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Medizinische Klinik, Intensivmedizin... Mar 2017
Topics: Administration, Oral; Anticoagulants
PubMed: 28255774
DOI: 10.1007/s00063-016-0246-9 -
Journal of the American Dental... Nov 1947
Topics: Administration, Oral; Gingivitis, Necrotizing Ulcerative; Humans; Penicillins
PubMed: 20266618
DOI: 10.14219/jada.archive.1947.0304 -
Nursing Times
Topics: Administration, Buccal; Administration, Oral; Administration, Sublingual; Drug Therapy; Humans
PubMed: 10568955
DOI: No ID Found -
Current Opinion in Immunology Dec 2013Food allergies are increasing in prevalence and present an emerging epidemic for westernized countries. Strict dietary avoidance is the only approved management for food... (Review)
Review
Food allergies are increasing in prevalence and present an emerging epidemic for westernized countries. Strict dietary avoidance is the only approved management for food allergy, but accidental exposures regularly occur, leading to significant patient anxiety and decreased quality of life. Over the past decade, oral and sublingual immunotherapies have emerged as potential treatments for food allergy. While several small clinical trials have demonstrated that immunotherapy can desensitize food-allergic individuals, strategies for further enhancing safety and definitively establishing long-term efficacy are needed. This review presents an overview of recent oral and sublingual immunotherapy trials, and provides a glimpse into what the next generation of food immunotherapy may entail.
Topics: Administration, Oral; Administration, Sublingual; Clinical Trials as Topic; Food Hypersensitivity; Humans; Immunotherapy; Sublingual Immunotherapy
PubMed: 23972904
DOI: 10.1016/j.coi.2013.07.011 -
The Veterinary Record Apr 2017
Topics: Administration, Oral; Animals; Cat Diseases; Cats
PubMed: 28385760
DOI: 10.1136/vr.j1391 -
The British Journal of Dermatology Apr 2024
Topics: Humans; Psoriasis; Administration, Oral; Heterocyclic Compounds
PubMed: 38407434
DOI: 10.1093/bjd/ljae087 -
Environment International Jul 2018
Topics: Administration, Oral; Benzhydryl Compounds; Humans; Phenols; Sulfones
PubMed: 29635094
DOI: 10.1016/j.envint.2018.03.042 -
The American Journal of Tropical... Jan 1959
Topics: Administration, Oral; Antimalarials; Humans; Pyrimethamine
PubMed: 13617598
DOI: 10.4269/ajtmh.1959.8.60 -
Wiener Medizinische Wochenschrift (1946) 1999Local routes for immunotherapy (IT) such as oral (OIT) and sublingual (SLIT) have the primary aim of avoiding or minimizing the risk of adverse events and of improving... (Review)
Review
Local routes for immunotherapy (IT) such as oral (OIT) and sublingual (SLIT) have the primary aim of avoiding or minimizing the risk of adverse events and of improving the compliance of the patients with IT itself. About the possible mechanisms of action, only few information are available since local IT has been deeply studied only in the last ten years. The current data about pharmacokinetics are controversial and not conclusive, since they are mostly derived from animal models. However, very recent studies have demonstrated that the sublingual/swallow modality is the most promising way of mucosal immunotherapy. Thus, SLIT could be shown to lead to systemic immunological effects and to a decreased responsiveness of target organs. Furthermore, no severe adverse events were reported in the SLIT-studies. Some studies indicate that SLIT is as effective as subcutaneous IT, whilst OIT is not recommended for the clinical practice. SLIT would appear particularly suitable for pediatric patients. Administration schedules include a build-up phase and a maintenance phase which can be administered either preseasonally or continuously, and rush schedules for preseasonal IT are also available. Furthermore, SLIT reduces time and money expenses usually required by SIT since it is self-administered.
Topics: Administration, Oral; Administration, Sublingual; Allergens; Humans; Hypersensitivity; Immunotherapy; Randomized Controlled Trials as Topic
PubMed: 10584288
DOI: No ID Found -
Medizinische Klinik (Munich, Germany :... Feb 1999The pharmaceutical and biopharmaceutical development of drug preparations comprehends the transformation of a drug in an applicable drug preparation with optimal... (Review)
Review
The pharmaceutical and biopharmaceutical development of drug preparations comprehends the transformation of a drug in an applicable drug preparation with optimal efficacy, safety and acceptance. Thus, a drug delivery system has to be developed that controls the onset, the duration and the intensity of the expected effect. Depending on the specific drug properties and to the special objectives different controlling principles have to be selected. These are for example delayed release (salivaresistance, gastroresistance), slow release, release in distinct regions of the gastrointestinal tract and accelerated release.
Topics: Administration, Oral; Biotransformation; Drug Compounding; Drug Delivery Systems; Humans; Pharmacokinetics
PubMed: 10194940
DOI: 10.1007/BF03042025