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Spine Oct 2009Clinically based systematic review. (Review)
Review
STUDY DESIGN
Clinically based systematic review.
OBJECTIVE
To define optimal clinical care for primary spinal aggressive "benign" osseous neoplasms using a systematic review with expert opinion.
METHODS
Predefined focused questions on treatment of osteoblastomas, aneurysmal bone cysts and giant cell tumors were refined by a panel of spine oncology surgeons, medical and radiation oncologist. Keywords were searched through Medline and pertinent abstracts and articles obtained. The quality of literature was rated as high, moderate, low or very low. Based on literature review and expert opinion recommendations were composed through the GRADE system and rated as either strong or weak.
RESULTS
The literature searches revealed very low quality evidence with no prospective or randomized studies. There are a limited number of patients with aggressive primary osseous tumors. The osteoblastoma initial search identified 211 articles of which 17 were pertinent to the spinal questions. The aneurysmal bone cysts initial search revealed 482 articles initially of which 6 were pertinent; and the search on giant cell tumors identified 178 articles of which only 8 were focused on the predefined treatment questions.
CONCLUSION
Spinal aggressive benign osseous neoplasms have varying histology. Despite these differences surgical treatment should be directed at gross resection of the tumor, understanding that this may be limited by anatomic confines and the potential for morbidity.
Topics: Bone Cysts, Aneurysmal; Giant Cell Tumor of Bone; Humans; Osteoblastoma; Spinal Diseases; Spinal Neoplasms
PubMed: 19829276
DOI: 10.1097/BRS.0b013e3181ba0024 -
Neurosurgery Clinics of North America Jan 2008Osteoid osteomas and osteoblastomas of the spine are rare primary spine tumors consisting of osteoblasts that produce osteoid and woven bone. They often involve the... (Review)
Review
Osteoid osteomas and osteoblastomas of the spine are rare primary spine tumors consisting of osteoblasts that produce osteoid and woven bone. They often involve the posterior spinal elements, with the thoracolumbar spine being the most common site of involvement. The authors review the clinical presentation, radiologic findings, and treatment in osteoid osteoma and osteoblastoma of the spine, with an emphasis on surgical management and outcomes in recent years.
Topics: Adolescent; Adult; Age Distribution; Diagnostic Imaging; Female; Humans; Male; Neurosurgical Procedures; Osteoblastoma; Osteoma, Osteoid; Pain; Scoliosis; Spinal Neoplasms; Treatment Outcome
PubMed: 18156049
DOI: 10.1016/j.nec.2007.09.003 -
Skeletal Radiology Oct 1993The benign bone lesions--osteoma, osteoid osteoma, and osteoblastoma--are characterized as bone-forming because tumor cells produce osteoid or mature bone. Osteoma is a... (Review)
Review
The benign bone lesions--osteoma, osteoid osteoma, and osteoblastoma--are characterized as bone-forming because tumor cells produce osteoid or mature bone. Osteoma is a slow-growing lesion most commonly seen in the paranasal sinuses and in the calvaria. When it occurs in the long bones, it is invariably juxtacortical and may need to be differentiated from, among others, parosteal osteosarcoma, sessile osteochondroma, and a matured juxtacortical focus of myositis ossificans. Osteoid osteoma and osteoblastoma appear histologically very similar. Their clinical presentations and distribution in the skeleton, however, are distinct: osteoid osteoma is usually accompanied by nocturnal pain promptly relieved by salicylates; osteoblastoma arises predominantly in the axial skeleton, spinal lesions constituting one-third of reported cases. This review focuses on the application of the various imaging modalities in the diagnosis, differential diagnosis, and evaluation of these lesions. Their histopathology also is discussed, and their treatment briefly outlined.
Topics: Bone Neoplasms; Diagnosis, Differential; Diagnostic Imaging; Humans; Osteoblastoma; Osteoma; Osteoma, Osteoid
PubMed: 8272884
DOI: 10.1007/BF00209095 -
Surgical Pathology Clinics Dec 2021Benign bone-forming tumors comprise osteomas, osteoid osteomas, and osteoblastomas. Osteomas affect a wide age range and are usually discovered incidentally. They occur... (Review)
Review
Benign bone-forming tumors comprise osteomas, osteoid osteomas, and osteoblastomas. Osteomas affect a wide age range and are usually discovered incidentally. They occur predominantly in the craniofacial skeleton and are classically composed of compact bone. Osteoid osteomas and osteoblastomas are painful lesions occurring in young patients. They are morphologically similar and characterized by FOS gene rearrangement and c-FOS expression at a protein level. Osteoid osteomas are usually smaller than 2 cm in maximum dimension with limited growth potential; osteoblastomas are larger than 2 cm and may be locally aggressive. Histologically both are composed of anastomosing trabeculae of woven bone.
Topics: Bone Neoplasms; Gene Rearrangement; Humans; Osteoblastoma; Osteoma, Osteoid; Soft Tissue Neoplasms
PubMed: 34742480
DOI: 10.1016/j.path.2021.06.002 -
European Archives of... Feb 2017The objectives of this study were to describe a case of osteoid osteoma arising from the temporal bone manifesting only as first bite syndrome as the sole clinical... (Meta-Analysis)
Meta-Analysis Review
The objectives of this study were to describe a case of osteoid osteoma arising from the temporal bone manifesting only as first bite syndrome as the sole clinical symptom, to perform a meta-analysis of previously reported cases, and to differentiate the clinical characteristics of osteoid osteoma from those of osteoblastoma arising from the temporal bone. In addition to our case, articles addressing osteoid osteoma or osteoblastoma arising from the temporal bone were selected using PubMed, Embase, and the Japan Medical Abstracts Society database (1954 through 2014), with no language preference. The database was searched using the keywords ["osteoid osteoma" OR "osteoblastoma" AND "temporal bone"]. After critical review of 88 studies, 10 cases of osteoid osteoma and 29 cases of osteoblastoma were selected; therefore, including the present case, a total of 40 cases were eligible for qualitative analyses. The mean size of osteoid osteoma was 1.2 cm, which was significantly smaller than that of osteoblastoma (5.1 cm). Radiologically, osteoid osteoma was associated with a lower prevalence of extension into more than two anatomically categorized spaces in comparison with osteoblastoma (P < 0.01). Again, a lower prevalence of erosion of the outer and/or inner tables of the skull in the osteoid osteoma cases was noted (P < 0.05). Conversely, there were no significant differences in the prevalence of representative clinical symptoms, including pain and swelling. According to the present systematic review, osteoid osteoma and osteoblastoma are clinically uniform other than their size or extension.
Topics: Adult; Bone Neoplasms; Facial Neuralgia; Female; Humans; Mastication; Osteoblastoma; Osteoma, Osteoid; Syndrome; Temporal Bone
PubMed: 27106094
DOI: 10.1007/s00405-016-4050-1 -
AJNR. American Journal of Neuroradiology Jun 2010Osteoblastoma is a rare bone tumor that usually affects the vertebrae. We present the first known case of osteoblastoma arising in the hyoid bone, in a patient who...
Osteoblastoma is a rare bone tumor that usually affects the vertebrae. We present the first known case of osteoblastoma arising in the hyoid bone, in a patient who presented with a neck mass and dysphagia. The radiographic appearance of the tumor is similar to that of low-grade chondrosarcoma, with well-defined expansion of the bone and central chondroid matrix.
Topics: Bone Cysts; Bone Neoplasms; Humans; Hyoid Bone; Male; Middle Aged; Osteoblastoma; Tomography, X-Ray Computed
PubMed: 19942701
DOI: 10.3174/ajnr.A1872 -
Surgical management of an osteoblastoma involving the entire C2 vertebra and a review of literature.European Spine Journal : Official... May 2016The purpose of this study was to evaluate the surgical management of an osteoblastoma involving the entire C2 vertebra. (Review)
Review
PURPOSE
The purpose of this study was to evaluate the surgical management of an osteoblastoma involving the entire C2 vertebra.
MATERIALS AND METHODS
A 14-year-old girl presented with unbearable neck pain. Her medical history was unremarkable. Computed tomography and magnetic resonance imaging revealed lytic and osteoblastic bone lesions involving the entire C2 vertebra. The tumor was resected in two stages with vertebral artery mobilization. Histological examination confirmed the diagnosis of osteoblastoma. The pain resolved postoperatively, and the patient had no further complaints. Sufficient fusion formation and no tumor recurrence with no complaints were seen in postoperatively 4 years.
CONCLUSION
Marginal resection remains the best treatment for osteoblastoma of the spine. If tumor tissue surrounds the vertebral artery, the vertebral artery should be mobilized and the surrounding tumor mass excised.
Topics: Adolescent; Cervical Vertebrae; Female; Humans; Magnetic Resonance Imaging; Neoplasm Recurrence, Local; Osteoblastoma; Spinal Neoplasms; Tomography, X-Ray Computed; Vertebral Artery
PubMed: 26879919
DOI: 10.1007/s00586-016-4445-0 -
Surgical Pathology Clinics Sep 2017Bone-forming tumors are defined by neoplastic cells that differentiate along the lines of osteoblasts that deposit neoplastic bone. The morphology and biological... (Review)
Review
Bone-forming tumors are defined by neoplastic cells that differentiate along the lines of osteoblasts that deposit neoplastic bone. The morphology and biological spectrum of bone-forming tumors is broad, and their accurate diagnosis requires the careful correlation of their clinical, morphologic, and radiologic characteristics. Immunohistochemical and molecular analyses have an important role in select instances. At present, the identification of neoplastic bone largely depends on histologic analysis, which can be subjective. The major types of osteosarcoma are defined according to their morphology, origin within or on the surface of the bone, and their histologic grade.
Topics: Bone Neoplasms; Diagnosis, Differential; Fibrous Dysplasia of Bone; Humans; Osteoblastoma; Osteoma, Osteoid; Osteosarcoma
PubMed: 28797500
DOI: 10.1016/j.path.2017.04.006 -
Cancer Genomics & Proteomics 2020Osteoblastoma is a rare benign tumor of the bones in which recurrent rearrangements of FOS have been found. Our aim was to investigate two osteoblastomas for possible...
BACKGROUND/AIM
Osteoblastoma is a rare benign tumor of the bones in which recurrent rearrangements of FOS have been found. Our aim was to investigate two osteoblastomas for possible genetic aberrations.
MATERIALS AND METHODS
Cytogenetic, RNA sequencing, and molecular analyses were performed.
RESULTS
A FOS-ANKH transcript was found in the first tumor, whereas a FOS-RUNX2 was detected in the second. Exon 4 of FOS fused with sequences either from intron 1 of ANKH or intron 5 of RUNX2. The fusion events introduced a stop codon and removed sequences involved in the regulation of FOS.
CONCLUSION
Rearrangements and fusions of FOS show similarities with those of HMGA2 (a feature of leiomyomas and lipomas) and CSF1 (tenosynovial giant cell tumors). The replacement of a 3'-untranslated region, controlling the gene's expression, by a new sequence is thus a common pathogenetic theme shared by FOS, HMGA2, and CSF1 in many benign connective tissue tumors.
Topics: Base Sequence; Bone Neoplasms; Child; Core Binding Factor Alpha 1 Subunit; Female; Gene Expression; Humans; Karyotype; Male; Oncogene Proteins, Fusion; Osteoblastoma; Phosphate Transport Proteins
PubMed: 32108038
DOI: 10.21873/cgp.20176 -
Orthopedics May 2019The authors report an osteoblastoma-like variant of osteosarcoma of the right ischial tuberosity in a 14-year-old boy. Radiographs initially showed a bone-forming lesion...
The authors report an osteoblastoma-like variant of osteosarcoma of the right ischial tuberosity in a 14-year-old boy. Radiographs initially showed a bone-forming lesion of the right ischial tuberosity. The patient underwent biopsy with curettage and bone grafting, with final pathology revealing osteoblastoma. Two years after the initial procedure, he presented with exuberant bone formation about the operative site concerning for recurrence. He underwent a second biopsy that showed transformation into a high-grade osteoblastoma-like osteosarcoma. Results from staging studies were negative for distant metastatic disease. The patient was treated with standard 3-drug chemotherapy along with wide resection of the right ischium with periacetabular reconstruction and total hip arthroplasty. [Orthopedics. 2019; 42(3):e343-e345.].
Topics: Adolescent; Bone Neoplasms; Cell Transformation, Neoplastic; Humans; Ischium; Male; Osteoblastoma; Osteosarcoma
PubMed: 30810758
DOI: 10.3928/01477447-20190221-05