-
Journal of Cardiothoracic Surgery Jun 2024Pulmonary papillary adenoma is an extremely rare benign tumor. It is derived from type II lung cells and club cells, suggesting that it may originate from stem cells... (Review)
Review
OBJECTIVE
Pulmonary papillary adenoma is an extremely rare benign tumor. It is derived from type II lung cells and club cells, suggesting that it may originate from stem cells with two-way differentiation. Only one case has been reported with FGFR2-IIIb overexpression.
METHODS
Two cases of pulmonary papillary adenoma with available data on clinical features, histological morphology, immunophenotype and molecular characteristics were analyzed.
RESULTS
Both tumors were well-circumscribed unencapsulated nodules composed of papillary structures with fibrovascular cores lined by a single layer of cuboidal or columnar epithelium without necrosis, nuclear atypia and mitoses, or invasion. But malignant transformation features include complex branching structures and significantly enlarged, irregular, and crowded malignant cells in one case. Immunohistochemistry showed that the tumor cells were strongly positive for TTF1, NapsinA, EMA and CK7 and negative for CEA and P63, with a low Ki-67 proliferation index. The EGFR somatic mutation exon19:c.2236_2256delinsATC (p.E746_S752delinsI) was found in one case by next-generation sequencing (NGS) technology.
CONCLUSION
Pulmonary papillary adenoma is very rare. Virtually all papillary adenomas are clinically silent and discovered incidentally. They are benign tumors, and resection is curative. An EGFR 19 exon deletion mutation in a patient with this tumor type was detected for the first time by NGS, and our results suggest that the malignant transformation of pulmonary papillary adenoma may be mediated by EGFR mutation.
Topics: Humans; Adenoma; ErbB Receptors; Immunohistochemistry; Lung Neoplasms; Mutation
PubMed: 38902753
DOI: 10.1186/s13019-024-02852-2 -
Journal of Digestive Diseases Jan 2023
Review
Topics: Humans; Pancreatitis; Acute Disease; Neoplasm Recurrence, Local; Duodenum; Adenoma; Duodenal Neoplasms
PubMed: 36790293
DOI: 10.1111/1751-2980.13160 -
International Journal of Surgical... Aug 2023MiT family translocation renal cell carcinomas harbor gene fusion involving members of MiT family of transcription factors. Their precursor lesions have not been...
MiT family translocation renal cell carcinomas harbor gene fusion involving members of MiT family of transcription factors. Their precursor lesions have not been identified. Herein, we report the first case of small papillary tumors morphologically resembling papillary adenomas but harboring gene alteration. The patient was a 23-year old man with multiple small papillary tumors in the right kidney discovered following a gunshot wound injury. These lesions were < 5 mm, well-circumscribed but not encapsulated tubulopapillary proliferation lined with a single layer of cuboidal cells with WHO/ISUP grade 1 or 2 nuclei. The tumor cells were immunoreactive to PAX8, AMACR, high molecular weight cytokeratin, and keratin 7 and negative for CD10, CA9, TTF1, and cathepsin K. Morphologically and immunohistochemically, these lesions were diagnosed as papillary adenomas. gene rearrangement was confirmed by fluorescence in-situ hybridization (FISH) using a break-apart probe. We term these tumors "papillary adenoma-like" renal tumor with TFE3 gene rearrangement. These tumors are likely a precursor to or represent an early event in the development of translocation renal cell carcinomas. An understanding of such tumors to translocation renal cell carcinoma progression can provide insight into the pathogenic mechanism, and ultimately aid the diagnosis and management of translocation renal cell carcinoma.
Topics: Humans; Carcinoma, Renal Cell; Wounds, Gunshot; Translocation, Genetic; Kidney Neoplasms; Adenoma; Gene Rearrangement; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Chromosomes, Human, X
PubMed: 35850545
DOI: 10.1177/10668969221108747 -
Zhonghua Bing Li Xue Za Zhi = Chinese... Jul 2021
Topics: Adenoma; Humans; Lung Neoplasms
PubMed: 34405626
DOI: 10.3760/cma.j.cn112151-20201117-00845 -
Histology and Histopathology Apr 2001Although infrequently, mucin secretion has previously been reported in papillary renal cell carcinoma. We here investigate the presence of mucin in a series of 93 renal...
Although infrequently, mucin secretion has previously been reported in papillary renal cell carcinoma. We here investigate the presence of mucin in a series of 93 renal papillary adenomas in 58 patients. Acid mucin was present in four cases (4.3% of the tumors; 6.9% of the patients), in which basophilic mucin secretion was evident with hematoxylin-eosin. To the best of our knowledge mucin secretion has not been reported in renal papillary adenoma. We describe two different types of mucin secretion: intracytoplasmic and luminal. The secretion was intracellular in numerous scattered tumor cells in two cases, focal luminal in one case, and mixed intracellular and luminal in another case. Mucin production, despite its low frequency, can be considered as an additional feature of renal papillary adenoma. Mucin production suggests that renal papillary adenoma and papillary renal cell carcinoma are actually not two independent biological processes, but a continuum of one biological process.
Topics: Adenoma; Adult; Aged; Aged, 80 and over; Female; Humans; Kidney Neoplasms; Male; Metaplasia; Middle Aged; Mucins; Prospective Studies; Retrospective Studies; Staining and Labeling
PubMed: 11332693
DOI: 10.14670/HH-16.387 -
Pathology, Research and Practice Mar 1993This is the first detailed clinical and histopathologic report of a tubulo-papillary adenoma (so-called nephrogenic adenoma) arising in the renal pelvis of a 35-year-old... (Review)
Review
This is the first detailed clinical and histopathologic report of a tubulo-papillary adenoma (so-called nephrogenic adenoma) arising in the renal pelvis of a 35-year-old woman. The tumor showed a polypoid exophytic growth and consisted of closely packed tubular formations lined by cuboidal to low columnar cells with an admixture of delicate papillary structures. Its benign nature was indicated by the lack of cellular atypias, the extremely low proliferative activity and the absence of invasiveness. We favor the metaplastic theory of origin rather than an embryologic (dysontogenetic) derivation from mesonephric remnants as the underlying histogenetic principle. The descriptive term "tubulo-papillary adenoma" seems more appropriate than the designation "nephrogenic adenoma". True tumors of this type should clearly be distinguished from metaplastic tubular, papillary or tubulo-papillary cuboidal hyperplasias of the urothelium (so-called nephrogenic metaplasia) which are considered preneoplastic and assumed to be immediate precursors of adenomas of the lower urinary tract.
Topics: Adenoma; Adult; Female; Humans; Kidney Neoplasms; Kidney Pelvis; Papilloma; Terminology as Topic
PubMed: 8321751
DOI: 10.1016/S0344-0338(11)80097-X -
Diagnostic Cytopathology Jun 2016Pulmonary papillary adenoma is a rare tumor of the lung. Some authors refer to it as papillary adenoma of type II pneumocytes. It demonstrates benign behavior, although... (Review)
Review
Pulmonary papillary adenoma is a rare tumor of the lung. Some authors refer to it as papillary adenoma of type II pneumocytes. It demonstrates benign behavior, although some references suggest that this tumor may rarely exhibit invasive characteristics. We report a case of pulmonary papilloma adenoma of the lung diagnosed by fine-needle aspiration biopsy and transbronchial biopsy. The patient is a 78-year-old woman, who presented to an outside facility with complaint of confusion after a missed episode of dialysis. On further workup, she was found to have a 3.8 cm irregular mass in the upper lobe of her right lung as visualized on chest CT. Fine-needle aspiration and a concurrent forceps-assisted transbronchial biopsy of the mass were performed. On microscopical examination, tumor cells formed small cohesive papillary fronds. On cytological evaluation, tumor cells were uniform medium-sized epithelial cells with moderate cytoplasm, fine chromatin, and inconspicuous nucleoli. The biopsies showed papillary arrangement of epithelial cells in a background of mild fibrosis and chronic inflammation. There was no piling up of cells and the nuclei were uniform with bland appearance. No mitoses were appreciated, and Ki-67 activity was low. The clinical decision was for observation. The patient suffered no complications after the procedures during 26 months of follow-up. We hereby present this case with a review of the literature. Diagn. Cytopathol. 2016;44:543-547. © 2016 Wiley Periodicals, Inc.
Topics: Adenoma; Aged; Diagnosis, Differential; Female; Humans; Lung Neoplasms
PubMed: 27040894
DOI: 10.1002/dc.23477 -
Zhonghua Bing Li Xue Za Zhi = Chinese... Dec 2020
Topics: Adenoma; Humans; Lung Neoplasms
PubMed: 33287525
DOI: 10.3760/cma.j.cn112151-20200417-00320 -
Journal of Neurosurgery Sep 1997This report describes a patient with von Hippel-Lindau disease who presented with an 8-year history of a slow-growing, locally invasive vascularized lesion of the... (Review)
Review
This report describes a patient with von Hippel-Lindau disease who presented with an 8-year history of a slow-growing, locally invasive vascularized lesion of the temporal bone involving the cerebellopontine angle. The mass, studied by computerized tomography scanning and magnetic resonance imaging techniques, was partly cystic in appearance. After removal of the mass, pathological studies confirmed a papillary cystic tumor with characteristics that have been described in tumors with an endolymphatic sac origin. These rare neoplasms constitute a distinct pathological entity and deserve wider recognition.
Topics: Adenoma; Adult; Diagnosis, Differential; Endolymphatic Sac; Female; Humans; Magnetic Resonance Imaging; Skull Neoplasms; Temporal Bone; Tomography, X-Ray Computed; von Hippel-Lindau Disease
PubMed: 9285613
DOI: 10.3171/jns.1997.87.3.0445 -
Seminars in Diagnostic Pathology Feb 1998Papillary renal adenomas are the commonest neoplasms of the renal tubular epithelium, occurring in up to 40% of adults. If these criteria are met, the diagnosis of... (Review)
Review
Papillary renal adenomas are the commonest neoplasms of the renal tubular epithelium, occurring in up to 40% of adults. If these criteria are met, the diagnosis of adenoma can be made with confidence: (1) papillary, tubular, or tubulopapillary architecture; (2) diameter less than or equal to 5 mm; and (3) does not histologically resemble clear cell, chromophobe, or collecting duct renal cell carcinomas. They are composed of epithelial cells with variable amounts of cytoplasm with variable tinctorial qualities including clear. Metanephric adenoma and metanephric adenofibroma are closely related neoplasms that appear to be benign. Although they have a morphological resemblance to Wilms' tumor, there is some genetic evidence relating them to papillary adenoma and papillary renal cell carcinoma. Metanephric adenoma and metanephric adenofibroma occur at all ages, have a 2:1 predominance of female patients, and are associated with polycythemia. No instance of malignant behavior has been reported. The adenomatous component is composed of uniform small cells arranged in tubular or papillary architectural patterns. The fibromatous component is moderately cellular and composed of bland spindle cells.
Topics: Adenofibroma; Adenoma; Adolescent; Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Child; Child, Preschool; Female; Histocytochemistry; Humans; Immunohistochemistry; Infant; Kidney Neoplasms; Lectins; Male; Middle Aged
PubMed: 9503505
DOI: No ID Found