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Zhonghua Jie He He Hu Xi Za Zhi =... Oct 1992Two rare cases of papillary adenoma of the lung were reported. Histologically, the tumor cells had noninfiltrating papillary growth, cuboidal to columnar with...
Two rare cases of papillary adenoma of the lung were reported. Histologically, the tumor cells had noninfiltrating papillary growth, cuboidal to columnar with eosinophilc granular cytoplasm and without nuclear atypia. Ultrastructurally, the tumor cells had cytoplasmic osmiophilic lamellar bodies. This benign papillary adenoma of the lung has morphologic characteristics consistent with aveolar type II pneumocyte differentiation.
Topics: Adult; Cystadenoma; Female; Humans; Lung Neoplasms; Male; Middle Aged
PubMed: 1306414
DOI: No ID Found -
International Journal of Surgical... Jan 2005We studied the significance of encapsulated Hürthle cell thyroid nodules with papillary structures lacking the nuclear features of papillary thyroid carcinoma (PTC); 19...
We studied the significance of encapsulated Hürthle cell thyroid nodules with papillary structures lacking the nuclear features of papillary thyroid carcinoma (PTC); 19 cases fulfilling these criteria were encountered The patients' ages ranged from 22 to 40 years (32+/-6), and the F:M ratio was 3:1 The tumors measured from 0.5-5 cm (2+/-1.1). The diameter of the tumor cell nuclei ranged from 5.6 to 7.2 microns. Many nodules had nuclei displaying a fine chromatin pattern somewhat resembling those of PTC, but these were present in <20% of the tumor cells. Immunohistochemically, there was reactivity for MIB-1 in the papillary structures, negativity to focally weak reactivity for HBME and galectin-3, and negativity to moderate diffuse reactivity for CK19. Clinical follow-up from 1 to 19 years revealed no evidence of metastases in any of the cases. It is unlikely that the papillary structures in the study cases represent degenerative changes in view of the proliferative activity we have demonstrated in them. In view of (1) the encapsulation and the uniformity of the constituent cells, (2) the negative or weak immunoreactivity for galectin-3 and HBME and negative to moderate immunoreactivity for CK19, and (3) the absence or paucity of nuclear criteria for the diagnosis of PTC and the absence of lymph node metastasis in all study cases, we believe that these lesions represent the papillary variant of oncocytic follicular adenoma (Hürthle cell adenoma). Recognition of this entity is important to avoid an overdiagnosis of oncocytic PTC.
Topics: Adenoma; Adenoma, Oxyphilic; Adult; Biomarkers, Tumor; Carcinoma, Papillary, Follicular; Chromatin; Diagnosis, Differential; Female; Humans; Male; Middle Aged; Thyroid Neoplasms
PubMed: 15735853
DOI: 10.1177/106689690501300105 -
Diagnostic Cytopathology Apr 2011Hyalinizing trabecular adenoma (HTA) is a rare primary thyroid neoplasm. Ever since its initial descriptions, controversy has surrounded the lesion, particularly in... (Review)
Review
Hyalinizing trabecular adenoma (HTA) is a rare primary thyroid neoplasm. Ever since its initial descriptions, controversy has surrounded the lesion, particularly in regard to its malignant potential and most appropriate terminology. HTA shares many features with medullary thyroid carcinoma and particularly papillary thyroid carcinoma, making it an especially treacherous lesion on fine-needle aspiration (FNA). This manuscript reviews the history and pathologic features of HTA, with particular attention to cytologic findings and differential diagnosis.
Topics: Adenoma; Biomarkers, Tumor; Biopsy, Fine-Needle; Diagnosis, Differential; Humans; Hyalin; Nuclear Proteins; Thyroglobulin; Thyroid Neoplasms; Thyroid Nuclear Factor 1; Transcription Factors
PubMed: 20730896
DOI: 10.1002/dc.21413 -
Modern Pathology : An Official Journal... Oct 2003Metanephric adenoma has morphologic similarities to papillary renal cell neoplasms. Cytogenetic studies of papillary renal cell carcinoma and papillary adenoma have...
Metanephric adenoma has morphologic similarities to papillary renal cell neoplasms. Cytogenetic studies of papillary renal cell carcinoma and papillary adenoma have shown frequent gains of chromosomes 7 and 17 and loss of the Y chromosome. Some cytogenetic studies have supported the hypothesis that metanephric adenoma is related to papillary renal cell neoplasia; others have not. Seven metanephric adenomas were studied with fluorescence in situ hybridization in paraffin sections using centromeric probes for chromosomes 7, 17, and Y diluted 1:100 with tDenHyb1 buffer. The signals in 100 to 200 nuclei were counted in each tumor. Samples of histologically normal renal cortical tubule epithelium were used as controls. In all seven metanephric adenomas, the results for chromosomes 7 and 17 were similar: a high percentage of nuclei with two signals (range, 75 to 85%; median, 79%). Normal kidney showed similar results (range, 78 to 88%; median, 84%). The Y chromosome was present in all three of the tumors from males (range, 86 to 89% of nuclei; median, 87%). Normal kidney gave similar results (range 82% to 91%, median 84%). The presence of chromosomes 7, 17, and Y in metanephric adenomas is similar to their presence in normal kidney. Metanephric adenoma lacks the frequent gains of chromosomes 7 and 17 and losses of the Y chromosome that are typical of papillary renal cell neoplasms, supporting the notion that metanephric adenoma is not related to papillary renal cell carcinoma and papillary adenoma. Genetic analysis of chromosomes 7, 17, and Y may facilitate discrimination of metanephric adenoma from papillary renal cell carcinoma in difficult cases.
Topics: Adenoma; Adult; Carcinoma, Papillary; Carcinoma, Renal Cell; Child, Preschool; Chromosome Deletion; Chromosomes, Human; Chromosomes, Human, Pair 17; Chromosomes, Human, Pair 7; Chromosomes, Human, Y; Female; Humans; In Situ Hybridization, Fluorescence; Kidney Neoplasms; Male; Middle Aged; Sex Chromosome Aberrations
PubMed: 14559991
DOI: 10.1097/01.MP.0000090923.50509.55 -
The American Journal of Surgical... Jun 2000It has recently been suggested that hyalinizing trabecular adenoma of the thyroid is an encapsulated variant of papillary carcinoma because of certain similarities of... (Comparative Study)
Comparative Study
It has recently been suggested that hyalinizing trabecular adenoma of the thyroid is an encapsulated variant of papillary carcinoma because of certain similarities of their histology, the occasional occurrence of both tumors in the same gland, and their similar pattern of expression of cytokeratins, including staining for cytokeratin 19. To investigate this notion further, we examined immunocytochemically the expression of a series of cytokeratins in 12 hyalinizing trabecular adenomas and six papillary carcinomas. Hyalinizing trabecular adenoma showed no or minimal reactivity for cytokeratin 19, whereas papillary carcinoma was almost always strongly reactive. Also, hyalinizing trabecular adenoma showed no staining for high-molecular-weight (HMW) cytokeratin, whereas papillary carcinoma was strongly positive. Thus, there are different patterns of cytokeratin 19 and HMW cytokeratin expression in hyalinizing trabecular adenoma and papillary carcinoma. The findings do not support the suggestion that hyalinizing trabecular adenoma is an encapsulated variant of papillary carcinoma.
Topics: Adenoma; Adult; Aged; Carcinoma, Papillary; Diagnosis, Differential; Female; Humans; Immunohistochemistry; Keratins; Male; Middle Aged; Staining and Labeling; Thyroid Neoplasms
PubMed: 10843292
DOI: 10.1097/00000478-200006000-00015 -
Rare Huge Tubular Papillary Adenoma on the Buttock Demonstrated by Magnetic Resonance Imaging (MRI).The American Journal of Case Reports Aug 2019BACKGROUND Tubular papillary adenoma is a rare eccrine-derivate dermal adnexal tumor, located in the scalp mostly. Earlier, the sebaceous cyst size was larger than 5 cm...
BACKGROUND Tubular papillary adenoma is a rare eccrine-derivate dermal adnexal tumor, located in the scalp mostly. Earlier, the sebaceous cyst size was larger than 5 cm in diameter and may be confused with subcutaneous tumor. Cases of the tumor on the buttock with rapid growth are rare, therefore magnetic resonance imaging (MRI) may be helpful to determine their precise size, nature, and invasion of nearby organs for further confirmation. CASE REPORT We report on a case of a 35-year-old male with a rapid-growth tumor on the buttock. Initially, he had received drainage by syringe and the amount of drainage was 50 mL. MRI favored diagnosis of sebaceous cyst. As for recurrent tumor, the pathology revealed tubular papillary adenoma. CONCLUSIONS MRI might play an important role on imaging of soft tissue to exclude some uncertain malignant tumors. This case report indicated a rare case of a large rapid-growing tubular papillary adenoma on the buttock that required further management.
Topics: Adult; Buttocks; Humans; Magnetic Resonance Imaging; Male; Sweat Gland Neoplasms; Tubular Sweat Gland Adenomas
PubMed: 31406100
DOI: 10.12659/AJCR.916438 -
Scandinavian Journal of Plastic and... 2006Aggressive digital papillary adenocarcinoma and aggressive digital papillary adenoma are rare tumours of the sweat glands. They are most common in the most distal part...
Aggressive digital papillary adenocarcinoma and aggressive digital papillary adenoma are rare tumours of the sweat glands. They are most common in the most distal part of the fingers and are locally aggressive with a 50% local recurrence rate; 14% of tumours metastasize. We present two cases.
Topics: Adenocarcinoma, Papillary; Adenoma; Aged; Amputation, Surgical; Fingers; Humans; Male; Middle Aged; Soft Tissue Neoplasms
PubMed: 16687341
DOI: 10.1080/02844310600763741 -
Thyroid : Official Journal of the... Jul 2016
Topics: Adenoma; Carcinoma, Papillary; Carcinoma, Papillary, Follicular; Humans; Neoplasm Invasiveness; Predictive Value of Tests; Prognosis; Terminology as Topic; Thyroid Cancer, Papillary; Thyroid Neoplasms; Tumor Burden
PubMed: 27214083
DOI: 10.1089/thy.2016.0244 -
Der Chirurg; Zeitschrift Fur Alle... Aug 2015Papillary tumors originate from the various structures of the ampulla of Vater; therefore, these rare tumors represent a heterogeneous group of tumor entities.... (Comparative Study)
Comparative Study Review
Papillary tumors originate from the various structures of the ampulla of Vater; therefore, these rare tumors represent a heterogeneous group of tumor entities. Intestinal differentiated adenomas are the most common benign lesions, whereas intestinal differentiated papillary carcinomas are the most common malignant tumors. Carcinomas with pancreaticobiliary differentiation have a poorer prognosis. Mesenchymal and neuroendocrine tumors are among the least frequent papillary tumors. Diagnosis is performed by side-view upper endoscopy and biopsy. In cases of suspected malignancy a complete staging with computed tomography (CT) and endoscopic ultrasound scanning is indicated to determine local tumor spread.Adenomas are removed by endoscopic snare papillectomy whereas the therapy of choice for papillary carcinomas is pancreatic head resection with systematic lymphadenectomy. Patients with papillary carcinomas are most likely to benefit from adjuvant therapy, which should be determined in an interdisciplinary consensus conference considering the histological differentiation of the tumor.
Topics: Adenoma; Ampulla of Vater; Carcinoma, Papillary; Common Bile Duct Neoplasms; Cooperative Behavior; Humans; Interdisciplinary Communication; Neoplasm Staging; Pancreas; Prognosis; Survival Rate; Tomography, X-Ray Computed
PubMed: 26223666
DOI: 10.1007/s00104-015-0048-2 -
Ultrasound Quarterly Mar 2017Papillary thyroid carcinoma (PTC) arising within a follicular adenoma is an exceptionally rare histopathological subtype that shows the nuclear features of PTC within a...
Papillary thyroid carcinoma (PTC) arising within a follicular adenoma is an exceptionally rare histopathological subtype that shows the nuclear features of PTC within a benign-appearing, circumscribed follicular adenoma. Although it is clinically significant because of its malignant nature, its ultrasonographic features have not been described previously. A 26-year-old man presented with a heterogeneous isoechoic solid nodule with a marked hypoechoic solid focus and a low echoic peripheral rim in the right thyroid gland on ultrasonography. On color Doppler images, markedly increased vascularity was seen in the hypoechoic solid component. An ultrasound-guided gun biopsy suggested a follicular neoplasm. In the evaluation of a hemithyroidectomy specimen, thyroid follicles and a thin fibrous capsule were seen, which favored a follicular adenoma with tumor cells in a focal area indicating papillary carcinoma. Here, we report a case of PTC arising within a follicular adenoma and discuss possible considerations in thyroid ultrasonographic examinations.
Topics: Adenoma; Adult; Biopsy, Fine-Needle; Carcinoma; Carcinoma, Papillary; Humans; Image-Guided Biopsy; Male; Thyroid Cancer, Papillary; Thyroid Gland; Thyroid Neoplasms; Ultrasonography
PubMed: 27110655
DOI: 10.1097/RUQ.0000000000000235