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Zentralblatt Fur Allgemeine Pathologie... 1967
Topics: Humans; Infant, Newborn; Infant, Premature; Larynx; Paraganglia, Nonchromaffin
PubMed: 5304270
DOI: No ID Found -
Tissue & Cell 1977
Topics: Aging; Animals; Aorta, Abdominal; Capillaries; Catecholamines; Cell Nucleus; Chromaffin System; Connective Tissue; Cytoplasmic Granules; Dogs; Paraganglia, Chromaffin; Retroperitoneal Space
PubMed: 929576
DOI: 10.1016/0040-8166(77)90005-2 -
World Journal of Radiology Jan 2014Paragangliomas are extra-adrenal pheochromocytomas that derive from chromaffin cells and arise along the sympathetic paraganglia in the body. In the majority of cases,...
Paragangliomas are extra-adrenal pheochromocytomas that derive from chromaffin cells and arise along the sympathetic paraganglia in the body. In the majority of cases, they are secretory tumors and most commonly present with palpitations. Plasma metanephrines are the standard screening tests for making the diagnosis which is confirmed by pathology. Imaging plays a very important role in establishing the diagnosis. However, there is no specific feature on imaging for paragangliomas; the vascularity of the tumor should show as hyper-enhancing lesions but this is not always the case. The diagnostic value of PET is yet a matter of debate. We present a very rare case of a paraganglioma arising at the renal hilum, splaying the renal artery and vein and causing vascular compromise to the left kidney. The patient presented with an atypical presentation of unrelenting fever that was followed by acute colicky pain. Based on imaging and blood metanephrine levels, the diagnosis of paraganglioma was made. Resection of the tumor was achieved and the patient is now asymptomatic.
PubMed: 24578788
DOI: 10.4329/wjr.v6.i1.15 -
Les Cahiers Du College de Medecine Des... Dec 1969
Review
Topics: Carotid Body; Carotid Body Tumor; Chromaffin System; Humans; Paraganglia, Nonchromaffin; Paraganglioma; Paraganglioma, Extra-Adrenal
PubMed: 4312701
DOI: No ID Found -
Comptes Rendus Des Seances de La... Nov 1950
Topics: Aortic Bodies; Humans; Paraganglia, Chromaffin
PubMed: 14822334
DOI: No ID Found -
Acta Anatomica 1975A study was made of the distribution of abdominal vagal paraganglia in the gastro-oesophageal region of 12 rats. In all rats 4-40 paraganglia were found embedded in, or... (Comparative Study)
Comparative Study
A study was made of the distribution of abdominal vagal paraganglia in the gastro-oesophageal region of 12 rats. In all rats 4-40 paraganglia were found embedded in, or closely associated with, the vagus nerves and their branches. The paraganglia consisted of groups of rounded, weakly chromaffin-positive cells surrounded by flattened cells and supplied by small nerves and blood vessels. The paraganglia were morphologically identical to simultaneously fixed carotid body tissue and showed similar fluorescence characteristics.
Topics: Animals; Carotid Body; Chromaffin System; Esophagus; Female; Male; Paraganglia, Chromaffin; Rats; Stomach; Vagus Nerve
PubMed: 1189897
DOI: 10.1159/000144493 -
Annali Italiani Di Chirurgia Dec 2014Paragangliomas are neural crest-derived neuroendocrine tumors, originating from paraganglia, which are dispersed neuroendocrine organs characterized by catecholamine and... (Review)
Review
AIM
Paragangliomas are neural crest-derived neuroendocrine tumors, originating from paraganglia, which are dispersed neuroendocrine organs characterized by catecholamine and peptide-producing cells. With an annual incidence estimated at 1/100,000, paragangliomas represent 10% of catecholamine secreting tumors.
MATERIAL OF STUDY
We report a case of a 76-year-old man who was submitted to a subtotal gastrectomy with omentectomy and gastrojejunal anastomosis. The Hystologic exam has revealed an ulcerative polypoid gastric carcinoma with cell poorly cohesive and infiltration of the muscular gastric wall and an incidental parietal gastric lesion which was a paraganglioma with immunocytochemical investigations positive for NSE and negative for CD117, S100, CD34 e SMA.
DISCUSSION
Pheochromocytoma indicates exclusively tumors arising from the adrenal medulla, while the extra-adrenal paraganglioma suggests tumors of the chromaffin cells with other locations. Gastric or paragastric localization, as in our case, is very rare for these neoplasms, and in literature there are only isolated case reports. Genetical predisposition is observed in 30% of these tumors and can be responsible of hereditary disease characterized for differences in tumor distribution, catecholamine production, risk of metastasis, and association with others types of tumors.
CONCLUSION
In asymptomatic patients and when biochemical and clinical suspicion of neuroendocrine tumor is strong, you have to perform anatomical and functional investigations to detect these neoplasms. The first line treatment for resectable tumors is complete surgical resection, that can be performed with open surgery or laparoscopic technique. Surgical therapy is also indicated to palliative intent when a complete eradication of disease is not achievable for metastatic status of malignancies.
Topics: Aged; Humans; Male; Paraganglioma; Stomach Neoplasms
PubMed: 25559752
DOI: No ID Found -
The British Journal of Clinical Practice 1976
Topics: Adult; Aortic Bodies; Female; Humans; Paraganglia, Nonchromaffin; Paraganglioma, Extra-Adrenal
PubMed: 188436
DOI: No ID Found -
Military Surgeon Oct 1951
Topics: Chromaffin System; Humans; Neoplasms; Paraganglia, Nonchromaffin; Paraganglioma
PubMed: 14874962
DOI: No ID Found -
Atherosclerosis Dec 2007The current understanding of the pathophysiology of atherosclerosis leading to coronary artery disease (CAD) emphasizes the role of inflammatory mediators. Given the... (Review)
Review
The current understanding of the pathophysiology of atherosclerosis leading to coronary artery disease (CAD) emphasizes the role of inflammatory mediators. Given the bidirectional communication between the immune and central nervous systems, an important question is whether the brain can be "informed" about and modulate CAD-related inflammation. A candidate communicator and modulator is the vagus nerve. Until now, the vagus nerve has received attention in cardiology mainly due to its role in the parasympathetic cardiovascular response. However, the vagus nerve can also "inform" the brain about peripheral inflammation since its paraganglia have receptors for interleukin-1. Furthermore, its efferent branch has a local anti-inflammatory effect. These effects have not been considered in research on the vagus nerve in CAD or in vagus nerve stimulation trials in CAD. In addition, various behavioural interventions, including relaxation, may influence CAD prognosis by affecting vagal activity. Based on this converging evidence, we propose a neuroimmunomodulation approach to atherogenesis. In this model, the vagus nerve "informs" the brain about CAD-related cytokines; in turn, activation of the vagus (via vagus nerve stimulation, vagomimetic drugs or relaxation) induces an anti-inflammatory response that can slow down the chronic process of atherogenesis.
Topics: Animals; Atherosclerosis; Coronary Artery Disease; Dogs; Humans; Inflammation; Neuroimmunomodulation; Paraganglia, Nonchromaffin; Rats; Relaxation Therapy; Vagus Nerve
PubMed: 17101139
DOI: 10.1016/j.atherosclerosis.2006.10.009