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Indian Journal of Dermatology,... 2017
Topics: Adult; Bone Diseases, Metabolic; Cutis Laxa; Female; Humans; Ossification, Heterotopic; Pseudoxanthoma Elasticum; Skin Diseases, Genetic
PubMed: 28540877
DOI: 10.4103/ijdvl.IJDVL_690_16 -
The American Journal of Dermatopathology Feb 2019Osteonevus of Nanta is a rare histopathologic variant of melanocytic nevus that results from ossification of the dermis between dermal nests of melanocytes. Most cases...
Osteonevus of Nanta is a rare histopathologic variant of melanocytic nevus that results from ossification of the dermis between dermal nests of melanocytes. Most cases described in the literature have been associated with long-standing intradermal nevi and were often located in the upper part of the body. We report a lesion on the shoulder of an elderly man showing the association of a common blue nevus and osteoma cutis, an exceptional feature which has been previously reported in 2 instances. We also describe for the first time the dermoscopic appearance of this "blue osteonevus."
Topics: Aged, 80 and over; Bone Diseases, Metabolic; Humans; Male; Nevus, Blue; Ossification, Heterotopic; Skin Diseases, Genetic; Skin Neoplasms
PubMed: 29933316
DOI: 10.1097/DAD.0000000000001211 -
Journal of Cosmetic Dermatology Jan 2022
Topics: Bone Diseases, Metabolic; Botulinum Toxins; Humans; Keratosis, Seborrheic; Ossification, Heterotopic; Skin Diseases, Genetic; Skin Neoplasms
PubMed: 34716640
DOI: 10.1111/jocd.14575 -
Dermatologic Clinics Apr 2016Acne vulgaris (AV) is considered a straightforward diagnosis made clinically without specific diagnostic testing. However, certain disorders may simulate AV, such as... (Review)
Review
Acne vulgaris (AV) is considered a straightforward diagnosis made clinically without specific diagnostic testing. However, certain disorders may simulate AV, such as multiple small epidermal cysts or deep milia, multiple osteoma cutis, multiple small adnexal neoplasms, and follicular and/or infections characterized by multiple small papules and/or pustules such as gram-positive folliculitis, gram-negative folliculitis, Malassezia folliculitis, keratosis pilaris, and flat warts. This can lead to an erroneous diagnosis and improper management. Acneiform eruptions, often associated with ingestion of certain drugs and chemicals, can confound the clinician regarding AV diagnosis. We present herein an interesting case that was originally misdiagnosed as AV.
Topics: Acne Vulgaris; Acneiform Eruptions; Dermatomycoses; Diagnosis, Differential; Folliculitis; Humans; Skin
PubMed: 27015783
DOI: 10.1016/j.det.2015.12.002 -
SAGE Open Medical Case Reports 2020Facial multiple miliary osteoma cutis is a variant of osteoma cutis usually occurring in women with a previous history of acne vulgaris. Successful ablative laser...
Facial multiple miliary osteoma cutis is a variant of osteoma cutis usually occurring in women with a previous history of acne vulgaris. Successful ablative laser treatment has been reported using both CO2 and Er:YAG lasers among other invasive treatment modalities, like surgical removal. We report a patient with biopsy-proven facial multiple miliary osteoma cutis responding to non-ablative Q-switched Nd:YAG laser therapy. The patient had excellent cosmesis without textural changes or hypopigmentation despite her Asian background after three sessions over 6 months. Multiple miliary osteoma cutis is therefore now amenable to non-surgical non-ablative therapy by using Q-switched Nd:YAG laser therapy reducing the risk of textural changes and hypopigmentation, especially in dark complexion and high-risk individuals. To our knowledge, this treatment approach has not been previously reported.
PubMed: 32180982
DOI: 10.1177/2050313X20910562 -
The British Journal of Dermatology Mar 2011Multiple miliary osteoma cutis (MMOC) is a rare nodular skin disease characterized by tiny bone nodules which usually form on the facial skin, typically in middle age.... (Review)
Review
BACKGROUND
Multiple miliary osteoma cutis (MMOC) is a rare nodular skin disease characterized by tiny bone nodules which usually form on the facial skin, typically in middle age. The aetiology of this phenomenon is poorly understood.
OBJECTIVES
To search for possible bone formation progenitors and to look for a possible association with mutations in the GNAS gene (encoding the G-protein α-stimulatory subunit) and related hormonal parameters in patients with MMOC. We also reviewed the literature and discuss the aetiology and pathogenesis of adult-onset primary osteomas.
METHODS
We report four cases of MMOC. Histological samples were analysed for bone morphogenetic protein (BMP)-2, BMP-4 and oestrogen receptor-α known to be involved in bone formation. Endocrinological laboratory investigations and hand X-rays were performed to exclude a systemic disease. The GNAS gene was sequenced from DNA extracted from peripheral blood in all four patients and from a skin sample in one patient to exclude somatic mutations.
RESULTS
Histological analyses revealed intramembranous cutaneous bone formation resembling the findings seen in GNAS gene-based osteoma cutis disorders. However, we did not find any germline or somatic GNAS gene mutations in our patients and all laboratory investigations gave normal results. BMP-2 and -4 were expressed normally in MMOC samples, but oestrogen receptor-α was not expressed. Altogether 47 MMOC cases, 41 female and six male, have been published between 1928 and 2009. Of these cases, 55% had a history of pre-existing acne and only 15% had extrafacial osteomas.
CONCLUSIONS
MMOC is a rare but distinct disease entity of unknown aetiology. Histologically, the tiny nodular osteomas show intramembranous superficial ossification but the aetiology appears to be different from GNAS-related disorders. The osteomas seem to increase slowly in number after appearing in middle age.
Topics: Adolescent; Adult; Aged; Bone Morphogenetic Protein 2; Bone Morphogenetic Protein 4; Chromogranins; Estrogen Receptor alpha; Facial Neoplasms; Female; GTP-Binding Protein alpha Subunits, Gs; Humans; Immunohistochemistry; Male; Middle Aged; Osteoma; Sequence Analysis, DNA; Skin Neoplasms; Young Adult
PubMed: 21062265
DOI: 10.1111/j.1365-2133.2010.10121.x -
Journal of Cutaneous Pathology Jul 2019
Topics: Bone Diseases, Metabolic; Female; Humans; Middle Aged; Nephrogenic Fibrosing Dermopathy; Ossification, Heterotopic; Skin Diseases, Genetic
PubMed: 31355484
DOI: 10.1111/cup.13409 -
International Journal of Dermatology Dec 2022
Topics: Humans; Cheek; Skin Diseases, Genetic; Ossification, Heterotopic; Bone Diseases, Metabolic; Skin Neoplasms
PubMed: 36256466
DOI: 10.1111/ijd.16453 -
Journal of the American Academy of... May 1991We describe the clinical, radiographic, histologic, and metabolic features of an unusual case of multiple miliary osteoma cutis in an otherwise healthy 57-year-old...
We describe the clinical, radiographic, histologic, and metabolic features of an unusual case of multiple miliary osteoma cutis in an otherwise healthy 57-year-old woman. Although the pathogenesis of this rarely reported entity is not fully understood, the novel application of a dynamic bone study revealed a high rate of internal bone remodeling within the lesion. This finding prompted a brief therapeutic trial of a diphosphonate, not previously reported in the treatment of this condition.
Topics: Bone and Bones; Calcification, Physiologic; Demeclocycline; Female; Humans; Middle Aged; Neoplasms, Multiple Primary; Osteoma; Oxytetracycline; Skin Neoplasms
PubMed: 1904888
DOI: 10.1016/0190-9622(91)70138-r -
The American Journal of Dermatopathology Aug 2021Parenteral gold has historically been used to treat several conditions, including rheumatoid arthritis. Gold administration leads to a variety of cutaneous reactions,...
Parenteral gold has historically been used to treat several conditions, including rheumatoid arthritis. Gold administration leads to a variety of cutaneous reactions, including chrysiasis, which is a permanent blue-grey hyperpigmentation of the skin due to dermal gold deposition. In this report, we describe the case of a patient who received parenteral gold injections 22 years before the onset of her chrysiasis for the treatment of rheumatoid arthritis. Biopsy of the macules showed dermal gold deposits aggregating around a melanocytic nevus, as well as around preexisting osteoma cutis. To the authors' knowledge, this is the first report in the literature describing a case of chrysiasis with gold deposits concentrated around a melanocytic nevus and an area of osteoma cutis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Aurothioglucose; Bone Diseases, Metabolic; Facial Dermatoses; Female; Gold; Humans; Hyperpigmentation; Middle Aged; Nevus, Pigmented; Ossification, Heterotopic; Skin Diseases, Genetic; Skin Neoplasms
PubMed: 33989211
DOI: 10.1097/DAD.0000000000001967