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Ocular Immunology and Inflammation Jun 2010To describe a case of orbital mucosa-associated lymphoid tissue (MALT) lymphoma masquerading as unilateral panuveitis.
PURPOSE
To describe a case of orbital mucosa-associated lymphoid tissue (MALT) lymphoma masquerading as unilateral panuveitis.
METHODS
Retrospective chart review.
RESULTS
A 53-year-old female patient with unilateral vitritis and exudative retinal detachment refractory to immunosuppressive treatment was eventually diagnosed with orbital MALT lymphoma. Following treatment with radiotherapy and rituximab, the patient's intraocular inflammation and retinal detachment resolved.
CONCLUSIONS
Orbital MALT lymphoma can masquerade as refractory unilateral panuveitis with exudative retinal detachment and appears to respond to a combination of radiotherapy and specific B-cell-targeted systemic therapy.
Topics: Antibodies, Monoclonal, Murine-Derived; Antineoplastic Agents; Diagnosis, Differential; Female; Fluorescein Angiography; Follow-Up Studies; Fundus Oculi; Humans; Lymphoma, B-Cell, Marginal Zone; Middle Aged; Orbital Neoplasms; Panuveitis; Radiotherapy, Adjuvant; Rituximab; Tomography, Optical Coherence; Tomography, X-Ray Computed
PubMed: 20482392
DOI: 10.3109/09273941003728947 -
BMC Ophthalmology Oct 2022
Topics: Diagnosis, Differential; Eye Abnormalities; Humans; Killer Cells, Natural; Lymphoma, T-Cell; Panuveitis
PubMed: 36203154
DOI: 10.1186/s12886-022-02527-3 -
Ocular Immunology and Inflammation 2019To report the pattern of posterior and panuveitis at a tertiary referral center in Singapore.
PURPOSE
To report the pattern of posterior and panuveitis at a tertiary referral center in Singapore.
METHODS
Subgroup retrospective analysis of 334 new posterior and panuveitis cases, from the Ocular Autoimmune Systemic Inflammatory Infectious Study (OASIS) database. Descriptive analysis was performed and visual outcome and complications were reported.
RESULTS
The etiology for posterior uveitis and panuveitis was infectious in 162 patients (48.5%), non-infectious in 144 patients (43.1%), and idiopathic in 28 patients (8.4%). More patients with bilateral disease had a non-infectious etiology (n = 82, 50.9%) (p = 0.012). The most common complication was epiretinal membrane (n = 20, 12.3%) for the infectious group and cystoid macular edema (n = 12, 8.3%) for the non-infectious group.
CONCLUSIONS
The proportion of etiologies in our cohort varies from other studies. Understanding the variations and demographic associations allows the diagnosis and management of posterior and panuveitis to be further improved.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Antiviral Agents; Autoimmune Diseases; Child; Eye Infections; Female; Glucocorticoids; Humans; Immunosuppressive Agents; Male; Middle Aged; Panuveitis; Retrospective Studies; Singapore; Tertiary Care Centers; Uveitis, Posterior; Visual Acuity
PubMed: 28991501
DOI: 10.1080/09273948.2017.1358377 -
Journal Francais D'ophtalmologie Mar 2018
Topics: Diagnosis, Differential; Female; Fluorescein Angiography; Fundus Oculi; Humans; Lymphoma, B-Cell, Marginal Zone; Magnetic Resonance Imaging; Middle Aged; Orbital Neoplasms; Panuveitis; Paraneoplastic Syndromes, Ocular; Tomography, Optical Coherence
PubMed: 29567022
DOI: 10.1016/j.jfo.2017.10.005 -
American Journal of Ophthalmology Jan 1994
Topics: Humans; Leptospira; Leptospirosis; Male; Middle Aged; Optic Disk; Optic Neuritis; Panuveitis; Retinal Diseases; Vasculitis
PubMed: 8291582
DOI: 10.1016/s0002-9394(14)73030-2 -
Bulletin de La Societe Belge... 1999Multifocal choroiditis and punctate inner choroidopathy cause scattered acute chorioretinal lesions in the fundus. Secondary choroidal neovascularization and, more... (Review)
Review
Multifocal choroiditis and punctate inner choroidopathy cause scattered acute chorioretinal lesions in the fundus. Secondary choroidal neovascularization and, more rarely, diffuse subretinal fibrosis without obvious neovascularization are associated with both syndromes and cause severe visual loss. Both disorders are of unknown etiology and have many similarities. It is our purpose to present four such cases with emphasis on their fluorescein and indocyanine green angiographic appearance. We review shortly the literature on the subject.
Topics: Adult; Choroid Diseases; Choroiditis; Diagnosis, Differential; Female; Fibrosis; Fluorescein Angiography; Humans; Indocyanine Green; Male; Neovascularization, Pathologic; Panuveitis; Retina
PubMed: 10546386
DOI: No ID Found -
Ocular Immunology and Inflammation Jul 2024To report a case of isolated conjunctival inflammation as initial manifestation of IgG4-related disease and subsequent development of panuveitis.
PURPOSE
To report a case of isolated conjunctival inflammation as initial manifestation of IgG4-related disease and subsequent development of panuveitis.
CASE REPORT
A 75-year-old female presented with a diffuse mass lesion in the temporal area of the left eye, involving the conjunctiva, and an abscessed corneal ulcer. An incisional biopsy was diagnostic of IgG4-related disease with an elevated IgG4/IgG ratio (>40%) and the presence of >10 cells that tested positive for IgG4/CGA. No other ocular, orbital or systemic manifestations were noted at the time of diagnosis. After a year of treatment with topical dexamethasone, oral prednisone, and methotrexate, the patient developed panuveitis, which was controlled by increasing steroids and switching to rituximab.
CONCLUSION
IgG4-related disease is a rare entity that can be particularly challenging to diagnose if it manifests in an atypical manner. Continuous follow-up of patients is crucial as relapses and worsening of symptoms can occur despite treatment.
Topics: Humans; Female; Panuveitis; Aged; Glucocorticoids; Immunoglobulin G4-Related Disease; Conjunctivitis; Immunoglobulin G; Rituximab; Prednisone; Dexamethasone; Methotrexate; Biopsy; Drug Therapy, Combination
PubMed: 37023396
DOI: 10.1080/09273948.2023.2191121 -
Ocular Immunology and Inflammation 2019: To describe the clinical characteristics and surgical outcomes of panuveitis over a 10-year period.: Data were collected on panuveitis etiology, treatment, surgery and...
: To describe the clinical characteristics and surgical outcomes of panuveitis over a 10-year period.: Data were collected on panuveitis etiology, treatment, surgery and change in vision.: Overall, 308 patients (594 eyes) were evaluated, 54.9% with non-granulomatous and 45.1% with granulomatous uveitis. Fifty-four patients had infectious and 254 had non-infectious uveitis. In infectious panuveitis, vision remained unchanged at last visit. The most frequent diagnosis was presumed intraocular tuberculosis (PIOTB) uveitis (48.1%). In the non-infectious subgroup vision increased significantly by 2 lines at last visit (= 0.020). The most common diagnose was Vogt-Koyanagi-Harada (VKH) disease (38.6%). Initial therapy was oral prednisone in 86.6% with non-infectious etiology followed by immunosuppressive agents. Surgery secondary to complications (mainly cataracts) was performed in 46.7% patients.: In Saudi Arabia, panuveitis was mainly due to VHK. PIOTB was the most common etiology for infectious panuveitis. Immunosuppressive therapy and surgery maintained BCVA in non-infectious panuveitis.
Topics: Adolescent; Adult; Aged; Child; Disease Management; Female; Fluorescein Angiography; Follow-Up Studies; Forecasting; Fundus Oculi; Humans; Incidence; Male; Middle Aged; Panuveitis; Retrospective Studies; Saudi Arabia; Surveys and Questionnaires; Tomography, Optical Coherence; Visual Acuity; Young Adult
PubMed: 30303435
DOI: 10.1080/09273948.2018.1523436 -
Journal of Child Neurology Mar 2005We report a case of an 11-year-old girl with bilateral panuveitis in association with pseudotumor cerebri. The patient underwent complete ophthalmologic, neurologic, and...
We report a case of an 11-year-old girl with bilateral panuveitis in association with pseudotumor cerebri. The patient underwent complete ophthalmologic, neurologic, and laboratory evaluations and was treated with therapy for pseudotumor cerebri. The patient met the diagnostic criteria for pseudotumor cerebri and also had panuveitis. Symptoms and findings of pseudotumor cerebri and panuveitis improved significantly after combination therapy of oral acetazolamide and weight reduction. The index case illustrates that pseudotumor cerebri can be associated with panuveitis. Therapy for pseudotumor cerebri might also help with the resolution of uveitis.
Topics: Child; Female; Humans; Panuveitis; Pseudotumor Cerebri
PubMed: 15832615
DOI: 10.1177/08830738050200031601 -
Romanian Journal of Ophthalmology 2022The diagnosis of bilateral panuveitis was made in a 9-year-old girl who was referred to our hospital for blurred vision accompanied by periorbital and abdominal pain....
The diagnosis of bilateral panuveitis was made in a 9-year-old girl who was referred to our hospital for blurred vision accompanied by periorbital and abdominal pain. Endothelial dusting, vitreous haze and optic nerve edema were deemed as signs of involvement of all segments of the eye. The bloodwork results were suggestive of infectious uveitis, with elevated inflammatory markers and the patient was treated with IV antibiotics. Cerebral-CT was normal, screening for common infectious causes of uveitis and cultures were negative. There was no history of autoimmune disease, and autoimmune antibody tests were negative. Pediatric inflammatory multisystem syndrome induced panuveitis, secondary to SARS-CoV-2 (PIMS), was suspected by the infectious disease consultant. The syndrome commonly affects school-age children and represents a generalized inflammatory response in the body that appears about one month after the initial infection with the SARS-CoV-2 virus. Initial symptoms include fever, abdominal pain, eye redness, rashes, dizziness, accompanied by laboratory evidence of inflammation unexplained by any other plausible cause. The patient's coronavirus IgG titer was positive, while the RT-PCR for SARS-CoV-2 virus, taken from the nasopharyngeal swab, was negative. As all the other investigations turned out negative, COVID-19 was the only presumptive cause for the pediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 (PIMS-TS). A diagnosis of probable COVID-19 induced uveitis was made and the patient started IV Dexamethasone, followed by oral steroids that were gradually tapered and made a full recovery. The aim of this report was to shed light and enrich the scarce literature available on Uveitis as a sign of pediatric inflammatory syndrome following COVID-19 infection. ACE2 = Angiotensin converting enzyme 2, ANA = Antinuclear antibodies, c-ANCA, p-ANCA = Cytoplasmic and perinuclear anti-neutrophil cytoplasm antibodies, BCVA = Best corrected visual acuity, CMV = Cytomegalovirus, COVID-19 = coronavirus disease 2019, CRE = Carbapenem-resistant Enterobacteriaceae, CRP = C-Reactive Protein, EBV = Epstein Barr virus, ESBL = Extended spectrum beta-lactamase, ESR = Erythrocyte Sedimentation Rate, FCoV = Feline coronavirus, MDR = Multidrug resistant, MRSA = methicillin-resistant Staphylococcus aureus, MHV = mouse hepatitis virus, MIS-C = multisystem inflammatory syndrome in children, NSAID = Nonsteroidal anti-inflammatory drug, NT pro BNP = precursor natriuretic brain peptide, PIMS-TS = Pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2, RNFL = Retinal nerve fiber layer, SARS CoV-2 = severe acute respiratory syndrome coronavirus 2, SD-OCT = Spectral domain optical coherence tomography, VRE = Vancomycin-resistant Enterococci.
Topics: Abdominal Pain; COVID-19; Epstein-Barr Virus Infections; Herpesvirus 4, Human; Humans; Methicillin-Resistant Staphylococcus aureus; Ophthalmologists; Panuveitis; SARS-CoV-2; Systemic Inflammatory Response Syndrome
PubMed: 35935086
DOI: 10.22336/rjo.2022.39