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Anatomical Record (Hoboken, N.J. : 2007) Dec 2017The occurrence of Pacinian corpuscles associated to lymph nodes is an anatomical rarity and very scarce information exists in this regard. Here we examined...
The occurrence of Pacinian corpuscles associated to lymph nodes is an anatomical rarity and very scarce information exists in this regard. Here we examined immunohistochemically four Pacinian corpuscles found in the close vicinity of the hiliar blood vessels of lymph nodes (2 cervical, 1 axillary, and 1 inguinal) during routine surgical pathology. Pacinian corpuscles were normally arranged and displayed a pattern of protein distribution as follows: the axon was positive for neurofilament proteins and neuron specific enolase, the inner core cells showed intense S100 protein and vimentin immunostaining while they were negative for glial fibrillary acidic protein, type IV collagen and glucose transporter 1; vimentin, type IV collagen, and glucose transporter 1 were also observed also in the outer-core and the capsule. These results are in agreement with those reported for cutaneous Pacinian corpuscles, demonstrating that the immunohistochemical profile of these corpuscles is independent of its anatomical localization. The possible functional significance of Pacinian corpuscles in lymph nodes is discussed. Anat Rec, 300:2233-2238, 2017. © 2017 Wiley Periodicals, Inc.
Topics: Acquired Immunodeficiency Syndrome; Aged; Aged, 80 and over; Hernia, Inguinal; Humans; Lymph Nodes; Middle Aged; Neoplasms; Pacinian Corpuscles
PubMed: 28806498
DOI: 10.1002/ar.23679 -
Pflugers Archiv : European Journal of... Feb 19761. Potassium and sodium concentrations within the Pacinian corpuscle fluid have been investigated in adult cats. The sodium and potassium contents of samples were...
1. Potassium and sodium concentrations within the Pacinian corpuscle fluid have been investigated in adult cats. The sodium and potassium contents of samples were estimated by means of integrative ultramicroflame photometry. 2. The analytical results showed the values of the potassium concentration in the Pacinian corpuscle fluid and in the blood plasma to be 6.19 +/- 0.72 and 2.78 +/- 0.38 mequiv/1, respectively. 3. The increasing excitability of the Pacinian corpuscle in potassium-rich solution was shown by electrophysiologic methods. In potassium-free solution two phases of changing receptor excitability were observed. 4. Removal of sodium from external solution reduced the receptor potential to 10% of its original value. 5. Some mechanisms of the increase in excitability of primary tissue mechanoreceptors and secondary mechanoreceptors of the sense organs are discussed.
Topics: Animals; Body Fluids; Cats; Evoked Potentials; Membrane Potentials; Pacinian Corpuscles; Physical Stimulation; Potassium; Sodium
PubMed: 943771
DOI: 10.1007/BF00587293 -
Microscopy Research and Technique Apr 2009This article reviews the biochemical, physiological, and experimental data cumulated during the last decade on the Meissner and Pacinian corpuscles. It includes... (Review)
Review
This article reviews the biochemical, physiological, and experimental data cumulated during the last decade on the Meissner and Pacinian corpuscles. It includes information about (i) the localization of molecules recently detected in sensory corpuscles; (ii) the unsolved problem of the accessory fibers in sensory corpuscles and the occurrence of myelin within them; (iii) the development of sensory corpuscles, especially their neuronal and growth factor dependency; (iv) the composition and functional significance of the extracellular matrix as an essential part of the mechanisms involved in the genesis of the stimuli generated in sensory corpuscles; (v) the molecular basis of mechanotransduction; (vi) a miscellaneous section containing sparse new data on the protein composition of sensory corpuscles, as well as in the proteins involved in live-death cell decisions; (vii) the changes in sensory corpuscles as a consequence of aging, the central, or peripheral nervous system injury; and finally, (viii) the special interest of Meissner corpuscles and Pacinian corpuscles for pathologists for the diagnosis of some peripheral neuropathies and neurodegenerative diseases.
Topics: Animals; Ganglia, Sensory; Humans; Mechanoreceptors; Pacinian Corpuscles; Skin
PubMed: 19012318
DOI: 10.1002/jemt.20651 -
JBJS Case Connector Jun 2021A 37-year-old man presented with pain and macrodactyly of a toe. Imaging and histology demonstrated findings consistent with macrodystrophia lipomatosa (MDL). We...
CASE
A 37-year-old man presented with pain and macrodactyly of a toe. Imaging and histology demonstrated findings consistent with macrodystrophia lipomatosa (MDL). We compared our findings with control tissue obtained from an identical site of a fresh-frozen cadaveric foot from the same anatomical site. Pacinian corpuscles (PCs) in the MDL tissue were increased in number, size, and shape compared with the control tissue and demonstrated edematous interstitial lamellae and vacuolar degenerative change. We also document the magnetic resonance imaging findings of the PCs.
CONCLUSION
Peculiar abnormalities of PCs in MDL underline nerve damage and may be a contributing factor in the pain associated with this unusual condition.
Topics: Adult; Fingers; Foot; Humans; Lower Extremity; Magnetic Resonance Imaging; Male; Pacinian Corpuscles
PubMed: 34129539
DOI: 10.2106/JBJS.CC.20.00785 -
Pancreas Apr 2010To analyze the immunohistochemical profile of the human pancreatic pacinian corpuscles in comparison with that of the cutaneous pacinian corpuscles. In addition, we...
OBJECTIVES
To analyze the immunohistochemical profile of the human pancreatic pacinian corpuscles in comparison with that of the cutaneous pacinian corpuscles. In addition, we studied a Pacinilike corpuscle found in the adventitia of a pancreatic artery.
METHODS
We used immunohistochemistry to detect specific antigens for corpuscular constituents, specific antibodies for the identification of Adelta- and C-sensory fibers and for the detection of several growth factor receptors, and some members of the degenerin/epithelial Na channel superfamily of proteins.
RESULTS
Approximately 62% of pancreatic pacinian corpuscles have 2 to 10 axonic profiles each enclosed by its own inner core: 1 or 2 of these axonic profiles displayed RT-97 immunoreactivity (specific marker of mechanical axons). The cutaneous pacinian corpuscles showed not more than 2 axonic profiles with identical immunohistochemical characteristics. The expression of glial fibrillary acidic protein, epithelial membrane antigen, and tyrosine receptor kinase B was different between pancreatic and cutaneous pacinian corpuscles; the pattern of distribution of degenerin/epithelial Na channel proteins was identical in both cases. The arterial Pacinilike corpuscles displayed a specific immunohistochemical profile.
CONCLUSIONS
Pancreatic pacinian corpuscles slightly differ from the cutaneous ones, and these differences could be related to topography, growth factor requirements, or function of pacinian corpuscles in the pancreas.
Topics: Acid Sensing Ion Channels; Adult; Degenerin Sodium Channels; Epithelial Sodium Channels; Glial Fibrillary Acidic Protein; Humans; Immunohistochemistry; Male; Middle Aged; Mucin-1; Nerve Tissue Proteins; Pacinian Corpuscles; Pancreas; Receptor, trkB; Receptors, Growth Factor; Sensory Receptor Cells
PubMed: 19910838
DOI: 10.1097/MPA.0b013e3181bc0372 -
Nature Jan 1958
Topics: Nerve Endings; Pacinian Corpuscles; Reproduction
PubMed: 13493622
DOI: 10.1038/181124b0 -
The Journal of the Acoustical Society... Jan 1985The effects of a wide range of stimulus parameters upon the psychophysical responses of subjects are important to an understanding of the functional characteristics of... (Review)
Review
The effects of a wide range of stimulus parameters upon the psychophysical responses of subjects are important to an understanding of the functional characteristics of neural systems that underlie responses to cutaneous mechanical stimulation and the interactions that may occur between these systems. This understanding may also be useful to design considerations in the development of devices for tactile communication. This paper begins with a brief description of the two major systems in terms of psychophysical measurements and then focuses on a more detailed examination of possible interactions between them. The effects of time and space variables, such as frequency, temporal and intensity relationships between stimuli, area of stimulation, and surface gradients on the skin, are considered.
Topics: Acoustic Stimulation; Adaptation, Physiological; Animals; Conditioning, Psychological; Humans; Mechanoreceptors; Pacinian Corpuscles; Perceptual Masking; Psychophysics; Skin; Touch; Vibration
PubMed: 3882801
DOI: 10.1121/1.392263 -
Foot & Ankle International Apr 2001A case of Pacinian hyperplasia of the right great toe is reported. Pacinian hyperplasia is a rare benign and recently recognized painful lesion composed of an excess of...
A case of Pacinian hyperplasia of the right great toe is reported. Pacinian hyperplasia is a rare benign and recently recognized painful lesion composed of an excess of well formed or hyperplastic Pacinian corpuscules, normaly involved in sensory innervation. This lesion that is usually observed in the hand, must be distinguished from nerve tumors harboring onion-bulb structure which are not true well formed Pacinian corpuscules and from Morton neuroma. Pacinian hyperplasia is considered a reactive lesion and not a true neoplasm. To our knowledge, this case is the first described in the foot.
Topics: Aged; Diagnosis, Differential; Female; Foot Diseases; Hallux; Humans; Hyperplasia; Immunohistochemistry; Neuroma; Pacinian Corpuscles; Pain
PubMed: 11354450
DOI: 10.1177/107110070102200413 -
The Hand Oct 1974
Topics: Adult; Female; Hand; Humans; Hyperplasia; Male; Mechanoreceptors; Middle Aged; Pacinian Corpuscles
PubMed: 4426528
DOI: 10.1016/0072-968x(74)90039-4 -
The Journal of Physiology Aug 1951
Topics: Acclimatization; Adaptation, Physiological; Axons; Nerve Endings; Pacinian Corpuscles
PubMed: 14874222
DOI: 10.1113/jphysiol.1951.sp004636