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South African Medical Journal =... Oct 1959
Topics: Organophosphate Poisoning; Parathion
PubMed: 14410012
DOI: No ID Found -
Residue Reviews 1977
Review
Topics: Animals; Biodegradation, Environmental; Fresh Water; Nitrophenols; Paraoxon; Parathion; Pesticide Residues; Soil; Water Supply
PubMed: 337436
DOI: 10.1007/978-1-4612-6355-5_4 -
IARC Monographs on the Evaluation of... Jan 1983
Topics: Animals; Carcinogens; Carcinogens, Environmental; Chemical Phenomena; Chemistry; Humans; Mutagens; Parathion; Reproduction
PubMed: 6578178
DOI: No ID Found -
Environmental Science. Processes &... Dec 2022Parathion, a once commonly used pesticide known for its potential toxicity, can follow several degradation mechanisms in the environment. Given the species stability and...
Parathion, a once commonly used pesticide known for its potential toxicity, can follow several degradation mechanisms in the environment. Given the species stability and persistence, parathion can be washed into waterways from rain, and therefore an atomistic perspective of the hydrolysis of parathion, and its byproduct paraoxon, is required in order to understand its fate in the environment. Experimental studies have determined that pH plays an important role in the calculated hydrolysis rate constants of parathion degradation. In this work, the degradation of parathion into either paraoxon or 4-nitrophenol, and the degradation of paraoxon to 4-nitrophenol are explored through density functional theory using the M06-2X functional. How the level of basicity affects the reaction mechanism is explored through two different hydroxide/water environments. Our calculations support the anticipated mechanisms determined by previous experimental work that the formation of 4-nitrophenol is the predominant pathway in hydrolysis of parathion.
Topics: Parathion; Paraoxon; Hydrolysis; Density Functional Theory
PubMed: 36129094
DOI: 10.1039/d2em00296e -
The New England Journal of Medicine Jun 1960
Topics: Parathion
PubMed: 14438877
DOI: 10.1056/NEJM196006162622415 -
Boletin Medico Del Hospital Infantil de... May 1989This study shows our clinical and therapeutical experience in 48 cases of infant COFA intoxication admitted in the Intensive Care Unit of "Emilio Civit Children...
This study shows our clinical and therapeutical experience in 48 cases of infant COFA intoxication admitted in the Intensive Care Unit of "Emilio Civit Children Hospital", Mendoza, Argentina in a periode of seven years. They were investigated to determine the presence of Parathion in blood and gastric washing with the sodium hydroxide qualitative method, and also cholinesterase was detected in blood with a colorimetric method (the monotest cholinesterase). Age range from one to ten years with predominance from 3 to 4 years; 27 were males and 21 females. In almost all the cases (90%) the toxic ingressed through several ways, and from 10 to 30 minutes appeared the characteristic signs: miosis and bronchorrhea. Clinically in 30 cases the intoxication was considered dangerous and mild in the others. The data obtained by laboratory techniques were diagnostic only in half of the cases. Atropine's sulphate was done to all cases until their recuperation, in doses from 2.5 mg to 20 mg. The evolution was highly satisfactory, only two died and two remained with seizures. Always had thanklessness and carelessness with the child from living together adults, who playing handle and waste the toxic. In two occasions the intoxication was familiar by contaminated food.
Topics: Child; Child, Preschool; Female; Humans; Infant; Male; Parathion
PubMed: 2757776
DOI: No ID Found -
Drug Metabolism Reviews 1981
Review
Topics: Animals; Chloramphenicol; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Humans; In Vitro Techniques; Liver; Parathion
PubMed: 7040015
DOI: 10.3109/03602538108994031 -
Belgisch Tijdschrift Voor Geneeskunde Mar 1961
Topics: Organophosphate Poisoning; Parathion
PubMed: 13725912
DOI: No ID Found -
Archives of Toxicology Jan 1988The plasma kinetics of parathion were studied in rabbits after i.v. administration of a dose of 1.5 mg/kg and oral administration of 3 mg/kg. The time course of...
The plasma kinetics of parathion were studied in rabbits after i.v. administration of a dose of 1.5 mg/kg and oral administration of 3 mg/kg. The time course of parathion plasma levels administered intravenously followed a three-compartment kinetic model statistically, whereas when administration was oral, the optimum kinetic model proved to be two-compartmental. The process of the absorption of parathion is very fast with a mean value for the absorption constant (ka) of 33 +/- 15.41 h-1. The slow disposition half-lives for i.v. and oral administration had mean values of 5.08 +/- 3.08 and 1.08 +/- 0.27 h, respectively. From the values established for the parameters defining the distribution process the wide accessibility of parathion to the different body organs and tissues may be seen. Although the compound has a high elimination constant, this process is not limiting to distribution.
Topics: Administration, Oral; Animals; Injections, Intravenous; Male; Parathion; Rabbits
PubMed: 3355364
DOI: 10.1007/BF00316634 -
IARC Monographs on the Evaluation of... Jan 1983
Topics: Animals; Carcinogens; Carcinogens, Environmental; Chemical Phenomena; Chemistry; Humans; Methyl Parathion; Mutagens; Parathion; Reproduction
PubMed: 6578177
DOI: No ID Found