-
Issues in Mental Health Nursing Dec 2017Many intercurrent factors may be involved in the modulation of the pain message and its expression, such as the previous experience of pain built along the life. In this...
UNLABELLED
Many intercurrent factors may be involved in the modulation of the pain message and its expression, such as the previous experience of pain built along the life. In this study, we aimed to determine whether susceptibility to experimentally induced pain is differentially influenced by the individual previous painful experience in subjects with schizophrenia (SC) major depression (MD), and controls (C).
METHODS
The SC (30), MD (32) and C (30) groups participated in experimental pain tests (application of pressure and induction of ischemia) after a semi-structured interview to make an inventory of the previous painful experiences, and the evaluation of anxiety either with autonomic (heart rate, blood pressure) or psychological (Hospital Anxiety Depression scale HAD) measures, and catastrophism.
RESULTS
The reported pain intensities, severities, duration, of the previous pain events, and the number of previous painful events were equivalent in the three groups, except for the number of painful events experimented before the last six months which was lower in the MD group. Experimental pain sensitivity was influenced by the diagnosis, the HAD scores or the number and intensities of previous lived painful events.
CONCLUSION
The lack of a past experience of pain was comparable for the different groups, suggesting that psychiatric disorders do not affect the experience of pain associated with daily life or past events. For each subject, the reported previous experience of pain influences the present feeling of pain.
Topics: Adult; Case-Control Studies; Depressive Disorder, Major; Female; Humans; Male; Middle Aged; Pain; Pain Perception; Prospective Studies; Schizophrenia; Schizophrenic Psychology
PubMed: 28766994
DOI: 10.1080/01612840.2017.1354103 -
Sheng Li Xue Bao : [Acta Physiologica... Oct 2008In the past two decades, pain perception in the human brain has been studied with EEG/MEG brain topography and PET/fMRI neuroimaging techniques. A host of cortical and...
In the past two decades, pain perception in the human brain has been studied with EEG/MEG brain topography and PET/fMRI neuroimaging techniques. A host of cortical and subcortical loci can be activated by various nociceptive conditions. The activation in pain perception can be induced by physical (electrical, thermal, mechanical), chemical (capsacin, ascoric acid), psychological (anxiety, stress, nocebo) means, and pathological (e.g. migraine, neuropathic) diseases. This article deals mainly on the activation, but not modulation, of human pain in the brain. The brain areas identified are named pain representation, matrix, neuraxis, or signature. The sites are not uniformly isolated across various studies, but largely include a set of cores sites: thalamus and primary somatic area (SI), second somatic area (SII), insular cortex (IC), prefrontal cortex (PFC), cingulate, and parietal cortices. Other areas less reported and considered important in pain perception include brainstem, hippocampus, amygdala and supplementary motor area (SMA). The issues of pain perception basically encompass both the site and the mode of brain function. Although the site issue is delineared to a large degree, the mode issue has been much less explored. From the temporal dynamics, IC can be considered as the initial stage in genesis of pain perception as conscious suffering, the unique aversion in the human brain.
Topics: Brain; Brain Mapping; Brain Stem; Cerebral Cortex; Humans; Magnetic Resonance Imaging; Pain Perception; Parietal Lobe; Prefrontal Cortex
PubMed: 18958377
DOI: No ID Found -
Annals of the New York Academy of... Mar 2022The shared-representation model of empathy is still debated. One of the major questions is whether empathy-eliciting stimuli depicting others' pain selectively activate...
The shared-representation model of empathy is still debated. One of the major questions is whether empathy-eliciting stimuli depicting others' pain selectively activate the representations of self-pain. To address this issue, we assessed the priming effects of empathy-eliciting pictures on firsthand pain and nonpain perception, as well as its associated neural processing. In Experiment 1, when compared with nonpainful pictures depicting individuals' body parts with no injury, participants primed by painful pictures showing individuals' body parts with injury reported higher ratings for perceived intensity, unpleasantness, and salience of nociceptive and auditory stimuli, but they only exhibited increased N2 amplitude in response to nociceptive stimuli. In Experiment 2, the results from another group of participants replicated the observations of Experiment 1 and validated the findings in the non-nociceptive somatosensory modality. Importantly, participants' concern ratings for priming pictures predicted their unpleasantness ratings for subsequent nociceptive stimuli, while participants' attention ratings predicted their unpleasantness ratings for subsequent auditory and tactile stimuli. This finding implies that empathy for pain might influence pain and nonpain perception via different psychological mechanisms. In summary, our findings highlight the existence of pain-selective representations in empathy for pain and contribute to a better understanding of the shared-representation model of empathy.
Topics: Empathy; Humans; Pain; Pain Perception
PubMed: 34877680
DOI: 10.1111/nyas.14723 -
The Journal of Neuroscience : the... May 2016The perception of pain is strongly influenced by cognitive processes, such as expectations toward the efficacy of pain medication. It is reasonable to assume that such...
UNLABELLED
The perception of pain is strongly influenced by cognitive processes, such as expectations toward the efficacy of pain medication. It is reasonable to assume that such processes, among other sources of fluctuation, are reflected in ongoing brain activity, which in turn influences perceptual processing. To identify specific prestimulus EEG activity, and connectivity patterns related to subsequent pain perception in humans, we contrasted painful with nonpainful sensations delivered at the individual threshold level determined by the psychophysical QUEST estimation method (Watson and Pelli, 1983). The 64-channel EEG was recorded using active electrodes during a constant stimulation procedure. The power contrast between trials sorted by rating revealed a signal decrease of 8% before stimulus onset in theta-band (4-7 Hz) at T7/FT7 as well as increased theta-power by 6% at T8/FT8. Gamma-band power was increased (12%, 28-32 Hz) at frontocentral sites (all p < 0.05). Changes in theta-band power are covarying with subsequent pain perception, as well as lowered frontolateral theta-band connectivity for painful percepts. A decrease in frontoparietal connectivity for painful sensations was also identified in the gamma-band (28-32 Hz). A single-trial logistic regression revealed significant information content in the EEG signal at temporal electrode T7 in theta-band (p < 0.01) and frontal electrode F1 in gamma-band (all p < 0.02). The observed patterns suggest top-down modulation of the theta-band effects by a frontocentral network node. These findings contribute to the understanding of ongoing subjective pain sensitivity, potentially relevant to both clinical diagnostics and pain management.
SIGNIFICANCE STATEMENT
The perceived intensity of a constant stimulus is known to vary considerably across multiple presentations. Here, we used state-of-the-art psychophysical methods in an EEG experiment to identify the specific neuronal activity before stimulus onset that reflects the subsequent perception of pain. We found specific oscillatory activity at the bilateral insular cortices as well as connectivity patterns that reflect and correlate with subsequent ratings. These results further the understanding of pain perception and are potentially relevant for the decoding of ongoing pain sensitivity and pain management.
Topics: Adult; Behavior; Brain Mapping; Electric Stimulation; Electroencephalography; Female; Frontal Lobe; Gamma Rhythm; Healthy Volunteers; Humans; Male; Neural Pathways; Pain Perception; Parietal Lobe; Theta Rhythm; Young Adult
PubMed: 27147655
DOI: 10.1523/JNEUROSCI.3325-15.2016 -
Neuron Mar 2019Since noxious stimulation usually leads to the perception of pain, pain has traditionally been considered sensory nociception. But its variability and sensitivity to a... (Review)
Review
Since noxious stimulation usually leads to the perception of pain, pain has traditionally been considered sensory nociception. But its variability and sensitivity to a broad array of cognitive and motivational factors have meant it is commonly viewed as inherently imprecise and intangibly subjective. However, the core function of pain is motivational-to direct both short- and long-term behavior away from harm. Here, we illustrate that a reinforcement learning model of pain offers a mechanistic understanding of how the brain supports this, illustrating the underlying computational architecture of the pain system. Importantly, it explains why pain is tuned by multiple factors and necessarily supported by a distributed network of brain regions, recasting pain as a precise and objectifiable control signal.
Topics: Avoidance Learning; Brain; Cognition; Conditioning, Classical; Conditioning, Operant; Humans; Learning; Motivation; Nociception; Pain; Pain Perception; Reinforcement, Psychology
PubMed: 30897355
DOI: 10.1016/j.neuron.2019.01.055 -
Pain Mar 2023A reciprocity between the stress and the pain system is recognized; however, the manner by which sex affects this reciprocity is unclear. Understanding the interactions...
A reciprocity between the stress and the pain system is recognized; however, the manner by which sex affects this reciprocity is unclear. Understanding the interactions of stress, pain, and sex may shed light on the apparent women's vulnerability to chronic pain, which often coexists with increased distress, and to affective disorders, which often coexist with chronic pain. The study's aim was to examine the effect of acute, validated, psychosocial stress on pain perception and modulation of women and men in a controlled manner. Participants were 82 women and 66 men. Heat-pain threshold, heat-pain tolerance, and pain modulation by temporal summation of pain (TSP), and pain adaptation were measured before and after exposure to the Montreal Imaging Stress Task (MIST) or to a sham task. The stress response was verified by perceived ratings of stress and anxiety, autonomic variables, and salivary cortisol. A significant stress response was obtained by the MIST among both sexes; however, women displayed a greater increase in perceived distress, and men displayed a greater increase in cortisol. Among women, TSP decreased and pain adaptation increased following the MIST, responses that were predicted by perceived distress levels. Among men, TSP increased following the MIST but was not predicted by the stress variables. In conclusion, acute stress manipulation seems to differentially affect both stress and pain responses of women and men: women exhibited stress-induced antinociception and men exhibited stress-induced pronociception. Higher perceived stress levels among women may trigger a temporary increase in pain inhibition mechanisms to serve evolutionary purposes.
Topics: Male; Humans; Female; Chronic Pain; Hydrocortisone; Pain Perception; Pain Threshold; Gender Identity; Stress, Psychological
PubMed: 35947086
DOI: 10.1097/j.pain.0000000000002743 -
Psychophysiology May 2016Chronic pain is a prevalent health issue with one in five people suffering from some form of chronic pain, with loss of productivity and medical costs of chronic pain...
Chronic pain is a prevalent health issue with one in five people suffering from some form of chronic pain, with loss of productivity and medical costs of chronic pain considerable. However, the treatment of pain can be difficult, as pain perception is complex and can be affected by factors other than tissue damage. This study investigated the effect of hypohydration (mild, voluntary dehydration from ∼24 h of limiting fluid intake, mimicking someone drinking less than usual) on a person's pain perception. Seventeen healthy males (age 27 ± 5 years) visited the laboratory on three occasions, once as a familiarization and then twice again while either euhydrated (urine specific gravity: 1.008 ± 0.005) or hypohydrated (urine specific gravity: 1.024 ± 0.003, and -1.4 ± 0.9% body mass). Each visit, they performed a cold pressor test, where their feet were placed in cold water (0-3 °C) for a maximum of 4 min. Measures of hydration status, pain sensitivity, pain threshold, and catastrophization were taken. We found that hypohydration predicted increased pain sensitivity (β = 0.43), trait pain catastrophizing, and baseline pain sensitivity (β = 0.37 and 0.47, respectively). These results are consistent with previous research, and suggest that a person's hydration status may be an important factor in their perception of acute pain.
Topics: Adult; Catastrophization; Cold Temperature; Dehydration; Humans; Male; Pain Perception; Pain Threshold; Self Report; Young Adult
PubMed: 26785699
DOI: 10.1111/psyp.12610 -
Handbook of Clinical Neurology 2018Pain was considered to be integrated subcortically during most of the 20 century, and it was not until 1956 that focal injury to the parietal opercular-insular cortex... (Review)
Review
Pain was considered to be integrated subcortically during most of the 20 century, and it was not until 1956 that focal injury to the parietal opercular-insular cortex was shown to produce selective loss of pain senses. The parietal operculum and adjacent posterior insula are the main recipients of spinothalamic afferents in primates. The innermost operculum appears functionally associated with the posterior insula and can be segregated histologically, somatotopically and neurochemically from the more lateral S2 areas. The Posterior Insula and Medial Operculum (PIMO) encompass functional networks essential to initiate cortical nociceptive processing. Destruction of this region selectively abates pain sensations; direct stimulation generates acute pain, and epileptic foci trigger painful seizures. Lesions of the PIMO have also high potential to develop central pain with dissociated loss of pain and temperature. The PIMO region behaves as a somatosensory area on its own, which handles phylogenetically old somesthetic capabilities based on thinly myelinated or unmyelinated inputs. It integrates spinothalamic-driven information - not only nociceptive but also innocuous heat and cold, crude touch, itch, and possibly viscero-somatic interoception. Conversely, proprioception, graphesthesia or stereognosis are not processed in this area but in S1 cortices. Given its anatomo-functional properties, thalamic connections, and tight relations with limbic and multisensory cortices, the region comprising the inner parietal operculum and posterior insula appears to contain a third somatosensory cortex contributing to the spinothalamic attributes of the final perceptual experience.
Topics: Animals; Humans; Neuralgia; Pain Perception; Parietal Lobe; Syndrome
PubMed: 29519459
DOI: 10.1016/B978-0-444-63622-5.00010-3 -
The Journal of Pain Nov 2014Individuals in pain often face the choice between avoiding pain and pursuing other equally valued goals. However, little is known about pain-related choice behavior and...
UNLABELLED
Individuals in pain often face the choice between avoiding pain and pursuing other equally valued goals. However, little is known about pain-related choice behavior and pain perception in goal conflict situations. Seventy-eight healthy volunteers performed a computerized task requiring repeated choices between incompatible options, differing in their effect on probability to receive painful stimulation and money. Depending on group assignment, participants chose between increased pain probability versus decreased money probability (avoidance-avoidance conflict situation); decreased pain probability versus increased money probability (approach-approach conflict situation); or decrease versus increase in both probabilities (double approach/avoidance conflict situation). During the choice task, participants rated painfulness, unpleasantness, threat, and fearfulness associated with the painful stimulation and how they felt. Longer choice latency and more choice switching were associated with higher retrospective ratings of conflict and of decision difficulty, and more equal importance placed on pain avoidance and earning money. Groups did not differ in choice behavior, pain stimulus ratings, or affect. Across groups, longer choice latencies were nonsignificantly associated with higher pain, unpleasantness, threat, and fearfulness. In the avoidance-avoidance group, more choice switching was associated with higher pain-related threat and fearfulness, and with more negative affect. These results of this study suggest that associations between choice behaviors, pain perception, and affect depend on conflict situation.
PERSPECTIVE
We present a first experimental demonstration of the relationship between pain-related choice behaviors, pain, and affect in different goal conflict situations. This experimental approach allows us to examine these relationships in a controlled fashion. Better understanding of pain-related goal conflicts and their resolution may lead to more effective pain treatment.
Topics: Adult; Choice Behavior; Decision Making; Female; Goals; Humans; Male; Motivation; Pain; Pain Perception; Young Adult
PubMed: 25218553
DOI: 10.1016/j.jpain.2014.08.011 -
Scientific Reports Jan 2021The response to pain is highly individual and can be influenced by complex emotional perception. This study aims to investigate the status of the pain-related emotional...
The response to pain is highly individual and can be influenced by complex emotional perception. This study aims to investigate the status of the pain-related emotional response, and the influence on headache characteristics and disability in migraine. We studied the pain-related emotional response in 145 consecutive migraine patients using the Pain Anxiety Symptoms Scale (PASS), the Pain Catastrophizing Scale (PCS), and the Pain Sensitivity Questionnaire (PSQ) and compared them with 106 healthy controls. We investigated the relationship between emotional factors and migraine characteristics. The effect of pain-related emotion on migraine-related disability assessed with the Headache Impact Test-6 (HIT-6) and the Migraine Disability Assessment (MIDAS). Migraine patients showed significantly higher scores on total PASS (p < 0.001), PCS (p < 0.001) and PSQ (p = 0.002) compared to the healthy controls. The HIT-6 was weakly correlated with PASS (r = 0.390, p < 0.001) and PCS (r = 0.354, p < 0.001). PASS-Total (p = 0.001), headache frequency (p = 0.003), and HADS-Anxiety (p = 0.028) were independent variables associated with HIT-6. Headache frequency (p < 0.001) was an independent variable associated with MIDAS. The structural equation model indicated that headache severity has direct loading on emotion and subsequently influenced migraine-related disability. Disability has a significant effect on the frequency of abortive medication use. Migraine patients have altered emotional responses to pain perception. Pain-related anxiety made an important contribution to headache-related disability. The present results suggest that the management of disability by considering various pain-related emotional factors may be necessary for the therapeutic aspects of migraine.
Topics: Adult; Aged; Anxiety; Emotions; Female; Humans; Male; Middle Aged; Migraine Disorders; Pain; Pain Perception; Surveys and Questionnaires; Young Adult
PubMed: 33436778
DOI: 10.1038/s41598-020-80094-7