-
American Journal of Medical Genetics.... Jun 2023
Topics: Female; Child; Humans; Paraparesis, Spastic; Mothers; Developmental Disabilities; Phenotype; Spastic Paraplegia, Hereditary; Transcription Factor 7-Like 2 Protein
PubMed: 36905089
DOI: 10.1002/ajmg.a.63173 -
Journal of Biomechanics May 2019Individuals with hereditary spastic paraparesis (HSP) are often impaired in their ability to control posture as a result of the neurological and musculoskeletal...
Individuals with hereditary spastic paraparesis (HSP) are often impaired in their ability to control posture as a result of the neurological and musculoskeletal implications of their condition. This research aimed to assess postural stability during gait in a group of adults with HSP. Ten individuals with HSP and 10 healthy controls underwent computerized gait analysis while walking barefoot along a 10-m track. Two biomechanics methods were used to assess stability: the center of pressure and center of mass separation (COP-COM) method, and the extrapolated center of mass (XCOM) method. Spatiotemporal and kinematic variables were also investigated. The XCOM method identified deficits in mediolateral stability for the HSP group at both heel strike and mid-stance. The group with HSP also had slower walking velocity, lower cadence, more time spent in double stance, larger step widths, and greater lateral trunk flexion than the control group. These results suggest that individuals with HSP adjust characteristics of their gait to minimize the instability arising from their impairments but have residual deficits in mediolateral stability. This may result in an increased risk of falls, particularly in the sideways direction.
Topics: Accidental Falls; Adult; Biomechanical Phenomena; Female; Gait; Humans; Male; Paraparesis, Spastic; Postural Balance; Range of Motion, Articular
PubMed: 30862381
DOI: 10.1016/j.jbiomech.2019.03.001 -
Annals of Vascular Surgery Aug 2011Thoracic endovascular aortic repair (TEVAR) is an important surgical option for the emergency treatment of ruptured thoracic aortic aneurysms, but is associated with a... (Review)
Review
Thoracic endovascular aortic repair (TEVAR) is an important surgical option for the emergency treatment of ruptured thoracic aortic aneurysms, but is associated with a risk of spinal cord ischemia (SCI). Although risk factors for the development of SCI have been well described, the effectiveness of treatment to increase spinal cord perfusion pressure remains incompletely understood. We report the successful treatment of delayed-onset paraparesis after revision TEVAR for acute descending thoracic aortic rupture with the combined use of blood pressure augmentation and cerebrospinal fluid drainage. The clinical manifestations, pathophysiology, and management of SCI after TEVAR are reviewed.
Topics: Aged, 80 and over; Aortic Aneurysm, Thoracic; Aortic Rupture; Aortography; Blood Pressure; Blood Vessel Prosthesis Implantation; Drainage; Endovascular Procedures; Humans; Male; Paraparesis; Recovery of Function; Spinal Cord Ischemia; Spinal Puncture; Time Factors; Tomography, X-Ray Computed; Treatment Outcome; Vasoconstrictor Agents
PubMed: 21621971
DOI: 10.1016/j.avsg.2010.12.043 -
The Journal of Pediatrics Oct 2018
Topics: Child; Humans; Hyperpigmentation; Injections, Intramuscular; Magnetic Resonance Imaging; Male; Paraparesis; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin B Complex
PubMed: 29730144
DOI: 10.1016/j.jpeds.2018.03.073 -
Journal of Veterinary Internal Medicine 2006
Topics: Animals; Camelids, New World; Fatal Outcome; Female; Intervertebral Disc; Magnetic Resonance Imaging; Paraparesis; Spondylitis; Thoracic Vertebrae
PubMed: 17063729
DOI: 10.1892/0891-6640(2006)20[1256:piaaaw]2.0.co;2 -
Acta Neurochirurgica Nov 2003Chronic spinal epidural haematomas are very rare and have been reported to occur only in the lumbar region. They usually become symptomatic through radicular pain or... (Review)
Review
Chronic spinal epidural haematomas are very rare and have been reported to occur only in the lumbar region. They usually become symptomatic through radicular pain or neurogenic claudication. The epidural bleeding is thought to originate from a rupture of an epidural vein due to a sudden increase in intra-abdominal pressure or due to trauma. The patient reported on here developed acute paraparesis about 8 weeks after a mild fall on the buttocks. MRI showed a spinal epidural mass located dorsolaterally at the level of L3-L5. The mass was surgically removed. Histological and immunohistological studies disclosed an organised haematoma. The clinical, radiological and intra-operative features of this case are described, and the relevant literature is analysed.
Topics: Acute Disease; Aged; Aged, 80 and over; Chronic Disease; Hematoma, Epidural, Cranial; Humans; Lumbar Vertebrae; Male; Paraparesis
PubMed: 14628208
DOI: 10.1007/s00701-003-0135-x -
The Journal of Small Animal Practice May 2014A case of protothecosis causing non-ambulatory paraparesis in a dog without clinical evidence of disseminated infection is described. A five-year-old female Labrador...
A case of protothecosis causing non-ambulatory paraparesis in a dog without clinical evidence of disseminated infection is described. A five-year-old female Labrador retriever was referred with a 10-day history of progressive non-ambulatory paraparesis and lumbar pain as the only physical and neurological abnormalities. Lumbar myelography revealed severe extradural spinal cord compression extending from L4 to L7 vertebrae, and a right hemilaminectomy was performed. Surgical findings included an adherent whitish hard ill-defined mass. Cytology and biopsy results disclosed the presence of algae enclosed in a matrix of chronic inflammatory infiltrate. Culture confirmed the presence of Prototheca species. Neurological improvement occurred within a month, and the dog received antifungal treatment without evidence of clinical disseminated disease for 6 months, but died after a generalised tonic-clonic seizure. Post-mortem examination revealed multiple foci of inflammatory granulomatous infiltrate and algae-like structures in the brain, lumbar intumescence and cauda equina. Prototheca zopfii was identified using molecular biology methods.
Topics: Animals; Dog Diseases; Dogs; Female; Infections; Paraparesis; Prototheca
PubMed: 24502403
DOI: 10.1111/jsap.12188 -
Journal of the Neurological Sciences Feb 2018
Topics: Adult; Brucellosis; Diagnosis, Differential; Hearing Loss, Sensorineural; Humans; Magnetic Resonance Imaging; Male; Paraparesis, Spastic
PubMed: 29406895
DOI: 10.1016/j.jns.2017.12.036 -
PM & R : the Journal of Injury,... May 2019Atraumatic spinal cord injuries can be due to inflammatory, vascular, and nutritional etiologies. Due to progression from these causes, the identification and initiation...
Atraumatic spinal cord injuries can be due to inflammatory, vascular, and nutritional etiologies. Due to progression from these causes, the identification and initiation of appropriate treatment are of significant importance. This article explores a case of copper deficiency myeloneuropathy in a patient initially thought to have an inflammatory transverse myelitis. The lack of response to antirheumatologic interventions prompted an extensive workup consistent with copper deficiency. This case stresses the importance of evaluating nutritional causes of myeloneuropathy. LEVEL OF EVIDENCE: V.
Topics: Copper; Humans; Male; Middle Aged; Paraparesis; Subacute Combined Degeneration; Trace Elements
PubMed: 30742362
DOI: 10.1002/pmrj.12005 -
BMJ Case Reports Oct 2019We describe the case of a 76-year-old man who presented with bilateral lower limb weakness associated with decreased urine output. His initial blood results showed acute...
We describe the case of a 76-year-old man who presented with bilateral lower limb weakness associated with decreased urine output. His initial blood results showed acute kidney injury (AKI) stage 3 with substantially raised serum creatine kinase concentration of 37 950 IU/L (normal range <171 U/L). He had been on high-dose rosuvastatin for 4 years with a recent brand change occurring 1 week prior to onset of symptoms. There was no history of pre-existing neuromuscular disease. Statin-related rhabdomyolysis was suspected and rosuvastatin was withheld. His muscle strength gradually improved. He required haemodialysis for 10 weeks. He was discharged home after a complicated course of hospitalisation. His renal function improved and he became dialysis-independent; however, he was left with residual chronic kidney disease.
Topics: Acute Kidney Injury; Aged; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Paraparesis; Renal Dialysis; Rhabdomyolysis; Rosuvastatin Calcium; Withholding Treatment
PubMed: 31601550
DOI: 10.1136/bcr-2019-229244