-
Psychiatry Research Dec 1993Hebephrenic-like (H) and paranoid-like (P) subtypes of schizophrenia have previously been described by Farmer et al. (1983, 1984). The stability of this subtypology of...
Hebephrenic-like (H) and paranoid-like (P) subtypes of schizophrenia have previously been described by Farmer et al. (1983, 1984). The stability of this subtypology of schizophrenia was explored using multivariate statistical techniques on a large independent data set. Both a discriminant function analysis and an admixture analysis produced strong evidence for a bimodel distribution of scores consistent with the H-like and P-like subtypes.
Topics: Adult; Discriminant Analysis; Female; Humans; Male; Psychiatric Status Rating Scales; Psychometrics; Psychotic Disorders; Reproducibility of Results; Schizophrenia, Disorganized; Schizophrenia, Paranoid
PubMed: 8177916
DOI: 10.1016/0165-1781(93)90061-k -
Acta Psychiatrica Scandinavica Aug 1991In a combined twin-family study, the concordance for subtype of schizophrenia was investigated. The sample included 31 monozygotic (MZ) and 28 dizygotic (DZ) twin...
In a combined twin-family study, the concordance for subtype of schizophrenia was investigated. The sample included 31 monozygotic (MZ) and 28 dizygotic (DZ) twin probands fulfilling the criteria of DSM-III-R schizophrenia. Their co-twins and first-degree relatives were personally interviewed and diagnosed in accordance with DSM-III-R. Any twin or relative diagnosed as schizophrenic was subclassified as either paranoid or nonparanoid. Schizophrenia was more often observed in co-twins of MZ probands with nonparanoid schizophrenia than in MZ probands with paranoid schizophrenia, indicating a stronger genetic influence in nonparanoid schizophrenia. Fifteen MZ pairs were concordant for schizophrenia, and 13 of these pairs were also concordant for subtype. Such a relationship was not observed in the first-degree relatives with schizophrenia. Our results indicate a complex etiology of subtypes in schizophrenia, and to some extent the etiology of subtypes may differ from the etiology of schizophrenia.
Topics: Adult; Diseases in Twins; Female; Humans; Male; Middle Aged; Norway; Psychiatric Status Rating Scales; Schizophrenia; Schizophrenia, Paranoid; Schizophrenic Psychology
PubMed: 1950618
DOI: 10.1111/j.1600-0447.1991.tb03129.x -
British Journal of Hospital Medicine Nov 1978Paranoid states is a term that covers a number of different disorders in which persecutory and grandiose ideas and delusions constitute a significant part of the...
Paranoid states is a term that covers a number of different disorders in which persecutory and grandiose ideas and delusions constitute a significant part of the symptoms. The most important are those conditions that are now generally accepted as being members of the group of schizophrenias. These symptoms become more important in conditions of social isolation and sensory deprivation. They appear in some organic cerebral conditions and may colour any breakdown that develops in some types of personality.
Topics: Hearing Disorders; Humans; Personality; Schizophrenia, Paranoid
PubMed: 737362
DOI: No ID Found -
Journal Der Deutschen Dermatologischen... Apr 2010Delusional parasitosis (DP) is the most frequent delusional disorder in dermatology. In DP there is a fixed belief of a usually skin-related invasion or infestation by a... (Review)
Review
Delusional parasitosis (DP) is the most frequent delusional disorder in dermatology. In DP there is a fixed belief of a usually skin-related invasion or infestation by a number of alleged infectious species (usually parasites and bacteria), whose identity has varied over the decades. Since 2002 worldwide an increasing number of patients have complained of unverifiable fibers and filaments in or on the skin, associated with numerous nonspecific complaints (arthralgias, altered cognitive function and extreme fatigue). This entity has been named "Morgellons disease" by the patients themselves, although medical evidence for its existence is lacking. As an example, we discuss a 55-year-old woman who complained of Morgellons disease and was treated as if she had DP. Currently the delusional assumption of infestation with Morgellons should be considered as a new type of DP with some kind of inanimate material. We therefore recommend in case of DP including Morgellons the use of the broader term "delusional infestation".
Topics: Female; Humans; Morgellons Disease; Schizophrenia, Paranoid; Skin Diseases, Parasitic; Terminology as Topic
PubMed: 19878403
DOI: 10.1111/j.1610-0387.2009.07219.x -
The Journal of Neuropsychiatry and... 1992Previous research found that both persons with schizophrenia and their unaffected relatives had significantly more neurologic signs than normal controls. As...
Previous research found that both persons with schizophrenia and their unaffected relatives had significantly more neurologic signs than normal controls. As hypothesized, in this study neurologic signs were significantly greater in patients with nonparanoid than paranoid schizophrenia; the difference was greatest for "hard" signs.
Topics: Adult; Chronic Disease; Female; Humans; Male; Neurocognitive Disorders; Neurologic Examination; Neuropsychological Tests; Schizophrenia; Schizophrenia, Paranoid; Schizophrenic Psychology
PubMed: 1422173
DOI: 10.1176/jnp.4.4.447 -
Schizophrenia Bulletin Mar 2014In his textbook from 1838, Esquirol made the first comprehensive psychopathological description of paranoia, which he labeled partial psychosis. This was a condition... (Review)
Review
In his textbook from 1838, Esquirol made the first comprehensive psychopathological description of paranoia, which he labeled partial psychosis. This was a condition with encapsulated, well organized, and persistent delusions. These are defended with a great deal of emotions and sharp argument. The individual appears quite convincing, especially because he or she otherwise behaves rationally. The intellectual capacity is used to achieve defined goals according to the delusional content. This condition is difficult to uncover because of dissimulation and adaptation. The frequency in the population is unknown, but the condition is rare in psychiatric treatment facilities, and usually only when the persons become litigious or criminal. In Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, the condition is covered by the concept of delusional disorder, but that concept also comprises benign acute/subacute conditions as well as cases that turn out to have the diagnosis changed to schizophrenia.
Topics: Diagnostic and Statistical Manual of Mental Disorders; Humans; Psychotic Disorders; Schizophrenia, Paranoid
PubMed: 24421383
DOI: 10.1093/schbul/sbt203 -
Journal of Abnormal Psychology Nov 1991This prospective longitudinal study examined symptoms and adjustment at 2 and 4 years posthospital discharge in Research Diagnostic Criteria (RDC) and Diagnostic and...
This prospective longitudinal study examined symptoms and adjustment at 2 and 4 years posthospital discharge in Research Diagnostic Criteria (RDC) and Diagnostic and Statistical Manual (DSM-III) schizophrenia subtypes and in DSM-III schizophreniform disorder. Delusions, hallucinations, thought disorder, anxiety, depression, and specific areas of community adjustment were assessed at each follow-up. RDC acute and subacute schizophrenia and DSM-III schizophreniform disorder were associated with more satisfactory overall adjustment and lower frequencies of psychotic symptoms over time. No significant differences in the course of symptoms or adjustment were found between paranoid and undifferentiated schizophrenia subtypes. Schizophrenia subtyping schemes based on length of illness features appear more prognostically viable than do symptom-based approaches.
Topics: Acute Disease; Adult; Chronic Disease; Diagnosis, Differential; Follow-Up Studies; Humans; Longitudinal Studies; Psychotic Disorders; Schizophrenia; Schizophrenia, Paranoid; Schizophrenic Psychology
PubMed: 1757674
DOI: 10.1037//0021-843x.100.4.600 -
European Psychiatry : the Journal of... Sep 2001Since reports have underscored that panic attacks (PA) may be an identifiable state occurring in schizophrenia, we studied the symptomatology of PA in a group of...
Since reports have underscored that panic attacks (PA) may be an identifiable state occurring in schizophrenia, we studied the symptomatology of PA in a group of schizophrenic patients. Of 40 patients (21 males and 19 females) attending a clinic for maintenance therapy of schizophrenia, 19 (36.8%) had a lifetime history of PA. Seven among those 19 patients (36.8%) had or had had spontaneous panic attacks, not related to phobic fears or delusional fears, and for the 12 remaining patients, the PA were related to paranoid ideas. Moreover, the paranoid subtype of schizophrenia tends to be more often associated with a history of panic attack than other subtypes of schizophrenia (52.6% vs 23.8%; chi2 = 3.5, P =.06). It seems that there are at least two types of PA in schizophrenic patients. The first one could be independent from the psychotic feature, with no psychopathological link. The second kind of PA could be directly related to a schizophrenic disorder, and found in patients with the paranoid subtype.
Topics: Adult; Female; Humans; Male; Panic Disorder; Psychiatric Status Rating Scales; Psychopathology; Schizophrenia; Schizophrenia, Paranoid; Schizophrenic Psychology
PubMed: 11585715
DOI: 10.1016/s0924-9338(01)00590-9 -
[Primary diagnosis of schizophrenia in the framework of inpatient forensic psychiatric examination].Zhurnal Nevrologii I Psikhiatrii Imeni... 2022To study the primary diagnosis of schizophrenia spectrum disorders within the framework of an inpatient forensic psychiatric examination.
OBJECTIVE
To study the primary diagnosis of schizophrenia spectrum disorders within the framework of an inpatient forensic psychiatric examination.
MATERIAL AND METHODS
A retrospective analysis of 52 accused, who underwent inpatient forensic psychiatric examination at Alexeev Mental Clinic No. 1 in the period 2018-2020, was carried out. Patients were divided into two groups. Group 1 included 39 patients newly diagnosed with paranoid schizophrenia and group 2 consisted of 13patients diagnosed with schizotypal disorder. Diagnosis was based on the ICD-10 criteria (F20 and F21). Clinical and psychopathological method was used as the main research tool.
RESULTS
The study group is represented mainly by young people (88.4%, =46) with secondary (78.8%, =41), less often higher (21.25, =11) education, with a decrease in social adaptation and signs of «social drift» (90.3%, =47). Difficulties in diagnosis at the initial stages of an endogenous disease are due to the presence of neurotic disorders that do not affect the nature of social functioning. In group 2, there was a slow increase in personality changes. The commission of unlawful actions by productive-psychopathological mechanisms was observed in 73% of cases (=38).
CONCLUSION
The primary diagnosis of endogenous mental disorders in a forensic situation, carried out during an inpatient forensic psychiatric examination, determines the correctness of the assessment of the level of danger and the choice of compulsory medical measures.
Topics: Adolescent; Humans; Inpatients; Psychopathology; Retrospective Studies; Schizophrenia, Paranoid; Schizotypal Personality Disorder
PubMed: 35238512
DOI: 10.17116/jnevro202212201255 -
European Psychiatry : the Journal of... Jan 2005Dysfunctions of glutamatergic and GABAergic neurotransmission are two important hypotheses for the pathogenesis of schizophrenia. Thus, genes in the pathway are...
Dysfunctions of glutamatergic and GABAergic neurotransmission are two important hypotheses for the pathogenesis of schizophrenia. Thus, genes in the pathway are candidates for schizophrenia susceptibility. Phosphate-activated glutaminase (GLS), glutamine synthetase (GLUL), glutamic acid decarboxylase (GAD), GABA transaminase (ABAT) and succinic semialdehyde dehydrogenase (ALDH5A1) are five primary enzymes in glutamate and GABA synthetic and degradative pathway. In order to investigate the possible involvement of these genes in the development of paranoid schizophrenia, we genotyped 80 paranoid schizophrenics from northern China and 108 matched controls by polymerase chain reaction (PCR) and restriction fragment length polymorphisms (RFLP) methods or directly sequencing of PCR product. Seven SNPs were found to be polymorphic in the population investigated. No significant differences in the genotype distributions or allele frequencies between patients and controls were found. Therefore, we conclude the polymorphisms studied in the five genes do not play major roles in pathogenesis of paranoid schizophrenia in the population investigated.
Topics: Adult; Asian People; Enzymes; Female; Glutamic Acid; Humans; Male; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Schizophrenia, Paranoid; Signal Transduction; gamma-Aminobutyric Acid
PubMed: 15642443
DOI: 10.1016/j.eurpsy.2004.09.028