-
Journal of Orthopaedic Surgery (Hong... Dec 2016An osteophyte is a fibrocartilage-capped bony outgrowth that is one of the features of osteoarthritis. This study reviewed the types, risk factors, pathophysiology,... (Review)
Review
An osteophyte is a fibrocartilage-capped bony outgrowth that is one of the features of osteoarthritis. This study reviewed the types, risk factors, pathophysiology, clinical presentations, and medical and surgical treatment of osteophytes. Extraspinal osteophytes are classified as marginal, central, periosteal, or capsular, whereas vertebral osteophytes are classified as traction or claw. Risk factors for development of osteophytes include age, body mass index, physical activity, and other genetic and environmental factors. Transforming growth factor β plays a role in the pathophysiology of osteophyte formation. Osteophytes can cause pain, limit range of motion, affect quality of life, and cause multiple symptoms at the spine. Medical treatment involves the use of bisphosphonates and other non-steroidal anti-inflammatory agents. Surgical treatment in the form of cheilectomy for impingement syndromes during joint replacement is recommended.
Topics: Humans; Osteophyte
PubMed: 28031516
DOI: 10.1177/1602400327 -
Reumatologia Clinica Nov 2021
Topics: Cervical Vertebrae; Deglutition Disorders; Humans; Osteophyte
PubMed: 34756319
DOI: 10.1016/j.reumae.2020.09.005 -
Clinical Neuroradiology Mar 2019
Topics: Adult; Cerebrospinal Fluid Leak; Dura Mater; Humans; Male; Osteophyte
PubMed: 29978235
DOI: 10.1007/s00062-018-0703-3 -
Osteoarthritis and Cartilage Jun 2020Osteophytes are common anatomical signs of advanced osteoarthritis. It remains unclear whether they develop from physio-molecular, and/or mechanical stimuli. This study...
OBJECTIVES
Osteophytes are common anatomical signs of advanced osteoarthritis. It remains unclear whether they develop from physio-molecular, and/or mechanical stimuli. This study examined the effects of mechanical impact on the knee joint periosteum leading to osteophyte formation.
DESIGN
Eighteen mature rats received one single impact load of 53 N (30 MPa) to the periosteum of the experimental medial femoral condyles. Contralateral knees were used as controls. Animals were sacrificed at 24 h, 3, 6 and 9 weeks post-impact. Distal femurs were harvested and prepared for histology. Hematoxylin and Eosin, and Masson's trichrome stained slides were examined by light microscopy. Nuclear density was quantified to assess the tissue reaction.
RESULTS
24 h: The synovium membrane, fibrous and cambium periosteum were damaged. Blood infiltration pooled in the impacted medial collateral ligament (MCL) region. Week 3: A cartilaginous tissue spur, chondrophyte, was found in every rat at the impacted site of the MCL. Chondrophytes were composed of fibrocartilage and cartilage matrix, with signs of cartilage mineralization and remodelling activity. Week 6: Chondrophytes presented signs of more advanced mineralisation, recognized as osteophytes. Week 9: Osteophytes appeared to be more mineralized with almost no cartilage tissue.
CONCLUSIONS
Osteophytes can be induced with a single mechanical impact applied to the periosteum in rat knees. These data indicate that a moderate trauma to the periosteal layer of the joint may play a role in osteophyte development.
Topics: Animals; Disease Models, Animal; Hindlimb; Joints; Mechanical Phenomena; Osteophyte; Rats; Rats, Sprague-Dawley
PubMed: 32147535
DOI: 10.1016/j.joca.2020.02.834 -
Journal of Medical Imaging and... Oct 2018
Topics: Humans; Lumbar Vertebrae; Osteophyte; Spinal Diseases
PubMed: 30309166
DOI: 10.1111/1754-9485.05_12786 -
Matrix Biology : Journal of the... 2016The temporomandibular joint (TMJ) is a diarthrodial joint that relies on lubricants for frictionless movement and long-term function. It remains unclear what temporal... (Review)
Review
The temporomandibular joint (TMJ) is a diarthrodial joint that relies on lubricants for frictionless movement and long-term function. It remains unclear what temporal and causal relationships may exist between compromised lubrication and onset and progression of TMJ disease. Here we report that Proteoglycan 4 (Prg4)-null TMJs exhibit irreversible osteoarthritis-like changes over time and are linked to formation of ectopic mineralized tissues and osteophytes in articular disc, mandibular condyle and glenoid fossa. In the presumptive layer of mutant glenoid fossa's articulating surface, numerous chondrogenic cells and/or chondrocytes emerged ectopically within the type I collagen-expressing cell population, underwent endochondral bone formation accompanied by enhanced Ihh expression, became entrapped into temporal bone mineralized matrix, and thereby elicited excessive chondroid bone formation. As the osteophytes grew, the roof of the glenoid fossa/eminence became significantly thicker and flatter, resulting in loss of its characteristic concave shape for accommodation of condyle and disc. Concurrently, the condyles became flatter and larger and exhibited ectopic bone along their neck, likely supporting the enlarged condylar heads. Articular discs lost their concave configuration, and ectopic cartilage developed and articulated with osteophytes. In glenoid fossa cells in culture, hedgehog signaling stimulated chondrocyte maturation and mineralization including alkaline phosphatase, while treatment with hedgehog inhibitor HhAntag prevented such maturation process. In sum, our data indicate that Prg4 is needed for TMJ integrity and long-term postnatal function. In its absence, progenitor cells near presumptive articular layer and disc undergo ectopic chondrogenesis and generate ectopic cartilage, possibly driven by aberrant activation of Hh signaling. The data suggest also that the Prg4-null mice represent a useful model to study TMJ osteoarthritis-like degeneration and clarify its pathogenesis.
Topics: Animals; Animals, Newborn; Disease Models, Animal; Gene Expression Regulation; Gene Knockdown Techniques; Hedgehog Proteins; Humans; Mice; Osteoarthritis; Osteophyte; Proteoglycans; Signal Transduction; Temporomandibular Joint Disorders
PubMed: 26945615
DOI: 10.1016/j.matbio.2016.03.001 -
Arthroscopy : the Journal of... Aug 2022Three goals are at the top of our minds when achieving optimal outcomes for the arthroscopic treatment of femoroacetabular impingement syndrome in the primary setting:...
Three goals are at the top of our minds when achieving optimal outcomes for the arthroscopic treatment of femoroacetabular impingement syndrome in the primary setting: (1) accurate bony correction, (2) labral function restoration-typically with labral repair-and (3) comprehensive capsular management-which involves capsular preservation and closure. Notwithstanding, additional intra-articular concomitant conditions require our attention as well. Central acetabular impingement is characterized by the presence of central acetabular osteophytes at the cotyloid fossa. It has been proposed that central acetabular osteophytes lead to lateralization of the femoral head with relative femoroacetabular incongruency that increases contact force and mechanical cartilage abrasion.
Topics: Acetabulum; Arthroscopes; Arthroscopy; Femoracetabular Impingement; Hip Joint; Humans; Osteophyte; Treatment Outcome
PubMed: 35940741
DOI: 10.1016/j.arthro.2022.03.020 -
AANA Journal Aug 2023Anterior cervical osteophytes (ACOs) are a common condition in the elderly, leading to dysphagia, odynophagia, aspiration, neck pain, dysphonia, and dyspnea. Transoral... (Review)
Review
Anterior cervical osteophytes (ACOs) are a common condition in the elderly, leading to dysphagia, odynophagia, aspiration, neck pain, dysphonia, and dyspnea. Transoral surgical resection is an approach to managing cervical (C1 and C2) ACOs where the endoscopic endonasal approach is contraindicated. Advantages of the transoral approach include it providing direct access to the cervical spine, limits injury to surrounding neurovascular structures, and eliminates scarring. Anesthesia considerations for transoral surgical resection of ACOs will be covered in the following case report. A review of the literature examines the prevalence of and anesthesia considerations for the transoral approach to anterior cervical osteophyte resection.
Topics: Humans; Aged; Osteophyte; Cervical Vertebrae; Deglutition Disorders
PubMed: 37527163
DOI: No ID Found -
Neuro-Chirurgie May 2024Rotational vertebral artery syndrome, also referred to as Bow Hunter's syndrome (BHS), manifests when the vertebral artery (VA) is compressed following head rotation.... (Review)
Review
BACKGROUND
Rotational vertebral artery syndrome, also referred to as Bow Hunter's syndrome (BHS), manifests when the vertebral artery (VA) is compressed following head rotation. This compression is often caused by an osteophyte and may lead to symptoms of a posterior stroke. This systematic review aims to shed light on the current management strategies for BHS resulting from osteophytes. Additionally, we present two illustrative cases where the VA compression by an osteophyte was effectively resolved by complete resection of the problematic bone spur.
METHODS
A literature search was conducted across Embase, PubMed and Medline in September 2023. Keywords related to vertebral artery [MESH], vertebrobasilar insufficiency [MESH] and osteophyte [MESH] were the focus of this review. Risk of bias in retained studies was assessed using the Joanna Briggs Institute Critical Appraisal tools for Qualitative Research. A narrative synthesis of our findings is presented.
RESULTS
A total of 30 studies were included in this review. Vertigo was the most reported symptom by patients (n = 16). On imaging, the VA was often compressed at C4-5 (n = 10) and C5-6 (n = 10) with no evident side predominance observed. Anterior cervical discectomy and fusion (ACDF, n = 13) followed by anterior decompression without fusion (n = 8) were the most performed surgical procedures to manage BHS.
CONCLUSION
Surgical decompression of the VA is a safe and effective intervention for patients experiencing symptomatic osteophytic compression during head rotation. This procedure restores normal vascular function and reduces the risk of ischemic events. This review highlights the importance of timely diagnosis and intervention in such cases.
Topics: Humans; Vertebrobasilar Insufficiency; Osteophyte; Male; Middle Aged; Female; Decompression, Surgical; Vertebral Artery; Aged; Spinal Fusion
PubMed: 38277863
DOI: 10.1016/j.neuchi.2023.101525 -
Journal of Orthopaedic Research :... Jun 2020Osteophytes are associated with later stage osteoarthritis and are most commonly described using semiquantitative radiographic grading systems. A detailed understanding...
Osteophytes are associated with later stage osteoarthritis and are most commonly described using semiquantitative radiographic grading systems. A detailed understanding of osteophyte formation is, in part, limited by the ability to quantify bone pathology. Osteophytes can be quantified relative to pre-osteoarthritic bone, or to the contralateral bone if it is healthy; however, in many cases, neither are available as references. We present a method for computing three-dimensional (3D) osteophyte models using a library of healthy control bones. An existing data set containing the computed tomography scans of 90 patients with first carpometacarpal osteoarthritis (OA) and 46 healthy subjects were utilized. A healthy bone that best fit each OA subject's bone was determined using a dissimilarity-excluding Procrustes registration technique (DEP) that minimized the influence of dissimilar features (ie, osteophytes). The osteophyte model was then computed through Boolean subtraction of the reference bone model from the OA bone model. DEP reference bones conformed significantly better to the OA bones (P < .0001) than by finite difference iterative closest point registration (root mean squared distances, 0.33 ± 0.05 and 0.41 ± 0.16 mm, respectively). The effect of library size on dissimilarity measure was investigated by leave-k-out cross-validation randomly reducing k from 46 to 1. A library of n ≥ 31 resulted in less than 10% difference from the theoretical minimum value. The proposed method enables quantification of osteophytes when the disease-free bone or the healthy contralateral bone is not available for any 3D data set. Quantifying osteophyte formation and growth may aid in understating the associated mechanisms in OA.
Topics: Adult; Aged; Bone and Bones; Carpometacarpal Joints; Female; Healthy Volunteers; Humans; Male; Middle Aged; Osteoarthritis; Osteophyte
PubMed: 31840852
DOI: 10.1002/jor.24569