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Infectious Diseases of Poverty Oct 2018Paragonimiasis, caused by helminths of the genus Paragonimus spp., is a neglected tropical disease. Human suffering from paragonimiasis is often misunderstood and its... (Review)
Review
BACKGROUND
Paragonimiasis, caused by helminths of the genus Paragonimus spp., is a neglected tropical disease. Human suffering from paragonimiasis is often misunderstood and its quantification by the disability weight of the disability-adjusted life years largely varies in different global burden of disease (GBD) estimates. This paper is to systematically review clinical paragonimiasis cases and requantify the disability weight of human paragonimiasis.
METHODS
A systematic analysis was conducted using articles from the following databases: PubMed, Institute for Scientific Information Web of Science, China National Knowledge Infrastructure, the Chinese scientific journal databases Wanfang Data and CQVIP, Africa Journal Online, and the System for Information on Grey Literature in Europe. Search terms were the combination of "paragonim*" with "clinical" or "infection". Only articles fulfilling the following conditions were recruited for this study: the occurrence of clinical signs and symptoms of paragonimiasis in human beings were reported; diagnosis was confirmed; no comorbidities were reported; the reviewed clinical cases or epidemiological findings were not already included in any other articles. The information and frequencies of paragonimiasis outcomes from included articles using predefined data fields were extracted two times by two separate individuals. Outcome disability weights were selected mainly from the GBD 2004 and GBD 2013 datasets. Frequencies and disability weights of paragonimiasis outcomes were modelled into a decision tree using the additive approach and multiplicative approach, respectively. Monte Carlo simulations were run 5000 times for an uncertainty analysis.
RESULTS
The disability weight estimates of paragonimiasis were simulated with 5302 clinical cases from 80 general articles. The overall disability weight was estimated at 0.1927 (median 0.1956) with a 95% uncertainty interval (UI) of 0.1632-0.2378 using the additive approach, and 0.1791 (median 0.1816) with a 95% UI of 0.1530-0.2182 using the multiplicative approach. The simulated disability weights of Paragonimus westermani cases were higher than that of P. skrjabini cases. Lung outcomes and headache were the top two contributors to disability weight for both species.
CONCLUSIONS
The use of paragonimiasis disability weight needs to be reconsidered with regard to availability of morbidity data and species variation. Calculating the disease burden of paragonimiasis requires further modification and thus has considerable implications for public health prioritization in research, monitoring, and control.
Topics: Animals; Cost of Illness; Decision Making; Decision Trees; Disabled Persons; Humans; Paragonimiasis; Paragonimus; Patient Outcome Assessment
PubMed: 30342548
DOI: 10.1186/s40249-018-0485-5 -
Advances in Parasitology 1999The review concentrates on literature that has appeared since the 1960s. Since then, numerous species of Paragonimus have been described, mainly from Asia but also from... (Review)
Review
The review concentrates on literature that has appeared since the 1960s. Since then, numerous species of Paragonimus have been described, mainly from Asia but also from Africa and the Americas. Some of these cause disease in humans. Recent information on life cycles and routes of transmission is summarized. All described species and their hosts are listed, with synonyms where known. For well-known species such as Paragonimus westermani, subspecific taxa and strains are reviewed and genetic studies discussed. Paragonimiasis in humans and experimental animals is discussed with emphasis on clinical manifestations and pathology, diagnosis, immune interactions with the host, treatment and public health issues.
Topics: Animals; Animals, Domestic; Cats; Dogs; Host-Parasite Interactions; Humans; Mollusca; Paragonimiasis; Paragonimus; Rats
PubMed: 10050273
DOI: 10.1016/s0065-308x(08)60149-9 -
Current Topics in Comparative... 1973
Review
Topics: Animals; Astacoidea; Brachyura; Cat Diseases; Cats; Dog Diseases; Dogs; Female; Larva; Lung Diseases, Parasitic; North America; Ovum; Paragonimiasis; Paragonimus; Serologic Tests; Snails; South America
PubMed: 4591645
DOI: 10.1016/b978-0-12-153402-8.50007-2 -
Seminars in Neurology Jun 1993
Review
Topics: Animals; Brain Diseases; Humans; Paragonimiasis
PubMed: 8356355
DOI: 10.1055/s-2008-1041126 -
Internal Medicine (Tokyo, Japan) May 2000
Review
Topics: Diagnosis, Differential; Humans; Japan; Lung Diseases, Parasitic; Paragonimiasis; Skin Diseases, Parasitic
PubMed: 10830172
DOI: 10.2169/internalmedicine.39.353 -
Annals of African Medicine Dec 2008An up-to-date review on human paragonimiasis in Africa was carried out to determine the current geographical distribution of human cases and analyze the animal... (Review)
Review
An up-to-date review on human paragonimiasis in Africa was carried out to determine the current geographical distribution of human cases and analyze the animal reservoir, snails and crustaceans which intervene in the local life cycle of Paragonimus species. Two countries, i.e., Cameroon and Nigeria, were mainly affected by this disease, while the distribution of human cases in the other eight states of the intertropical zone was scattered. Infected patients were currently few in number and two Poragonimus species: P. africanus and P. uterobilateralis, were found. The animal reservoir is mainly constituted by crab-eating mammals. The identity of the host snail remains doubtful and was either a prosobranch, or a land snail. Seven crab species belonging to Callinectes, Liberonautes and Sudononautes genera are able to harbour paragonimid metacercariae. Due to the current low prevalence of human paragonimiasis recorded in Africa and the high cost of wide-scale screenings for this disease, training of technicians in anti-tuberculosis centers would be the most realistic attitude to detect mycobacteria and/or Paragonimus eggs during the same sputum examination.
Topics: Africa; Animals; Disease Reservoirs; Humans; Paragonimiasis; Paragonimus; Prevalence
PubMed: 19623916
DOI: 10.4103/1596-3519.55660 -
Trends in Parasitology Jul 2008The lung fluke, Paragonimus westermani, is of major socioeconomic importance in Asia. The parasite is transmitted via snails to freshwater crabs or crayfish, then to... (Review)
Review
The lung fluke, Paragonimus westermani, is of major socioeconomic importance in Asia. The parasite is transmitted via snails to freshwater crabs or crayfish, then to humans and other mammals, such as cats and dogs, and causes paragonimiasis. This review provides a background on the parasite and its life cycle; summarizes key aspects regarding the pathogenesis, diagnosis and treatment of paragonimiasis; describes the geographic distribution and prevalence of paragonimiasis; and makes some recommendations for future research and the control of this important disease in China.
Topics: Animals; China; Food Contamination; Food Parasitology; Host-Parasite Interactions; Humans; Paragonimiasis; Paragonimus; Seafood; Snails; Zoonoses
PubMed: 18514575
DOI: 10.1016/j.pt.2008.03.014 -
Journal of Helminthology Mar 2014Nine cases of paragonimiasis have been reported from cats (4), dogs (2) and children (3) in South Africa, with an additional suspected case in an adult female patient.... (Review)
Review
Nine cases of paragonimiasis have been reported from cats (4), dogs (2) and children (3) in South Africa, with an additional suspected case in an adult female patient. Details of these cases are reviewed. All nine cases, and perhaps the adult case as well, were from the province of KwaZulu-Natal but locality data are only available for six of them. These six cases represent four localities which all lie below 100 m above sea level in the province's lowlands, suggesting that there may be a focus of transmission here. The molluscan first intermediate host must be one of the two prosobranch snail species present in the area, Melanoides tuberculata or Tomichia natalensis, and the decapod second intermediate host the common river crab Potamonautes sidneyi. All infected cats and dogs had pulmonary infections, while two human cases for which there is sufficient information had extrapulmonary infections. Transmission appears to be ongoing but the invasive snail Tarebia granifera may be competing with both M. tuberculata and T. natalensis. If so, this may bring transmission to an end.
Topics: Animals; Cat Diseases; Cats; Dog Diseases; Dogs; Female; Humans; Lung; Paragonimiasis; South Africa
PubMed: 23253517
DOI: 10.1017/S0022149X12000831 -
Emerging Infectious Diseases Oct 2022Paragonimiasis is a food-borne infection caused by several species of the Paragonimus fluke. Clinical manifestations can mimic tuberculosis and contribute to diagnostic...
Paragonimiasis is a food-borne infection caused by several species of the Paragonimus fluke. Clinical manifestations can mimic tuberculosis and contribute to diagnostic delay. We report a cluster of paragonimiasis in a community in Ecuador, where active surveillance was set up after detection of the first 2 cases.
Topics: Animals; Delayed Diagnosis; Ecuador; Humans; Paragonimiasis; Paragonimus
PubMed: 36148987
DOI: 10.3201/eid2810.220927 -
Meditsinskaia Parazitologiia I... 1991
Review
Topics: Anthelmintics; Diagnosis, Differential; Humans; Paragonimiasis
PubMed: 1795689
DOI: No ID Found