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Clinical Oral Implants Research Jul 2013Restoration of an adequate blood supply is essential for the bone healing process and is key to the success of bone augmentation procedures. In this study, we evaluated...
OBJECTIVES
Restoration of an adequate blood supply is essential for the bone healing process and is key to the success of bone augmentation procedures. In this study, we evaluated angiogenesis in rat calvarial flat bone defects using in vivo microfocus computed tomography (micro-CT).
MATERIALS AND METHODS
Twenty rats were used. The calvarium was exposed and calvarial bone defects of critical (5-mm diameter) and non-critical (2.7-mm diameter) sizes were prepared. Bone regeneration and angiogenesis were evaluated by image analysis using micro-CT and histological examination.
RESULTS
Critical- and non-critical-sized calvarial bone defects showed bone regeneration and angiogenesis around the midsagittal suture. Critical-sized calvarial bone defects showed approximately 1.2% reossification of the original surgical defect, whereas the non-critical-sized defects showed approximately 43.3% reossification at day 28. Furthermore, angiogenesis was observed later in the critical-sized calvarial bone defects (about 38.2%), whereas angiogenesis was observed early in the non-critical-sized calvarial bone defects (about 75.5%) at day 28. New blood vessel networks were observed around defects of both sizes.
CONCLUSIONS
Angiogenesis preceded bone regeneration around critical- and non-critical-sized calvarial bone defects. Angiogenesis led to full bone formation in non-critical-sized defects.
Topics: Angiography; Animals; Bone Diseases; Bone Regeneration; Connective Tissue; Cranial Sutures; Image Processing, Computer-Assisted; Male; Neovascularization, Physiologic; Osteogenesis; Parietal Bone; Rats; Rats, Inbred F344; Time Factors; X-Ray Microtomography
PubMed: 22458557
DOI: 10.1111/j.1600-0501.2012.02458.x -
Anatomischer Anzeiger 19821500 skulls have been studies for the preinterparietal bone. It has been found in 6 skulls (0.4%), occupying the superior angle of the occipital bone lying posterior to...
1500 skulls have been studies for the preinterparietal bone. It has been found in 6 skulls (0.4%), occupying the superior angle of the occipital bone lying posterior to the parieto-occipital suture. In this study the dispute regarding the preinterparietal bone, whether a wormian bone or a separate entity, has been widely taken into account and discussed.
Topics: Humans; Parietal Bone
PubMed: 7165116
DOI: No ID Found -
Zhong Nan Da Xue Xue Bao. Yi Xue Ban =... Jan 2017Cholesteatoma is a destructive and expanding growth benign tumor, mainly consisting of stratified squamous epithelium. It possesses the capacity of eroding bone and can...
Cholesteatoma is a destructive and expanding growth benign tumor, mainly consisting of stratified squamous epithelium. It possesses the capacity of eroding bone and can exist in a nonaggressive state, remaining undetected for years. Once cholesteatoma appeared, it grows relentlessly and threats to invade intra-temporal structures. Most cholesteatomas occurred in the petrous bone and also affected the labyrinth and middle cranial fossa. Here, we report a preliminary wrongly-diagnosed case. The patient was wrongly diagnosed as "sebaceous cyst with infection" by local hospital. The definite diagnosis was made after the surgery performed by our department, which was confirmed by pathological result. So far, there were few reports of giant cholesteatoma which occurs in fronto-parietal part of skull with bone defect.
Topics: Cholesteatoma; Diagnosis, Differential; Diagnostic Errors; Epidermal Cyst; Humans; Parietal Bone
PubMed: 28216507
DOI: 10.11817/j.issn.1672-7347.2017.01.018 -
Anales Espanoles de Pediatria Oct 2001
Topics: Bone Diseases; Child; Humans; Male; Parietal Bone; Radiography
PubMed: 11578555
DOI: No ID Found -
Archives of Oral Biology Aug 1968
Topics: Animals; Cephalometry; Parietal Bone; Radiography; Rats; Sex Factors; Staining and Labeling
PubMed: 4179700
DOI: 10.1016/0003-9969(68)90004-6 -
The British Journal of Radiology Jun 1975The parietal bone seems to be the target for a number of different developmental conditions of the calvaria some of which are congenital whilst others develop in later... (Review)
Review
The parietal bone seems to be the target for a number of different developmental conditions of the calvaria some of which are congenital whilst others develop in later life. The characteristic radiological patterns of a number of these lesions are described and illustrated, and an attempt is made to correlate the pathology with alterations in bone growth.
Topics: Adult; Age Factors; Aged; Bone Diseases, Developmental; Central Nervous System Diseases; Child; Child, Preschool; Dermoid Cyst; Female; Humans; Infant; Infant, Newborn; Male; Parietal Bone; Radiography; Scalp; Skull
PubMed: 776315
DOI: 10.1259/0007-1285-48-570-421 -
Endocrinology Nov 1991Previous studies have shown that both interleukin-1 (IL-1) and glucocorticoids inhibit collagen synthesis in bone organ and cell cultures. In this study we examined...
Previous studies have shown that both interleukin-1 (IL-1) and glucocorticoids inhibit collagen synthesis in bone organ and cell cultures. In this study we examined their interactions in cultured neonatal mouse parietal bones. IL-1 alpha stimulated [3H]thymidine incorporation. Cortisol decreased thymidine incorporation, but did not block the effect of IL-1. Both cortisol and IL-1 alpha decreased the incorporation of [3H]proline into collagenase-digestible protein (CDP) and reduced alpha 1(I)procollagen mRNA levels at 72 h. Noncollagen protein (NCP) labeling was increased by IL-1 and decreased by cortisol. In the presence of cortisol, IL-1 alpha (6 pM) increased CDP as well as NCP labeling. The increase in CDP labeling was paralleled by an increase in alpha 1(I)procollagen mRNA, suggesting a pretranslational site for the cortisol-IL-1 alpha interaction. In the same bones, cortisol consistently blocked IL-1 alpha-stimulated 45Ca release and prostaglandin E2 (PGE2) production. The ability of IL-1 alpha to increase CDP in the presence of cortisol was the same in the presence or absence of indomethacin, an inhibitor of PGE2 synthesis, or aphidicholin (30 microM), an inhibitor of DNA synthesis, indicating that the reversal was neither PG mediated nor dependent on cell proliferation. In conclusion, our results demonstrate that IL-1 inhibits collagen, but not NCP or DNA, synthesis and that cortisol inhibits IL-1 alpha-induced bone resorption and PGE2 production and reverses its inhibitory effect on collagen synthesis in cultured neonatal mouse calvariae.
Topics: Animals; Bone Resorption; Collagen; Dose-Response Relationship, Drug; Hydrocortisone; Indomethacin; Interleukin-1; Mice; Organ Culture Techniques; Osmolar Concentration; Osteogenesis; Parietal Bone; Prostaglandins; Thymidine
PubMed: 1935798
DOI: 10.1210/endo-129-5-2699 -
Journal of Neurosurgery Aug 1972
Topics: Adolescent; Bone Cysts; Female; Hemangioma; Humans; Parietal Bone; Skull
PubMed: 5046093
DOI: 10.3171/jns.1972.37.2.0237 -
The Journal of Craniofacial Surgery Jan 2019To evaluate the utility and efficacy of bioabsorbable hydroxyapatite and collagen complex (HA/Col) for cranioplasty repair of cranial bone defects in children.
PURPOSE
To evaluate the utility and efficacy of bioabsorbable hydroxyapatite and collagen complex (HA/Col) for cranioplasty repair of cranial bone defects in children.
METHODS
Two patients (a 6-year-old male and 11-year-old female) with Treacher Collins syndrome received zygoma and orbital floor reconstruction using a full thickness of parietal bone. The bone grafts were taken from each patient's parietal cranium. The right parietal cranial defect was repaired with autologous bone dust, and the left side was repaired with HA/Col in each patient. Computed tomography scans were taken immediately after and at 12 months following surgery. The osteosynthesis areas and thicknesses were measured using computer-aided engineering.
RESULTS
Both patients experienced no complications, including infection. In the 6- and 11-year-old patients, the extent of osteosynthesis for HA/Col was 92.2% and 89.4%, respectively; and for the autologous bone dust was 78.5% and 53.2%, respectively. Because of the small sample size, a significant difference could not be calculated; however, the percentage of osteosynthesis for HA/Col was higher than for the autologous bone dust.
CONCLUSION
This study showed that HA/Col can be effectively used in cranial defects and can be considered an alternative graft material for cranial reconstruction.
Topics: Absorbable Implants; Biocompatible Materials; Bone Regeneration; Bone Transplantation; Child; Durapatite; Female; Humans; Male; Mandibulofacial Dysostosis; Parietal Bone; Plastic Surgery Procedures; Tomography, X-Ray Computed
PubMed: 30444784
DOI: 10.1097/SCS.0000000000004974 -
Annals of Plastic Surgery Apr 2016Inlay cranioplasty in children is challenging because autologous bone is limited. Cranial particulate bone graft effectively closes defects when placed over normal dura....
BACKGROUND
Inlay cranioplasty in children is challenging because autologous bone is limited. Cranial particulate bone graft effectively closes defects when placed over normal dura. The purpose of this study was to determine if particulate bone graft will ossify when used for secondary cranioplasty over scarred dura.
METHODS
A 17 × 17-mm critical-sized defect was made in the parietal bone of 16 rabbits. Four animals had no implant (group 1). Twelve animals had the defect remade 16 weeks postoperatively, which was managed in 2 ways: group 2 (no implant; n = 6) and group 4 (particulate bone graft; n = 6). Particulate graft was obtained using a brace and bit from the frontal bone. Computed tomography was used to determine the area of ossification and thickness of the healed graft. Eight animals previously managed with particulate bone graft over normal dura were used as an additional control (group 3).
RESULTS
Critical-sized defects filled with particulate bone graft over scarred dura (group 4) exhibited superior healing of the area (83.8%; range, 73.0%-90.6%) compared to control defects over normal dura (group 1: 62.9%; range, 56.5%-73.4%) or scarred dura (group 2: 56.9%; range, 40.0%-68.3%) (P = 0.0004). Particulate bone on scarred dura exhibited less ossified area (P = 0.002), and thinner bone (0.95 mm, range, 0.71-1.32 mm) compared to defects in which graft was placed over normal dura (group 3: area, 99.2%; range, 96.8%-100%; thickness, 1.9 mm, range; 1.1-3.1 mm) (P = 0.04).
CONCLUSIONS
Particulate bone graft ossifies inlay cranial defects over scarred dura although inferior to placement over normal dura. Clinically, particulate bone graft may be used for secondary inlay cranioplasty.
Topics: Animals; Bone Transplantation; Cicatrix; Craniotomy; Dura Mater; Frontal Bone; Osteogenesis; Parietal Bone; Rabbits; Plastic Surgery Procedures; Reoperation
PubMed: 25643186
DOI: 10.1097/SAP.0000000000000396