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Proceedings of the Society For... Jun 1948
Topics: Administration, Oral; Bacitracin; Humans
PubMed: 18869358
DOI: 10.3181/00379727-68-16496 -
American Professional Pharmacist Oct 1947
Topics: Administration, Oral; Humans; Penicillins
PubMed: 20270063
DOI: No ID Found -
Canadian Medical Association Journal Jul 1948
Topics: Administration, Oral; Humans; Penicillins
PubMed: 18864238
DOI: No ID Found -
Canadian Medical Association Journal Oct 1949
Topics: Administration, Oral; Psoriasis; Undecylenic Acids
PubMed: 18140580
DOI: No ID Found -
The New England Journal of Medicine May 1954
Topics: Acetazolamide; Administration, Oral; Carbonic Anhydrase Inhibitors; Diuretics; Heart Failure
PubMed: 13165901
DOI: 10.1056/NEJM195405132501902 -
Public Health Reports (Washington, D.C.... Dec 1949
Topics: Administration, Oral; Brucella; Humans; Male
PubMed: 15399324
DOI: No ID Found -
Stroke Oct 1992
Topics: Administration, Oral; Glycerol; Hemolysis; Humans
PubMed: 1412592
DOI: No ID Found -
ACS Nano Jun 2016The oral route is preferred for systemic drug administration and provides direct access to diseased tissue of the gastrointestinal (GI) tract. However, many drugs have...
The oral route is preferred for systemic drug administration and provides direct access to diseased tissue of the gastrointestinal (GI) tract. However, many drugs have poor absorption upon oral administration due to damaging enzymatic and pH conditions, mucus and cellular permeation barriers, and limited time for drug dissolution. To overcome these limitations and enhance oral drug absorption, micron-scale devices with planar, asymmetric geometries, termed microdevices, have been designed to adhere to the lining of the GI tract and release drug at high concentrations directly toward GI epithelium. Here we seal microdevices with nanostraw membranes-porous nanostructured biomolecule delivery substrates-to enhance the properties of these devices. We demonstrate that the nanostraws facilitate facile drug loading and tunable drug release, limit the influx of external molecules into the sealed drug reservoir, and increase the adhesion of devices to epithelial tissue. These findings highlight the potential of nanostraw microdevices to enhance the oral absorption of a wide range of therapeutics by binding to the lining of the GI tract, providing prolonged and proximal drug release, and reducing the exposure of their payload to drug-degrading biomolecules.
Topics: Administration, Oral; Drug Delivery Systems; Nanostructures; Pharmaceutical Preparations
PubMed: 27268699
DOI: 10.1021/acsnano.6b00809 -
Chimia Jun 2021Peptides have a number of attractive properties that make them an interesting modality for drug development, including their ability to bind challenging targets, their... (Review)
Review
Peptides have a number of attractive properties that make them an interesting modality for drug development, including their ability to bind challenging targets, their high target specificity, and their non-toxic metabolic products. However, a major limitation of peptides as drugs is their typically poor oral availability, hindering their convenient and flexible application as pills. Of the more than 60 approved peptide drugs, the large majority is not orally applicable. The oral delivery of peptides is hampered by their metabolic instability and/or limited intestinal uptake. In this article, we review the barriers peptides need to overcome after their oral administration to reach disease targets, we highlight two recent successes of pharma companies in developing orally applicable peptide drugs, and we discuss efforts of our laboratory towards the generation of bioavailable cyclic peptides.
Topics: Administration, Oral; Drug Delivery Systems; Peptides; Peptides, Cyclic
PubMed: 34233815
DOI: 10.2533/chimia.2021.514 -
Postgraduate Medicine Nov 1950
Topics: Administration, Oral; Chlorophyll; Deodorants; Humans
PubMed: 14780948
DOI: 10.1080/00325481.1950.11694031