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Kisaengch'unghak Chapchi. the Korean... Dec 1990The lung fluke, Paragonimus, and lung fluke disease, were reviewed, especially on the works performed in Korea. Among 43 species of Paragonimus recorded in the world... (Review)
Review
The lung fluke, Paragonimus, and lung fluke disease, were reviewed, especially on the works performed in Korea. Among 43 species of Paragonimus recorded in the world literature, P. westermani, P. pulmonalis, and P. iloktsuenensis are known to distribute in Korea. Biological studies on P. westermani have revealed that its snail intermediate host is Semisulcospira spp. and major second intermediate hosts are crabs such as Eriocheir japonicus and E. sinensis or crayfish such as Cambaroides similis and C. dauricus. The final hosts other than man are dogs, cats, pigs, and wild animals. Paragonimiasis has been known to distribute widely over the south Korea, however, the prevalence among people and intermediate hosts is gradually decreasing in recent years. In Korean people, the lung fluke have caused pulmonary infections in a great many of cases but as well extrapulmonary ones including cerebral, spinal, subcutaneous, hepatic, splenic, abdominal, urinary, gynecologic, and other types. The definite diagnosis of paragonimiasis can be executed by the recovery of eggs from sputum or feces of patients, however, immunological methods such as intradermal test, complement-fixation test, precipitin reactions, immunofluorescent techniques, enzyme-linked immunosorbent assay (ELISA) are greatly helpful for egg-negative or extrapulmonary cases. Various drugs have been introduced for the treatment of paragonimiasis, and among them, bithionol, niclofolan and praziquantel have shown high therapeutic efficacy. The most recommendable one is considered praziquantel. For control of this disease, mass chemotherapy of patients seems to be the most efficient and feasible measure.
Topics: Animals; Humans; Korea; Paragonimiasis; Paragonimus
PubMed: 2133425
DOI: 10.3347/kjp.1990.28.suppl.79 -
Turkish Neurosurgery 2020To investigate the clinical manifestations and radiologic characteristics in diagnosing and treating hemorrhagic cerebral paragonimiasis. (Review)
Review
AIM
To investigate the clinical manifestations and radiologic characteristics in diagnosing and treating hemorrhagic cerebral paragonimiasis.
MATERIAL AND METHODS
The study retrospectively analyzed the data of three cases of hemorrhagic paragonimiasis who received treatment in the hospital from January 2014 to March 2017. All three patients were diagnosed with paragonimiasis by positive detection of paragonimiasis antibody. Based on the imaging data, the disease was confirmed as hemorrhagic cerebral paragonimiasis. One of the three patients was treated with oral praziquantel alone, one with praziquantel and thoracentesis, and one with praziquantel in combination with closed thoracic drainage and craniotomy.
RESULTS
All the lesions disappeared after computed tomography scan during the follow-up. Two of the three patients had no dysneuria, and one had mild dysneuria.
CONCLUSION
Hemorrhagic cerebral paragonimiasis should be diagnosed as early as possible using antibodies against paragonimiasis for patients with unexplained intracerebral hemorrhage, especially young patients with atypical imaging findings and multiple systemic lesions. It is possible to avoid craniotomy and improve the cure rate by the early, full-dose, and sufficient course of anti-parasitic treatment.
Topics: Cerebral Hemorrhage; Child; Combined Modality Therapy; Craniotomy; Humans; Male; Paragonimiasis; Praziquantel; Retrospective Studies; Tomography, X-Ray Computed; Young Adult
PubMed: 30984986
DOI: 10.5137/1019-5149.JTN.22666-18.3 -
Journal of Neurosurgery Apr 1971
Topics: Adolescent; Adult; Brain Diseases; Calcinosis; Carotid Arteries; Epilepsies, Partial; Epilepsy; Female; Frontal Lobe; Headache; Hemianopsia; Humans; Japan; Lung Diseases, Parasitic; Male; Neurologic Manifestations; Occipital Lobe; Paragonimiasis; Paragonimus; Parietal Lobe; Pneumoencephalography; Seizures; Skull; Temporal Lobe; Vomiting
PubMed: 4995126
DOI: 10.3171/jns.1971.34.4.0515 -
Journal of the Neurological Sciences 1968
Topics: Adolescent; Adult; Aged; Child; China; Cysts; Diagnosis, Differential; Female; Granuloma; Humans; Hypesthesia; Japan; Korea; Male; Middle Aged; Muscle Spasticity; Paragonimiasis; Prognosis; Sex Factors; Spinal Diseases; Spinal Neoplasms; Spine
PubMed: 5644938
DOI: 10.1016/0022-510x(68)90130-5 -
The Brazilian Journal of Infectious... Feb 2008
Topics: Animals; Brazil; Humans; Paragonimiasis; Paragonimus
PubMed: 18553004
DOI: 10.1590/s1413-86702008000100001 -
Revue de Pneumologie Clinique Dec 1998Paragonimiasis is a helminthic disease of carnivorous animals. Man is infected accidentally. It has a worldwide distribution but is mainly encountered in Southeast Asia,...
Paragonimiasis is a helminthic disease of carnivorous animals. Man is infected accidentally. It has a worldwide distribution but is mainly encountered in Southeast Asia, particularly in Korea. Other endemic areas include Africa and South America. Cerebral paragonimiasis is not rare, but pleuropulmonary manifestations are the most prevalent. They include hemoptysis (frequently rusty-colored), unilateral or bilateral pleural effusions, and pulmonary infiltrates or cavities. This constellation of symptoms often mimics those of tuberculosis. Cerebral and lung involvement has recently been investigated by CT-scan and NMR. The diagnosis is based on the identification of parasite eggs in sputum or feces, and on ELISA serology. The treatment of choice is praziquantel.
Topics: Anthelmintics; Bithionol; Brain Diseases; Diagnosis, Differential; Female; Hemoptysis; Humans; Lung Diseases, Parasitic; Male; Paragonimiasis; Pleural Effusion; Praziquantel; Radiography, Thoracic
PubMed: 10100349
DOI: No ID Found -
Internal Medicine Journal Mar 2009
Topics: Adult; Anthelmintics; Feces; Humans; Lung; Lung Diseases, Parasitic; Male; Paragonimiasis; Parasite Egg Count; Praziquantel; Sputum; Tomography, X-Ray Computed
PubMed: 19383070
DOI: 10.1111/j.1445-5994.2008.01894.x -
Clinics in Chest Medicine Jun 2002Paragonimiasis is a zoonosis caused by adult trematodes of the Paragonimus genus. The infection in humans is a result of a complex transmission cycle that includes two... (Review)
Review
Paragonimiasis is a zoonosis caused by adult trematodes of the Paragonimus genus. The infection in humans is a result of a complex transmission cycle that includes two obligate intermediate hosts, a snail and a crustacean or a crayfish, and a definitive mammalian host. It has been shown that 9 of the more than 40 species of Paragonimus described affect humans in over 39 countries in Asia, Africa and America. It is estimated that 20.7 million people have paragonimiasis and it is calculated that 195 million people are at risk of being infected. The illness usually is caused once the parasite has settled in the lung at the site of the main clinical symptoms: cough, thoracic pain and hemoptysis. The diagnosis of paragonimiasis is based on the patient's history, the parasitological findings (ova in sputum and in feces), and the result of radiological and immunological tests. In severe cases, the patient may suffer from life-threatening hemoptysis or pneumothorax. Currently, praziquantel is the drug of choice.
Topics: Animals; Colombia; Humans; Lung Diseases, Parasitic; Paragonimiasis; Paragonimus
PubMed: 12092036
DOI: 10.1016/s0272-5231(02)00003-5 -
Clinical Infectious Diseases : An... Sep 2009Paragonimiasis (human infections with the lung fluke Paragonimus westermani) is an important public health problem in parts of Southeast Asia and China. Paragonamiasis... (Review)
Review
Paragonimiasis (human infections with the lung fluke Paragonimus westermani) is an important public health problem in parts of Southeast Asia and China. Paragonamiasis has rarely been reported from North America as a zoonosis caused by Paragonimus kellicotti. Paragonimus species have complex life cycles that require 2 intermediate hosts, namely, snails and crustaceans (ie, crabs or crayfish). Humans acquire P. kellicotti when they consume infected raw crayfish. Humans with paragonimiasis usually present with fever and cough, which, together with the presentation of hemoptysis, can be misdiagnosed as tuberculosis. Only 7 autochthonous cases of paragonimiasis have been previously reported from North America. Our study describes 3 patients with proven or probable paragonimiasis with unusual clinical features who were seen at a single medical center during an 18-month period. These patients acquired their infections after consuming raw crayfish from rivers in Missouri. It is likely that other patients with paragonimiasis have been misdiagnosed and improperly treated. Physicians should consider the possibility that patients who present with cough, fever, hemoptysis, and eosinophilia may have paragonimiasis.
Topics: Adult; Animals; Anthelmintics; Astacoidea; Diagnosis, Differential; Female; Food Contamination; Food Parasitology; Hemoptysis; Humans; Lung Diseases, Parasitic; Male; Missouri; Paragonimiasis; Paragonimus westermani; Praziquantel; Shellfish; Tuberculosis
PubMed: 19681705
DOI: 10.1086/605534 -
PLoS Neglected Tropical Diseases Dec 2023Pulmonary paragonimiasis, a food-borne zoonotic helminthiasis, is a parasitic disease of the lung caused by infection with trematodes species of the genus Paragonimus....
BACKGROUND
Pulmonary paragonimiasis, a food-borne zoonotic helminthiasis, is a parasitic disease of the lung caused by infection with trematodes species of the genus Paragonimus. Although pneumothorax has been reported as occuring with paragonimiasis, to date no study has been performed concerning the clinical features and predictive risk factors for this condition.
METHODS
This retrospective study, which aims to fill this gap, was conducted at Jeonbuk National University Hospital. All patients (aged ≥19 years) were diagnosed with paragonimiasis between May 2011 and December 2021. Medical records were reviewed and information concerning age, sex, vital signs, underlying diseases, clinical signs and symptoms, laboratory findings, radiologic findings, treatment, and clinical outcomes was collected. An odds ratio (OR) for the risk factors associated with pneumothorax was calculated using the binary logistic regression model.
RESULTS
Among 179 consecutive patients diagnosed with pulmonary paragonimiasis, the postive rate of pneumothorax was 10.6% (19/179). Pneumothorax occurred mostly in the right lung (78.9%, 15/19), and intrapulmonary parenchymal lesions showed an ipsilateral relationship with pneumothorax (94.7%, 18/19). Fifteen patients (78.9%, 15/19) of pneumothorax associated with pulmonary paragonimiasis are accompanied by pleural effusion. Most of patients with pneumothorax (89.5%, 17/19) underwent chest tube insertion as a first treatment. Three patients (15.8%) showed relapses but in no case was a death recorded. Asthma (odds ratio [OR] 8.10, 95% confidence interval [CI] 1.43-45.91), chest pain (OR 8.15, 95% CI 2.70-24.58), and intrapulmonary lesions (OR 8.94, 95% CI 1.12-71.36) were independent risk factors for pulmonary paragonimiasis-associated pneumothorax.
CONCLUSIONS
Our findings suggest that clinicians should keep in mind the possibility of pneumothorax when approached by patients with pulmonary paragonimiasis complaining of chest pain, accompanied by intrapulmonary lesions or with asthma as an underlying disease.
Topics: Animals; Humans; Paragonimiasis; Pneumothorax; Retrospective Studies; Paragonimus; Risk Factors; Asthma; Chest Pain
PubMed: 38100524
DOI: 10.1371/journal.pntd.0011828