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Medicine Sep 2014We report on a rare case of a laryngeal carcinoma arising in a multifocal pharyngolaryngeal oncocytic papillary cystadenoma (OPC). The disease of a 63-year-old man is... (Review)
Review
We report on a rare case of a laryngeal carcinoma arising in a multifocal pharyngolaryngeal oncocytic papillary cystadenoma (OPC). The disease of a 63-year-old man is well documented by computed and positron emission tomography, histology, and electron microscopy. We could show that an OPC can even develop in the pharynx. The coexistence of both tumors makes this a challenging diagnosis for pathologists. Treated by surgery and radiotherapy, both lesions dissolved. Based on the literature available, we discuss the theory that the laryngeal carcinoma might be the result of a true metaplasia facilitated by chronic irritation and recommend a regular follow-up for OPC too. As in benign oncocytic lesions, we could show that the detection of numerous mitochondria is a diagnostic indicator for malignant variants as well.
Topics: Carcinoma, Squamous Cell; Combined Modality Therapy; Cystadenoma, Papillary; Humans; Laryngeal Neoplasms; Laryngectomy; Male; Middle Aged; Oxyphil Cells; Pharyngeal Neoplasms; Radiotherapy; Treatment Outcome
PubMed: 25211046
DOI: 10.1097/MD.0000000000000070 -
The Journal of Urology May 1988There have been 33 previously reported cases of papillary cystadenoma of the epididymis. To our knowledge we report the first case of this benign neoplasm in...
There have been 33 previously reported cases of papillary cystadenoma of the epididymis. To our knowledge we report the first case of this benign neoplasm in Scandinavia. The cystic tumor occurred unilaterally in a 44-year-old man who had no signs of von Hippel-Lindau's syndrome or infertility. Papillary cystadenoma of the epididymis must be distinguished from neoplasms of the testis, particularly teratoma.
Topics: Adult; Cystadenoma; Denmark; Diagnosis, Differential; Epididymis; Humans; Male; Teratoma; Testicular Neoplasms
PubMed: 3361646
DOI: 10.1016/s0022-5347(17)42773-x -
Oral Surgery, Oral Medicine, Oral... Jan 2013The aim of this study was to investigate the expression of p63 protein in mucoepidermoid carcinoma and papillary cystadenoma of the salivary glands, and to evaluate the...
OBJECTIVE
The aim of this study was to investigate the expression of p63 protein in mucoepidermoid carcinoma and papillary cystadenoma of the salivary glands, and to evaluate the usefulness of this protein in distinguishing these tumors.
STUDY DESIGN
Immunoexpression of p63 protein was studied and quantified in 9 formalin-fixed paraffin-embedded mucous retention cysts, 4 papillary cystadenomas, and 19 low-grade and 9 high-grade mucoepidermoid carcinomas.
RESULTS
All cases were positive for p63 immunoexpression; however, it was observed that p63 labeling in mucous retention cysts and papillary cystadenomas was limited to the basal layers of the cystic spaces, whereas in low-grade mucoepidermoid carcinomas, positive nuclear staining was also found diffusely in the suprabasal layers. Mucoepidermoid carcinoma presented increased immunoexpression of p63 compared with the other groups.
CONCLUSIONS
P63 immunohistochemical expression pattern can be helpful in distinguishing low-grade mucoepidermoid carcinoma from papillary cystadenoma of the salivary glands.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analysis of Variance; Biomarkers, Tumor; Carcinoma, Mucoepidermoid; Cystadenoma, Papillary; Female; Humans; Immunoenzyme Techniques; Male; Middle Aged; Salivary Gland Neoplasms; Salivary Glands, Minor; Transcription Factors; Tumor Suppressor Proteins
PubMed: 23217538
DOI: 10.1016/j.oooo.2012.09.005 -
The Journal of Otolaryngology Jun 1986"Papillary cystadenoma lymphomatosum syndrome" is an unusual clinical constellation that was first described in 1970 as infected adenolymphoma syndrome. A case of...
"Papillary cystadenoma lymphomatosum syndrome" is an unusual clinical constellation that was first described in 1970 as infected adenolymphoma syndrome. A case of papillary cystadenoma lymphomatosum syndrome is presented demonstrating the specific histopathology of the lesion as well as the typical clinical history of all reported papillary cystadenoma lymphomatosum complicated by acute onset of pain and sudden increase in size. Five other cases noted in the literature are compared to complete the clinical and histopathologic review of the entity.
Topics: Adenolymphoma; Humans; Lymph Nodes; Male; Middle Aged; Parotid Gland; Parotid Neoplasms; Syndrome
PubMed: 3723655
DOI: No ID Found -
Pathology, Research and Practice Oct 2017We describe the case of an oncocytic papillary cystadenoma with mucinous differentiation of the parotid gland in a 64-year-old male. Histologically, the tumor exhibited...
We describe the case of an oncocytic papillary cystadenoma with mucinous differentiation of the parotid gland in a 64-year-old male. Histologically, the tumor exhibited distinctive areas of intracystic papillary growth pattern with microcystic and macrocystic spaces containing mucinous secretions and small crystals. The cyst wall and papillary fronds were lined by oncocytic admixed with numerous mucocytes. Lymphoid tissue and invasive features were not identified. The tumor showed strong expression of CK7 and mammaglobin in oncocytes, and BRST-2 and MUC4 in mucocytes. p63, ER, PR, SOX10, DOG-1, and S100 stains were negative. No rearrangement of the MAML2 gene region or ETV6-NTRK3 fusion transcript was detected. The diagnosis of oncocytic papillary tumor with prominent mucinous differentiation is particularly problematic owing to the large number of potential mimics and should prompt consideration of appropriate molecular studies.
Topics: Biomarkers, Tumor; Biopsy; Cell Differentiation; Cystadenoma, Papillary; Diagnosis, Differential; Humans; Immunohistochemistry; Male; Middle Aged; Neoplasms, Cystic, Mucinous, and Serous; Oxyphil Cells; Parotid Neoplasms; Predictive Value of Tests
PubMed: 28756976
DOI: 10.1016/j.prp.2017.06.018 -
Journal of Oral and Maxillofacial... Jan 1995
Topics: Aged; Cystadenoma, Papillary; Diagnosis, Differential; Epithelium; Female; Follow-Up Studies; Humans; Mucins; Mucocele; Salivary Gland Diseases; Salivary Gland Neoplasms; Salivary Glands, Minor
PubMed: 7799126
DOI: 10.1016/0278-2391(95)90506-5 -
Medicina Oral, Patologia Oral Y Cirugia... Jul 2008Cystadenoma and cystadenocarcinoma are rare salivary gland tumours histologically characterized by prominent cystic and frequently papillary growth. We present two cases...
Cystadenoma and cystadenocarcinoma are rare salivary gland tumours histologically characterized by prominent cystic and frequently papillary growth. We present two cases of cystadenoma of a minor salivary gland (upper lip) and parotid cystadenocarcinoma respectively, captured between 834 salivary gland tumors studied in our hospital from 1980 to 2004. The authors review the clinical, histological, and biological features of these two unusual tumours, and differential diagnosis with other salivary glands neoplasms. Both entities usually reveal papillary proliferation of the epithelial lining and are composed of cells that possess bland cytomorphologic features. Differentiation of tumour types depends largely on the identification of actual infiltration of salivary gland parenchyma or surrounding connective tissue by either cystic or solid epithelium in cystadenocarcinomas. Step sections of a borderline tumour may yield unequivocal evidence of invasion. The authors discuss the problematic diagnosis between these rare neoplasms and with other tumours and compare histological findings of these two entities.
Topics: Adult; Aged; Cystadenocarcinoma; Cystadenoma, Papillary; Humans; Male; Salivary Gland Neoplasms
PubMed: 18587312
DOI: No ID Found -
Acta Cytologica 2009Papillary cystadenoma is a rare salivary gland neoplasm, and oncocytic change can be focal or marked. Papillary oncocytic cystadenoma has been reported mainly in the...
BACKGROUND
Papillary cystadenoma is a rare salivary gland neoplasm, and oncocytic change can be focal or marked. Papillary oncocytic cystadenoma has been reported mainly in the minor salivary glands and occasionally in the parotid glands. The cytologic features vary.
CASES
A 26-year-old female presented with a 2.4-cm, cystic right parotid gland mass present for 4 months. Fine needle aspiration (FNA) showed cellular smears with sheets of oncocytic cells and some with micropapillary architecture. The diagnosis ofa neoplasm was rendered and excisional biopsy recommended. Oncocytic neoplasm was diagnosed during intraoperative consultation, and final surgical histology showed a unilocular, cystic, oncocytic neoplasm with variable papillary projections. A 52-year-old male presented with a 1.5-cm, cystic left parotid mass enlarging for the past few months. FNA showed less cellular smears with extensive necrotic debris and a few large sheets of epithelial cells with vague papillary architecture. Oncocytic neoplasm was diagnosed during intraoperative consultation, and final surgical histology showed a unilocular cystic lesion with multiple papillary fronds lined with oncocytic cells and focal metaplastic squamous cells.
CONCLUSION
Papillary cystadenoma is rare in the parotid glands, and cytologic features may vary. Warthin's tumor, oncocytoma, intraductal papilloma and acinic cell carcinoma may arise in the differential diagnosis. In cases with extensive necrotic debris and metaplastic squamous cells, branchial cyst and cystic metastatic squamous carcinoma may also need to be considered.
Topics: Adult; Biopsy, Fine-Needle; Cystadenoma, Papillary; Female; Humans; Male; Middle Aged; Parotid Neoplasms
PubMed: 19697734
DOI: 10.1159/000325350 -
Hinyokika Kiyo. Acta Urologica Japonica Jan 2012A 68-year-old male presented with painless left scrotal enlargement of one year duration. Ultrasound, computed tomography (CT) and magnetic resonance imaging showed a... (Review)
Review
A 68-year-old male presented with painless left scrotal enlargement of one year duration. Ultrasound, computed tomography (CT) and magnetic resonance imaging showed a multilocular cystic mass, 10×7.5× 8.5 cm in size, in the left scrotum. The intracystic fluid was partially hemorrhagic. A solid part of the tumor, seen at the base of the scrotum, was partially calcified and was enhanced by contrast medium. The left testis could not be identified by imaging studies. Although CT imaging showed a simple cyst in the right kidney, no other lesions in the kidneys, adrenal glands, pancreas or the central nervous system were detected. Serum tumor marker values for testicular cancer were within the normal range. Under the pre-operative diagnosis of a left testicular tumor, left high orchiectomy was performed. Grossly the specimen consisted of a multilocular cystic tumor, 12.5×8.5×8.5 cm in size, with a 2.7 cm tan-colored solid component within the wall of the cyst. The left testis was atrophic, 1.3 cm in size, and demonstated no continuity with the solid part of the tumor. Histologically, the solid component of the tumor showed tubular and papillary growth of cuboidal and columnar tumor cells with clear cytoplasm. Histopathological diagnosis of papillary cystadenoma of the epididymis (PCE) was made. Von Hippel-Lidau disease was ruled out by subsequent genetic analysis. After follow up for 18 months, there was no sign of recurrence. To our knowledge, this is the 33rd and the largest case of PCE reported in Japan.
Topics: Aged; Cystadenoma, Papillary; Diagnosis, Differential; Epididymis; Genital Neoplasms, Male; Humans; Magnetic Resonance Imaging; Male; Testicular Neoplasms; Tomography, X-Ray Computed; Ultrasonography
PubMed: 22343743
DOI: No ID Found -
Actas Urologicas Espanolas Oct 2000Contribution of one case report of papillary cystadenoma, a very uncommon benign epithelial tumour. Related to von Hippel-Lindau's disease, it may be associated to...
Contribution of one case report of papillary cystadenoma, a very uncommon benign epithelial tumour. Related to von Hippel-Lindau's disease, it may be associated to infertility. It tends to occur in young adults, lesions being bilateral in one third of cases. It is diagnosed through palpation and particularly with ultrasound techniques. Management is via surgical exeresis and subsequent watchful follow-up. Two cases reported transformation of epididymis cystadenoma to cystadenocarcinoma.
Topics: Adult; Cystadenoma, Papillary; Epididymis; Humans; Male; Testicular Neoplasms
PubMed: 11132450
DOI: 10.1016/s0210-4806(00)72541-1