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Retina (Philadelphia, Pa.) Jan 2014To describe the clinical characteristics and progression of patients with multifocal choroiditis lesions who had minimal or no evidence of anterior uveitis and/or...
PURPOSE
To describe the clinical characteristics and progression of patients with multifocal choroiditis lesions who had minimal or no evidence of anterior uveitis and/or vitritis.
METHODS
Retrospective, observational, single-center consecutive case series. Clinical histories, examination, and multimodal imaging findings were analyzed.
RESULTS
Sixty-five eyes of 41 patients were identified. The mean age at diagnosis was 38.4 years (median, 35 years; range, 15-81 years), and 70.7% of the patients were women. Involvement was bilateral in 21 patients (51.2%) at presentation. The 60-month bilateral event-free survival was 75.0% (95% confidence interval, 49.8-91.2%). The mean visual acuity was 20/46 (median, 20/25; range, 20/20 to count fingers at 2 feet) at presentation and 20/42 (median, 20/25; range, 20/20-5/400) at the last recorded visit. The 60-month "20/50 or worse" event-free survival was 100%. Between the first presentation and final follow-up (a mean duration of 92.6 months; range, 0-343 months), 46.7% of the eyes developed new or larger chorioretinal spots and 32.6% developed new or recurrent choroidal neovascularization. The 60-month choroidal neovascularization event-free survival was 68.1% (95% confidence interval, 39.2-85.4%).
CONCLUSION
Patients with multifocal choroiditis lesions, but with minimal or no anterior uveitis or vitritis, tended to be young women. Approximately half of the patients presented with bilateral involvement, which is less than has been reported in most case series of multifocal choroiditis with panuveitis. One quarter of all unilaterally affected patients will develop bilateral involvement by 60 months.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Choroiditis; Coloring Agents; Disease Progression; Female; Fluorescein Angiography; Humans; Indocyanine Green; Male; Middle Aged; Multifocal Choroiditis; Panuveitis; Retrospective Studies; Tomography, Optical Coherence; Visual Acuity; Young Adult
PubMed: 23670288
DOI: 10.1097/IAE.0b013e31829234cb -
Retinal Cases & Brief Reports Jan 2023To report a case of syphilitic outer retinopathy revealed after progression to panuveitis after a course of oral steroids for suspected poison ivy.
PURPOSE
To report a case of syphilitic outer retinopathy revealed after progression to panuveitis after a course of oral steroids for suspected poison ivy.
METHODS
Retrospective case report.
RESULTS
A 44-year-old diabetic man presented with progressive symptoms of nyctalopia and color vision changes associated with outer retinal disruption on macular imaging but minimal evidence of intraocular inflammation on examination. A short course of oral steroids for an unrelated skin condition induced rapid progression to frank panuveitis with retinal vascular sheathing and retinal whitening. Systemic workup identified syphilis as the etiology. The patient's visual symptoms and disruption of the photoreceptor and retinal pigment epithelial layers on OCT improved after treatment with IV penicillin.
CONCLUSION
Syphilitic outer retinopathy represents an unusual manifestation of ocular syphilis that can present with minimal examination findings. We present here a case of oral steroid use resulting in the progression of syphilitic outer retinopathy to a more fulminant form of syphilitic uveitis that ultimately revealed the correct diagnosis and prompted the correct intervention. This case highlights the importance of maintaining a high level of suspicion for this treatable condition.
Topics: Male; Humans; Adult; Syphilis; Retrospective Studies; Anti-Bacterial Agents; Panuveitis; Retinal Diseases; Uveitis; Steroids
PubMed: 33323897
DOI: 10.1097/ICB.0000000000001106 -
Journal Francais D'ophtalmologie Dec 2013Ocular involvement secondary to thyroid carcinomas is uncommon. Uveal metastasis may occur. More rarely, they can be responsible for paraneoplastic syndromes. We report...
Ocular involvement secondary to thyroid carcinomas is uncommon. Uveal metastasis may occur. More rarely, they can be responsible for paraneoplastic syndromes. We report the case of a 64-year-old woman who presented with a severe bilateral panuveitis with venous vasculitis associated with hyperthyroidism from a multinodular goiter, complicated by papillary carcinoma. Systemic steroid therapy was initiated; ocular symptoms resolved completely after total thyroidectomy. Other causes of panuveitis with venous vasculitis were ruled out. This is the first reported case of panuveitis associated with papillary thyroid carcinoma. The occurrence of the ocular symptoms with hyperthyroidism and their remission after surgery supports the possibility that this association may not be coincidental. A paraneoplastic phenomenon is suspected.
Topics: Carcinoma; Carcinoma, Papillary; Female; Goiter, Nodular; Humans; Hyperthyroidism; Middle Aged; Panuveitis; Thyroid Cancer, Papillary; Thyroid Neoplasms; Thyroidectomy
PubMed: 24211307
DOI: 10.1016/j.jfo.2012.12.009 -
Leukemia & Lymphoma Apr 2009
Topics: Aged; CD3 Complex; CD56 Antigen; Diagnosis, Differential; Humans; Immunohistochemistry; Lymphoma, Extranodal NK-T-Cell; Male; Panuveitis; Visual Acuity
PubMed: 19241207
DOI: 10.1080/10428190802713539 -
Romanian Journal of Ophthalmology 2017We present the case of a 49-year-old patient who was treated with Aripriprazole in context of Paranoid Schizophrenia. The patient had a history of numerous Panuveitis...
We present the case of a 49-year-old patient who was treated with Aripriprazole in context of Paranoid Schizophrenia. The patient had a history of numerous Panuveitis recurrences for the left eye, which led to a marked decrease of the vision VA-NLP and was diagnosed with Multifocal Choroiditis and Panuveitis for the right eye. The examination revealed VA of 20/ 200 for right eye, keratic precipitates, and vitritis. Fundus aspect of the right eye showed multiple discrete, ovoid, yellowish-grey lesions at the posterior pole and periphery, optic disc oedema was present. The Human leukocyte antigen typing of group A, ancillary investigation (OCT, Angiofluorography, B-mode ultrasonography) and fundus examination confirmed the diagnosis of Multifocal Choroiditis and Panuveitis but we did not exclude antipsychotic-related chorioretinopathy or a Birdshot-like Syndrome.
Topics: Adult; Choroiditis; Fluorescein Angiography; Fundus Oculi; Humans; Multifocal Choroiditis; Panuveitis; Syndrome
PubMed: 29516050
DOI: No ID Found -
International Journal of STD & AIDS Sep 2006We report a case of sight-threatening secondary syphilis with HIV co-infection where atypical pattern of skin manifestations resulted in a delay in making the correct...
We report a case of sight-threatening secondary syphilis with HIV co-infection where atypical pattern of skin manifestations resulted in a delay in making the correct diagnosis. However, despite marked visual loss by the time correct diagnosis was made, the patient responded well, albeit slowly, to a course of intravenous benzyl penicillin.
Topics: Adult; Anti-Bacterial Agents; Cardiolipins; Cholesterol; Doxycycline; Drug Hypersensitivity; Follow-Up Studies; HIV Infections; Humans; Male; Neurosyphilis; Panuveitis; Penicillins; Phosphatidylcholines; Syphilis; Syphilis Serodiagnosis; Time Factors; Treatment Outcome; White People
PubMed: 16942657
DOI: 10.1258/095646206778113122 -
Ocular Immunology and Inflammation Nov 2021: To report a case of a patient who suffered from Sweet's syndrome with panuveitis in both eyes.: Retrospective interventional case report.: A 54-year-old Chinese male...
: To report a case of a patient who suffered from Sweet's syndrome with panuveitis in both eyes.: Retrospective interventional case report.: A 54-year-old Chinese male patient complained of fever, painful skin lesions and blurry vision in both eyes lasting for 4 days. His visual acuity was hand motion in both eyes. Slit-lamp examination showed the hypopyon and severe vitreous opacification in both eyes. A skin pathology from head skin lesion demonstrated diffuse neutrophilic infiltration in the dermis with karyorrhexis. Based on the inspection above, the patient was diagnosed with Sweet's syndrome and given systemic corticosteroids therapy. However, he developed secondary rhegmatogenous retinal detachment in the right eye during his treatment.: The association of bilateral uveitis with Sweet's syndrome has been described in this report.
Topics: Diabetes Mellitus; Endotamponade; Fluorescein Angiography; Glucocorticoids; Humans; Intraocular Pressure; Male; Middle Aged; Panuveitis; Retinal Detachment; Retrospective Studies; Slit Lamp Microscopy; Sweet Syndrome; Triamcinolone Acetonide; Visual Acuity; Vitrectomy; Vitreous Body
PubMed: 32394773
DOI: 10.1080/09273948.2020.1746357 -
BMJ Case Reports Jun 2014Most panuveitis in children are caused by infectious agents. A detailed clinical history and clinical examination are helpful in the diagnosis, but specific techniques...
Most panuveitis in children are caused by infectious agents. A detailed clinical history and clinical examination are helpful in the diagnosis, but specific techniques are sometimes required to identify the causing specimen. We report the first published case of panuveitis in a child caused by simultaneous ocular infection by Toxocara canis and a fly larva and the innovative use of immunodiffusion technique in the vitreous for the diagnosis.
Topics: Animals; Antibodies, Helminth; Child; Coinfection; Eye Infections, Parasitic; Humans; Larva Migrans, Visceral; Male; Myiasis; Panuveitis; Toxocara canis; Vitreous Body
PubMed: 24916981
DOI: 10.1136/bcr-2014-204475 -
Journal of Pediatric Ophthalmology and... Apr 2016Idiopathic orbital inflammation or orbital pseudotumor is rare in the pediatric population and may present with ocular findings not normally seen in the adult...
Idiopathic orbital inflammation or orbital pseudotumor is rare in the pediatric population and may present with ocular findings not normally seen in the adult population. The authors report the case of a 14-year-old boy with idiopathic orbital inflammation who presented with bilateral panuveitis to highlight the features that make this diagnosis more difficult in the pediatric population.
Topics: Adolescent; Fluorescein Angiography; Glucocorticoids; Humans; Magnetic Resonance Imaging; Male; Orbital Pseudotumor; Panuveitis; Prednisone
PubMed: 27112170
DOI: 10.3928/01913913-20160406-03 -
Ocular Immunology and Inflammation Jan 2021: To describe the results of tocilizumab treatment in children with refractory non-anterior uveitis.: A case series of seven children with refractory non-anterior...
: To describe the results of tocilizumab treatment in children with refractory non-anterior uveitis.: A case series of seven children with refractory non-anterior uveitis (onset ≤16 years) with leakage on fluorescein angiogram (FA) were treated with tocilizumab intravenously every 4 weeks (eight mg/kg). Minimum follow-up was 6 months. Reported outcomes are changes in BCVA, central macular thickness (CMT) on OCT image, FA scores, dose of systemic steroids, complications and side effects.: In all patients, there was an improvement of macular edema and capillary leakage on FA. The median FA score decreased from 14 (10-18) at baseline to 8 (2-9) after 6 months of treatment (p = .018). The CMT decreased from 321 (314-384) to 295 (255-312) (p = .043). BCVA improved in five eyes and worsened in one eye due to cataract. No systemic or ocular complications were reported.: Tocilizumab is an effective therapeutic option for reducing disease activity in children with refractory non-anterior uveitis.
Topics: Antibodies, Monoclonal, Humanized; Child; Child, Preschool; Dose-Response Relationship, Drug; Female; Fluorescein Angiography; Follow-Up Studies; Fundus Oculi; Humans; Infusions, Intravenous; Male; Panuveitis; Retrospective Studies; Treatment Outcome; Visual Acuity
PubMed: 32058831
DOI: 10.1080/09273948.2020.1712431