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Clinical Autonomic Research : Official... Dec 2003Endoscopic thoracic sympathetic surgery is a safe and effective method of treating palmar hyperhidrosis. Although hand dryness is the positive outcome of surgery, a...
Endoscopic thoracic sympathetic surgery is a safe and effective method of treating palmar hyperhidrosis. Although hand dryness is the positive outcome of surgery, a residual amount of moisture in the hand is believed to improve the quality of life. Reflex sweating is a well-recognized and annoying complication that surgeons endeavor to avoid. From May 1, 2002 to July 31, 2002, 52 patients suffering from palmar hyperhidrosis were operated on by means of endoscopic clipping of the upper part of the T4-sympathetic ganglion (Upper ESB4). There were 24 males and 28 females with a mean age of 25 years. The mean follow-up period was 8.3 months. The patients answered a detailed questionnaire addressing the following issues: the recurrence rate, the degree of hand dryness, the extent of and areas of reflex sweating, the occurrence of gustatory and facial sweating, and the degree of satisfaction. The surgical outcome was satisfactory. Most patients demonstrated no or only slight hand sweating. Moderate sweating without discomfort was experienced in 9% of patients. Only 25% of patients required the use of lotion for hand dryness. Reflex sweating was observed in 87.5% of the patients but extremely uncomfortable in only 3.2%. Ninety-four percent of patients were satisfied. The remaining 6% were not satisfied but did not regret the operation. Although the duration of the follow-up period in this study was relatively short, we could obtain results comparable to other data in the literature. This is a simpler procedure and less damaging to the sympathetic system.
Topics: Adult; Body Water; Female; Ganglia, Sympathetic; Hand; Humans; Hyperhidrosis; Male; Ointments; Patient Satisfaction; Postoperative Period; Recurrence; Retrospective Studies; Skin; Surveys and Questionnaires; Sweating; Sympathectomy; Thoracoscopy; Treatment Outcome
PubMed: 14673674
DOI: 10.1007/s10286-003-1112-4 -
Experimental Physiology Nov 2017What is the central question of this study? In the present study, a reproducible model of maternal voluntary physical activity was developed to evaluate the adaptive...
What is the central question of this study? In the present study, a reproducible model of maternal voluntary physical activity was developed to evaluate the adaptive response of physical activity by attenuating the effects of maternal undernutrition on physical features, reflex ontogeny and growth trajectory of offspring during development. What is the main finding and its importance? Maternal physical activity may induce neuronal maturation of sensorimotor connections impacting on the patterns of locomotor activity in malnourished offspring. Thus, physical activity should be considered as a therapeutic means of countering the effects of maternal undernutrition, by providing a useful strategy for enhancing the neuronal activity of children born to mothers who experience a restricted diet during pregnancy. This study evaluated the effects of maternal voluntary physical activity during pregnancy and lactation on somatic growth (SG), reflex ontogeny (RO) and locomotor activity (LA) of rats whose mothers were protein restricted. Virgin female Wistar rats were divided into the following six groups: control, normal protein (C-NP, n = 4); control, low protein (C-LP, n = 4); inactive, normal protein (I-NP, n = 8); inactive, low protein (I-LP, n = 7); very active, normal protein (VA-NP, n = 8); and very active, low protein (VA-LP, n = 6). Voluntary physical activity was recorded daily in dams. The LP groups were fed an 8% casein diet, whereas control groups were fed a 17% casein diet during pregnancy and lactation. Offspring were evaluated in terms of SG (body weight and length, latero-lateral skull axis and anteroposterior head axis) and RO (palmar grasp, righting, free-fall righting, negative geotaxis, cliff avoidance, auditory startle response and vibrissa placing). The LA was evaluated at 23, 45 and 60 days old in the open field. Voluntary physical activity was reduced during pregnancy and lactation independent of the maternal diet. Pups from LP dams showed delayed SG, reflex maturation and patterns of LA when compared with control pups. The C-LP and I-LP pups showed a delayed SG, RO and LA. Pups from VA-LP mothers showed no delay in SG and RO and presented a faster development of patterns of LA. Maternal voluntary physical activity attenuated the effects of LP diet on indicators of neurodevelopment and patterns of LA of offspring.
Topics: Age Factors; Animal Nutritional Physiological Phenomena; Animals; Behavior, Animal; Disease Models, Animal; Female; Gestational Age; Lactation; Maternal Nutritional Physiological Phenomena; Motor Activity; Nervous System; Neurodevelopmental Disorders; Nutritional Status; Physical Conditioning, Animal; Pregnancy; Prenatal Exposure Delayed Effects; Protein-Energy Malnutrition; Rats, Wistar; Volition
PubMed: 28833822
DOI: 10.1113/EP086400 -
Psychophysiology Nov 2020Advances in mobile and wireless technology have expanded the scope of electrodermal research. Since traditional electrodermal measurement sites are not always suitable... (Comparative Study)
Comparative Study
Advances in mobile and wireless technology have expanded the scope of electrodermal research. Since traditional electrodermal measurement sites are not always suitable for laboratory research and are rarely appropriate for ambulatory measurements, there is a need to explore and contrast alternate measurement locations. We evaluated bilateral electrodermal activity (EDA) from five measurement sites (fingers, feet, wrists, shoulders, and calves). In a counterbalanced, randomized, within-subjects design study, participants (N = 115) engaged in a 4-min-long breathing exercise and were exposed to emotionally laden and neutral stimuli. High within-subject correlations were found between the EDA measured from fingers bilaterally (r = .89), between the left fingers and both feet (r = .72). Moderate correlations were found between EDA measured from the left fingers and wrists (r = .30 and r = .33), low correlations between the left fingers and the shoulders (r = -.03 and r = -.06) or calves (r = .05 and r = .14). Response latency was the shortest on the fingers while it was the longest on the lower body. Short response windows would miss some of the responses from the palmar surfaces and a substantial number from other evaluated locations. The fingers and the feet are the most reliable locations to measure from, followed by the wrists. We suggest setting site-specific response windows for different measurement locations. An investigation of repeatability showed that within-subject correlations, response frequencies, response amplitudes show a similar pattern from the first measurement time to a later one.
Topics: Adolescent; Adult; Emotions; Female; Fingers; Foot; Galvanic Skin Response; Humans; Leg; Male; Neuropsychological Tests; Random Allocation; Shoulder; Wrist; Young Adult
PubMed: 32931044
DOI: 10.1111/psyp.13645 -
Neurology India 2007
Topics: Action Potentials; Carpal Tunnel Syndrome; Electric Stimulation; Hand; Humans; Median Nerve; Reflex; Sensory Receptor Cells; Skin
PubMed: 18040129
DOI: 10.4103/0028-3886.37106 -
European Journal of Dermatology : EJD 2011
Randomized Controlled Trial
Topics: Adult; Breathing Exercises; Female; Galvanic Skin Response; Humans; Hyperhidrosis; Imagery, Psychotherapy; Iontophoresis; Male; Water
PubMed: 21398202
DOI: 10.1684/ejd.2010.1214 -
Electroencephalography and Clinical... Sep 1998To characterize the sympathetic skin responses (SSRs) recorded from non-palmar and non-plantar (non-Pa/P1) skin sites and to evaluate their clinical usefulness.
OBJECTIVE
To characterize the sympathetic skin responses (SSRs) recorded from non-palmar and non-plantar (non-Pa/P1) skin sites and to evaluate their clinical usefulness.
METHODS
SSRs were recorded from 6 non-Pa/P1 sites as well as palmar and plantar (Pa/P1) sites using magnetic neck stimulation in 33 normal subjects, 17 neurological patients with dysautonomia and one patient with lumbar sympathectomy. A conventional thermoregulatory sweat test (TST) was also carried out in 3 patients.
RESULTS
Clear and reproducible SSRs were obtained from all recording sites in all of the normal subjects when the skin temperatures of the subjects were maintained above 34 degrees C and the subjects drank 100-200 ml of hot water. The distribution of absent SSRs was closely correlated with that of anhidrosis or a sweating delay shown by the TST in the patients. Nine of the 17 neurological patients (53%) showed normal responses at Pa/P1 sites, and abnormal responses at non-Pa/P1 sites.
CONCLUSIONS
Recording SSRs from multiple skin sites including non-Pa/P1 sites after magnetic stimulation is more sensitive in detecting sudomotor dysfunction than is the conventional method of recording SSRs from only Pa/P1 sites. In addition, this new method is very useful for the objective clinical evaluation of thermal sweating.
Topics: Adrenoleukodystrophy; Adult; Aged; Autonomic Nervous System Diseases; Body Height; Electric Stimulation; Female; Galvanic Skin Response; Hand; Hot Temperature; Humans; Magnetics; Male; Middle Aged; Reaction Time; Skin; Sweating; Sympathetic Nervous System; Thromboangiitis Obliterans
PubMed: 9780018
DOI: 10.1016/s0168-5597(98)00025-2 -
Journal of the Neurological Sciences Sep 2021Delirium is a common complication in acute ischemic stroke, possibly caused by alterations in the regulation of the sympathetic autonomic nervous system. We investigated...
Delirium is a common complication in acute ischemic stroke, possibly caused by alterations in the regulation of the sympathetic autonomic nervous system. We investigated whether such an association could be demonstrated with two easy-to-use measurement techniques: Measurement of palmar skin conductance level (SCL) and pupillometry measuring the dilation velocity in the pupillary light reflex (PLR). The cohort study included 64 patients admitted with acute ischemic stroke. During the study period (median 4.1 days, interquartile range 2.1 days) patients were assessed for delirium once daily as well as with measurements of SCL and PLR up to twice daily. SCL and PLR during delirium were lower than without delirium present. For SCL the unadjusted difference was -40.8% (95% CI (-55.1 to -22.0), P value <.001) and for PLR the unadjusted difference was -0.22 mm/s (95% CI (-0.42 to -0.01), P value = .041). The results demonstrate changes in sympathetic autonomic nervous system regulation during delirium in acute stroke patients.
Topics: Autonomic Nervous System; Brain Ischemia; Cohort Studies; Delirium; Humans; Reflex, Pupillary; Stroke
PubMed: 34284172
DOI: 10.1016/j.jns.2021.117582 -
Scandinavian Journal of Gastroenterology Apr 1992Cutaneous focal blood perfusion and an index of cutaneous vascular resistance were determined on the dorsum and palm of the hand of 34 patients with liver cirrhosis and...
Cutaneous focal blood perfusion and an index of cutaneous vascular resistance were determined on the dorsum and palm of the hand of 34 patients with liver cirrhosis and of 24 healthy control subjects. Tests were performed with a laser-Doppler technique before and during stimulation of the vasoconstrictor venoarterial reflex, performed by means of venous occlusion of the forearm. The mean arterial blood pressure of the cirrhotics turned out to be lower than that of the controls. On the dorsum of their hands a normal blood perfusion and a reduced vascular resistance were verified, suggesting the intervention of a local autoregulatory phenomenon of the blood flow. The blood perfusion turned out to be higher, whereas the vascular resistance was lower than the norm on the palm of the hands of cirrhotic patients who had palmar erythema, showing the presence of an anomalous non-autoregulatory vasodilation. The extent of venoarterial reflex on the dorsum of the hand turned out to be identical in the patients and controls, whereas that on the palm turned out depressed. This anomaly was present also in patients without palmar erythema, although less marked than in those with erythema. The data obtained suggest the presence of a disturbance in the functioning of the arteriovenous anastomoses (numerous in the palm but very scarce in the dorsum), superimposed on the venoarterial reflex. It may depend on the existence, in hepatic cirrhosis, of an impairment of the specialized autonomic nervous mechanisms that control temperature loss.
Topics: Blood Pressure; Body Temperature Regulation; Erythema; Female; Hand; Humans; Lasers; Liver Cirrhosis; Male; Middle Aged; Reflex, Abnormal; Regional Blood Flow; Skin; Vascular Resistance; Vasoconstriction
PubMed: 1589711
DOI: 10.3109/00365529209000082 -
Neurological Sciences : Official... Nov 2022Here , we aimed to assess the frequency and phenomenology of autonomic and neuropathic complaints of long-COVID and to evaluate them by means of electrophysiology.
PURPOSE
Here , we aimed to assess the frequency and phenomenology of autonomic and neuropathic complaints of long-COVID and to evaluate them by means of electrophysiology.
METHODS
Step 1. Patients with prior COVID-19 infection were screened by COMPASS-31 and mTORONTO to create the target population for further evaluation. Step 2. Patients with high scores were invited for a detailed history of their complaints and electrophysiological analysis, which included nerve conduction studies, cutaneous silent period (CSP), and sympathetic skin response (SSR). We also constituted a control group composed of healthy subjects of similar age and sex for electrophysiological analysis.
RESULTS
There were 106 patients, who matched the study criteria. Among them, thirty-eight patients (%35.8) had neuropathic or autonomic complaints or both. Fatigue and headache were significantly more frequent in patients with autonomic and neuropathic complaints. Detailed examination and electrophysiological evaluation were performed in 14 of 38 patients. Neuropathic complaints were patchy and proximally located in the majority. The entire CSP suppression index was higher in the patients (p = 0.002). There was no difference in palmar and plantar SSR between patients and healthy subjects. mTORONTO scores were negatively correlated with palmar and plantar SSR amplitudes, and the correlation was moderate.
CONCLUSION
Neuropathic or autonomic complaints were seen in more than one-third of patients with long-COVID. Neuropathic complaints were generally patchy, proximally predominant, asymmetric, or diffuse. The CSP suppression index was abnormal whereas SSRs were normal.
Topics: Humans; COVID-19; Autonomic Nervous System; Galvanic Skin Response; Diabetic Neuropathies; Skin; Post-Acute COVID-19 Syndrome
PubMed: 35994135
DOI: 10.1007/s10072-022-06350-y -
Reproduction, Fertility, and Development Sep 2019The aim of this study was to evaluate whether paternal exposure to bupropion hydrochloride (BUP), an inhibitor of dopamine and noradrenaline reuptake, would affect the...
The aim of this study was to evaluate whether paternal exposure to bupropion hydrochloride (BUP), an inhibitor of dopamine and noradrenaline reuptake, would affect the postnatal development of offspring. Male mice were divided into a BUP-treated (40mgkg-1day-1 by gavage, 45 days) or control (saline by gavage, 45 days) group (n=20 in each group). From Day 35 to Day 45 of treatment, males were allowed to mate with drug-naïve female mice. Postnatal development of the offspring (both sexes) was evaluated from Postnatal day (PND) 1 to PND60. Physical development parameters (weight gain, body length, incisor eruption, pinna detachment), anogenital distance, vaginal opening, reflexes (palmar grasp, surface righting, negative geotaxis and adult gait) and some behavioural parameters (locomotor activity and anxiety-like behaviour) were altered in the offspring of BUP-treated males. The results demonstrate that paternal exposure to BUP induces long-lasting changes in the postnatal development of the offspring.
Topics: Animals; Animals, Newborn; Behavior, Animal; Bupropion; Female; Growth and Development; Male; Mice; Motor Activity; Paternal Exposure; Pregnancy; Prenatal Exposure Delayed Effects; Reflex
PubMed: 31270008
DOI: 10.1071/RD18403