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Neurology Jul 1995
Topics: Antibodies; ELAV Proteins; Female; Humans; Infant; Myoclonus; Nerve Tissue Proteins; Neuroblastoma; Ocular Motility Disorders; Paraneoplastic Syndromes; RNA-Binding Proteins
PubMed: 7677891
DOI: 10.1212/wnl.45.7.1421 -
Journal Francais D'ophtalmologie Feb 2019Brown's syndrome is related to an abnormality of the superior oblique muscle: it is manifested by an oculomotor disorder with active and passive limitation of elevation... (Review)
Review
Brown's syndrome is related to an abnormality of the superior oblique muscle: it is manifested by an oculomotor disorder with active and passive limitation of elevation in adduction, the field of action of the inferior oblique muscle. The origin is congenital or acquired secondary to multiple causes - inflammatory-infectious, traumatic or iatrogenic. The clinical and paraclinical signs are suggestive. Cerebral and orbital imaging including CT and magnetic resonance imaging (MRI) is essential for the diagnosis and management of congenital or acquired Brown's syndrome. The course may yield improvement (spontaneous or after etiological treatment) or a steady state. Treatment is rarely surgical. The indication for surgery requires specific functional and clinical signs: torticollis, hypotropia in primary position, associated strabismus and impaired binocular vision; the long-term results of the various surgical techniques are variable.
Topics: Humans; Magnetic Resonance Imaging; Ocular Motility Disorders; Oculomotor Muscles; Strabismus; Syndrome
PubMed: 30711379
DOI: 10.1016/j.jfo.2018.06.012 -
Acta Neurologica Taiwanica Jun 2012Opsoclonus is a rare neurological disorder in adult. The etiology of opsoclonus includes parainfectious, paraneoplastic, toxic, and metabolic disorders. We reported an... (Review)
Review
PURPOSE
Opsoclonus is a rare neurological disorder in adult. The etiology of opsoclonus includes parainfectious, paraneoplastic, toxic, and metabolic disorders. We reported an old female with post-infectious opsoclonus who had a benign clinical course and reversible brain MRI lesions, and its review of the literature.
CASE REPORT
A 67-year-old woman presented with opsoclonus and truncal ataxia for two weeks. The magnetic resonance imaging (MRI) showed the hyperintensity lesions in bilateral medial thalamus, hypothalamus, and tegmentum of pons on Fluid-attenuated inversion recovery (FLAIR) imaging. Investigations of neoplasm and autoimmune disorders showed negative findings. Clinical symptoms subsided in two-week duration and MRI abnormalities also disappeared one month later.
CONCLUSION
A benign clinical course and reversible MRI lesions could be found in the patients with postinfectious opsoclonus such as our case. However, detailed investigations and long-term follow-up are needed to exclude paraneoplastic or other systemic and immunological disorders.
Topics: Acyclovir; Aged; Antiviral Agents; Brain; Central Nervous System Viral Diseases; Female; Fluorodeoxyglucose F18; Follow-Up Studies; Humans; Magnetic Resonance Imaging; Ocular Motility Disorders; Positron-Emission Tomography
PubMed: 22879117
DOI: No ID Found -
Cerebellum (London, England) Aug 2023
Topics: Humans; Cerebellar Ataxia; Eye Movements; Ocular Motility Disorders; Cerebellum; Nystagmus, Pathologic; Saccades
PubMed: 35881323
DOI: 10.1007/s12311-022-01444-x -
The Journal of Pediatrics Apr 1995
Topics: Ataxia; Humans; Myoclonus; Neuroblastoma; Ocular Motility Disorders; Paraneoplastic Syndromes
PubMed: 7699555
DOI: 10.1016/s0022-3476(95)70378-0 -
Journal of Optometry 2020
Topics: Evidence-Based Practice; Humans; Ocular Motility Disorders; Optometry
PubMed: 32553271
DOI: 10.1016/j.optom.2020.06.001 -
Journal of Postgraduate Medicine 2012Scrub typhus is a mite borne infectious disease caused by Orientia tsutsugamushi. It is a common cause of undifferentiated febrile illness in the Indian subcontinent. We...
Scrub typhus is a mite borne infectious disease caused by Orientia tsutsugamushi. It is a common cause of undifferentiated febrile illness in the Indian subcontinent. We present a case of scrub typhus with a rare ophthalmic manifestation.Our patient presented with fever and opsoclonus, was diagnosed to have scrub typhus and completely improved upon treatment. Opsoclonus complicates various medical diseases, including viral infections, toxin, encephalitis, brain tumors, and paraneoplastic syndromes. There has been only one previously reported case of opsoclonus in scrub typhus. This phenomenon highlights the increasingly complex presentation of common diseases. It also indicates there is much to be discovered about the immunopathogenesis of this infectious disease.
Topics: Anti-Bacterial Agents; Diagnosis, Differential; Doxycycline; Fever; Humans; Immunoglobulin M; Male; Middle Aged; Ocular Motility Disorders; Orientia tsutsugamushi; Saccades; Scrub Typhus; Treatment Outcome; Visual Acuity
PubMed: 23298927
DOI: 10.4103/0022-3859.105453 -
Cerebellum (London, England) Aug 2016We describe novel deficits of gaze holding and ocular alignment in patients with spinocerebellar ataxia type 3, also known as Machado-Joseph disease (MJD). Twelve MJD...
We describe novel deficits of gaze holding and ocular alignment in patients with spinocerebellar ataxia type 3, also known as Machado-Joseph disease (MJD). Twelve MJD patients were studied. Clinical assessments and quantitative ocular alignment measures were performed. Eye movements were quantitatively assessed with corneal curvature tracker and video-oculography. Strabismus was seen in ten MJD patients. Four patients had mild to moderate intermittent exotropia, three had esotropia, one had skew deviation, one had hypotropia, and one patient had moderate exophoria. Three strabismic patients had V-pattern. Near point of convergence was normal in two out of three patients with exotropia. Gaze holding deficits were also common. Eight patients had gaze-evoked nystagmus, and five had micro-opsoclonus. Other ocular motor deficits included saccadic dysmetria in eight patients, whereas all had saccadic interruption of smooth pursuit. Strabismus and micro-opsoclonus are common in MJD. Coexisting ophthalmoplegia or vergence abnormalities in our patients with exotropia that comprised 50 % of the cohort could not explain the type of strabismus in our patients. Therefore, it is possible that involvement of the brainstem, the deep cerebellar nuclei, and the superior cerebellar peduncle are the physiological basis for exotropia in these patients. Micro-opsoclonus was also common in MJD. Brainstem and deep cerebellar nuclei lesion also explains micro-opsoclonus, whereas brainstem deficits can describe slow saccades seen in our patients with MJD.
Topics: Adolescent; Adult; Aged; Cohort Studies; Eye Movement Measurements; Female; Humans; Machado-Joseph Disease; Male; Middle Aged; Ocular Motility Disorders; Prevalence; Pursuit, Smooth; Saccades; Young Adult
PubMed: 26306823
DOI: 10.1007/s12311-015-0718-0 -
Neurological Sciences : Official... Sep 2015
Topics: Adult; Autoantibodies; Autoimmune Diseases of the Nervous System; Electronystagmography; Eye Movements; Female; Humans; Ocular Motility Disorders; Receptors, Glutamate
PubMed: 26007195
DOI: 10.1007/s10072-015-2264-4 -
Journal of Neurology Aug 1998
Topics: Adult; Epstein-Barr Virus Infections; Humans; Male; Ocular Motility Disorders
PubMed: 9747923
DOI: 10.1007/s004150050244