animal Feed; Animals; Arthropod Vectors; Blood; DNA Viruses; Ecology; Gammaretrovirus; Oncogenic Viruses; Papillomaviridae; Polyomavirus; Poxviridae; RNA Viruses; Reoviridae; Vertebrates; Virus Diseases
PubMed: 179307
DOI: 10.1016/s0065-3527(08)60504-7 -
Cancer May 1988
Review
Topics: Animals; Cell Transformation, Neoplastic; Cell Transformation, Viral; Colonic Neoplasms; Gene Expression Regulation; Humans; Mice; Molecular Biology; Neoplasms; Neoplasms, Experimental; Oncogenes; Oncogenic Viruses; Proto-Oncogenes; Retroviridae; Tumor Virus Infections; Urinary Bladder Neoplasms
PubMed: 3282638
DOI: 10.1002/1097-0142(19880515)61:10<1963::aid-cncr2820611005>3.0.co;2-8 -
Critical Reviews in Oncology/hematology May 2019Human cancers attributed to viral infections represent a growing proportion of the global cancer burden, with these types of cancers being the leading cause of morbidity... (Review)
Review
Human cancers attributed to viral infections represent a growing proportion of the global cancer burden, with these types of cancers being the leading cause of morbidity and mortality in some regions. The concept that viruses play a causal role in human cancers is not new, but the mechanism thereof, while well described for some viruses, still remains elusive and complex for others, especially in the case of HIV-associated B-cell derived cancers. In the last decade, compelling evidence has demonstrated that cellular microRNAs are deregulated in cancers, with an increasing number of studies identifying microRNAs as potential biomarkers for human cancer diagnosis, prognosis and therapeutic targets or tools. Recent research demonstrates that viruses and viral components manipulate host microRNA expressions to their advantage, and the emerging picture suggests that the virus/microRNA pathway interaction is defined by a plethora of complex mechanisms. In this review, we highlight the current knowledge on virus/microRNA pathway interactions in the context of cancer and provide new insights on HIV as an oncogenic virus.
Topics: Animals; Carcinogenesis; HIV; Humans; MicroRNAs; Neoplasms; Oncogenic Viruses; Prognosis
PubMed: 31014506
DOI: 10.1016/j.critrevonc.2019.02.007 -
Oncotarget Jul 2016The Kaposi sarcoma-associated herpesvirus (KSHV) is the causative agent of Kaposi sarcoma (KS), the most common HIV/AIDS-associated tumor worldwide. Involvement of the...
The Kaposi sarcoma-associated herpesvirus (KSHV) is the causative agent of Kaposi sarcoma (KS), the most common HIV/AIDS-associated tumor worldwide. Involvement of the oral cavity portends a poor prognosis for patients with KS, but the mechanisms for KSHV regulation of the oral tumor microenvironment are largely unknown. Infiltrating fibroblasts are found within KS lesions, and KSHV can establish latent infection within human primary fibroblasts in vitro and in vivo, but contributions for KSHV-infected fibroblasts to the KS microenvironment have not been previously characterized. In the present study, we used Illumina microarray to determine global gene expression changes in KSHV-infected primary human oral fibroblasts (PDLF and HGF). Among significantly altered candidates, we found that a series of interferon-induced genes were strongly up-regulated in these KSHV-infected oral cells. Interestingly, some of these genes in particular ISG15 and ISG20 are required for maintenance of virus latency through regulation of specific KSHV microRNAs. Our data indicate that oral fibroblasts may represent one important host cellular defense component against viral infection, as well as acting as a reservoir for herpesvirus lifelong infection in the oral cavity.
Topics: Cell Line, Tumor; Cytokines; Exonucleases; Exoribonucleases; Fibroblasts; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Herpesvirus 8, Human; Humans; Interferons; MicroRNAs; Oncogenic Viruses; RNA Interference; RNA, Small Interfering; RNA, Viral; Sarcoma, Kaposi; Tumor Microenvironment; Ubiquitins; Up-Regulation; Virus Latency
PubMed: 27363016
DOI: 10.18632/oncotarget.9720 -
British Medical Bulletin Jan 1991The fact that viruses can cause cancer in animals has been appreciated since the turn of the century. The widely held belief that viruses had little to do with cancer in... (Review)
Review
The fact that viruses can cause cancer in animals has been appreciated since the turn of the century. The widely held belief that viruses had little to do with cancer in humans has only recently been dispelled. Two classes of human retrovirus (HTLV and HIV) have been discovered in the last decade and the malignant potential of hepatitis B virus, Epstein Barr Virus and the human papilloma virus have been documented not only by confirming their association with disease by large scale epidemological studies but also at the molecular level. Indeed detailed investigation of the way viruses can cause cancer can reveal new insights into 'final common pathways' and hopefully provide new approaches for treatment over and above the real possibility that virus associated cancers can potentially be vaccinated against.
Topics: Animals; Hepatitis B virus; Herpesvirus 4, Human; Humans; Neoplasms; Oncogenic Viruses; Papillomaviridae; Retroviridae; Tumor Virus Infections
PubMed: 1650623
DOI: 10.1093/oxfordjournals.bmb.a072457 -
Journal of Virology Nov 2007
Review
Topics: Animals; Apoptosis; Birds; Genome, Viral; Humans; Inflammation; Oncogenic Viruses; Phylogeny; Polyomavirus
PubMed: 17715213
DOI: 10.1128/JVI.01178-07 -
Lack of involvement of known oncogenic DNA viruses in Epstein-Barr virus-negative Hodgkin's disease.British Journal of Cancer Apr 1998Epstein-Barr virus (EBV) is associated with around one-third of cases, but young adult cases are rarely EBV associated. In this study, known oncogenic DNA viruses,...
Epstein-Barr virus (EBV) is associated with around one-third of cases, but young adult cases are rarely EBV associated. In this study, known oncogenic DNA viruses, including human adenoviruses, papovaviruses and the human herpesviruses-6 (HHV-6) and -8 (HHV-8) were not detected in Hodgkin's disease lesions. These results suggest that an as yet unidentified infectious agent is involved in the pathogenesis of non-EBV-associated Hodgkin's disease.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; DNA Viruses; DNA, Viral; Female; Herpesvirus 4, Human; Hodgkin Disease; Humans; Male; Middle Aged; Oncogenic Viruses
PubMed: 9569037
DOI: 10.1038/bjc.1998.174 -
Progress in Experimental Tumor Research 1963
Review
Topics: Animals; Avian Leukosis Virus; Cell Biology; Cell Division; Cell Nucleus; Chromosomes; Cytoplasm; Cytoplasmic Granules; Humans; Leukemia; Leukemia, Experimental; Neoplasms; Neoplasms, Experimental; Oncogenic Viruses; Papilloma; Papillomaviridae; Polyomavirus; Tumor Virus Infections
PubMed: 14148381
DOI: 10.1159/000385959