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Diabetes Care Oct 2018Blood glucose monitoring is fundamental for hyperglycemia management during pregnancy, but are the devices up to the job? Studies assessing the accuracy of 10... (Review)
Review
Blood glucose monitoring is fundamental for hyperglycemia management during pregnancy, but are the devices up to the job? Studies assessing the accuracy of 10 commercially available glucose meters during pregnancy showed that although >98-99% of the meter values were in the acceptable zones of the error grid for the majority of the meters, the meter performance varied, with the majority showing positive bias and a few showing minimal negative bias. The mean difference between meter and laboratory plasma values varied between -0.33 and 0.73 mmol/L. Three meters showed deviations from laboratory results with a change in maternal hematocrit levels. No meters had a total analytical error <5%, and no studies evaluated meters using recent International Organization for Standardization 15197:2013 criteria. The Continuous Glucose Monitoring in Women With Type 1 Diabetes in Pregnancy Trial (CONCEPTT) recently showed that an antenatal continuous glucose monitoring system (CGMS), as an adjunct to capillary monitoring, was associated with a lower incidence of large-for-gestational-age babies, fewer neonatal intensive care unit admissions (>24 h), and a lower incidence of neonatal hypoglycemia. The flash glucose monitoring system shows good accuracy in pregnant women but has not been marketed widely in the U.S. We suggest that meters cannot be assumed to be sufficiently accurate during pregnancy and that manufacturers should ensure a total error <5%, with bias and imprecision <2% during pregnancy. Large studies are needed to evaluate the usefulness of CGMS among pregnant women with type 2 diabetes and gestational diabetes mellitus.
Topics: Blood Glucose; Blood Glucose Self-Monitoring; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Humans; Monitoring, Physiologic; Pregnancy; Pregnancy in Diabetics; Reference Standards; Reproducibility of Results
PubMed: 30237233
DOI: 10.2337/dc18-0833 -
The Journal of Veterinary Medical... Sep 2019The aim of this study was to evaluate the accuracy and precision of portable blood glucose meters, such as i-STAT 1 and Precision Xceed, for use in calves. Whole blood...
The aim of this study was to evaluate the accuracy and precision of portable blood glucose meters, such as i-STAT 1 and Precision Xceed, for use in calves. Whole blood and plasma samples were obtained from eleven calves that received 2.5 or 5.0% dextrose-containing polyelectrolyte isotonic solutions. Measurements using the i-STAT 1 (r=0.99, P<0.0001) and Precision Xceed (r=0.96, P<0.0001) were well correlated with those by the hexokinase method, which is the gold standard. Although the accuracy of i-STAT 1 was equivalent to that of the hexokinase method, there was an autocorrelation in the residuals between the results from the Precision Xceed and the hexokinase method. Thus, the i-STAT 1 can be used to measure the blood glucose concentration in cattle.
Topics: Animals; Blood Chemical Analysis; Blood Glucose; Cattle; Glucose; Isotonic Solutions; Point-of-Care Systems
PubMed: 31308294
DOI: 10.1292/jvms.19-0272 -
Terapevticheskii Arkhiv Dec 2023A point-of-care glucose testing (POCT) is an essential component of care in patients with hyperglycemia and hypoglycemia in inpatient and outpatient settings. In Russian...
BACKGROUND
A point-of-care glucose testing (POCT) is an essential component of care in patients with hyperglycemia and hypoglycemia in inpatient and outpatient settings. In Russian medical facilities (MFs), conventional glucose meters designed for self-monitoring by patients with diabetes are commonly used for POCT. These home-use meters have two serious disadvantages: the first is large measurement bias and the second - they can't be integrated into laboratory information systems, so measurement data have to be recorded into patient charts manually. Both factors may lead to medical errors. It is reasonable to use in the MFs specialized POCT glucose meters, as they are superior to conventional ones in accuracy and may be easily connected to laboratory information systems. With this in mind, physicians at the Russian Children's Clinical Hospital decided to substitute conventional meters with the Accu-Chek Inform II POCT meter, however, after preliminary performance assessment of the model.
AIM
To test the Accu-Chek Inform II performance characteristics: accuracy, linearity, repeatability, and mean absolute relative difference (MARD).
MATERIALS AND METHODS
Performance of the Accu-Chek Inform II was tested by comparing the results of parallel C measurements with the meter and reference laboratory analyzer in capillary blood samples. Overall, 99 parallel C measurements were made in 45 samples. Accuracy was evaluated according to the ISO 15197-2013 and POCT12-A3 criteria.
RESULTS
The Accu-Chek Inform II meter met the requirements of ISO 15197-2013 and POCT12-A3 and demonstrated high linearity (correlation coefficient, =1,0), good repeatability (mean coefficient of variation, CV=1,38%) and acceptable MARD (4,9%).
CONCLUSION
The Accu-Chek Inform II POCT glucose meter may be efficiently and safely used in inpatient and outpatient MFs and particularly in pediatric clinics.
Topics: Humans; Blood Glucose; Blood Glucose Self-Monitoring; Russia; Point-of-Care Systems; Point-of-Care Testing; Reproducibility of Results; Diabetes Mellitus
PubMed: 38785055
DOI: 10.26442/00403660.2023.12.202522 -
Journal of Animal Science Jul 2009The objective of this study was to evaluate the precision and accuracy of an indwelling ruminal pH measurement system that could be used in small ruminants (small...
The objective of this study was to evaluate the precision and accuracy of an indwelling ruminal pH measurement system that could be used in small ruminants (small ruminant ruminal pH measurement system; SRS) without requiring ruminal cannulation. The outer diameter, length, and weight of the SRS were 20.6 mm, 138 mm, and 245 g, respectively. This device was capable of logging pH, temperature, and battery voltage. In Exp. 1, a ruminally cannulated sheep (94 kg) was infused with a 40% (wt/vol) glucose solution to supply 5 g of glucose/kg of BW into the rumen. Ruminal pH was recorded every 30 s simultaneously using a portable pH meter and the SRS. In Exp. 2, 30 noncannulated sheep (72 +/- 10 kg of BW) were orally administered with a 40% glucose solution as described above (5 g of glucose/kg of BW; n = 22) or an equivalent volume of water (12.5 mL/kg of BW; n = 8). Sheep were slaughtered 3 h after the oral drench, and immediately after slaughter ruminal pH readings were measured manually using a portable pH meter and were compared with measurements recorded by the SRS. In Exp. 1, the relationship between manual pH measurement using a portable pH meter and the SRS (226 data pairs) had a Pearson correlation coefficient and concordance correlation coefficient of 0.97 and 0.96, respectively. Furthermore, the scale shift and location shift observed in Exp. 1 were 1.28 and 0.00, respectively. The relationship between measurements conducted manually using a portable pH meter and the SRS in Exp. 2 had Pearson and concordance correlation coefficients of 0.96 and 0.95, respectively. The respective scale and location shifts for Exp. 2 were 1.16 and 0.04. These results indicate that the measurements obtained from SRS were in agreement with simultaneous measurements manually conducted using a portable pH meter, suggesting that the SRS can be used to measure ruminal pH in noncannulated small ruminants.
Topics: Animals; Clinical Chemistry Tests; Female; Hydrogen-Ion Concentration; Male; Monitoring, Physiologic; Rumen; Sheep
PubMed: 19329478
DOI: 10.2527/jas.2008-1665 -
Psychological Research Mar 2013We examined the influence of incidental exposure to varied metrical patterns from different musical cultures on the perception of complex metrical structures from an... (Comparative Study)
Comparative Study
We examined the influence of incidental exposure to varied metrical patterns from different musical cultures on the perception of complex metrical structures from an unfamiliar musical culture. Adults who were familiar with Western music only (i.e., simple meters) and those who also had limited familiarity with non-Western music were tested on their perception of metrical organization in unfamiliar (Turkish) music with simple and complex meters. Adults who were familiar with Western music detected meter-violating changes in Turkish music with simple meter but not in Turkish music with complex meter. Adults with some exposure to non-Western music that was unmetered or metrically complex detected meter-violating changes in Turkish music with both simple and complex meters, but they performed better on patterns with a simple meter. The implication is that familiarity with varied metrical structures, including those with a non-isochronous tactus, enhances sensitivity to the metrical organization of unfamiliar music.
Topics: Adult; Auditory Perception; Cross-Cultural Comparison; Female; Humans; Male; Music; Recognition, Psychology; Young Adult
PubMed: 22367155
DOI: 10.1007/s00426-012-0427-y -
Journal of Dairy Science Aug 2020Commonly used lactose assays [enzymatic spectrophotometric absorbance (EZA) and HPLC] for dairy ingredients are relatively expensive and time consuming. A blood glucose...
Commonly used lactose assays [enzymatic spectrophotometric absorbance (EZA) and HPLC] for dairy ingredients are relatively expensive and time consuming. A blood glucose meter (BGM)-based method has successfully been documented as a rapid lactose assay in milk. However, the BGM-based method has not been evaluated in dairy ingredients. The objective of this study was to evaluate the BGM-based lactose analysis method in whey-derived (WD) and skim milk-derived (SMD) ingredients. The study was carried out in 4 phases. In phase 1, the effect of pH and lactose concentrations on the BGM reading was investigated using a factorial design with 2 factors: pH (6.02-7.50) and lactose (0.2 or 0.4%). We found that BGM readings were significantly affected by lower pH values at both lactose levels. In phase 2, the effect of total solids and ingredient type was investigated using a factorial design with 2 factors: ingredient type (WD or SMD) and total solids (0-8%). It was observed that the BGM reading was significantly affected by ingredient type and total solids. Phase 3 involved developing a linear relationship between the BGM reading and the EZA reference method to ascertain the accuracy of the proposed BGM method. Different ingredient types (WD or SMD) and non-lactose solids (0.5-27%) model ingredient dilutions prepared over a range of lactose contents (0.08-0.62%) were measured using the BGM and EZA methods. The average absolute percentage bias difference between the BGM method and EZA reference method results for these model dilutions was found to be between 2.2 and 7.3%. In phase 4, 15 samples procured from commercial sources ranging from 0.01 to 81.9% lactose were evaluated using the BGM method and EZA reference method. The average absolute percentage bias difference for lactose results between the 2 methods ranged from 3.6 to 5.0% and 5.3 to 9.7% for well-performing and poorly performing meters, respectively. Overall, the BGM method is a promising tool for rapid and low-cost analysis of lactose in both high-lactose and low-lactose dairy ingredients.
Topics: Animals; Biosensing Techniques; Blood Glucose; Cattle; Dairy Products; Lactose; Milk; Whey; Whey Proteins
PubMed: 32505394
DOI: 10.3168/jds.2019-17903 -
Produits Pharmaceutiques Nov 1955
Topics: Hydrogen-Ion Concentration
PubMed: 13289903
DOI: No ID Found -
Transfusion Nov 2011pH measurements of platelet (PLT) components remain a key parameter when assessing how storage and shipping conditions influence the retention of PLT properties. Studies...
BACKGROUND
pH measurements of platelet (PLT) components remain a key parameter when assessing how storage and shipping conditions influence the retention of PLT properties. Studies were conducted to characterize variations in pH measured with two pH meters and a blood gas analyzer.
STUDY DESIGN AND METHODS
Samples were obtained from apheresis PLT units that were stored with or without continuous agitation to measure a range of pH values. pH values were determined with pH meters at room temperature (20-24°C) upon placing of samples in 5-mL sterile polypropylene tubes and with the blood gas analyzer at 37°C upon injection of identical samples, with conversion to 22°C.
RESULTS
The calculated coefficient of variation (%CV) of pH measurements using pH meters (n = 10) was 0.43% or less. The %CV values were comparable with different samples having pH values ranging from 6.0 to 7.4. The %CV levels with the blood gas analyzer were comparable to those observed with the pH meters. The difference in the mean pH values for the two pH meters was no greater than 0.10 units, with 9 of 10 samples having differences in values of 0.05 or less; however, greater differences of values (0.1 to 0.2) were observed between pH measured using the blood gas analyzer and pH meters.
CONCLUSION
Our data show good precision and comparability of pH measurements with two pH meters. Differences in pH values were greater on comparison of the blood gas analyzer with the pH meters.
Topics: Blood Gas Analysis; Blood Platelets; Humans; Hydrogen-Ion Concentration; Plateletpheresis; Regression Analysis; Temperature
PubMed: 21564103
DOI: 10.1111/j.1537-2995.2011.03167.x -
Alimentary Pharmacology & Therapeutics Jun 1990Gastrointestinal pH in 11 healthy subjects with ileostomy was determined with a pH-sensitive, radiotransmitting capsule. Median pH was 7.0 in duodenum, dropped to pH 6.3...
Gastrointestinal pH in 11 healthy subjects with ileostomy was determined with a pH-sensitive, radiotransmitting capsule. Median pH was 7.0 in duodenum, dropped to pH 6.3 in the proximal part, but rose to 7.3 in the distal part of the small intestine. In five subjects the pH of the ileostomy effluents was determined with the pH capsule as well as with a pH meter. Median pH was 7.2 measured with the capsule and 7.4 with the pH meter. The difference between the results obtained with the two methods ranged from 0.1 to 0.3 pH units. The median gastrointestinal transit time of the capsule was 10.5 h (range 6.2-12.8 h). Gastric residence time was 0.6 h (range 0.2-3.8 h), and small intestinal transit time was 10.3 h (range 5.6-11.9 h). Thus the small intestinal transit time in ileostomates is slightly increased compared with values reported from studies on subjects with intact gut. However, no statistically significant correlation was found between the small intestinal transit time and the time elapsed after the creation of the ileostomy. We conclude that colectomy does not alter small intestinal pH but seems to increase the small intestinal transit time of single units.
Topics: Adult; Female; Gastric Acid; Gastrointestinal Transit; Humans; Hydrogen-Ion Concentration; Ileostomy; Intestinal Mucosa; Male; Middle Aged; Reference Values
PubMed: 2104088
DOI: 10.1111/j.1365-2036.1990.tb00469.x -
Journal of Sports Sciences Jul 2017Mobile power meters provide a valid means of measuring cyclists' power output in the field. These field measurements can be performed with very good accuracy and... (Review)
Review
Mobile power meters provide a valid means of measuring cyclists' power output in the field. These field measurements can be performed with very good accuracy and reliability making the power meter a useful tool for monitoring and evaluating training and race demands. This review presents power meter data from a Grand Tour cyclist's training and racing and explores the inherent complications created by its stochastic nature. Simple summary methods cannot reflect a session's variable distribution of power output or indicate its likely metabolic stress. Binning power output data, into training zones for example, provides information on the detail but not the length of efforts within a session. An alternative approach is to track changes in cyclists' modelled training and racing performances. Both critical power and record power profiles have been used for monitoring training-induced changes in this manner. Due to the inadequacy of current methods, the review highlights the need for new methods to be established which quantify the effects of training loads and models their implications for performance.
Topics: Athletic Performance; Bicycling; Humans; Physical Conditioning, Human; Reproducibility of Results
PubMed: 27686573
DOI: 10.1080/02640414.2016.1215504