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International Journal of Obstetric... Nov 2022
Topics: Pregnancy; Female; Humans; Sulfates; Ferric Compounds; Cesarean Section; Administration, Oral
PubMed: 36183608
DOI: 10.1016/j.ijoa.2022.103597 -
The American Journal of Managed Care Feb 2013
Topics: Administration, Oral; Dietary Supplements; Humans; United States
PubMed: 23448108
DOI: No ID Found -
Yakugaku Zasshi : Journal of the... 2023Lipid-based formulations (LBFs) are isotropic mixtures typically comprising lipids, surfactants, and/or co-solvents, in which drugs are pre-solubilized. After oral... (Review)
Review
Lipid-based formulations (LBFs) are isotropic mixtures typically comprising lipids, surfactants, and/or co-solvents, in which drugs are pre-solubilized. After oral administration, LBFs are piggybacked into endogenous lipid digestion pathways. This triggers drug super-saturation and improves absorption. However, super-saturation poses a risk of drug precipitation, which generally leads to poor drug absorption. Furthermore, a series of aqueous colloidal species including digestion products (typically fatty acids and monoglycerides) and endogenous molecules (bile acids and phospholipids) increase the drug solubilization capacity of the intestinal fluid (compared with that of the normal intestinal fluid). However, the solubilization/precipitation behavior may change according to the LBF composition (e.g., the drug loading amount and type of formulation excipients), which may ultimately lead to differences in oral absorption. This review summarizes the results of the evaluation and prediction of the effect of LBFs composition on oral absorption and provides an in-depth understanding of the drug absorption mechanisms when using LBFs.
Topics: Pharmaceutical Preparations; Water; Administration, Oral; Chemical Phenomena; Fatty Acids
PubMed: 37661438
DOI: 10.1248/yakushi.23-00092 -
Journal of Controlled Release :... Nov 2023The formation of a biomolecular corona on exogenous particles in plasma is well studied and is known to dictate the biodistribution and cellular interactions of... (Review)
Review
The formation of a biomolecular corona on exogenous particles in plasma is well studied and is known to dictate the biodistribution and cellular interactions of nanomedicine formulations. In contrast, while the oral route is the most favorable administration method for pharmaceuticals, little is known about the formation and composition of the corona formed by biomolecules on particles within the gastrointestinal tract. This work reviews the current literature understanding of (1) the formation of drug particles after oral administration, (2) the formation of a biomolecular corona within the gastrointestinal tract ("the gastrointestinal corona"), and (3) the possible implications of the formation of a gastrointestinal corona on the interactions of drug particles with their biological environment. In doing so, this work aims to establish the significance of the formation of a gastrointestinal corona in oral drug delivery to ultimately arrive at new avenues to control the behavior of orally administered pharmaceuticals.
Topics: Tissue Distribution; Nanoparticles; Gastrointestinal Tract; Administration, Oral; Pharmaceutical Preparations
PubMed: 37776905
DOI: 10.1016/j.jconrel.2023.09.049 -
Nanomedicine (London, England) Aug 2020The purpose of this report is to summarize and critically analyze emerging trends in phospholipid vesicles for the oral delivery of natural compounds. Liposomes have... (Review)
Review
The purpose of this report is to summarize and critically analyze emerging trends in phospholipid vesicles for the oral delivery of natural compounds. Liposomes have long been used as delivery systems, thanks to their ability to incorporate diverse bioactives, their biocompatibility and safety. However, the efficacy of oral liposomes is hampered by their low stability under the harsh conditions of the gastrointestinal tract. Different approaches have been utilized with the aim of improving the stability of liposomes and the payload after oral administration. This report provides an overview on the phospholipid vesicles used for oral delivery of natural compounds, exploring the current strategies to improve their performance by modifying the lipid bilayer composition and assembly or the physical state.
Topics: Administration, Oral; Lipid Bilayers; Liposomes; Phospholipids
PubMed: 32698672
DOI: 10.2217/nnm-2020-0085 -
International Journal of Pharmaceutics Apr 2021Fucoidan is well known to have various biological functions and is often investigated for pharmaceutical applications. Several studies have been conducted on clinical... (Review)
Review
Fucoidan is well known to have various biological functions and is often investigated for pharmaceutical applications. Several studies have been conducted on clinical applications of fucoidan in recent years, especially regarding its oral drug delivery. Although fucoidan has shown promising results in various dosage forms, its potential applications as a dietary supplement have been demonstrated, and recent studies show that oral administration of fucoidan is preferred. However, the focus on the oral delivery of fucoidan in recent studies has caused its potency in therapy to be understudied. This review aims to provide results on the promising fucoidan activity by oral administration with in vivo studies. In addition to using it as an active ingredient, the utilization of fucoidan as an excipient in oral drug delivery systems will be discussed. An overview of fucoidan administration by oral delivery in recent promising studies will provide a direction for further investigations in clinical applications, particularly for fucoidan, which has a broad spectrum of bioactive properties.
Topics: Administration, Oral; Drug Delivery Systems; Excipients; Polysaccharides
PubMed: 33581274
DOI: 10.1016/j.ijpharm.2021.120371 -
The British Journal of Ophthalmology Sep 1997
Topics: Administration, Oral; Animals; Antigens; Eye Diseases; Mice
PubMed: 9422919
DOI: 10.1136/bjo.81.9.714 -
European Journal of Hospital Pharmacy :... Jan 2023
'To crush or not to crush, that is the question!' An algorithm can help with the proper administration of solid oral medicines in patients where the oral route is compromised.
Topics: Humans; Administration, Oral; Pharmaceutical Preparations; Algorithms
PubMed: 34183456
DOI: 10.1136/ejhpharm-2021-002928 -
Journal of Controlled Release :... Nov 2022The oral route is the most convenient and simplest mode of administration. Nevertheless, orally administration of some commonly used therapeutic drugs, such as... (Review)
Review
The oral route is the most convenient and simplest mode of administration. Nevertheless, orally administration of some commonly used therapeutic drugs, such as polypeptides, therapeutic proteins, small-molecule drugs, and nucleic acids, remains a major challenge due to the harsh gastrointestinal environment and the limited oral bioavailability. Extracellular vesicles (EVs) are diverse, nanoscale phospholipid vesicles that are actively released by cells and play crucial roles in intercellular communications. Some EVs have been shown to survive with the gastrointestinal tract (GIT) and can cross biological barriers. The potential of EVs to cross the GIT barrier makes them promising natural delivery carriers for orally administered drugs. Here, we introduce the uniqueness of EVs and their feasibility as oral drug delivery vehicles (ODDVs). Then we provide a general description of the different cellular EVs based oral drug delivery systems (ODDSs) currently under study and emphasize the contribution of endogenous features and multifunctional properties of EVs to the delivery performance. The current obstacles of moving EVs based ODDSs from bench to bedside are also discussed.
Topics: Drug Delivery Systems; Extracellular Vesicles; Nucleic Acids; Biological Availability; Administration, Oral
PubMed: 36179765
DOI: 10.1016/j.jconrel.2022.09.043 -
International Dental Journal Aug 2021
Topics: Administration, Oral; Humans; Oral Health; World Health Organization
PubMed: 34256923
DOI: 10.1016/j.identj.2021.06.003