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Transactions of the Royal Society of... 2000Five newly discovered endemic foci for paragonimiasis in Colombia are described for the first time. The disease was diagnosed in 24 people from the Embera Indian...
Five newly discovered endemic foci for paragonimiasis in Colombia are described for the first time. The disease was diagnosed in 24 people from the Embera Indian communities located at the Colombian Pacific Coast and investigated in 1993-98. We also describe the clinical, epidemiological and treatment response aspects. In these foci an Aroapyrgus sp. snail different from A. colombiensis was found to be the first intermediate host, and the crab Hypolobocera emberarum nsp. the second intermediate host.
Topics: Adolescent; Adult; Animals; Brachyura; Child; Child, Preschool; Colombia; Female; Host-Parasite Interactions; Humans; Male; Middle Aged; Paragonimiasis; Paragonimus; Snails
PubMed: 11198651
DOI: 10.1016/s0035-9203(00)90223-2 -
Scientific Reports Jan 2021Diagnosis of pediatric paragonimiasis is difficult because of its non-specific clinical manifestations. We retrospectively reviewed the records of pediatric...
Diagnosis of pediatric paragonimiasis is difficult because of its non-specific clinical manifestations. We retrospectively reviewed the records of pediatric paragonimiasis in Children's Hospital of Fudan University from January 2011 to May 2019. The confirmed diagnosis of paragonimiasis was based on positive anti-parasite serological tests from the local Center for Disease Control (CDC). A total of 11 patients (mean age: 7.7 ± 3.1, male-female ratio: 7:4) diagnosed as paragonimiasis were included. 81.8% were from endemic areas such as Sichuan and Yunnan, and 36% had a clear history of raw crab or crayfish consumption. The characteristic clinical features of pediatric paragonimiasis were eosinophilia (100%), pleural effusion (81.8%), hepatomegaly (54.5%), ascites (54.5%), and subcutaneous nodules (45.5%). Misdiagnosed with other diseases including tuberculosis (18.2%), pneumonia (9.1%), intracranial space-occupying lesions (9.1%) and brain abcess (9.1%) led to rehospitalization and prolonged hospitalization. For treatment, a 3-day course of 150 mg/kg praziquantel (PZQ) didn't show ideal treatment effectivity and 63.6% needed more than one course of PZQ, while triclabendazole in a total dose of 10 mg/kg had a better efficacy to stubborn manifestations. This study indicated that pediatric paragonimiasis was often misdiagnosed, and the treatment with a 3-day course of 150 mg/kg PZQ had a high rate of failure.
Topics: Animals; Anthelmintics; Child; Child Health; China; Diagnosis, Differential; Diagnostic Errors; Female; Hospitals; Humans; Lung Diseases, Parasitic; Male; Paragonimiasis; Paragonimus; Pleural Effusion; Praziquantel; Retrospective Studies; Risk Factors
PubMed: 33479468
DOI: 10.1038/s41598-021-81694-7 -
Internal Medicine (Tokyo, Japan) May 2004Paragonimiasis is a typical food-borne parasitic disease mainly endemic in Southeast Asia. In Japan, the disease has been re-emerging since the 1980s. In addition,... (Comparative Study)
Comparative Study
OBJECTIVE
Paragonimiasis is a typical food-borne parasitic disease mainly endemic in Southeast Asia. In Japan, the disease has been re-emerging since the 1980s. In addition, recently we encountered an increasing number of immigrants with paragonimiasis in Japan. In this study we summarized the clinical features of immigrants.
PATIENTS AND METHODS
Among a total of 152 paragonimiasis cases referred to and diagnosed in our laboratory during 1998 to 2002, 18 were immigrants. Their clinical features including laboratory data such as eosinophilia and total IgE level were gathered from the consultation sheets from attending physicians.
RESULTS
Among a total of 18 immigrant cases, 16 were from China and 2 from Thailand. A majority of immigrants had eaten freshwater crabs. Most of the Chinese patients were infected as small groups of family and/or compatriots. Chest radiographic findings were variable and multiple lung lesions were seen in about one-half of the patients. About 80% of patients had peripheral blood eosinophilia and 65% had elevated serum IgE level.
CONCLUSION
The clinical features of paragonimiasis in immigrants in Japan were much more severe compared to those of Japanese patients.
Topics: Adolescent; Adult; Age Distribution; Aged; Animals; Antibodies, Helminth; Cohort Studies; Emigration and Immigration; Enzyme-Linked Immunosorbent Assay; Eosinophilia; Female; Humans; Incidence; Japan; Male; Middle Aged; Paragonimiasis; Paragonimus; Praziquantel; Prognosis; Retrospective Studies; Severity of Illness Index; Sex Distribution
PubMed: 15206550
DOI: 10.2169/internalmedicine.43.388 -
BMC Research Notes Jan 2018Paragonimiasis is a foodborne trematode infection of the lungs caused by Paragonimus spp., presenting clinically with similar symptoms to active tuberculosis (TB)....
OBJECTIVE
Paragonimiasis is a foodborne trematode infection of the lungs caused by Paragonimus spp., presenting clinically with similar symptoms to active tuberculosis (TB). Worldwide, an estimated 20.7 million people are infected with paragonimiasis, but relatively little epidemiological data exists for Africa. Given a recently reported case, we sought to establish whether paragonimiasis should be considered as an important differential diagnosis for human TB in The Gambia, West Africa.
RESULTS
We developed a novel PCR-based diagnostic test for Paragonimus species known to be found in West Africa, which we used to examine archived TB negative sputum samples from a cross-sectional study of volunteers with tuberculosis-like symptoms from communities in the Western coastal region of The Gambia. Based on a "zero patient" design for detection of rare diseases, 300 anonymised AFB smear negative sputum samples, randomly selected from 25 villages, were screened for active paragonimiasis by molecular detection of Paragonimus spp. DNA. No parasite DNA was found in any of the sputa of our patient group. Despite the recent case report, we found no evidence of active paragonimiasis infection masking as TB in the Western region of The Gambia.
Topics: Adolescent; Adult; Aged; Child; Diagnosis, Differential; Female; Gambia; Humans; Male; Middle Aged; Paragonimiasis; Polymerase Chain Reaction; Tuberculosis; Young Adult
PubMed: 29334998
DOI: 10.1186/s13104-018-3134-y -
Medicine Apr 2016Pulmonary paragonimiasis is a food-borne zoonosis with a wide variety of radiologic findings, which sometimes can be confused with tuberculosis and carcinoma. Therefore,...
Pulmonary paragonimiasis is a food-borne zoonosis with a wide variety of radiologic findings, which sometimes can be confused with tuberculosis and carcinoma. Therefore, differential diagnosis is always warranted. A 43-year-old male farmer, with productive cough, blood-tinged sputum and chest pain, as well as patchy consolidation and pleural effusions in chest computer tomography, was misdiagnosed of community-acquired pneumonia and tuberculosis. Complete blood cell count, sputum smear and culture, chest computer tomography, thoracoscopy, and biopsy. The diagnosis of pulmonary paragonimiasis was established due to the finding of Charcot-Leyden crystals in the pleural necrosis, and antibodies against Paragonimus westermani in enzyme-linked immunosorbent assay. Paragonimiasis should be considered as a possibility in the differential diagnosis of tuberculosis. Thoracoscopy is an effective and valuable technology that can help make an accurate diagnosis.
Topics: Adult; Animals; Diagnosis, Differential; Diagnostic Errors; Enzyme-Linked Immunosorbent Assay; Humans; Male; Paragonimiasis; Paragonimus westermani; Pleurisy; Pneumonia; Sputum; Thoracoscopy; Tomography, X-Ray Computed; Tuberculosis
PubMed: 27082624
DOI: 10.1097/MD.0000000000003436 -
Hawaii Medical Journal Sep 1974
Topics: Adolescent; Hawaii; Humans; Lung Diseases, Parasitic; Male; Paragonimiasis
PubMed: 4430598
DOI: No ID Found -
Seminars in Roentgenology Oct 1997
Review
Topics: Brain; Brain Diseases; Humans; Lung; Lung Diseases, Parasitic; Magnetic Resonance Imaging; Paragonimiasis; Tomography, X-Ray Computed
PubMed: 9362099
DOI: 10.1016/s0037-198x(97)80024-7 -
Indian Journal of Ophthalmology Oct 2019
Topics: Animals; Anthelmintics; Antibodies, Helminth; Child, Preschool; Diagnosis, Differential; Drug Therapy, Combination; Eye Infections, Parasitic; Female; Glucocorticoids; Humans; Magnetic Resonance Imaging; Methylprednisolone; Ophthalmologic Surgical Procedures; Orbital Diseases; Paragonimiasis; Paragonimus; Praziquantel
PubMed: 31546545
DOI: 10.4103/ijo.IJO_295_19 -
Bulletin of the World Health... 1974Human paragonimiasis has been recorded in 4 West African countries but there is clear evidence of endemicity only in certain parts of Nigeria and Cameroon. In Nigeria,...
Human paragonimiasis has been recorded in 4 West African countries but there is clear evidence of endemicity only in certain parts of Nigeria and Cameroon. In Nigeria, the dominant parasite species is Paragonimus uterobilateralis, while in Cameroon it is P. africanus. Both the fresh water crab Sudanonautes africanus and the land crab S. aubryi are proved vectors in Nigeria. Epidemiological studies using Paragonimus skin tests suggest an infection rate of between 5% and 10% in some endemic areas. African paragonimiasis, like its Asian counterpart, responds well to treatment with bithionol.
Topics: Adolescent; Adult; Arthropod Vectors; Bithionol; Brachyura; Cameroon; Child; Child, Preschool; Female; Geography; Humans; Infant; Infant, Newborn; Male; Middle Aged; Nigeria; Paragonimiasis; Skin Tests
PubMed: 4549201
DOI: No ID Found -
Proceedings of the Australian... 1968
Topics: Adolescent; Adult; Brain Diseases; Calcinosis; Cerebral Angiography; Cerebral Ventriculography; Child; Craniotomy; Diagnosis, Differential; Electroencephalography; Eosinophils; Humans; Leukocyte Count; Lung Diseases; Myocardial Infarction; Neurologic Manifestations; Paragonimiasis; Radiography, Thoracic; Skin Tests
PubMed: 5304244
DOI: No ID Found