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American Journal of Clinical Pathology Oct 2019Thyroid-like low-grade nasopharyngeal papillary adenocarcinoma (TLLGNPPA) is a relatively rare nasopharyngeal tumor. We performed morphological characterization,... (Review)
Review
OBJECTIVES
Thyroid-like low-grade nasopharyngeal papillary adenocarcinoma (TLLGNPPA) is a relatively rare nasopharyngeal tumor. We performed morphological characterization, immunohistochemical profiling, and investigated gene mutations. We also provide clinical follow-up data and brief review of the literature.
METHODS
Immunohistochemistry was used to evaluate the expression of TTF-1, CK19, CK7, EMA, TG, Pax-8, CK5/6, S100, and Ki-67. Additionally, in situ hybridization was utilized to identify the presence of EBV. We investigated mutations in hot-spot exons of KRAS/NRAS/BRAF to rule out common mutations seen in thyroid tumors.
RESULTS
Histopathologic examination of four cases identified tumors that were mainly occupied by papillary architectures. One case had a predominantly glandular structure. The tumors expressed TTF-1 and CK19, while TG and Pax-8 were negative. S100 was moderately expressed focally in three cases.
CONCLUSIONS
While TLLGNPPA displays a morphological resemblance to papillary thyroid carcinoma (PTC), it is vital to differentiate nasopharyngeal metastasis from PTC for appropriate treatment.
Topics: Adenocarcinoma, Papillary; Adult; Biomarkers, Tumor; DNA-Binding Proteins; Diagnosis, Differential; Female; Humans; Immunohistochemistry; Male; Mutation; Nasopharyngeal Neoplasms; S100 Proteins; Thyroid Cancer, Papillary; Tomography, X-Ray Computed; Transcription Factors
PubMed: 31287861
DOI: 10.1093/ajcp/aqz082 -
Journal of the College of Physicians... Nov 2019Low-grade nasopharyngeal papillary adenocarcinoma is a rare tumor, and only a limited number of cases are reported in the literature. The case reported in this study had...
Low-grade nasopharyngeal papillary adenocarcinoma is a rare tumor, and only a limited number of cases are reported in the literature. The case reported in this study had long-term nasal catarrh with a runny nose and was admitted to the hospital. Computed tomography (CT) examination revealed polypoid mass in the nasopharynx. Pathological examination revealed typical papillary growth pattern of glandular epithelial cells. Immunohistochemical (IHC) staining showed the tumor cells to be diffusely positive for cytokeratin 7 (CK7), vimentin, and thyroid transcription factor 1 (TTF-1). The Ki-67 proliferation index was approximately 1%. In situ hybridization for latent Ebstein-virus (EBV) injection was negative. The patient did not exhibit recurrence or metastasis of the tumor.
Topics: Adenocarcinoma, Papillary; Aged; Biomarkers, Tumor; Biopsy; Diagnosis, Differential; Female; Humans; Nasopharyngeal Neoplasms; Neoplasm Grading; Tomography, X-Ray Computed
PubMed: 31659975
DOI: 10.29271/jcpsp.2019.11.1114 -
Cancer Research and Treatment Jan 2017Primary low-grade thyroid-like papillary adenocarcinomas are extremely rare neoplasms that generally originate in the nasopharynx. Here, we describe a novel case of a... (Review)
Review
PURPOSE
Primary low-grade thyroid-like papillary adenocarcinomas are extremely rare neoplasms that generally originate in the nasopharynx. Here, we describe a novel case of a 15-year-old Chinese girl who was diagnosed with low-grade thyroid-like papillary adenocarcinoma, including a brief review of the literature to reveal the clinicopathological features of low-grade thyroid-like nasopharyngeal papillary adenocarcinoma.
MATERIALS AND METHODS
Immunohistochemistry was used to evaluate the expression of pan-cytokeratin (CKpan), cytokeratin (CK) 7, thyroid transcription factor 1 (TTF-1), vimentin, epithelial membrane antigen (EMA), thyroglobulin, CD15, S100, P40, CK20, CDX-2, glial fibrillary acidic protein (GFAP), and Ki-67. Additionally, hybridization investigation was utilized to identify the presence of small Epstein-Barr virus (EBV)-encoded RNA.
RESULTS
Histopathological analysis revealed florid proliferation of papillary structures lined by columnar epithelial cells with fibrovascular cores. Immunohistochemically, the neoplastic cells were positive for CKpan, CK7, TTF-1, vimentin, and EMA, but negative for thyroglobulin, CD15, S100, P40, CK20, CDX-2, and GFAP. The Ki-67-labeling index reached 5% in the most concentrated spot. hybridization for EBV was negative.
CONCLUSION
Due to the distinct rarity of low-grade thyroid-like papillary adenocarcinomaswith a favorable clinical outcome, a nationwide effort to raise public awareness of this neoplasm is required.
Topics: Adenocarcinoma, Papillary; Adolescent; Biomarkers; Biopsy; Carcinoma; Endoscopy; Female; Humans; Immunohistochemistry; Nasal Septum; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms
PubMed: 27384157
DOI: 10.4143/crt.2016.195 -
Acta Otorrinolaringologica Espanola 2019
Review
Topics: Adenocarcinoma, Papillary; Adult; Female; Humans; Nasopharyngeal Neoplasms; Neoplasm Grading; Tomography, X-Ray Computed
PubMed: 30075860
DOI: 10.1016/j.otorri.2018.04.007 -
Clinical and Experimental Dermatology Mar 2010Vigorous treatment of aggressive digital papillary adenocarcinoma (ADPA), including amputation, has been recommended by most authors, but the appropriateness and... (Review)
Review
Vigorous treatment of aggressive digital papillary adenocarcinoma (ADPA), including amputation, has been recommended by most authors, but the appropriateness and effectiveness of excision as an alternative to amputation has not been systematically evaluated. To evaluate the appropriateness and effectiveness of excision as an alternative to amputation in the treatment of ADPA, we reviewed the clinical presentations, treatments and patient outcomes presented in case reports on ADPA available on Ovid MEDLINE. We also assessed the results of immunohistochemical staining for proliferation markers in one patient in order to explain the nonaggressive nature of ADPA noted in that patient. Except for the duration of lesions, there was no significant difference in clinical outcome between the excision and amputation groups. We also found that p63 may be a useful marker for distinguishing primary ADPA from metastatic adenocarcinomas. In addition, the intensity of Ki67 expression in tumour cells may be a marker of aggressive behaviour and thus be helpful in therapeutic decision-making. Wide excision with or without sentinel lymph-node biopsy is a feasible alternative to amputation. It should be considered in patients who present with a long-standing history of ADPA without evidence of underlying bone invasion or distant metastasis and with low-intensity expression of proliferation markers.
Topics: Adenocarcinoma, Papillary; Amputation, Surgical; Fingers; Humans; Skin Neoplasms; Time Factors; Toes
PubMed: 19874325
DOI: 10.1111/j.1365-2230.2009.03490.x -
Medicine Dec 2018Endoscopic submucosal dissection (ESD) is a primary treatment for the early gastric cancer (EGC) who has a negligible risk of lymph node metastasis. Papillary... (Review)
Review
BACKGROUND
Endoscopic submucosal dissection (ESD) is a primary treatment for the early gastric cancer (EGC) who has a negligible risk of lymph node metastasis. Papillary adenocarcinoma (PAC) of stomach is a rare histologic variant of gastric cancer and categorized into EGC with differentiated-histology. However, aggressive features such as higher rate of lymphovascular invasion (LVI) or submucosal invasion have been reported, whereas comparable lymph node metastasis (LNM) rate to the lesions meeting the current ESD criteria also has been reported. This study aimed to evaluate the feasibility of ESD for EGC with PAC.
METHODS
We will search the core databases (MEDLINE (through PubMed), the Cochrane Library, and Embase) from their inception to December 2018 by 2 independent evaluators. The P.I.C.O. is as follows; Patients: who have EGC with PAC, Intervention: ESD or surgery, Comparison: none, Outcome: at least one among the rate of complete resection, curative resection, en bloc resection, recurrence, procedure-related adverse event, LVI or LNM that enabled an evaluation of the feasibility of ESD. All types of study design with full text will be sought and included. The risk of bias will be assessed using the ROBINS-I tool. Descriptive data synthesis is planned, and quantitative synthesis will be used if the included studies are sufficiently homogenous. Publication bias will be assessed with quantitative analyses if more than 10 articles are enrolled.
RESULTS
The results will provide evidence for efficacy and safety of ESD for EGC with PAC.
CONCLUSION
This study will provide evidence of ESD for EGC with PAC.
Topics: Adenocarcinoma, Papillary; Endoscopic Mucosal Resection; Humans; Lymphatic Metastasis; Research Design; Stomach Neoplasms
PubMed: 30593208
DOI: 10.1097/MD.0000000000013905 -
International Journal of Surgical... Dec 2010A 44-year-old male with a mediastinal mass measuring 3.5 × 3.5 × 3 cm was diagnosed with papillary adenocarcinoma of the thymus. Other origins of papillary... (Review)
Review
A 44-year-old male with a mediastinal mass measuring 3.5 × 3.5 × 3 cm was diagnosed with papillary adenocarcinoma of the thymus. Other origins of papillary adenocarcinoma were excluded by clinical, imaging, and immunocytochemical methods before assuming this diagnosis. Residual thymus was seen under the microscope. Focal CD5 immunoreactivity was present. There was no associated thymoma. The patient underwent surgery, radiotherapy, and chemotherapy. He disclosed systemic recurrence at 18 months (subcutaneous nodule). He is alive after 24 months of follow-up with active disease. There had been only 7 cases of this rare entity published before.
Topics: Adenocarcinoma, Papillary; Adult; Antineoplastic Agents; Bronchitis, Chronic; Combined Modality Therapy; Humans; Immunohistochemistry; Male; Radiotherapy; Smoking; Thymectomy; Thymus Neoplasms
PubMed: 18611939
DOI: 10.1177/1066896908319776 -
European Journal of Obstetrics,... Sep 1999Villoglandular papillary adenocarcinoma of the uterine cervix was recently (1989) described by three main histological features: exophytic proliferation, papillary... (Review)
Review
Villoglandular papillary adenocarcinoma of the uterine cervix was recently (1989) described by three main histological features: exophytic proliferation, papillary architecture and mild to moderate cellular atypicality. The authors report a case of villoglandular papillary adenocarcinoma, clinical stage IB, which was peculiar because of its association with a co-existing and simultaneously discovered invasive squamous cell carcinoma. These two patterns were juxtaposed and not intermingled. The patient was treated with radical hysterectomy followed by vaginal radiation therapy. She remains without evidence of recurrence after 12 months of follow-up. Five main clinicopathological features of the villoglandular papillary adenocarcinoma could be stressed: rare histological variant (72 described cases), young age of patients (25-45 years old), superficial stromal invasion, usual association with other tumoral patterns (in situ or invasive adenocarcinoma as well as in situ or invasive squamous cell carcinoma) and excellent prognosis. For selected cases, a conservative surgical approach (cervical conization) was possible.
Topics: Adenocarcinoma, Papillary; Adult; Carcinoma, Squamous Cell; Female; Humans; Hysterectomy; Neoplasm Invasiveness; Neoplasm Staging; Neoplasms, Multiple Primary; Radiotherapy; Uterine Cervical Neoplasms
PubMed: 10471150
DOI: 10.1016/s0301-2115(99)00047-0 -
Der Hautarzt; Zeitschrift Fur... Mar 2019Digital papillary adenocarcinoma is a rare but well characterized carcinoma of the sweat glands, which apart from very few exceptions is localized in acral skin. This... (Review)
Review
Digital papillary adenocarcinoma is a rare but well characterized carcinoma of the sweat glands, which apart from very few exceptions is localized in acral skin. This type of sweat gland carcinoma tends to recur locally and may cause delayed metastases in a few cases. We describe the clinical findings and the broad histopathologic spectrum of four cases of this rare adnexal carcinoma and give a short summary of the literature.
Topics: Adenocarcinoma, Papillary; Adult; Female; Fingers; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Sweat Gland Neoplasms; Sweat Glands; Treatment Outcome
PubMed: 30478600
DOI: 10.1007/s00105-018-4313-4 -
International Journal of Dermatology Oct 2017Aggressive digital papillary adenocarcinoma (ADPA) is a rare adenocarcinoma of the sweat glands. (Review)
Review
BACKGROUND
Aggressive digital papillary adenocarcinoma (ADPA) is a rare adenocarcinoma of the sweat glands.
AIMS
We wish to report the treatment of two cases of ADPA with Mohs micrographic surgery and review the presentation, management, and prognosis of this rare malignancy.
MATERIALS & METHODS
Cases of ADPA were identified from recent surgery logs. Demographic, tumor, and treatment characteristics were extracted. A PubMed database search for English language full-text articles of aggressive digital papillary adenocarcinoma was performed, and relevant articles were summarized.
RESULTS
Two cases of ADPA were identified. A 53-year-old man presented with ADPA on his right third fingernail, and a 65-year-old man presented with ADPA on his right thumb. Both patients underwent Mohs micrographic surgery and negative sentinel lymph node biopsy, remaining recurrence free at 34 and 9 months, respectively.
DISCUSSION
ADPA frequently presents as a solitary mass on the digit. Treatment of ADPA with local excision or amputation has historically been fraught with high recurrence rates. Regional lymph node spread and distant metastasis have been reported. Mohs micrographic surgery may be an alternative treatment for ADPA.
CONCLUSION
Mohs micrographic surgery is a viable option for ADPA and warrants further exploration. Long-term follow-up is important, and additional studies will need to identify the role of sentinel lymph node biopsy.
Topics: Adenocarcinoma, Papillary; Aged; Humans; Male; Middle Aged; Mohs Surgery; Skin Neoplasms; Thumb
PubMed: 28832985
DOI: 10.1111/ijd.13712