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The Journal of Craniofacial Surgery Mar 2004Benign osteoblastoma is a rare primary bone tumor that constitutes approximately 1% of all primary bone tumors. Its occurrence in the craniomaxillofacial region as also... (Review)
Review
Benign osteoblastoma is a rare primary bone tumor that constitutes approximately 1% of all primary bone tumors. Its occurrence in the craniomaxillofacial region as also rare and represents only 15% of all osteoblastomas. The tumor shows a predilection for the male gender and constitutes less than 1% of all tumors of the maxillofacial region. In the maxillofacial region, the mandible is affected more frequently than the maxilla, and the coronoid process of the mandible is the area most rarely affected by osteoblastoma. Before this report, 53 cases have been reported in the literature. In this report, a rare location of osteoblastoma, namely, the coronoid process of the mandible, is described.
Topics: Adult; Facial Pain; Female; Humans; Mandibular Neoplasms; Osteoblastoma
PubMed: 15167234
DOI: 10.1097/00001665-200403000-00009 -
Annales de Chirurgie de La Main :... 1983One case of a benign osteoblastoma, localised on the proximal phalanx of right thumb is reported. Three points are emphasized: the low frequency in the hand, only six... (Review)
Review
One case of a benign osteoblastoma, localised on the proximal phalanx of right thumb is reported. Three points are emphasized: the low frequency in the hand, only six observations are reported in the English literature, one from Jaffe (1932) and four from Lichtenstein (1964) and one from Mosher and coll (1978). The non-specificity of the signs and X-ray are must consider chondroma, giant cell tumor, chondrosarcoma or aneurysmal cyst. The lesion is benign and so the treatment must be conservative.
Topics: Adult; Bone Cysts, Aneurysmal; Bone Neoplasms; Chondroma; Chondrosarcoma; Diagnosis, Differential; Female; Giant Cell Tumor of Bone; Humans; Osteoblastoma; Radiography; Thumb
PubMed: 9382646
DOI: 10.1016/s0753-9053(83)80012-x -
The Journal of Pathology. Clinical... Oct 2020Osteoblastoma is a locally aggressive tumour of bone. Until recently, its underlying genetic features were largely unknown. During the past two years, reports have...
Osteoblastoma is a locally aggressive tumour of bone. Until recently, its underlying genetic features were largely unknown. During the past two years, reports have demonstrated that acquired structural variations affect the transcription factor FOS in a high proportion of cases. These rearrangements modify the terminal exon of the gene and are believed to stabilise both the FOS transcript and the encoded protein, resulting in high expression levels. Here, we applied in-depth genetic analyses to a series of 29 osteoblastomas, including five classified as epithelioid osteoblastoma. We found recurrent homozygous deletions of the NF2 gene in three of the five epithelioid cases and in one conventional osteoblastoma. These events were mutually exclusive from FOS mutations. Structural variations were determined by deep whole genome sequencing and the number of FOS-rearranged cases was less than previously reported (10/23, 43%). One conventional osteoblastoma displayed a novel mechanism of FOS upregulation; bringing the entire FOS gene under the control of the WNT5A enhancer that is itself activated by FOS. Taken together, we show that NF2 loss characterises a subgroup of osteoblastomas, distinct from FOS-rearranged cases. Both NF2 and FOS are involved in regulating bone homeostasis, thereby providing a mechanistic link to the excessive bone growth of osteoblastoma.
Topics: Adolescent; Adult; Biomarkers, Tumor; Bone Neoplasms; Child; Child, Preschool; Enhancer Elements, Genetic; Epithelioid Cells; Europe; Female; Gene Deletion; Gene Rearrangement; Genetic Predisposition to Disease; Humans; Male; Middle Aged; Neurofibromin 2; Osteoblastoma; Osteogenesis; Phenotype; Proto-Oncogene Proteins c-fos; Wnt-5a Protein; Young Adult
PubMed: 32542935
DOI: 10.1002/cjp2.172 -
The American Journal of Case Reports Feb 2021BACKGROUND Osteoblastoma is a very rare bone tumor accounting for 1% of all bone tumors. Most of the time it involves the spine and long bones and it involves the ribs...
BACKGROUND Osteoblastoma is a very rare bone tumor accounting for 1% of all bone tumors. Most of the time it involves the spine and long bones and it involves the ribs very rarely. While osteoblastoma occurrence in the first rib has been reported, causing neurogenic thoracic outlet syndrome (TOS) has never been reported. CASE REPORT A 23-year-old woman presented with a left cervical mass associated with pain and paresthesia in the medial aspect of the left upper extremity and 4th and 5th fingers for the previous 3 months. The patient denied any previous illness or trauma in her history. Physical examination revealed a hard mass in the posterior triangle of the left neck with altered sensation in the left 4th and 5th fingers. The patient was investigated by a chest roentgenogram, nerve conduction study, computer tomography (CT) of the chest, and magnetic resonance image (MRI), as well as incisional biopsy. Although all radiological investigations were suggesting osteochondroma with a differential diagnosis of chondrosarcoma, the incisional biopsy showed osteoblastoma. Radical surgical excision of the lesion followed through a left supraclavicular approach. The patient's preoperative symptoms were relieved completely and there was no recurrence of the tumor at 2 years. CONCLUSIONS Osteoblastoma of the first rib is very rare tumor and to present with TOS is extremely rare. The nonspecific radiological characteristics of the tumor, especially on CT, makes the preoperative certainty of the diagnosis unlikely.
Topics: Adult; Female; Humans; Magnetic Resonance Imaging; Neoplasm Recurrence, Local; Osteoblastoma; Ribs; Thoracic Outlet Syndrome; Young Adult
PubMed: 33556044
DOI: 10.12659/AJCR.928548 -
Journal of Oral and Maxillofacial... Nov 2000
Review
Topics: Adolescent; Humans; Male; Mandibular Neoplasms; Osteoblastoma; Radiography, Panoramic; Tomography, X-Ray Computed
PubMed: 11078147
DOI: 10.1053/joms.2000.16637 -
Neuro-Chirurgie Jul 2021Osteoblastoma of the skull is a rare entity, and they account only for 2-4% of all the cases of osteoblastoma. We perform a comprehensive review of the pertinent...
Osteoblastoma of the skull is a rare entity, and they account only for 2-4% of all the cases of osteoblastoma. We perform a comprehensive review of the pertinent literature on the subject and we report a case of a 3-year-old girl presenting with a 6-month history of a supraorbital mass and exophthalmos due to an osteoblastoma of the frontal and ethmoid bones involving the orbit and anterior skull base. A 3D printed model of the patient's skull was used for the preoperative planning and reconstruction strategy. Total en-bloc resection of the tumor followed by immediate reconstruction was achieved. No recurrence was detected 3 years after the surgery. Gross total resection is strongly advised with skull osteoblastoma, especially in young age, because of the risk of the recurrence and malignant transformation. 3D printing is proven to be a valuable tool to enhance surgical performance by avoiding complications while achieving total resection with accurate reconstruction. Long-term follow-up is important to detect recurrences and improve the management of these young patients.
Topics: Bone Neoplasms; Child, Preschool; Female; Follow-Up Studies; Humans; Osteoblastoma; Printing, Three-Dimensional; Plastic Surgery Procedures; Skull; Treatment Outcome
PubMed: 33049284
DOI: 10.1016/j.neuchi.2020.05.010 -
Modern Pathology : An Official Journal... Nov 1993A series of 11 osteosarcomas that histologically resembles osteoblastoma was reviewed. The ages of the seven males and four females ranged from 19 to 47 yr (average 29)....
A series of 11 osteosarcomas that histologically resembles osteoblastoma was reviewed. The ages of the seven males and four females ranged from 19 to 47 yr (average 29). In six patients the roentgenograms showed cortical destruction and poorly defined borders on the lesion; this roentgenographic presentation was suggestive of malignancy. Histologically, the tumor permeation of the surrounding host tissue allowed us to differentiate osteoblastoma-like osteosarcoma from osteoblastoma. The differential diagnosis can be very difficult or even impossible on a small biopsy. The first diagnosis was considered benign in nine of our cases. Osteoblastoma-like osteosarcoma is a rare variety of osteosarcoma (1.1% of all osteosarcoma). It is a low-grade malignant lesion in which recurrence is the rule when adequate surgical margins were not achieved (five patients). Two of these patients died from tumors after inadequate surgical treatment of the primary tumor as well as of the recurrences. The six patients who were treated with wide surgical margins were alive without recurrence. One of them had lung metastasis, twice, treated with wide-wedge resection. Osteoblastoma-like osteosarcoma is a low-grade variety of osteosarcoma with characteristic histopathologic features. It needs to be recognized by the pathologist to achieve the right treatment which is wide surgical procedure.
Topics: Adult; Bone Neoplasms; Diagnosis, Differential; Female; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Osteoblastoma; Osteosarcoma; Survival Analysis; Tomography, X-Ray Computed
PubMed: 8302813
DOI: No ID Found -
Journal of X-ray Science and Technology 2017Osteoblastoma is a rare benign primary bone tumor, which occurs in any part of the skeleton. Extraskeletal osteoblastoma is rather rare. We presented an extremely rare...
Osteoblastoma is a rare benign primary bone tumor, which occurs in any part of the skeleton. Extraskeletal osteoblastoma is rather rare. We presented an extremely rare case of extraskeletal osteoblastoma located in the breast. The tumor recurred 7 months later after resection and transformed to aggressive osteoblastoma. The histopathological features, ultrasonic manifestations and ultrasonic differential diagnoses of the primary and recurrent tumors were discussed. The recommended treatment of the tumor is surgical excision. Due to its tendency of recurrence and potential malignant transformation, adequate resection and careful follow up is essential.
Topics: Breast; Breast Neoplasms; Female; Humans; Image Interpretation, Computer-Assisted; Learning Curve; Machine Learning; Neural Networks, Computer; Osteoblastoma; ROC Curve; Recurrence; Ultrasonography, Doppler, Color
PubMed: 28506022
DOI: 10.3233/XST-16235 -
Genes, Chromosomes & Cancer May 2024Osteoblastomas (OBs) are benign neoplasms constituting approximately 1% of primary bone tumors with a predilection for the spine and sacrum. We describe an OB of the... (Review)
Review
Osteoblastomas (OBs) are benign neoplasms constituting approximately 1% of primary bone tumors with a predilection for the spine and sacrum. We describe an OB of the proximal phalanx of the left thumb in a 38-year-old female. MRI of left hand demonstrated a 29-mm mildly expansile enhancing lesion involving the entire proximal phalanx of the first digit. Histology displayed a bone-forming tumor consisting of trabeculae of remodeled woven bone framed by plump osteoblasts in a vascularized background. Next-generation sequencing analysis identified a PRSS44::ALK fusion gene.
Topics: Humans; Female; Adult; Thumb; Osteoblastoma; Bone Neoplasms; Oncogene Proteins, Fusion
PubMed: 38738966
DOI: 10.1002/gcc.23241 -
AJR. American Journal of Roentgenology Nov 1998
Topics: Adult; Cervical Vertebrae; Humans; Male; Osteoblastoma; Radiography; Spinal Neoplasms
PubMed: 9798854
DOI: 10.2214/ajr.171.5.9798854