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Internal Medicine (Tokyo, Japan) Jun 2023Cytomegalovirus (CMV) oophoritis is an extremely rare and fatal condition. We encountered a 63-year-old woman with CMV oophoritis who had been treated for Burkitt's... (Review)
Review
Cytomegalovirus (CMV) oophoritis is an extremely rare and fatal condition. We encountered a 63-year-old woman with CMV oophoritis who had been treated for Burkitt's lymphoma. Positron emission tomography/computed tomography performed after chemotherapy showed a high F-fluoro-2deoxy-D-glucose uptake in both ovaries, which required distinguishing relapse. CMV oophoritis was diagnosed on histology following bilateral salpingo-oophorectomy. Although the patient later developed recurrent episodes of CMV antigenemia, after which complications of CMV retinitis appeared, and she ultimately died of CMV meningitis, surgical resection with antiviral medication resolved her abdominal symptoms and cleared CMV antigenemia for several weeks. It is therefore worth considering surgical resection in combination with antiviral drugs as a treatment option.
Topics: Female; Humans; Middle Aged; Burkitt Lymphoma; Cytomegalovirus; Oophoritis; Neoplasm Recurrence, Local; Antiviral Agents; Cytomegalovirus Infections
PubMed: 36261376
DOI: 10.2169/internalmedicine.0517-22 -
Reproductive Sciences (Thousand Oaks,... Jan 2024Autoimmune primary ovarian insufficiency (POI) is a devastating disease with limited clinical guidance. The objective of this systematic review was to identify... (Review)
Review
Autoimmune primary ovarian insufficiency (POI) is a devastating disease with limited clinical guidance. The objective of this systematic review was to identify treatments for autoimmune POI and analyze their efficacy. A comprehensive search of CINAHL, Cochrane, Embase, PubMed, Scopus, and Web of Science was performed from inception to April 2022. English language publications that evaluated women with autoimmune POI after a documented intervention were included. Animal models of autoimmune POI were also included. Risk of bias was assessed with the SYRCLE's risk of bias tool for animal studies or the NIH Quality Assessment Tool for Case Series as appropriate. Twenty-eight studies were included in this review, with 11 RCTs, 15 case reports, and 2 case series. Seventeen studies were in humans, and 11 were in animal models. No completed RCTs, cohort studies, or case-control studies were identified in humans. In observational human studies, corticosteroids were effective in select patients. In many case reports, adequate treatment of comorbid autoimmune conditions resulted in return of menses, hormonal normalization, or spontaneous pregnancy. In terms of assisted reproductive technologies, there was case report evidence for both in vitro fertilization (IVF) and in vitro maturation (IVM) in women wishing to conceive with their own oocytes. Ovulation induction, IVF, and IVM resulted in a total of 15 pregnancies and 14 live births. In animal models, there was additional evidence for stem cell therapies and treatments used in traditional Chinese medicine, although this research may not be generalizable to humans. Furthermore, litter size was not evaluated in any of the animal studies. Additional research is needed to establish the efficacy of current treatments for autoimmune POI with a controlled experimental design and larger sample size. Additionally, there is a critical need to develop novel therapies for this condition, as understanding of its pathophysiology and available tools to modulate the immune response have progressed.
Topics: Animals; Female; Humans; Pregnancy; Fertilization in Vitro; Infertility, Female; Live Birth; Oophoritis; Polyendocrinopathies, Autoimmune; Pregnancy Rate; Reproductive Techniques, Assisted
PubMed: 37500976
DOI: 10.1007/s43032-023-01299-5 -
Annals of the New York Academy of... 2008Autoimmune oophoritis presents in adolescents as a component of autoimmune polyendocrine syndrome type I or type II. Autoimmune oophoritis can be diagnosed in women with... (Review)
Review
Autoimmune oophoritis presents in adolescents as a component of autoimmune polyendocrine syndrome type I or type II. Autoimmune oophoritis can be diagnosed in women with primary ovarian insufficiency in the presence of adrenal cortical or steroid cell antibodies, and/or antibodies to adrenal and ovarian steroidogenic enzymes. The ovaries are cystic macroscopically, with a lymphocytic infiltrate in the steroidogenic theca cells. The immune infiltrate results in low estradiol levels and a compensatory increase in FSH levels. Granulosa cells are spared, and inhibin A and B levels are normal to high. Treatment is aimed at symptom relief with further investigation needed to assess treatment options such as immunosuppression.
Topics: Adolescent; Autoantibodies; Estradiol; Female; Follicle Stimulating Hormone; Humans; Immunosuppressive Agents; Inhibins; Oophoritis; Ovary; Polyendocrinopathies, Autoimmune
PubMed: 18574216
DOI: 10.1196/annals.1429.006 -
Emergency Medicine Practice Dec 2022Pelvic inflammatory disease is associated with complications that include infertility, chronic pelvic pain, ruptured tubo-ovarian abscess, and ectopic pregnancy. The... (Review)
Review
Pelvic inflammatory disease is associated with complications that include infertility, chronic pelvic pain, ruptured tubo-ovarian abscess, and ectopic pregnancy. The diagnosis may be delayed when the presentation has nonspecific signs and symptoms. Even when properly diagnosed, pelvic inflammatory disease is often treated suboptimally. This review provides evidence-based recommendations for the diagnosis, treatment, disposition, and follow-up of patients with pelvic inflammatory disease. Arranging follow-up of patients within 48 to 72 hours and providing clear patient education are fundamental to ensuring good patient outcomes. Emerging issues, including new pathogens and\ evolving resistance patterns among pelvic inflammatory disease pathogens, are reviewed.
Topics: Pregnancy; Female; Humans; Pelvic Inflammatory Disease; Oophoritis; Abdominal Abscess; Emergency Service, Hospital; Pregnancy, Ectopic
PubMed: 36378827
DOI: No ID Found -
BMJ Case Reports May 2022Xanthogranulomatous salpingo-oophoritis (XGSO) is an exceptionally rare entity. Its clinical manifestations and imaging modalities can mimic benign and malignant adnexal...
Xanthogranulomatous salpingo-oophoritis (XGSO) is an exceptionally rare entity. Its clinical manifestations and imaging modalities can mimic benign and malignant adnexal diseases, making it difficult to diagnose. Here we report a case of XGSO in a young woman who was operated with suspicion of a borderline ovarian tumour. Preoperative diagnosis of XGSO should be considered to avoid radical surgical treatment, especially in young patients.
Topics: Female; Granuloma; Humans; Oophoritis; Ovarian Neoplasms; Salpingitis; Xanthomatosis
PubMed: 35589272
DOI: 10.1136/bcr-2021-248197 -
American Journal of Clinical Pathology Jan 1984A 43-year-old para 3 woman presented with a six-year history of progressive oligomenorrhea and hypomenorrhea. A total abdominal hysterectomy with bilateral...
A 43-year-old para 3 woman presented with a six-year history of progressive oligomenorrhea and hypomenorrhea. A total abdominal hysterectomy with bilateral salpingo-oophorectomy was performed for the suspicion of ovarian cysts. On histologic examination, the ovaries contained lymphocytic and plasma cell infiltrates in relation to the theca interna of growing follicles, to the corpora lutea and to the endocrine hilar cells. The infiltrates increased in density with the follicular maturation and culminated against the corpora lutea. The plasma cell population was polyclonal. No antibodies to ovarian tissue components could be demonstrated in the patient's serum by means of immunohistochemistry; but antibodies to the zona glomerulosa of adrenal cortex were detected by serologic means. Although a rare disease, autoimmune oophoritis must be recognized histologically because it is a cause of ovarian failure and because it indicates that the patient is at risk of developing associated Addison's disease.
Topics: Adrenal Cortex; Adult; Autoantibodies; Autoimmune Diseases; Female; Humans; Oophoritis; Ovary
PubMed: 6691297
DOI: 10.1093/ajcp/81.1.105 -
Xanthogranulomatous oophoritis secondary to talcum powder. Case report and review of the literature.Le Journal Medical Libanais. the... 2012Xanthogranulomatous inflammation of the ovary (xanthogranulomatous oophoritis) is a rare condition, usually representing a complication of tubo-ovarian abscess following... (Review)
Review
Xanthogranulomatous inflammation of the ovary (xanthogranulomatous oophoritis) is a rare condition, usually representing a complication of tubo-ovarian abscess following pelvic inflammatory disease (PID). We report a case of xanthogranulomatous oophoritis that occurred in a 31-year-old Lebanese lady, eight years following an open appendectomy as a reaction to talcum powder present on surgical gloves.
Topics: Adult; Female; Granuloma, Foreign-Body; Humans; Oophoritis; Talc; Xanthomatosis
PubMed: 23198459
DOI: No ID Found -
Ryoikibetsu Shokogun Shirizu 2000
Review
Topics: Autoantibodies; Autoimmune Diseases; Diagnosis, Differential; Estrogen Replacement Therapy; Female; Gonadotropins; Humans; Oophoritis; Ovary; Primary Ovarian Insufficiency; Prognosis; Zona Pellucida
PubMed: 11269030
DOI: No ID Found -
Journal of Ayub Medical College,... 2017Xanthogranulomatous inflammation is characterized by destruction of the tissues of the organ involved and replacement by chronic inflammatory cells such as lymphocytes,...
Xanthogranulomatous inflammation is characterized by destruction of the tissues of the organ involved and replacement by chronic inflammatory cells such as lymphocytes, plasma cells, occasional neutrophils with or without multinucleated or Touton giant cells. Exact aetiology is not known but the theory of infection with organisms like Proteus, E coli, and Bacteroides fragilis is most popular. Xanthogranulomatous inflammation of the female genital tract is not common and usually involves the endometrium; however, xanthogranulomatous inflammation of the ovaries is a rare entity.
Topics: Escherichia coli; Female; Giant Cells; Granuloma; Humans; Inflammation; Middle Aged; Oophoritis; Xanthomatosis
PubMed: 28712201
DOI: No ID Found -
Postgraduate Medical Journal Mar 1986A previously healthy nulliparous caucasian female presented with lower abdominal pain and a history of diarrhoea and vomiting for 2 weeks. Repeated stool examinations...
A previously healthy nulliparous caucasian female presented with lower abdominal pain and a history of diarrhoea and vomiting for 2 weeks. Repeated stool examinations and blood culture were negative. A lump in the lower abdomen became more apparent over the next 2 weeks and a subsequent laparotomy revealed bilateral tubo-ovarian abscess formation. One ovary which was endometriotic and both the tubes were excised and the pus yielded a heavy growth of Salmonella stanley.
Topics: Adult; Female; Humans; Oophoritis; Salmonella Infections; Salpingitis
PubMed: 3714612
DOI: 10.1136/pgmj.62.725.227