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The Journal of Urology Jul 1984Papillary adenoma of the prostatic urethra is a common cause of hemospermia and hematuria in young men in our country. Between November 1982 and June 1983, 25 such...
Papillary adenoma of the prostatic urethra is a common cause of hemospermia and hematuria in young men in our country. Between November 1982 and June 1983, 25 such patients have been treated. Of these patients 18 were between 19 and 29 years old, 6 were between 30 and 39 years old, and 1 was 40 years old. The lesion presents a classic histologic pattern with orderly columnar cells covering a delicate vascularized stalk and subepithelial infolding cells forming prostate-like glands. The lesion was located on the verumontanum in 5 instances (20 per cent), in the paramontanal gutter in 19 (76 per cent), and in the paramontanal gutter and at the bladder neck in 1. The lesion is believed to be completely benign, since no cases of malignant transformation have been reported to date. The suggested treatment is cautious fulguration.
Topics: Adult; Blood; Cystadenoma; Hematuria; Humans; Male; Semen; Urethra; Urethral Neoplasms
PubMed: 6726938
DOI: 10.1016/s0022-5347(17)49494-8 -
Clinical Hemorheology and... 2021Gallbladder cancer is a malignant tumor with high mortality. Early diagnosis is significance to improve the prognosis of patients. Gallbladder adenoma is recognized as a...
Gallbladder cancer is a malignant tumor with high mortality. Early diagnosis is significance to improve the prognosis of patients. Gallbladder adenoma is recognized as a kind of precancerous disease, for the past few years, contrast-enhanced ultrasound was used in the diagnosis of biliary tumors. This case is about gallbladder papillary adenoma with carcinogenesis. There is rare literature on the contrast-enhanced ultrasound manifestations of this type of disease. We hope that this report can help improve the recognition of contrast-enhanced ultrasound features and improve the accuracy of early diagnosis of gallbladder cancer.
Topics: Adenoma; Aged; Carcinogenesis; Carcinoma, Papillary; Contrast Media; Female; Gallbladder Neoplasms; Humans; Prognosis; Ultrasonography
PubMed: 33579828
DOI: 10.3233/CH-200940 -
Virchows Archiv : An International... Mar 2008The unique clinicopathological features of a giant solitary renal cyst with a parietal clear cell carcinoma in contiguity with a focus of osseous metaplasia and a... (Review)
Review
Huge renal cyst with parietal renal cell carcinoma, osseous metaplasia and a papillary adenoma: a case report with unique clinicopathological features and literature review.
The unique clinicopathological features of a giant solitary renal cyst with a parietal clear cell carcinoma in contiguity with a focus of osseous metaplasia and a papillary adenoma are reported. Ultrasonography and computed tomography showed a single cyst with a focal wall irregularity. During surgery, a frozen section revealed the presence of a renal cell carcinoma of clear cell type, so a nephrectomy was performed. After extensive pathological sampling of the cyst's wall, a focus of osseous metaplasia in contiguity with the main tumour and a microscopic papillary adenoma were found. Diagnostic implications for the present case are discussed within a pertinent literature review.
Topics: Adenoma; Carcinoma, Renal Cell; Humans; Immunohistochemistry; Keratin-7; Kidney; Kidney Diseases, Cystic; Kidney Neoplasms; Male; Metaplasia; Middle Aged; Neprilysin; Radiography; Ultrasonography
PubMed: 18080136
DOI: 10.1007/s00428-007-0547-8 -
Pediatric Pulmonology Jun 1994
Topics: Adenoma; Female; Humans; Inclusion Bodies; Infant; Lung Neoplasms
PubMed: 8090612
DOI: 10.1002/ppul.1950170611 -
Gastrointestinal Endoscopy Jun 2001
Topics: Adenoma; Bile Duct Neoplasms; Cholangiopancreatography, Endoscopic Retrograde; Common Bile Duct; Endosonography; Follow-Up Studies; Humans; Jaundice; Male; Middle Aged; Stents; Treatment Refusal
PubMed: 11375588
DOI: 10.1067/mge.2001.115012 -
International Journal of Urology :... Aug 2003Papillary adenoma of the prostatic urethra is a rare cause of hematuria, hemospermia and lower urinary tract obstruction, especially in young adults. We report two cases...
Papillary adenoma of the prostatic urethra is a rare cause of hematuria, hemospermia and lower urinary tract obstruction, especially in young adults. We report two cases of papillary adenoma and their endoscopic views. One of the patients had a lesion located on the verumontanum and presented with hematuria, hemospermia and symptoms of lower urinary tract obstruction. The other patient had papillary lesions located in the paramontanal gutter and presented with persistent painless hematuria. The origin of both lesions was proven to be prostatic epithelial differentiation using immunohistochemical identification of prostate-specific antigen. Papillary adenoma is believed to be benign, therefore, both lesions were carefully excised and fulgurated transurethrally.
Topics: Adenoma; Adult; Blood; Endoscopy; Follow-Up Studies; Hematuria; Hemorrhage; Humans; Male; Polyps; Prostatic Neoplasms; Semen; Spermatozoa; Treatment Outcome; Urethral Diseases; Urethral Neoplasms
PubMed: 12887371
DOI: 10.1046/j.1442-2042.2003.00650.x -
Medicine Oct 2020Pulmonary papillary adenoma is extremely rare. The limited number of published articles describing pulmonary papillary adenoma emphasize that it is always detected by...
Pulmonary papillary adenoma is extremely rare. The limited number of published articles describing pulmonary papillary adenoma emphasize that it is always detected by physical examination, is difficult to diagnose, and has malignant potential. To further expand our understanding of this disease, we report on 15 cases of pulmonary papillary adenoma diagnosed from 2013 to 2019 in our hospital.The clinical and pathological data of 15 cases of pulmonary papillary adenoma were collected from the medical record system of our hospital. All the clinical data were checked by 2 independent researchers. All pathology outcomes were independently reassessed by 2 pathologists. A review of the relevant literature was performed.Of 15 patients identified, 6 were men and 9 were women, and the average age at disease onset was 61.3 years. Chest computed tomography (CT) indicated pneumonia, an isolated nodule, bronchiectasis, a mass, ground glass opacity, and local interstitial fibrosis under the pleura. Thirteen cases had benign histopathology upon microscopy and immunohistochemistry examination: a papillary morphology, grade 2 or 3 papillary branches, and a slender nipple axis composed of fibers and vessels. More than 80% of the papillary epithelial cells were columnar or cubic, and single-layered or pseudostratified, with a round nucleus at the bottom of the cell. The cytoplasm was rich in mucus and neutral mucopolysaccharides. Except the above-mentioned features, there was also local epithelial dysplasia, carcinogenesis, and interstitial infiltration in two cases. The 2 patients with a cancerous mass underwent surgical resection, whereas the other patients were kept under surveillance. While one patient with cancer is deceased, follow-up indicates that the remaining patients have experienced a good outcome.Pulmonary papillary adenoma is very rare in clinical practice, and its clinical manifestations and CT images are not specific. Some cases may be cancerous and surgical resection should be the preferred treatment.
Topics: Adenoma; Adult; Aged; Female; Humans; Lung Neoplasms; Male; Middle Aged; Retrospective Studies; Tomography, X-Ray Computed
PubMed: 33126399
DOI: 10.1097/MD.0000000000023066 -
The American Journal of Surgical... Apr 2021We identified an unusual pattern of renal tubular proliferation associated with chronic renal disease, found in 23 patients, diffusely (n=12), or focally (n=11)....
We identified an unusual pattern of renal tubular proliferation associated with chronic renal disease, found in 23 patients, diffusely (n=12), or focally (n=11). Incidence was 5% of end-stage renal disease kidneys from one institution (8/177) and 7/23 patients with acquired cystic kidney disease-associated renal cell carcinoma from another. Most (19 patients) had 1 or more neoplasms including papillary (n=9), acquired cystic kidney disease (n=8), clear cell (n=4), or clear cell papillary (n=3) renal cell carcinoma. All (20 men, 3 women) had end-stage renal disease. The predominant pattern (n=18) was the indentation of chronic inflammation into renal tubules forming small polypoid structures; however, 5 had predominantly hyperplastic epithelium with less conspicuous inflammation. In 14 patients both patterns were appreciable, whereas the remainder had only the inflammatory pattern. Immunohistochemistry was positive for cytokeratin 7, high-molecular-weight cytokeratin, PAX8, and GATA3. Staining for alpha-methylacyl-CoA racemase was negative or weak, dramatically less intense than papillary neoplasms or proximal tubules. CD3 and CD20 showed a mixture of B and T lymphocytes in the inflammatory areas. Fluorescence in situ hybridization showed no trisomy 7 or 17 or loss of Y (n=9). We describe a previously uncharacterized form of renal tubular proliferation that differs from papillary adenoma (with weak or negative alpha-methylacyl-CoA racemase, lack of trisomy 7 or 17, and sometimes diffuse distribution). On the basis of consistent staining for high-molecular-weight cytokeratin and GATA3, we propose the name distal tubular hyperplasia for this process. Future studies will be helpful to assess preneoplastic potential and etiology.
Topics: Adenoma; Adult; Aged; Biomarkers, Tumor; Carcinoma, Renal Cell; Cell Proliferation; Diagnosis, Differential; Female; Humans; Hyperplasia; Immunohistochemistry; In Situ Hybridization, Fluorescence; Kidney Diseases, Cystic; Kidney Failure, Chronic; Kidney Neoplasms; Kidney Tubules; Male; Middle Aged; Precancerous Conditions; Predictive Value of Tests; United States; Young Adult
PubMed: 33560656
DOI: 10.1097/PAS.0000000000001680 -
Virchows Archiv : An International... Jun 1996Papillary adenoma of type II pneumocytes is a rare tumour. It is considered to be a benign neoplasm and is derived from immature cells in the bronchioloalveolar...
Papillary adenoma of type II pneumocytes is a rare tumour. It is considered to be a benign neoplasm and is derived from immature cells in the bronchioloalveolar epithelium, however, its biological nature has not been elucidated. We report a case of an adenomatous tumour; a papillary adenoma of type II pneumocytes, which we regard as possessing malignant potential. Light microscopically, as well circumscribed, papillary tumour of predominantly cuboidal cells resembling type II pneumocytes was found, but Clara type and ciliated cells were also present. Immunohistochemically, the tumour cells reacted positively with antibodies to surfactant apoproteins (A, B), carcinoembryonic antigen, cytochrome P-450 1A1-2 and 2B1-2. Ultrastructurally, many osmiophilic lamellar bodies and electron-dense granules were demonstrated. Semi-serial sections revealed signs of transbronchial dissemination and vascular invasion. Morphometry using 12-dimensional cluster analysis disclosed features of the tumour cells which resembled those of pneumocyte type II adenocarcinoma. These findings suggest that the present case has some malignant characteristics and originates from immature bronchiolar or alveolar cells, with a potential to develop into both type II pneumocyte and Clara cell type adenocarcinomas.
Topics: Adenoma; Adult; Apoproteins; Aryl Hydrocarbon Hydroxylases; Carcinoembryonic Antigen; Cytochrome P-450 Enzyme System; Humans; Immunohistochemistry; Lung Neoplasms; Male; Microscopy, Electron; Pulmonary Surfactant-Associated Proteins; Pulmonary Surfactants; Steroid Hydroxylases
PubMed: 8688974
DOI: 10.1007/BF00200662 -
Large cervical mass and head and neck cancer. First report of ectopic papillary adenoma of the lung.Oral Oncology Apr 2022We aim to report the first case of ectopic papillary adenoma of the lung (PAL), identified in the neck.
AIM
We aim to report the first case of ectopic papillary adenoma of the lung (PAL), identified in the neck.
METHODS
A 62-year-old woman with a known history of thyroid cancer treated several years ago, presented at our department because affected by an unpainful latero-cervical neck mass. The patient performed neck ultrasound echography, blood tests and computed tomography (CT) of head, neck and thorax to exclude the recurrence of the thyroid tumor or other unknown cancer of head and neck.
RESULTS
Her CT with contrast identified a large mass in the left thyroid loggia, with well-defined margins without post-contrast enhancement; the mass laterally displaced the trachea, without reduction of airways caliber. The tumor was removed. The histologic analysis showed aspects typical of PAL. Because the mass was completely removed, and no lymph nodes were identified, additional treatments were excluded.
CONCLUSIONS
Despite the ectopic tissue can be rarely identified in the neck, it should be always considered because it might degenerate and cause, as in our case, a tumor like PAL. The diagnostic plan is fundamental to well manage latero-cervical mass avoiding risks for patients.
Topics: Adenoma; Carcinoma, Papillary; Female; Humans; Lung; Lymph Nodes; Middle Aged; Neck; Thorax; Thyroid Cancer, Papillary; Thyroid Neoplasms
PubMed: 35306384
DOI: 10.1016/j.oraloncology.2022.105823