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International Journal of Women's... Jun 2021Pacinian corpuscle hyperplasia typically presents as a tender nodule on the volar aspect of the palm or digit, often after trauma. Histologically, it presents as one to... (Review)
Review
OBJECTIVE
Pacinian corpuscle hyperplasia typically presents as a tender nodule on the volar aspect of the palm or digit, often after trauma. Histologically, it presents as one to multiple normal-sized to enlarged Pacinian corpuscles in the deep dermis or subcutaneous adipose tissue. Given its rarity, its pathogenesis is debated and nomenclature is poorly defined. Herein, we present a case of Pacinian corpuscle hyperplasia and review the current literature.
METHODS
A literature review was conducted using PubMed with the following search terms: Pacinian corpuscle hyperplasia, Pacinian corpuscle neuroma, Pacinioma, Pacinian corpuscle hypertrophy, and heterotopic Pacinian corpuscles. All case reports and case series were reviewed for histopathologic evidence of true Pacinian corpuscle hyperplasia. Cadaveric studies, cases without true Pacinian corpuscles, and noncutaneous cases were excluded from our analysis.
RESULTS
Sixty patients with Pacinian corpuscle hyperplasia of the hands and feet (65 cases, some with >1 location) were reviewed. The mean age of presentation was 49.5 years, and women accounted for 60% of cases. Pain was the most commonly reported symptom (55 of 65 cases; 84.6%). Forty-five cases (69.2%) were localized to a digit, most commonly the second digit (17 of 65 cases; 26.2%), and 18 of 65 cases (27.6%) affected the palm, primarily the distal palm. Surgical excision was curative in 50 of 65 cases (76.9%).
CONCLUSION
Although relatively uncommon, Pacinian corpuscle hyperplasia should be considered in the differential diagnosis of a tender nodule on the digit or distal palm, particularly after trauma.
PubMed: 34222593
DOI: 10.1016/j.ijwd.2020.10.005 -
Pathology Jun 2022
Topics: Humans; Pacinian Corpuscles
PubMed: 34565604
DOI: 10.1016/j.pathol.2021.06.126 -
Pediatric Dermatology 2023We present a rare case of Pacinian corpuscle hyperplasia (PCH) presenting with typical finger pain in a 6-year-old girl. As appendages in children are smaller than those...
We present a rare case of Pacinian corpuscle hyperplasia (PCH) presenting with typical finger pain in a 6-year-old girl. As appendages in children are smaller than those in adults, diagnostic criteria are needed for pathological confirmation of PCH in pediatric patients.
Topics: Adult; Female; Humans; Child; Pacinian Corpuscles; Hyperplasia; Pain
PubMed: 37194374
DOI: 10.1111/pde.15349 -
The Journal of Hand Surgery Sep 1991Proliferation of pacinian corpuscles adjacent to the digital nerves in the hand is very rare. Patients are usually seen initially with a history of previous trauma and... (Review)
Review
Proliferation of pacinian corpuscles adjacent to the digital nerves in the hand is very rare. Patients are usually seen initially with a history of previous trauma and severe localized pain. The symptoms, signs, and surgical treatment of previously reported cases are reviewed and histological criteria from this case are proposed to define this condition. In addition to a neuroma or glomus tumor, pacinian corpuscle hyperplasia should be considered in the differential diagnosis of digital or palmar pain.
Topics: Diagnosis, Differential; Female; Glomus Tumor; Hand; Humans; Hyperplasia; Middle Aged; Neuroma; Pacinian Corpuscles; Pain
PubMed: 1658118
DOI: 10.1016/s0363-5023(10)80151-0 -
The Journal of Dermatology Oct 2020
Topics: Glomus Tumor; Humans; Neuroma; Pacinian Corpuscles; Peripheral Nervous System Neoplasms
PubMed: 32734616
DOI: 10.1111/1346-8138.15524 -
Romanian Journal of Morphology and... 2020Lamellar (Pacinian) corpuscle is a cutaneous encapsulated sensory corpuscle, mainly functioning as a rapidly adapting low-threshold mechanoreceptor with characteristic...
Lamellar (Pacinian) corpuscle is a cutaneous encapsulated sensory corpuscle, mainly functioning as a rapidly adapting low-threshold mechanoreceptor with characteristic "onion skin"-like appearance. Even though the Pacinian corpuscle is typically located in the skin, histomorphologically and confirmed by using immunohistochemical methods, we have identified it within the interstitium of the thymus of a newborn with congenital heart defect. To the best of our knowledge, this is the first such account ever to be published. The structure of the thymic Pacinian corpuscle was the same as the Pacinian corpuscle in the skin. The ectopic thymic Pacinian corpuscle can be hypothetically explained as the consequence of impaired migration of neural crest cells, since neural crest-derived cells play an important role in the development of the Pacinian corpuscle, as well as the thymus and heart. In general, the occurrence of ectopic Pacinian corpuscle in different organs is rare. In the scientific literature, there are reports of its sporadic presence in the pancreas, in the lymph nodes, inside the prostate and the urinary bladder wall. Our report presents the first described case of the Pacinian corpuscle in a heterotopic location in the thymus. Similar to other incidental findings of this anatomic structure, explanation of its ectopic development, as well as its local function remains only speculative.
Topics: Humans; Infant, Newborn; Male; Pacinian Corpuscles; Thymus Gland
PubMed: 32747922
DOI: 10.47162/RJME.61.1.33 -
Foot (Edinburgh, Scotland) Dec 2021Pacinian hyperplasia in the human body has been rarely described in the literature with most cases reported involving the hand (Fassola et al., 2019). This hyperplasia...
Pacinian hyperplasia in the human body has been rarely described in the literature with most cases reported involving the hand (Fassola et al., 2019). This hyperplasia is considered a reactive lesion as opposed to a neoplasm (Satge et al., 2001), with the most common presenting complaint being pain and swelling (Fassola et al., 2019). In this study, a case of bilateral Pacinian corpuscle hyperplasia in the adult foot not previously described in the literature is presented.
Topics: Adult; Hand; Humans; Hyperplasia; Neuroma; Pacinian Corpuscles; Peripheral Nervous System Neoplasms
PubMed: 33036838
DOI: 10.1016/j.foot.2020.101709 -
Pathology Dec 2021
Topics: Aged; Diagnosis, Differential; Female; Humans; Pacinian Corpuscles; Peritoneal Neoplasms; Peritoneum
PubMed: 33941381
DOI: 10.1016/j.pathol.2021.01.012 -
Pancreas Jul 2001During our systematic examination of the distribution of cytochrome P450 enzymes in the normal and diseased human pancreas, we observed a Pacinian corpuscle in a serial...
During our systematic examination of the distribution of cytochrome P450 enzymes in the normal and diseased human pancreas, we observed a Pacinian corpuscle in a serial section of a tissue from a pancreatic cancer patient. We report the histologic and immunohistochemical patterns in this corpuscle and review the literature. The Pacinian corpuscle was situated within the pancreas of a 76-year-old woman with cancer in the head of the pancreas. We could demonstrate immunoreactivity within the corpuscle for the neurofilament protein. neuron-specific enolase, S-100 Protein, and for four cytochrome P450-isozymes. The possible function of Pacinian corpuscles in the mammalian and human pancreas is discussed.
Topics: Aged; Biomarkers; Cytochrome P-450 Enzyme System; Female; Humans; Immunoenzyme Techniques; Isoenzymes; Nerve Tissue Proteins; Neurofilament Proteins; Pacinian Corpuscles; Pancreas; Phosphopyruvate Hydratase; S100 Proteins; Species Specificity
PubMed: 11451145
DOI: 10.1097/00006676-200107000-00005 -
The Journal of Hand Surgery... Jun 2023The human hand is a specialised organ for fine motion and sensation and has a relatively large representation in the homunculus. The pathway of sensation starts from...
The human hand is a specialised organ for fine motion and sensation and has a relatively large representation in the homunculus. The pathway of sensation starts from information sent by mechanoreceptors in the hand. This study reports the topography of the Pacinian corpuscle in the fingertips of a human cadaver. All 10 digits from both hands of a fresh-frozen cadaver were examined. Glabrous skin distal to the distal interphalangeal joint was harvested superficial to the periosteum including fat and subcutaneous tissue. The glabrous skin were divided into 10 sections that included five distal and five proximal sections. Modified gold chloride staining was performed. Sectioned specimens were observed under a light microscope and the density of Pacinian corpuscles was determined in each segment. The density of the corpuscles was compared between the radial/ulnar and proximal/distal segments and also between digits from the right hand versus those from the left hand. Pacinian corpuscles were observed only in the subcutaneous tissue. There was no significant difference in density of the corpuscles between the distal and proximal segments or between the right and left hands. There was a statistically significant greater density of Pacinian corpuscles on the radial segments of all digits except the thumb. There is a greater density of Pacinian corpuscles on the radial side of the human fingertip in all digits except the thumb.
Topics: Humans; Pacinian Corpuscles; Fingers; Hand; Thumb; Cadaver
PubMed: 37501544
DOI: 10.1142/S2424835523500455