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Revista Espanola de Patologia :... 2020Pacinian neurofibroma (PNF) is a lobulated benign neural tumor with prominent structures resembling pacinian bodies. These tumors most commonly occur in areas where...
Pacinian neurofibroma (PNF) is a lobulated benign neural tumor with prominent structures resembling pacinian bodies. These tumors most commonly occur in areas where normal pacinian bodies are found, such as the hands and feet. Although pacinian bodies are common in the penis, no cases of penile PNF have been reported to date. We present a case of PNF on the dorsal glans penis of a 47-year-old man. The lesion presented as a single flesh-colored papule and the biopsy showed a dermal neurofibroma consisting of bland spindle cells with wavy nuclei, without mitoses or atypia, and some nodular structures with a concentric arrangement and a pacinian appearance. Immunohistochemistry demonstrated positivity for CD34 and Vimetin and negativity for Epithelial Membrane Antigen (EMA). S100 was highly positive in the most central areas of the pacinian-like nodules, while the periphery and non-nodular parts of the neurofibroma were less intensively expressed.
Topics: Antigens, CD34; Humans; Male; Middle Aged; Neurofibroma; Pacinian Corpuscles; Penile Neoplasms; S100 Proteins; Vimentin
PubMed: 32199595
DOI: 10.1016/j.patol.2019.03.008 -
Journal of Biomechanics Oct 2017The Pacinian corpuscle (PC) is a cutaneous mechanoreceptor sensitive to high-frequency vibrations (20-1000Hz). The PC is of importance due to its integral role in...
The Pacinian corpuscle (PC) is a cutaneous mechanoreceptor sensitive to high-frequency vibrations (20-1000Hz). The PC is of importance due to its integral role in somatosensation and the critical need to understand PC function for haptic feedback system development. Previous theoretical and computational studies have modeled the physiological response of the PC to sustained or vibrating mechanical stimuli, but they have used estimates of the receptor's mechanical properties, which remain largely unmeasured. In this study, we used micropipette aspiration (MPA) to determine an apparent Young's modulus for PCs isolated from a cadaveric human hand. MPA was applied in increments of 5mm HO (49Pa), and the change in protrusion length of the PC into the pipette was recorded. The protrusion length vs. suction pressure data were used to calculate the apparent Young's modulus. Using 10 PCs with long-axis lengths of 2.99±0.41mm and short-axis lengths of 1.45±0.22mm, we calculated a Young's modulus of 1.40±0.86kPa. Our measurement is on the same order of magnitude as those approximated in previous models, which estimated the PC to be on the same order of magnitude as skin or isolated cells, so we recommend that a modulus in the kPa range be used in future studies.
Topics: Elastic Modulus; Female; Humans; Microdissection; Middle Aged; Pacinian Corpuscles; Pressure
PubMed: 28842172
DOI: 10.1016/j.jbiomech.2017.08.005 -
Bioinspiration & Biomimetics May 2020A vibration sensor is presented mimicking the structure of the Pacinian corpuscle. A multi-step casting process is used to create a 5 mm diameter sensor with a liquid...
A vibration sensor is presented mimicking the structure of the Pacinian corpuscle. A multi-step casting process is used to create a 5 mm diameter sensor with a liquid metal core, elastomer dielectric, and graphite counter electrode creating a spherical capacitive sensing element with sensitivities on the order of 10 Δ pF/mm. A model for the capacitance change of the spherical capacitor as it is formed is developed and its findings support the sensitivities observed. Various elastomer dielectric compositions with integrated barium titanate nanoparticles are tested to increase the dielectric constant. The biological acoustic filter within the corpuscle is mimicked using alternating cast layers of oligomers and elastomers around the spherical sensor element. Vibration sensing is characterized over the low frequency range of 10-300 Hz and the minimum detectable sensitivity is found to be 1 µm with a low power requirement of 7 mW. The artificial Pacinian corpuscle has potential applications in tactile sensing and seismic monitoring devices.
Topics: Animals; Barium Compounds; Biomimetic Materials; Biosensing Techniques; Humans; Nanoparticles; Pacinian Corpuscles; Titanium; Vibration
PubMed: 32106099
DOI: 10.1088/1748-3190/ab7ab6 -
Skeletal Radiology Jun 2021Pacinian corpuscles represent special nerve endings that serve as mechanoreceptors sensitive to vibration and pressure and are crucial for proprioception. This work...
Pacinian corpuscles represent special nerve endings that serve as mechanoreceptors sensitive to vibration and pressure and are crucial for proprioception. This work demonstrates that the complex network of Pacinian corpuscles in hands and feet can be examined with three-dimensional Dual Echo Steady State (DESS) MR imaging at 7 T, while previous dedicated MRI reports were either limited to two-dimensional images or focused on the hands. The high-resolution MR images show the detailed architecture of the complex receptor network and reveal a "chain-like" arrangement of Pacinian corpuscles, a predilection for clustering around metacarpophalangeal/metatarsophalangeal joints, proximal phalanges and fingertips, and specific sensor locations both in the superficial subcutaneous tissue and adjacent to deep soft tissue structures such as tendons and joint capsules.
Topics: Hand; Healthy Volunteers; Humans; Magnetic Resonance Imaging; Mechanoreceptors; Pacinian Corpuscles
PubMed: 33156397
DOI: 10.1007/s00256-020-03667-7 -
International Journal of Surgical... Oct 2017
Topics: Choristoma; Humans; Male; Middle Aged; Pacinian Corpuscles; Prostate; Prostatectomy; Prostatic Neoplasms
PubMed: 28420304
DOI: 10.1177/1066896917705200 -
Joint Diseases and Related Surgery 2022Pacinian disorders are exceedingly rare, and the exact pathogenesis is still unknown. The most common symptoms are pain, sensory changes, and a visible or palpable mass,...
Pacinian disorders are exceedingly rare, and the exact pathogenesis is still unknown. The most common symptoms are pain, sensory changes, and a visible or palpable mass, and diagnosis is usually made by pathological examination after the excision of the painful nodule. In this case report, we present the case of a 49-year-old male with Pacinian corpuscle hyperplasia located on the metacarpophalangeal joint, emerging at the same hand of the patient two years after the treatment due to complex regional pain syndrome (CRPS). To the best of our knowledge, this is the first case report revealing the association of CRPS with hyperplasia of Pacinian corpuscles.
Topics: Complex Regional Pain Syndromes; Hand; Humans; Hyperplasia; Male; Middle Aged; Pacinian Corpuscles; Pain
PubMed: 35361103
DOI: 10.52312/jdrs.2022.512 -
Journal of the European Academy of... Nov 2006
Topics: Female; Fingers; Humans; Middle Aged; Neuroma; Pacinian Corpuscles; Peripheral Nervous System Neoplasms
PubMed: 17062093
DOI: 10.1111/j.1468-3083.2006.01737.x -
The Journal of Hand Surgery Dec 2018Pacinian corpuscles are rapidly adapting mechanoreceptors distributed in the dermis of the fingers and palm of the hand. A neuroma of the pacinian corpuscle is rare and...
Pacinian corpuscles are rapidly adapting mechanoreceptors distributed in the dermis of the fingers and palm of the hand. A neuroma of the pacinian corpuscle is rare and extremely painful, with only a few cases reported in the literature. A 71-year-old man with pain and swelling on his left index finger, initially diagnosed as tenosynovitis resistant to nonsurgical treatment, was referred to our center. During surgery, a cluster of spherical, gray lesions close to the digital nerve was found and excised. The pathological diagnosis was neuroma of the pacinian corpuscles. Two years later, he reported the same clinical findings on his right index finger with no improvement after nonsurgical treatment. During surgery, the same lesions were found and also identified as pacinian corpuscle neuromas.
Topics: Aged; Fingers; Humans; Male; Neuralgia; Neuroma; Pacinian Corpuscles; Peripheral Nervous System Neoplasms
PubMed: 29627280
DOI: 10.1016/j.jhsa.2018.03.007 -
The Journal of Physiology May 1949
Topics: Humans; Pacinian Corpuscles; Peripheral Nervous System
PubMed: 18229235
DOI: No ID Found -
Plastic and Reconstructive Surgery Jul 1993A case is presented in which the patient's chief complaint was severe digital pain radiating to the arm. Even light touch was enough to produce unbearable pain, which... (Review)
Review
A case is presented in which the patient's chief complaint was severe digital pain radiating to the arm. Even light touch was enough to produce unbearable pain, which prevented the patient from carrying out simple daily tasks. She had complete relief of her symptoms following removal of the hyperplastic pacinian corpuscle and returned to her normal life. A review of the literature revealed few reported cases of hypertrophied pacinian corpuscles in the hand. We believe that this diagnosis must be considered in the differential diagnosis of digital pain of unknown etiology.
Topics: Female; Fingers; Humans; Hyperplasia; Middle Aged; Neuroma; Pacinian Corpuscles; Pain
PubMed: 8516392
DOI: 10.1097/00006534-199307000-00024