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Haemophilia : the Official Journal of... May 2024Patients with haemophilia (PwH) suffer from chronic pain due to joint alterations induced by recurring haemorrhage.
BACKGROUND
Patients with haemophilia (PwH) suffer from chronic pain due to joint alterations induced by recurring haemorrhage.
OBJECTIVES
This study aimed to investigate the relationship between structural alterations and pain perception at the ankle joint in PwH.
PATIENTS/METHODS
Ankle joints of 79 PwH and 57 healthy controls (Con) underwent ultrasound examination (US) and assessment of pain sensitivity via pressure pain thresholds (PPT). US discriminated between joint activity (synovitis) and joint damage (cartilage and/or bone degeneration) applying the HEAD-US protocol. Based on US-findings, five subgroups were built: PwH with activity/damage, PwH with activity/no damage, PwH with no activity/no damage, controls with activity/no damage and controls with no activity/no damage.
RESULTS
Joint activity and joint damage were significantly increased in ankles of PwH compared to Con (p ≤.001). Subgroup analysis revealed that structural alterations negatively impact pain perception. This is particularly evident when comparing PwH with both activity/damage to PwH with no activity/no damage at the tibiotalar joint (p = .001). At the fibulotalar joint, no significant differences were observed between PwH subgroups. Further analysis showed that both joint activity and joint damage result in an increase in pain sensitivity (p ≤.001).
CONCLUSION
The data suggest a relation between joint activity, joint damage and pain perception in PwH. Even minor changes due to synovitis appear to affect pain perception, with the effect not intensifying at higher levels of inflammation. In terms of joint damage, severe degeneration leads to a sensitised pain state most robustly, whereas initial changes do not seem to significantly affect pain perception.
Topics: Humans; Hemophilia A; Ankle Joint; Male; Adult; Pain Perception; Female; Middle Aged; Young Adult; Ultrasonography; Pain Threshold
PubMed: 38600680
DOI: 10.1111/hae.15011 -
Pain Sep 2018
Review
Topics: Health Knowledge, Attitudes, Practice; Humans; Motivation; Pain; Pain Perception
PubMed: 30113941
DOI: 10.1097/j.pain.0000000000001272 -
Hand Clinics Feb 2016Pain is a unique somatosensory perception that can dramatically affect our ability to function. It is also a necessary perception, without which we would do irreparable... (Review)
Review
Pain is a unique somatosensory perception that can dramatically affect our ability to function. It is also a necessary perception, without which we would do irreparable damage to ourselves. In this article, the authors assess the impact of pain on function of the hand. Pain can be categorized into acute pain, chronic pain, and neuropathic pain. Hand function and objective measurements of hand function are analyzed as well as the impact of different types of pain on each of these areas.
Topics: Chronic Pain; Hand; Humans; Neuralgia; Pain Perception
PubMed: 26611383
DOI: 10.1016/j.hcl.2015.08.002 -
The Journal of Clinical Pediatric... 2013To determine changes in orofacial pain perception in community-based children by assessing the pressure pain threshold (PPT) with an algometer and pain intensity by... (Comparative Study)
Comparative Study
PURPOSE
To determine changes in orofacial pain perception in community-based children by assessing the pressure pain threshold (PPT) with an algometer and pain intensity by manual palpation (MP).
METHODS
A total of 100 children from the community aged 7 to 12 years were assessed. Thirty-eight children reported pain in the orofacial region. Of these children,10 reported joint pain (GJ), 12 reported joint and muscle pain (GJMM), 5 reported muscle pain (GMM), 11 reported pain during mastication (GMAST), and 62 reported no pain. An ANOVA (p < 0.05) was used to determine the differences in pain intensity and PPT among groups.
RESULTS
Significantly higher pain intensity upon MP was observed for the temporalis muscle in the GJMM, GMAST and GJ groups compared to the remaining groups. The PPT values were significantly lower in the masseter temporalis muscles, TMJ and thenar region in the GJMM group compared to the other groups.
CONCLUSION
MP more accurately differentiated symptomatic subjects from symptom-free TMD subjects, and PPT values were more sensitive to the discrimination of pain in the orofacial sites assessed. In addition, the changes in perception at a larger number of sites among children reporting mixed pain may suggest the presence of a possible mechanism of central sensitization.
Topics: Arthralgia; Central Nervous System Sensitization; Child; Discrimination, Psychological; Facial Pain; Female; Humans; Male; Masseter Muscle; Mastication; Pain Perception; Pain Threshold; Palpation; Surveys and Questionnaires; Temporal Muscle; Temporomandibular Joint Disorders; Temporomandibular Joint Dysfunction Syndrome; Tendons
PubMed: 23855180
DOI: 10.17796/jcpd.37.3.013017332p40j65u -
Anesthesiology Mar 2013Sedation or anesthesia is used to facilitate many cases of an estimated 45 million diagnostic and therapeutic medical procedures in the United States. Preclinical... (Randomized Controlled Trial)
Randomized Controlled Trial
BACKGROUND
Sedation or anesthesia is used to facilitate many cases of an estimated 45 million diagnostic and therapeutic medical procedures in the United States. Preclinical studies have called attention to the possibility that sedative-hypnotic drugs can increase pain perception, but whether this observation holds true in humans and whether pain-modulating effects are agent-specific or characteristic of IV sedation in general remain unclear.
METHODS
To study this important clinical question, the authors recruited 86 healthy volunteers and randomly assigned them to receive one of three sedative drugs: midazolam, propofol, or dexmedetomidine. The authors asked participants to rate their pain in response to four experimental pain tasks (i.e., cold, heat, ischemic, or electrical pain) before and during moderate sedation.
RESULTS
Midazolam increased cold, heat, and electrical pain perception significantly (10-point pain rating scale change, 0.82 ± 0.29, mean ± SEM). Propofol reduced ischemic pain and dexmedetomidine reduced both cold and ischemic pain significantly (-1.58 ± 0.28, mean ± SEM). The authors observed a gender-by-race interaction for dexmedetomidine. In addition to these drug-specific effects, the authors observed gender effects on pain perception; female subjects rated identical experimental pain stimuli higher than male subjects. The authors also noted race-drug interaction effects for dexmedetomidine, with higher doses of drug needed to sedate Caucasians compared with African Americans.
CONCLUSIONS
The results of the authors' study call attention to the fact that IV sedatives may increase pain perception. The effect of sedation on pain perception is agent- and pain type-specific. Knowledge of these effects provides a rational basis for analgesia and sedation to facilitate medical procedures.
Topics: Adult; Female; Humans; Hypnotics and Sedatives; Infusions, Intravenous; Male; Pain; Pain Measurement; Pain Perception; Treatment Outcome; Young Adult
PubMed: 23314164
DOI: 10.1097/ALN.0b013e318281592d -
Nature Genetics Nov 2013A new study shows that a specific mutation in SCN11A, which encodes the Nav1.9 voltage-gated sodium channel, underlies a human disorder characterized by insensitivity to...
A new study shows that a specific mutation in SCN11A, which encodes the Nav1.9 voltage-gated sodium channel, underlies a human disorder characterized by insensitivity to pain. This finding provides fresh insights into human pain perception and suggests a new avenue for the development of analgesic drugs.
Topics: Animals; Humans; NAV1.9 Voltage-Gated Sodium Channel; Pain; Pain Perception
PubMed: 24165728
DOI: 10.1038/ng.2810 -
Turkish Neurosurgery 2015Perception, definition and tolerance of pain vary individually because of its subjective character. This study aimed to determine the perception differences between...
AIM
Perception, definition and tolerance of pain vary individually because of its subjective character. This study aimed to determine the perception differences between patients with mechanical low back pain (MLBP) and their physicians regarding the assessments of the patients' pain severity.
MATERIAL AND METHODS
181 patients with MLBP and 2 physicians took part in the study. Before the initial examination, the patients filled out a questionnaire consisting of demographic data, pain characteristics, Modified Oswestry Disability Questionnaire (MODQ) and Visual Analog Scale (VAS). The patients' forms were concealed from the physicians. Then physicians examined their patients and rated their pain severity using a different VAS form.
RESULTS
The mean age of the patients was 36.2 ± 12.3 years. 64.6% (n:117) were female, 71.9% (n:13) were highly educated and 57.1% (n:103) were obese. Physicians always rated the patients' pain severity significantly lower than the patients rated their own pain regardless of all demographic data (p < 0.001). Correlation between the VAS scores of patients and physicians were detected as 0.41 (p < 0.001) and the power of the study was calculated as 91.5%. The mean MODQ score of the patients was calculated as 54.4 ± 21.1. Reliability of the questions in MODQ was calculated as alpha:0.87. A moderate correlation between VAS ratings and MODQ was observed (r:0.52, p < 0.001).
CONCLUSION
As a main factor directly affecting many outcomes, good communication between patient and physician, is essential to assess the patients' pain more accurately.
Topics: Adult; Female; Humans; Low Back Pain; Male; Middle Aged; Pain Measurement; Pain Perception; Physician-Patient Relations; Physicians; Surveys and Questionnaires
PubMed: 26037188
DOI: 10.5137/1019-5149.JTN.13481-14.1 -
PloS One 2017Commensal as well as pathogenic bacteria can influence a variety of gut functions, thereby leading to constipation and diarrhea in severe cases. In fact, several... (Observational Study)
Observational Study
BACKGROUND
Commensal as well as pathogenic bacteria can influence a variety of gut functions, thereby leading to constipation and diarrhea in severe cases. In fact, several researchers have reported evidence supporting the association between stool consistency or constipation and the Gut microbiome (GM) composition and dysbiosis. GM influences the human health and disease via the gut-brain axis. We thus hypothesized that the pathogenic bacteria increases pain perception to some extent, which means that there could be an association between stool consistency or constipation and pain perception of healthy subjects.
DESIGN
Observational study.
OBJECTIVES
The aim of the present study was to investigate the association between stool consistency or constipation and pain perception of healthy subjects.
METHODS
Thirty-eight healthy subjects participated in this study. The participants were assessed on their usual stool form (the Bristol Stool Form Scale: BSFS), constipation (the Cleveland Clinic Constipation score: CCS), degree of obesity, pain perception by mechanical stimulus, cold pain threshold, and a questionnaire on psychological state.
RESULTS
The BSFS was significantly and positively associated with pain perception, and showed a significant association with anxiety states. Furthermore, pain perception was significantly associated with anxiety states. However, there were no significant associations between the CCS and any independent variables. In addition, we found that a significant predictor to the pain perception was BSFS. Moreover, there were significant relationships among the psychological states, BSFS and obesity.
CONCLUSION
These results suggest that the stool form is associated with pain perception and anxiety status.
Topics: Adult; Feces; Female; Healthy Volunteers; Humans; Male; Pain Measurement; Pain Perception; Pain Threshold; Surveys and Questionnaires; Young Adult
PubMed: 28793322
DOI: 10.1371/journal.pone.0182859 -
Pain Aug 2015
Topics: Chronic Pain; Female; Humans; Male; Pain Perception; Pain Threshold; Sleep; Sleep Initiation and Maintenance Disorders
PubMed: 26176807
DOI: 10.1097/j.pain.0000000000000144 -
Somatosensory & Motor Research Dec 2017Pain perception is associated with different phenotypic characteristics such as sex, eye, and hair color. Hence, it is assumed that ABO blood type can also affect pain...
AIM OF THE STUDY
Pain perception is associated with different phenotypic characteristics such as sex, eye, and hair color. Hence, it is assumed that ABO blood type can also affect pain perception.
MATERIALS AND METHODS
In order to investigate this hypothesis, an experimental study with healthy volunteers (18-40 years) was designed. The experimental procedure included a blood type test and two rounds of pressure pain threshold assessments separated by a cold pressor test. Pressure pain threshold was assessed bilaterally at the temporalis, masseter, and deltoid muscles, where the muscle sites were randomized. Cold pressor test was conducted by immersion of participants' non-dominant hand into iced water of 1-4 °C for 2 min.
RESULTS
Thirty-seven healthy volunteers, distributed in the four blood type groups, completed the study. Participants with blood type B scored the highest pressure pain thresholds at the examined craniofacial muscles, while participants with blood type AB tended to score the lowest. Furthermore, participants with blood type AB displayed the highest elevation in pressure pain thresholds after cold pressor test.
CONCLUSIONS
Participants with blood type B displayed the lowest mechanical pain sensitivity and the blood type AB group exhibited the strongest conditioned pain modulation effect. These findings emphasize the necessity of considering ABO blood types in future pain research.
Topics: ABO Blood-Group System; Adolescent; Adult; Analysis of Variance; Area Under Curve; Blood Grouping and Crossmatching; Female; Healthy Volunteers; Humans; Male; Pain Perception; Pain Threshold; Pressure; Sex Characteristics; Young Adult
PubMed: 29363387
DOI: 10.1080/08990220.2018.1425675