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Developmental Dynamics : An Official... Nov 2004The development of crural Pacinian corpuscles was explored in neonatal mutant mice lacking nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF),... (Comparative Study)
Comparative Study
The development of crural Pacinian corpuscles was explored in neonatal mutant mice lacking nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT3) or neurotrophin-4 (NT4), or their cognate Trk receptors. Deficits of the corpuscles and their afferents were greatest in NT3, less in BDNF, and least in NT4 null mice. Deletion of NGF or p75(NTR) genes had little or no impact. No Pacinian corpuscles were present in NT3;BDNF and NT3;NT4 double or NT3;BDNF;NT4 triple null mice. Deficits were larger in NT3 than TrkC mutants and were comparable to deficits observed in TrkB or TrkA mutants. Afferents of all corpuscles coexpressed TrkA and TrkB receptors, and some afferents coexpressed all three Trk receptors. Our results suggest that multiple neurotrophins, in particular NT3, regulate the density of crural Pacinian corpuscles, most likely by regulating the survival of sensory neurons. In addition, NT3/TrkB and/or NT3/TrkA signaling plays a greater role than NT3/TrkC signaling in afferents to developing Pacinian corpuscles.
Topics: Animals; Animals, Newborn; Brain-Derived Neurotrophic Factor; Mice; Mice, Mutant Strains; Nerve Growth Factor; Nerve Growth Factors; Neurons, Afferent; Neurotrophin 3; Pacinian Corpuscles; Receptor, Nerve Growth Factor; Receptor, trkA; Receptor, trkB; Receptor, trkC; Receptors, Nerve Growth Factor; Signal Transduction
PubMed: 15376326
DOI: 10.1002/dvdy.20156 -
Plastic and Reconstructive Surgery Jul 1985
Topics: Humans; Mechanoreceptors; Neurosurgical Procedures; Pacinian Corpuscles
PubMed: 4011771
DOI: No ID Found -
Integrative Biology : Quantitative... Nov 2016The Pacinian corpuscle (PC) is a dermal mechanoreceptor that responds to high-frequency (20-1000 Hz) vibrations. The PC's structure allows transmission of vibrations...
The Pacinian corpuscle (PC) is a dermal mechanoreceptor that responds to high-frequency (20-1000 Hz) vibrations. The PC's structure allows transmission of vibrations through its layers (lamellae) to the centrally-located nerve fiber (neurite). This work combines mechanical models of the PC with an electrochemical model of peripheral nerves to simulate the tactile response of the entire system. A three-stage model of response to a vibratory input was developed, consisting of (1) outer core mechanics, (2) inner core mechanics, and (3) neurite electrochemistry. The model correctly predicts the band-pass nature of the PC's frequency response, showing that the PC structure can amplify oscillatory strains within its target frequency band. Specifically, strain induced by a vibratory stimulus is amplified by a factor of 8-12 from the PC surface to the neurite. Our results also support the hypothesis that PC rapid adaptation is affected by the lamellar structures without requiring neuronal adaptivity. Simulated different-sized PCs showed a shift in frequency response, suggesting that clusters of different-sized PCs could enable more nuanced tactile encoding than uniform clusters. By modeling the PC's mechano-to-neural transduction, we can begin to characterize the mechanosensation of other receptors to understand how multiple receptors interact to create our sensation of touch.
Topics: Afferent Pathways; Computer Simulation; Humans; Mechanotransduction, Cellular; Models, Biological; Neurites; Pacinian Corpuscles; Stress, Mechanical; Touch; Vibration
PubMed: 27723847
DOI: 10.1039/c6ib00157b -
Southern Medical Journal Jan 1975Symptoms and incapacitation due to abnormal aggregations of pacinian corpuscles are uncommon. Indeed, only three reports have been found in the scientific literature. A...
Symptoms and incapacitation due to abnormal aggregations of pacinian corpuscles are uncommon. Indeed, only three reports have been found in the scientific literature. A case is presented in which the patient's chief complaint was pain and localized tenderness in the hand which interfered with normal activity. Surgical exploration of the palm showed abnormalities of pacinian corpuscles attached to the median digital nerve in the form of a grape-like cluster and a single enlarged corpuscle beneath the epineurium; the abnormality attached to the ulnar digital nerve appeared as an offshoot of hyperplastic corpuscles lying in tandem. The abnormal corpuscles were excised. The symptoms have not recurred to date. These abnormalities in size, position, and number of pacinian corpuscles are compared to the findings of the few other reports in the literature. The neuroma formation found attached to this ulnar nerve has not been cited previously.
Topics: Adult; Follow-Up Studies; Hand; Humans; Male; Mechanoreceptors; Neuroma; Pacinian Corpuscles; Peripheral Nervous System Neoplasms; Ulnar Nerve
PubMed: 1154066
DOI: 10.1097/00007611-197501000-00023 -
The Journal of Hand Surgery, European... Nov 2019Tumours involving Pacinian corpuscles are rare. The literature identifies two main pathological disorders: the Pacinian corpuscle neuroma or hyperplasia and the Pacinian...
Tumours involving Pacinian corpuscles are rare. The literature identifies two main pathological disorders: the Pacinian corpuscle neuroma or hyperplasia and the Pacinian corpuscle neurofibroma. Published data are confusing and at times conflicting. This systematic review summarizes the available data in order to support clinicians in the differential diagnosis with other tumours responsible for unclear symptoms in the hands and fingers. We identified 67 pertinent articles. Although some similarities have been described, the two tumours have relevant differences, specifically when comparing age of the patient, location, symptoms, characteristic of a mass, and aetiology. All these factors should be taken into account in order to improve diagnostic accuracy. Despite the low incidence of unsuccessful surgeries, extraordinary measures are occasionally necessary to achieve complete resolution of symptoms.
Topics: Diagnosis, Differential; Hand; Humans; Hyperplasia; Neurofibroma; Neuroma; Pacinian Corpuscles
PubMed: 31156019
DOI: 10.1177/1753193419852118 -
Histopathology Mar 1978
Topics: Humans; Mechanoreceptors; Myxoma; Neoplasms; Nervous System Diseases; Neurofibroma; Pacinian Corpuscles
PubMed: 669593
DOI: 10.1111/j.1365-2559.1978.tb01703.x -
Histopathology Jul 1977At rare intervals in the literature, reports have appeared of a skin tumour containing structures resembling Pacinian corpuscles. Four such tumours collected over the...
At rare intervals in the literature, reports have appeared of a skin tumour containing structures resembling Pacinian corpuscles. Four such tumours collected over the course of 20 years are described and the literature reviewed.
Topics: Adolescent; Adult; Cell Nucleus; Cytoplasm; Female; Humans; Male; Mechanoreceptors; Neurofibroma; Pacinian Corpuscles; Peripheral Nervous System Neoplasms; Skin
PubMed: 615838
DOI: 10.1111/j.1365-2559.1977.tb01664.x -
The Journal of Hand Surgery Sep 1992
Topics: Adult; Aged; Female; Hand; Humans; Hyperplasia; Male; Middle Aged; Pacinian Corpuscles
PubMed: 1401819
DOI: 10.1016/0363-5023(92)90484-7 -
IEEE Transactions on Haptics 2019Recognizing and discriminating vibrotactile stimuli is an essential function of the Pacinian corpuscle. This function has been studied at length in both a computational...
Recognizing and discriminating vibrotactile stimuli is an essential function of the Pacinian corpuscle. This function has been studied at length in both a computational and an experimental setting, but the two approaches have rarely been compared, especially when the computational model has a high level of structural detail. In this paper, we explored whether the predictions of a multiscale, multiphysical computational model of the Pacinian corpuscle can predict the outcome of a corresponding psychophysical experiment. The discrimination test involved either two simple stimuli with frequency in the 160-500 Hz range, or two complex stimuli formed by combining the waveforms for a 100-Hz stimulus with a second stimulus in the 160-500 Hz range. The subjects' ability to distinguish between the simple stimuli increased as the frequency increased, a result consistent with the model predictions for the same stimuli. The model also predicted correctly that subjects would find the complex stimuli more difficult to distinguish than the simple ones and also that the discriminability of the complex stimuli would show no trend with frequency difference.
Topics: Discrimination, Psychological; Humans; Models, Theoretical; Pacinian Corpuscles; Sensory Thresholds; Touch; Touch Perception; Vibration
PubMed: 30932849
DOI: 10.1109/TOH.2019.2903500 -
Ultrasound in Medicine & Biology Dec 2018The aim of this study was to evaluate the possibility of visualizing Pacinian corpuscles in the palm of the hand with high-resolution ultrasound (HRUS). In this...
The aim of this study was to evaluate the possibility of visualizing Pacinian corpuscles in the palm of the hand with high-resolution ultrasound (HRUS). In this prospective study, HRUS with a high-frequency probe (22 MHz) was used. The palms of two fresh cadaveric hands were screened for potential Pacinian corpuscles. Still ultrasound images and dynamic video sequences were obtained. In five regions with large amounts of suspected Pacinian corpuscles, tissue blocks were excised and histologically processed, and corresponding slices were compared with ultrasound images. Further, the transverse diameters of five Pacinian corpuscles, at the level of the metacarpal heads in the palm, were assessed on both sides (in total 100) in healthy volunteers. On ultrasound, Pacinian corpuscles presented as echolucent dots in the subcutis, adjacent to digital nerves and vessels and located 2-3 mm beneath the surface. On histologic sections, these echolucent dots corresponded to Pacinian corpuscles with respect to their position and topographic relationships. The mean transverse diameter for all volunteers was 1.40 ± 0.23 mm (range: 0.8-2.2 mm). This study confirms the ability to reliably visualize Pacinian corpuscles with HRUS, which contributes to our basic understanding of ultrasonographically visible subcutaneous structures and may enhance the diagnosis of pathologies related to Pacinian corpuscles.
Topics: Adult; Aged; Female; Hand; Humans; Male; Pacinian Corpuscles; Prospective Studies; Ultrasonography; Young Adult
PubMed: 30220423
DOI: 10.1016/j.ultrasmedbio.2018.08.001