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Revista Da Escola de Enfermagem Da U S P Oct 2011The objective of this integrative literature review was to find evidence to support using ozone as a sterilizing agent for health products. The search was performed on... (Review)
Review
The objective of this integrative literature review was to find evidence to support using ozone as a sterilizing agent for health products. The search was performed on the following bases: MEDLINE, SCOPUS, COCHRANE, COMPENDEX, INSPEC and ENGINEERING RESEARCH DATABASE; using ozone and sterilization as descriptors. Five articles were found between 1990 and 2008, which tested ozone as a sterilizer. All studies used the same type of investigation (experimental laboratory study) and achieved sterilization with ozone, but with different scopes and products, besides using different methodological procedures. Considering the ever-growing technology for new products, with the vast range of forms and materials, the findings point at ozone sterilization as a promising method, but still in an initial phase of investigation. Further experimental studies are needed to provide broader evidence regarding the possibilities and limitations of ozone sterilization.
Topics: Ozone; Sterilization
PubMed: 22031389
DOI: 10.1590/s0080-62342011000500030 -
The Review of Scientific Instruments Aug 2020A portable device for cleaning and ozone sterilization of small-sized delicate dental instruments that cannot withstand the high heat and humidity of standard...
A portable device for cleaning and ozone sterilization of small-sized delicate dental instruments that cannot withstand the high heat and humidity of standard autoclaving has been developed. The device contains a remote unit for magnetic mechanical washing, an ultrasonic bath for pre-cleaning treatment, and a container for ozone sterilization with a reactor based on dielectric barrier discharge. The maximum ozone concentration in water reached 8.5 mg/l for 10 min of operation at a water temperature of 19 °C. The results of inactivation of Pseudomonas aeruginosa, Escherichia coli, and Staphylococcus aureus are presented. Distilled water with such seeded micro-organisms was bubbled with an ozone-air mixture at an ozone concentration of 5.8 mg/l at 17 °C for 5 min, 10 min, 20 min, and 30 min. The maximum bactericidal effect was manifested for Pseudomonas aeruginosa cells with their total elimination within 10 min. Inactivation of Escherichia coli bacteria was monitored after 20 min of treatment, and Staphylococcus aureus-after 30 min of treatment.
Topics: Dental Instruments; Electric Impedance; Mechanical Phenomena; Microbial Viability; Ozone; Sterilization; Temperature; Time Factors; Ultrasonic Waves; Water
PubMed: 32872939
DOI: 10.1063/1.5145279 -
Infection Control and Hospital... Oct 2020
Topics: Bacterial Infections; Burns; Humans; Leg Ulcer; Ozone; Pressure Ulcer; Sterilization
PubMed: 32389146
DOI: 10.1017/ice.2020.157 -
Zhongguo Zhong Yao Za Zhi = Zhongguo... Aug 2015Microbial contamination, growth and reproduction have a great influence on the quality of traditional Chinese medicine (TCM) and its preparation. TCM may be polluted by... (Review)
Review
Microbial contamination, growth and reproduction have a great influence on the quality of traditional Chinese medicine (TCM) and its preparation. TCM may be polluted by microbial in the production process due to ambient air, facilities and appliances and operating personnel, which affects the quality and efficacy of the final product. The GMP certification inspection standard of TCM manufacturing enterprises clearly established: "Sterilization methods of Chinese herbal medicine, intermediate products, finished products should follow the principle whether or not to change its quality", "TCM powder that used as medicine directly should follow the principle whether to do microbiological examinations". So it's particularly important for product quality, corporate energy consumption and its efficiency to choose the scientific and effective sterilization techniques and methods. Ozone is a kind of safe, environmentally friendly, efficient and no residue emerging sterilization technology. It has been widely applied in various fields of medical and health care and production and living. This paper mainly analyzed the ozone sterilization technology of TCM, aiming to explore the principle of ozone sterilization, the advantages, application status and existing problems and so on. The management regulations and implementation rules of ozone sterilization were summarized to make sterilization of Chinese medicine in the production, management, quality control and other aspects standardized, reasonable and scientific, and to provide the theoretical reference of the ozone sterilization technology for TCM and its preparation.
Topics: Bacteria; Drug Contamination; Drugs, Chinese Herbal; Humans; Ozone; Plants, Medicinal; Sterilization
PubMed: 26790281
DOI: No ID Found -
Annals of Biomedical Engineering May 2024Human amniotic membrane (hAM) is an important biomaterial for Tissue Engineering, due to its great regenerative properties and potential use as a scaffold. The most used...
Human amniotic membrane (hAM) is an important biomaterial for Tissue Engineering, due to its great regenerative properties and potential use as a scaffold. The most used procedure to sterilize biomaterials is gamma-irradiation, but this method can affect several properties, causing damage to the structure and reducing the growth factors. The present work evaluated the efficiency of a new method based on ozonated dynamic water for hAM sterilization. HAM fragments were experimentally contaminated with Staphylococcus aureus, Escherichia coli, Candida albicans, Staphylococcus epidermidis, and Clostridium sporogenes (10 CFU/mL) and submitted to sterilization process for 5, 10 and 15 min. The analyses did not reveal microbial activity after 10 min for S. aureus and C. sporogenes and after 15 min for E. coli and S. epidermidis. The microbial activity of C. albicans was reduced with the exposure time increase, but the evaluated time was insufficient for complete sterilization. The depyrogenation process was investigated for different ozonation times (15, 20, 25, 30, and 35 min) to evaluate the ozone sterilization potential and presented promising results after 35 min. The ozone effect on hAM structure was evaluated by histological analysis. A decrease in epithelium average thickness was observed with the exposure time increase. Furthermore, some damage in the epithelium was observed when hAM was exposed for 10 and 15 min. It can indicate that ozone, besides being effective in sterilization, could promote the hAM sample's de-epithelization, becoming a possible new method for removing the epithelial layer to use hAM as a scaffold.
Topics: Humans; Staphylococcus aureus; Escherichia coli; Ozone; Amnion; Hydrodynamics; Biocompatible Materials; Sterilization
PubMed: 38411861
DOI: 10.1007/s10439-024-03467-3 -
Journal of Healthcare Materiel... Jul 1989
Topics: Central Supply, Hospital; Ozone; Sterilization; Time Factors; United States
PubMed: 10293993
DOI: No ID Found -
American Journal of Infection Control May 2016A review of regulatory clearances for selected new sterilization and disinfection products for the period January 2012-June 2015 indicates continued leverage of... (Review)
Review
A review of regulatory clearances for selected new sterilization and disinfection products for the period January 2012-June 2015 indicates continued leverage of established technologies for steam and low-temperature sterilization, and high-level disinfection. New products in these areas were typically modified and improved versions of existing products, with the exception of a new combination hydrogen peroxide/ozone sterilizer. Development of new low-temperature sterilization technologies to address continued evolution of complex medical devices is expected to continue.
Topics: Cross Infection; Humans; Sterilization
PubMed: 27131131
DOI: 10.1016/j.ajic.2016.02.022 -
Canadian Operating Room Nursing Journal Jun 2006How many times have procedures in your operating rooms been delayed because the instruments needed were still in the sterilizer? As Perioperative nurses you are likely... (Review)
Review
How many times have procedures in your operating rooms been delayed because the instruments needed were still in the sterilizer? As Perioperative nurses you are likely to be quite familiar with the constant pressure to ensure that scarce instrumentation is available when needed. In 2003, a Canadian company developed a unique sterilization process employing ozone as the sterilizing agent. This technology is a safe, rapid and economical alternative to other low temperature sterilization modalities and may relieve some of the pressure experienced when instruments in short supply are in high demand. This article will discuss the principles of the sterilizer and the cycle and will explore the advantages of using this sterilization technology.
Topics: Canada; Equipment Contamination; Equipment Reuse; Equipment Safety; Humans; Infection Control; Oxidants, Photochemical; Ozone; Sterilization; Technology Assessment, Biomedical
PubMed: 16869464
DOI: No ID Found -
Chemosphere Dec 2022Sterilization and disinfection of pollutants and microorganisms have been extensively studied in order to address the problem of environmental contamination, which is a... (Review)
Review
Sterilization and disinfection of pollutants and microorganisms have been extensively studied in order to address the problem of environmental contamination, which is a crucial issue for public health and economics. Various form of hazardous materials/pollutants including microorganisms and harmful gases are released into the environment that enter into the human body either through inhalation, adsorption or ingestion. The human death rate rises due to various respiratory ailments, strokes, lung cancer, and heart disorders related with these pollutants. Hence, it is essential to control the environmental pollution by applying economical and effective sterilization and disinfections techniques to save life. In general, numerous forms of traditional physical and chemical sterilization and disinfection treatments, such as dry and moist heat, radiation, filtration, ethylene oxide, ozone, hydrogen peroxide, etc. are known along with advanced techniques. In this review we summarized both advanced and conventional techniques of sterilization and disinfection along with their uses and mode of action. This review gives the knowledge about the advantages, disadvantages of both the methods comparatively. Despite, the effective solution given by the advanced sterilization and disinfection technology, joint technologies of sterilization and disinfection has proven to be more effective innovation to protect the indoor and outdoor environments.
Topics: Disinfection; Environmental Pollutants; Ethylene Oxide; Hazardous Substances; Humans; Hydrogen Peroxide; Ozone; Sterilization
PubMed: 36165840
DOI: 10.1016/j.chemosphere.2022.136404 -
Biocontrol Science 2013A high-level aseptic environment must be maintained in bio-cleanrooms used for the manufacture of sterile products. In the past, formaldehyde gas was most commonly used...
A high-level aseptic environment must be maintained in bio-cleanrooms used for the manufacture of sterile products. In the past, formaldehyde gas was most commonly used to sterilize bio-cleanrooms, but due to strict residual limitations there has been a need to develop a less toxic alternative choice. The authors have developed a revolutionary new sterilization system using a high concentration of ozone gas and used this system to sterilize an actual bio-cleanroom. This system integrates the ozone gas generator with the air conditioning system by proper control. The design specifications for the system included an ozone gas concentration of 200 ppm or more, relative humidity of 80% or more, and a sterilizing time of 120 min. Blow vents and suction ports were placed to ensure a uniform airflow which would extend through the entire room during ozone gas sterilization. Tests regarding long-term material exposure to ozone gas were conducted when the system was introduced to distinguish usable and unusable materials. In an actually constructed cleanroom, simulations were used to predict the evenness of the diffusion of ozone gas concentration and relative humidity during ozone gas sterilization, and measurements of the actual indoor ozone gas concentration, temperature and relative humidity during sterilization revealed that the ozone concentration and relative humidity needed for sterilization had been achieved generally throughout the entire environment. In addition, the CT value (mg/m(3) (=ppm) × min) , derived by multiplying the ozone gas concentration during ozone gas sterilization by the sterilization time, was equal to or greater than the target value of 24 × 10(3) (ppm·min) . When the results of sterilization in a cleanroom were confirmed using a biological indicator (BI) , negative results were obtained at all measurement points, demonstrating that sterilization was being performed effectively in the actual factory at which the ozone gas sterilization system had been introduced.
Topics: Disinfectants; Environment, Controlled; Facility Design and Construction; Ozone; Sterilization; Time Factors
PubMed: 23538847
DOI: 10.4265/bio.18.9