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European Journal of Dermatology : EJD Nov 2022
Topics: Humans; Bone Diseases, Metabolic; Skin Diseases, Genetic
PubMed: 36856402
DOI: 10.1684/ejd.2022.4386 -
JAAD Case Reports Apr 2022
PubMed: 35242977
DOI: 10.1016/j.jdcr.2022.01.023 -
The Journal of Clinical and Aesthetic... Nov 2020The development of calcium salt deposits in the skin can occur in the presence or absence of membranous ossification and are categorized into osteoma cutis (i.e.,...
The development of calcium salt deposits in the skin can occur in the presence or absence of membranous ossification and are categorized into osteoma cutis (i.e., cutaneous osteoma) and calcinosis cutis. For the former, distinction into primary or secondary osteoma cutis is mainly based on clinical and histopathological parameters, as primary osteoma cutis originates without any underlying intradermal inflammatory or neoplastic process, as opposed to a far greater number of secondary osteoma cutis that occur on the grounds of inflammation or tumors. Genetic disorders might predispose a person to the formation of these overall rare tumors. However, some patients develop primary osteoma cutis in the absence of any genetic background. In pre-menopausal women with fair skin, the condition of multiple miliary osteoma cutis is a relevant differential diagnosis for solid subcutaneous facial nodules. While pathogenesis remains unclear, most affected individuals have suffered from acne vulgaris at some point. Excision might be a viable option for disturbing lesions, as are ablative lasers. Here, we discuss and review relevant causes of calcium salt deposits in the skin based on a notable case of multiple primary osteoma cutis of the face in an otherwise healthy woman.
PubMed: 33282099
DOI: No ID Found -
Indian Dermatology Online Journal 2023
PubMed: 37266104
DOI: 10.4103/idoj.idoj_321_22 -
European Journal of Dermatology : EJD Aug 2018Multiple miliary osteoma cutis consists of heterotopic foci of bone tissue in the dermis and subcutaneous tissue. Patients usually present with multiple, asymptomatic... (Review)
Review
Multiple miliary osteoma cutis consists of heterotopic foci of bone tissue in the dermis and subcutaneous tissue. Patients usually present with multiple, asymptomatic facial papules of several millimetres in diameter which cause distress regarding their cosmetic appearance. The condition is described as rare, as only a few cases have been reported since its first description in 1864 by Virchow. We therefore carried out a comprehensive literature search and review, in which 102 published cases were retrieved and analysed. The demographic and clinical aspects, as well as current therapy solutions, of this probably overlooked condition are discussed.
Topics: Bone Density Conservation Agents; Bone Diseases, Metabolic; Dermatologic Surgical Procedures; Diagnosis, Differential; Humans; Ossification, Heterotopic; Retinoids; Skin Diseases, Genetic
PubMed: 30325330
DOI: 10.1684/ejd.2018.3365 -
Pediatrics International : Official... Apr 2013
Topics: Biopsy; Bone Diseases, Metabolic; Diagnosis, Differential; Humans; Infant; Male; Ossification, Heterotopic; Skin; Skin Diseases, Genetic
PubMed: 23679170
DOI: 10.1111/ped.12062 -
Dermatology Online Journal Oct 2011Plate-like osteoma cutis is a rare disorder that has been historically classified as a congenital syndrome. It has a possible relationship to a mutation in the gene... (Review)
Review
Plate-like osteoma cutis is a rare disorder that has been historically classified as a congenital syndrome. It has a possible relationship to a mutation in the gene (GNAS1) that encodes the α-subunit of the stimulatory G protein, which regulates adenyl cyclase activity. We report a case of extensive plaque-like masses on the scalp and face with no abnormalities in calcium or phosphate metabolism and no preceding inflammatory cutaneous conditions. With less than ten reported cases, to our knowledge, this is one the few cases of acquired plate-like osteoma cutis described in the literature.
Topics: Calcium; Chromogranins; Facial Dermatoses; GTP-Binding Protein alpha Subunits, Gs; Humans; Male; Middle Aged; Ossification, Heterotopic; Osteoma; Phosphorus; Scalp Dermatoses; Skin Diseases; Thigh; Thorax
PubMed: 22031627
DOI: No ID Found -
Clinical and Experimental Dermatology Jun 2023
Topics: Humans; Scalp; Skin Diseases, Genetic; Ossification, Heterotopic; Alopecia; Skin Neoplasms
PubMed: 36897160
DOI: 10.1093/ced/llad087 -
Dermatology Online Journal Apr 2017We report a healthy, 44-year-old woman presenting with an at least a 20-year history of hardened papules in the forehead region, extending to the scalp. The biopsy and... (Review)
Review
We report a healthy, 44-year-old woman presenting with an at least a 20-year history of hardened papules in the forehead region, extending to the scalp. The biopsy and histopathologic exam confirmed a diagnosis of osteoma cutis. We review the literature review and discuss the classification of the cutaneous ossification process presented, along with the results of the surgical treatment.
Topics: Adult; Biopsy; Bone Diseases, Metabolic; Dermoscopy; Facial Dermatoses; Female; Forehead; Humans; Ossification, Heterotopic; Skin; Skin Diseases, Genetic
PubMed: 28541879
DOI: No ID Found